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WO2003076004A2 - Dispositif de pointage laser pour la localisation d'un site de radioactivite dans un corps - Google Patents

Dispositif de pointage laser pour la localisation d'un site de radioactivite dans un corps Download PDF

Info

Publication number
WO2003076004A2
WO2003076004A2 PCT/US2003/007020 US0307020W WO03076004A2 WO 2003076004 A2 WO2003076004 A2 WO 2003076004A2 US 0307020 W US0307020 W US 0307020W WO 03076004 A2 WO03076004 A2 WO 03076004A2
Authority
WO
WIPO (PCT)
Prior art keywords
detector head
laser
laser beam
source
head surface
Prior art date
Application number
PCT/US2003/007020
Other languages
English (en)
Other versions
WO2003076004A3 (fr
Inventor
William L. Ashburn
Original Assignee
Digirad Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Digirad Corporation filed Critical Digirad Corporation
Priority to AU2003220086A priority Critical patent/AU2003220086A1/en
Priority to EP03716376A priority patent/EP1581117A2/fr
Priority to JP2003574269A priority patent/JP2005532532A/ja
Priority to CA002478686A priority patent/CA2478686A1/fr
Publication of WO2003076004A2 publication Critical patent/WO2003076004A2/fr
Publication of WO2003076004A3 publication Critical patent/WO2003076004A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4258—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • G01T1/164—Scintigraphy
    • G01T1/1641—Static instruments for imaging the distribution of radioactivity in one or two dimensions using one or several scintillating elements; Radio-isotope cameras
    • G01T1/1647—Processing of scintigraphic data

Definitions

  • BACKGROUND [0002] Localization of gamma photon-emitting radioactive accumulations in the body is commonly performed by using a gamma camera to produce an image of the distribution of radioactivity in the body. It may be relatively easy to relate the source of radioactivity to surrounding structures if there are adjacent anatomical references, e.g., other radioactivity, but it is difficult to precisely localize single sources. This is particularly true when, for example, a surgeon wants to biopsy a specific site indicated by focal radioactive uptake. This is made even more difficult when the procedure is performed in the operating room under sterile conditions.
  • the invention permits the precise localization of a gamma emitting source of radioactivity in the body as viewed by a nuclear gamma camera or similar radioisotope imaging device.
  • the radioactivity within the body is caused by a radioactive chemical having been administered by intravenous injection, orally, or by surgical implantation.
  • a gamma camera or similar planar (2-D) imager plus a laser pointer that slides over the face of the camera the operator can locate the source of radioactivity in the body from the location of the laser beam on the surface of the patient.
  • the laser localizer may include a laser pointer on a handle adapted to be placed co-parallel against the surface of a detector head of the gamma camera and a mirror angled to direct the laser beam normal with respect to the detector head surface.
  • the source of radiation may be a button containing cobalt-57 (Co-57) or other radioactive material such as technetium-99m (Tc-99m) positioned to be coaxial with the laser beam.
  • Figure 1 illustrates images of radioactive sources shown on a gamma camera monitor.
  • Figure 2 is a side view of a laser localizer in an operating position.
  • Figure 3 is a flowchart describing a real-time laser-guide localization technique.
  • Figure 4 is a perspective view of the laser localizer in use.
  • Figure 5 is a perspective view of a laser localizer according to an alternative implementation.
  • FIG. 6 illustrates images of radioactive sources, including that from the laser localizer, on the gamma camera monitor.
  • DETAILED DESCRIPTION In nuclear medicine imaging, very low-level radioactive chemicals (called radionuclides, radiopharmaceuticals, or radiotracers) are introduced into the body. The radioactive chemicals may, be introduced orally, intravenously, or by surgical implantation. The radioactive chemicals may be taken up by the organs in the body and then emit gamma rays the spatial distribution of which are measured by a gamma camera .
  • radionuclides radiopharmaceuticals, or radiotracers
  • a gamma camera has one or more crystal detector (s), called scintillation crystal (s). These crystals detect the emitted gamma rays and convert the energy of the gamma ray into optical photons . The intensity and spatial location of these photons are then converted to electric signals, which are digitized and are reconstructed into an image by a computer. Other types of gamma cameras may have detectors that directly convert the gamma ray energy into an electric signal. Regardless of the method of conversion, the resulting image is viewed on a system monitor.
  • s crystal detector
  • s scintillation crystal
  • Reference sources may be used to relate the position of a source of radioactive uptake shown on the monitor to a position on the patient's body.
  • a calibrated radiation source may be placed on the skin, an image 105 of which shows up on the system monitor 100, as shown in Figure 1.
  • the source of radioactive uptake 110 e.g., a sentinel lymph node, may be identified by its relative position to the injection site 115 and the calibrated source on the patient's skin.
  • a laser localizer device is used to precisely localize sources of radioactive uptake in the patient.
  • Figure 2 shows an exemplary laser localizer 200.
  • the laser localizer may include a laser pointer 205 on a handle 210 and a mirror 215 angled to reflect a laser beam 220 from the laser pointer at a 90 degree angle to the plane of the handle.
  • a source of radiation 225 is positioned under the mirror 215.
  • the source of radiation may be, e.g., a removable button containing the cobalt-57 (Co-57) radioactive isotope.
  • Figure 3 is a flowchart describing a real-time laser-guided localization operation 300 according to an embodiment.
  • a radioactive material is introduced into the patient (block 305) .
  • the patient is imaged with a gamma camera (block 310) , and a source of radioactive uptake is identified on the system monitor (block 315) .
  • the laser localizer 200 is placed flat against the detector head 405 of the camera (block 320), which has a flat, two-dimensional surface 410, as shown in Figure 4.
  • the laser pointer 205 may then be activated (block 325) .
  • the laser pointer on the handle 210, and hence the laser beam exiting the laser source, are parallel to the plane of the detector head surface 410.
  • the mirror 215 bends the laser beam so that it is normal to the detector head surface 410.
  • a large, flat base 505 may also be provided on the laser localizer under the mirror to help keep the device flat and the laser beam perpendicular to the detector head surface 410, as shown in Figure 5.
  • the laser beam illuminates a spot 250 on the patient's body 255 corresponding to the position of the radioactive button 225 on the detector head surface 410.
  • the radioactive button (Tc-99m is shown) appears as a hot spot 600 on the monitor, as shown in Figure 6.
  • the operator slides the laser localizer over the surface of the detector until the image of the radioactive button 600 is superimposed over the image of the radioactive uptake source 605 shown on the system monitor (block 330) .
  • Superimposition of the images as viewed on the monitor indicates that the laser beam is pointing directly at the site of radioactive uptake (block 335) , which may be beneath the surface of the skin or other tissue.
  • the localization technique may be used for a variety of imaging applications.
  • the laser localizer may be used to identify sentinel lymph nodes when screening for breast cancer. Sentinel node localization and skin marking can be performed outside of the operating room as long as the correct position of the patient is maintained. Alternatively, the node localization may be performed in the operating room. Furthermore, imaging immediately following surgical removal of the sentinel nodes can provide assurance that all nodes were removed.
  • the real-time laser-guided localization technique may be advantageous in instances when marking the patient's skin prior to surgery is impractical, e.g., when screening for colorectal cancer where the skin and tissue over the source of radioactive uptake needs to be moved or removed.
  • other tracking technologies may be applied, which may eliminate the need for the radioactive button on the laser localizer.
  • a pressure-sensitive, radiation-transparent (at least to radiation of interest) tablet may be placed over the detector head surface and a tip placed under the mirror. The tablet may translate the position of the tip on the tablet, and hence on the detector head surface, to a position on the system monitor.

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

La présente invention a trait à un appareil de localisation par laser pouvant comporter un pointeur laser monté sur une poignée destiné à être disposé mutuellement en parallèle contre la surface d'une tête de détection d'une caméra gamma et un miroir incliné pour orienter le faisceau laser perpendiculairement par rapport à la surface de la tête de détection. La source de rayonnement peut être un bouton contenant du cobalt 57 ou autre matériau radioactif disposé sous le miroir. Lors de la superposition de l'image du matériau radioactif dans l'appareil de localisation par laser sur une image d'une source d'apport radioactif chez le patient sur un moniteur du système, le faisceau laser effectuera automatiquement un pointage vers la source au sein du corps.
PCT/US2003/007020 2002-03-08 2003-03-06 Dispositif de pointage laser pour la localisation d'un site de radioactivite dans un corps WO2003076004A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003220086A AU2003220086A1 (en) 2002-03-08 2003-03-06 Laser pointer device to localize site of radioactivity in the body
EP03716376A EP1581117A2 (fr) 2002-03-08 2003-03-06 Dispositif de pointage laser pour la localisation d'un site de radioactivite dans un corps
JP2003574269A JP2005532532A (ja) 2002-03-08 2003-03-06 体内の放射能発生場所を特定するためのレーザポインタ装置
CA002478686A CA2478686A1 (fr) 2002-03-08 2003-03-06 Dispositif de pointage laser pour la localisation d'un site de radioactivite dans un corps

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36267302P 2002-03-08 2002-03-08
US60/362,673 2002-03-08
US38323003A 2003-03-05 2003-03-05
US10/383,230 2003-03-05

Publications (2)

Publication Number Publication Date
WO2003076004A2 true WO2003076004A2 (fr) 2003-09-18
WO2003076004A3 WO2003076004A3 (fr) 2005-07-28

Family

ID=33422731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/007020 WO2003076004A2 (fr) 2002-03-08 2003-03-06 Dispositif de pointage laser pour la localisation d'un site de radioactivite dans un corps

Country Status (5)

Country Link
EP (1) EP1581117A2 (fr)
JP (1) JP2005532532A (fr)
AU (1) AU2003220086A1 (fr)
CA (1) CA2478686A1 (fr)
WO (1) WO2003076004A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008510136A (ja) * 2004-08-12 2008-04-03 ナヴォテック メディカル リミテッド 被験者の体内の放射線源の位置標定
JP2008523405A (ja) * 2004-12-14 2008-07-03 コミッサリア タ レネルジー アトミーク 改良型ガンマ線撮像装置
WO2015047454A3 (fr) * 2013-08-06 2015-05-14 Nutec Solutions, Inc. Système de détection de rayonnement portable

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5011238B2 (ja) 2008-09-03 2012-08-29 株式会社日立製作所 放射線撮像装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5165410A (en) * 1987-05-15 1992-11-24 Medical & Scientific Enterprises, Inc. Position indicating system for a multidiagnostic scanner
US5305759A (en) * 1990-09-26 1994-04-26 Olympus Optical Co., Ltd. Examined body interior information observing apparatus by using photo-pulses controlling gains for depths
US6210425B1 (en) * 1999-07-08 2001-04-03 Light Sciences Corporation Combined imaging and PDT delivery system

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008510136A (ja) * 2004-08-12 2008-04-03 ナヴォテック メディカル リミテッド 被験者の体内の放射線源の位置標定
JP2008523405A (ja) * 2004-12-14 2008-07-03 コミッサリア タ レネルジー アトミーク 改良型ガンマ線撮像装置
RU2399929C2 (ru) * 2004-12-14 2010-09-20 Коммиссариат А Л'Энержи Атомик Усовершенствованный прибор для получения гамма-изображений
WO2015047454A3 (fr) * 2013-08-06 2015-05-14 Nutec Solutions, Inc. Système de détection de rayonnement portable

Also Published As

Publication number Publication date
AU2003220086A1 (en) 2003-09-22
AU2003220086A8 (en) 2003-09-22
EP1581117A2 (fr) 2005-10-05
JP2005532532A (ja) 2005-10-27
CA2478686A1 (fr) 2003-09-18
WO2003076004A3 (fr) 2005-07-28

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