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WO2003069309A3 - Immunocapture and functional assay for mitochondrial complex i - Google Patents

Immunocapture and functional assay for mitochondrial complex i Download PDF

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Publication number
WO2003069309A3
WO2003069309A3 PCT/US2003/004567 US0304567W WO03069309A3 WO 2003069309 A3 WO2003069309 A3 WO 2003069309A3 US 0304567 W US0304567 W US 0304567W WO 03069309 A3 WO03069309 A3 WO 03069309A3
Authority
WO
WIPO (PCT)
Prior art keywords
complex
diseases
screening
activity
immunocapture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/004567
Other languages
French (fr)
Other versions
WO2003069309A2 (en
Inventor
Michael F Marusich
Roderick A Capaldi
Devin Oglesbee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oregon
Oregon State
Original Assignee
University of Oregon
Oregon State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oregon, Oregon State filed Critical University of Oregon
Priority to AU2003211083A priority Critical patent/AU2003211083A1/en
Publication of WO2003069309A2 publication Critical patent/WO2003069309A2/en
Publication of WO2003069309A3 publication Critical patent/WO2003069309A3/en
Anticipated expiration legal-status Critical
Priority to US10/997,819 priority patent/US20050153381A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Complex I defects are one of the most frequent causes of diseases and disorders associated with mitochondrial respiratory chain disorders, including genetically related diseases and late onset neurodegenerative diseases. The invention provides methods for using monoclonal antibodies that react with 39-, 30-, 20-, 18-, 15-, and 8-kDa subunits of Complex I to aid in diagnosis of Complex I deficiencies and that can be used for rapid screening to detect onset or stage of a variety of diseases. The invention further provides methods for screening agents, such as drugs, for their effect upon Complex I activity and for screening patients to detect those with impairment of Complex I activity and those suspected of having a late onset disease associated with post-translational modification of one or more subunits of Complex I.
PCT/US2003/004567 2002-02-14 2003-02-14 Immunocapture and functional assay for mitochondrial complex i Ceased WO2003069309A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003211083A AU2003211083A1 (en) 2002-02-14 2003-02-14 Immunocapture and functional assay for mitochondrial complex i
US10/997,819 US20050153381A1 (en) 2002-02-14 2004-11-24 Immunocapture of mitochondrial protein complexes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35744102P 2002-02-14 2002-02-14
US60/357,441 2002-02-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US91725404A Continuation 2002-02-14 2004-08-11

Publications (2)

Publication Number Publication Date
WO2003069309A2 WO2003069309A2 (en) 2003-08-21
WO2003069309A3 true WO2003069309A3 (en) 2003-12-31

Family

ID=27734751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/004567 Ceased WO2003069309A2 (en) 2002-02-14 2003-02-14 Immunocapture and functional assay for mitochondrial complex i

Country Status (2)

Country Link
AU (1) AU2003211083A1 (en)
WO (1) WO2003069309A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989005976A1 (en) * 1987-12-22 1989-06-29 Pharmacia Ab Diagnostic method for primary biliary cirrhosis and antibodies suitable to be used in the method
US5888498A (en) * 1995-03-03 1999-03-30 Mitokor Cellular and animal models for diseases associated with mitochondrial defects

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989005976A1 (en) * 1987-12-22 1989-06-29 Pharmacia Ab Diagnostic method for primary biliary cirrhosis and antibodies suitable to be used in the method
US5888498A (en) * 1995-03-03 1999-03-30 Mitokor Cellular and animal models for diseases associated with mitochondrial defects

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FANG ET AL.: "Isolation and characterization of complex I, rotenone-sensitive NADH:ubiquinone oxidoreductase, from the procyclic forms of trypanosoma brucei", EUR. J. BIOCHEM., vol. 268, 2001, pages 3075 - 3082, XP002967161 *
PETTUS ET AL.: "Immunocytochemical characterization of the mitochondrially encoded ND1 subunit of complex I (NADH;Ubiquinone oxidoreductase) in rat brain", JOURNAL OF NEUROCHEMISTRY, vol. 75, no. 1, 2000, pages 383 - 392, XP002967160 *
WILLIAMS ET AL.: "Immunological phenotyping of fibroblast cultures from patients with a mitochondrial respiratory chain deficit", LABORATORY INVESTIGATION, vol. 81, 2001, pages 1069 - 1077, XP002967159 *

Also Published As

Publication number Publication date
AU2003211083A8 (en) 2003-09-04
WO2003069309A2 (en) 2003-08-21
AU2003211083A1 (en) 2003-09-04

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