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WO2003082923A1 - Procede de reticulation de polypeptides - Google Patents

Procede de reticulation de polypeptides Download PDF

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Publication number
WO2003082923A1
WO2003082923A1 PCT/JP2002/008179 JP0208179W WO03082923A1 WO 2003082923 A1 WO2003082923 A1 WO 2003082923A1 JP 0208179 W JP0208179 W JP 0208179W WO 03082923 A1 WO03082923 A1 WO 03082923A1
Authority
WO
WIPO (PCT)
Prior art keywords
crosslinking
polypeptides
surrounded
amino acids
low
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/008179
Other languages
English (en)
Japanese (ja)
Inventor
Haruhiko Fujiwara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU2002323960A priority Critical patent/AU2002323960A1/en
Publication of WO2003082923A1 publication Critical patent/WO2003082923A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y110/00—Oxidoreductases acting on diphenols and related substances as donors (1.10)
    • C12Y110/03—Oxidoreductases acting on diphenols and related substances as donors (1.10) with an oxygen as acceptor (1.10.3)
    • C12Y110/03001—Catechol oxidase (1.10.3.1), i.e. tyrosinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un procédé de réticulation de polypeptides contenant de la tyrosine entourée par des acides aminés non chargés possédant des chaînes latérales de faible poids moléculaire au moyen du traitement d'un tel polypeptide avec une phénol oxydase. Cette réticulation est catalysée par des phénol oxydases, telles que la tyrosinase, et cette catalyse est spécifique de la tyrosine entourée par des acides aminés non chargés présentant des chaînes latérales de faible poids moléculaire. Ce procédé est utilisé dans la réticulation de polypeptides arbitraires.
PCT/JP2002/008179 2002-04-03 2002-08-09 Procede de reticulation de polypeptides Ceased WO2003082923A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002323960A AU2002323960A1 (en) 2002-04-03 2002-08-09 Process for crosslinking polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002101185A JP2005287302A (ja) 2002-04-03 2002-04-03 ポリペプチドの架橋方法
JP2002-101185 2002-04-03

Publications (1)

Publication Number Publication Date
WO2003082923A1 true WO2003082923A1 (fr) 2003-10-09

Family

ID=28672100

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008179 Ceased WO2003082923A1 (fr) 2002-04-03 2002-08-09 Procede de reticulation de polypeptides

Country Status (3)

Country Link
JP (1) JP2005287302A (fr)
AU (1) AU2002323960A1 (fr)
WO (1) WO2003082923A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8969299B2 (en) 2011-06-08 2015-03-03 Kai Pharmaceuticals, Inc. Therapeutic agents for regulating serum phosphorus
US8987200B2 (en) 2006-11-16 2015-03-24 Kai Pharmaceuticals, Inc. Polycationic calcium modulator peptides for the treatment of hyperparathyroidism and hypercalcemic disorders
US8999932B2 (en) 2009-07-29 2015-04-07 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6185400A (ja) * 1984-09-13 1986-04-30 ジェネックス・コーポレイション 生物接着剤製造用タンパク質
EP0947142A2 (fr) * 1998-03-31 1999-10-06 Amano Pharmaceutical Co., Ltd. Procédé de réticulation des protéines par des enzymes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6185400A (ja) * 1984-09-13 1986-04-30 ジェネックス・コーポレイション 生物接着剤製造用タンパク質
EP0947142A2 (fr) * 1998-03-31 1999-10-06 Amano Pharmaceutical Co., Ltd. Procédé de réticulation des protéines par des enzymes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FUJIWARA H.: "Cross-link of cuticle protein GCP1 by phenol oxidase activity", ZOOLOGICAL SCIENCE, vol. 18, 2001, pages 52, XP002960267 *
JIANYONG LI: "Egg chorion tanning in Aedes aegypti mosquito", COMP BIOCHEM. PHYSIOL., vol. 190A, no. 4, 1994, pages 835 - 843, XP000983202 *
KRAMER KARL J. ET AL.: "Oxidative conjugation of catechols with proteins in insect skeletal systems", TETRAHEDRON, vol. 57, 2001, pages 385 - 392, XP004228504 *
SUZUKI Y. ET AL.: "Ecdysteroid-dependent expression of a novel cuticle protein gene BMCPG1 in the silkworm, Bombyx mori", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 32, no. 6, 2002, pages 599 - 607, XP002960268 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8987200B2 (en) 2006-11-16 2015-03-24 Kai Pharmaceuticals, Inc. Polycationic calcium modulator peptides for the treatment of hyperparathyroidism and hypercalcemic disorders
US8999932B2 (en) 2009-07-29 2015-04-07 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels
US9278995B2 (en) 2009-07-29 2016-03-08 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels
US9567370B2 (en) 2009-07-29 2017-02-14 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels
US9701712B2 (en) 2009-07-29 2017-07-11 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels
US10280198B2 (en) 2009-07-29 2019-05-07 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels
US8969299B2 (en) 2011-06-08 2015-03-03 Kai Pharmaceuticals, Inc. Therapeutic agents for regulating serum phosphorus

Also Published As

Publication number Publication date
AU2002323960A1 (en) 2003-10-13
JP2005287302A (ja) 2005-10-20

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