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WO2003082819A1 - Derive de n-phenyl-n-(4-piperidinyl)amide - Google Patents

Derive de n-phenyl-n-(4-piperidinyl)amide Download PDF

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Publication number
WO2003082819A1
WO2003082819A1 PCT/JP2003/003948 JP0303948W WO03082819A1 WO 2003082819 A1 WO2003082819 A1 WO 2003082819A1 JP 0303948 W JP0303948 W JP 0303948W WO 03082819 A1 WO03082819 A1 WO 03082819A1
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl
piperidinyl
amide derivative
derivative
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2003/003948
Other languages
English (en)
Japanese (ja)
Inventor
Toshihiro Takahashi
Kunio Kobayashi
Shinichi Yoshida
Tsuyoshi Endo
Nobutaka Mochiduki
Tomio Yamakawa
Kiichi Shika
Toru Kawasaki
Kenji Hirate
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP2003580287A priority Critical patent/JPWO2003082819A1/ja
Priority to AU2003220898A priority patent/AU2003220898A1/en
Publication of WO2003082819A1 publication Critical patent/WO2003082819A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention a trait à un dérivé de N-phényl-N-(4-pipéridinyl)amide représenté par la formule générale (I), dans laquelle : R1 représente alkyle en C1-C6 ; R2 et R4 représentent chacun phényle éventuellement substitué ; R3 représente hydrogène, alcoxycarbonyle en C2-C8, ou méthyle substitué par alcoxy en C1-C6 ; R5 représente un résidu d'acide aminé tel que glycine, alanine, leucine, ou phénylalanine ; et m et n représente 1 ou 2 ; ou un sel du dérivé. L'invention a trait également à un analgésique contenant le dérivé ou sel en tant que principe actif.
PCT/JP2003/003948 2002-04-01 2003-03-28 Derive de n-phenyl-n-(4-piperidinyl)amide Ceased WO2003082819A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2003580287A JPWO2003082819A1 (ja) 2002-04-01 2003-03-28 Ｎ−フェニル−ｎ−（４−ピペリジニル）アミド誘導体
AU2003220898A AU2003220898A1 (en) 2002-04-01 2003-03-28 N-phenyl-n-(4-piperidinyl)amide derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002-098443 2002-04-01
JP2002098443 2002-04-01

Publications (1)

Publication Number Publication Date
WO2003082819A1 true WO2003082819A1 (fr) 2003-10-09

Family

ID=28671952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/003948 Ceased WO2003082819A1 (fr) 2002-04-01 2003-03-28 Derive de n-phenyl-n-(4-piperidinyl)amide

Country Status (3)

Country Link
JP (1) JPWO2003082819A1 (fr)
AU (1) AU2003220898A1 (fr)
WO (1) WO2003082819A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046107A1 (fr) * 2002-11-19 2004-06-03 Takeda Pharmaceutical Company Limited Derives d'indole servant d'antagoniste de somatostatine
WO2005030722A1 (fr) * 2003-09-29 2005-04-07 Nippon Chemiphar Co., Ltd. Derive d'amide de n-(4-piperidinyle) n-substitue
WO2006030931A1 (fr) * 2004-09-14 2006-03-23 Nippon Chemiphar Co., Ltd. Derive d’amide n-(4-piperidinyl) n-substitue
JP2008511576A (ja) * 2004-08-31 2008-04-17 チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド 有機材料の安定化
US10766925B2 (en) * 2016-04-11 2020-09-08 Arizona Board Of Regents On Behalf Of The University Of Arizona Opioid receptor modulators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028931A1 (fr) * 1994-04-26 1995-11-02 Merck & Co., Inc. Azacycles spiro-substitues utilises en tant qu'antagonistes de neurokinine-3
JPH08337569A (ja) * 1995-06-15 1996-12-24 Sankyo Co Ltd 鎮痛活性物質
WO1999045011A1 (fr) * 1998-03-06 1999-09-10 Janssen Pharmaceutica N.V. Inhibiteurs du transport de la glycine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028931A1 (fr) * 1994-04-26 1995-11-02 Merck & Co., Inc. Azacycles spiro-substitues utilises en tant qu'antagonistes de neurokinine-3
JPH08337569A (ja) * 1995-06-15 1996-12-24 Sankyo Co Ltd 鎮痛活性物質
WO1999045011A1 (fr) * 1998-03-06 1999-09-10 Janssen Pharmaceutica N.V. Inhibiteurs du transport de la glycine

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046107A1 (fr) * 2002-11-19 2004-06-03 Takeda Pharmaceutical Company Limited Derives d'indole servant d'antagoniste de somatostatine
WO2005030722A1 (fr) * 2003-09-29 2005-04-07 Nippon Chemiphar Co., Ltd. Derive d'amide de n-(4-piperidinyle) n-substitue
JP2008511576A (ja) * 2004-08-31 2008-04-17 チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド 有機材料の安定化
US9051448B2 (en) 2004-08-31 2015-06-09 Basf Se Stabilization of organic materials
WO2006030931A1 (fr) * 2004-09-14 2006-03-23 Nippon Chemiphar Co., Ltd. Derive d’amide n-(4-piperidinyl) n-substitue
US10766925B2 (en) * 2016-04-11 2020-09-08 Arizona Board Of Regents On Behalf Of The University Of Arizona Opioid receptor modulators

Also Published As

Publication number Publication date
AU2003220898A1 (en) 2003-10-13
JPWO2003082819A1 (ja) 2005-08-04

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