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WO2003069346A3 - Diagnostic method for stroke - Google Patents

Diagnostic method for stroke Download PDF

Info

Publication number
WO2003069346A3
WO2003069346A3 PCT/EP2003/001462 EP0301462W WO03069346A3 WO 2003069346 A3 WO2003069346 A3 WO 2003069346A3 EP 0301462 W EP0301462 W EP 0301462W WO 03069346 A3 WO03069346 A3 WO 03069346A3
Authority
WO
WIPO (PCT)
Prior art keywords
stroke
diagnostic method
polypeptide
subject
body fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/001462
Other languages
French (fr)
Other versions
WO2003069346A2 (en
Inventor
Denis Francois Hochstrasser
Jean-Charles Sanchez
Elisabeth Guillaume
Laure Allard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Geneve
Original Assignee
Universite de Geneve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite de Geneve filed Critical Universite de Geneve
Priority to AU2003210267A priority Critical patent/AU2003210267B2/en
Priority to JP2003568416A priority patent/JP4287282B2/en
Priority to EP03739491A priority patent/EP1476759A2/en
Priority to CA002474670A priority patent/CA2474670A1/en
Publication of WO2003069346A2 publication Critical patent/WO2003069346A2/en
Publication of WO2003069346A3 publication Critical patent/WO2003069346A3/en
Priority to US10/909,761 priority patent/US20050153360A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Stroke is diagnosed in a subject by using mass spectrometry to observe a polypeptide in a sample of body fluid taken from the subject. The polypeptide is differentially contained in the body fluid of stroke-affected subjects and non-stroke-affected subjects, and has a molecular weight in the range of from 3000 to 30000.
PCT/EP2003/001462 2002-02-18 2003-02-13 Diagnostic method for stroke Ceased WO2003069346A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003210267A AU2003210267B2 (en) 2002-02-18 2003-02-13 Diagnostic method for stroke
JP2003568416A JP4287282B2 (en) 2002-02-18 2003-02-13 Test methods for use in diagnosing stroke
EP03739491A EP1476759A2 (en) 2002-02-18 2003-02-13 Diagnostic method for stroke
CA002474670A CA2474670A1 (en) 2002-02-18 2003-02-13 Diagnostic method for stroke
US10/909,761 US20050153360A1 (en) 2002-02-18 2004-08-02 Diagnostic method for stroke

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0203768.7 2002-02-18
GBGB0203768.7A GB0203768D0 (en) 2002-02-18 2002-02-18 Diagnostic method for stroke

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/909,761 Continuation US20050153360A1 (en) 2002-02-18 2004-08-02 Diagnostic method for stroke

Publications (2)

Publication Number Publication Date
WO2003069346A2 WO2003069346A2 (en) 2003-08-21
WO2003069346A3 true WO2003069346A3 (en) 2004-03-11

Family

ID=9931265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/001462 Ceased WO2003069346A2 (en) 2002-02-18 2003-02-13 Diagnostic method for stroke

Country Status (6)

Country Link
EP (1) EP1476759A2 (en)
JP (1) JP4287282B2 (en)
AU (1) AU2003210267B2 (en)
CA (1) CA2474670A1 (en)
GB (1) GB0203768D0 (en)
WO (1) WO2003069346A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2404981A (en) * 2003-08-15 2005-02-16 Univ Geneve Diagnostic method for stroke
EP2357477B1 (en) * 2003-09-20 2017-11-08 Electrophoretics Limited Diagnostic method for brain damage-related disorders based on the detection of NDKA

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225047B1 (en) * 1997-06-20 2001-05-01 Ciphergen Biosystems, Inc. Use of retentate chromatography to generate difference maps
US6235489B1 (en) * 1999-02-26 2001-05-22 Syn X Pharma Method for diagnosing and distinguishing stroke and diagnostic devices for use therein
WO2002012892A2 (en) * 2000-08-04 2002-02-14 Cis Biotech, Inc. Rapid multiple panel of biomarkers in laboratory blood tests for tia/stroke

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225047B1 (en) * 1997-06-20 2001-05-01 Ciphergen Biosystems, Inc. Use of retentate chromatography to generate difference maps
US6235489B1 (en) * 1999-02-26 2001-05-22 Syn X Pharma Method for diagnosing and distinguishing stroke and diagnostic devices for use therein
WO2002012892A2 (en) * 2000-08-04 2002-02-14 Cis Biotech, Inc. Rapid multiple panel of biomarkers in laboratory blood tests for tia/stroke

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MISSLER ULRICH ET AL: "S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke.", STROKE, vol. 28, no. 10, 1997, pages 1956 - 1960, XP002250344, ISSN: 0039-2499 *
STEVENS H ET AL: "Neurone-specific enolase and N-acetyl-aspartate as potential peripheral markers of ischaemic stroke.", EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. ENGLAND JAN 1999, vol. 29, no. 1, January 1999 (1999-01-01), pages 6 - 11, XP002250345, ISSN: 0014-2972 *

Also Published As

Publication number Publication date
JP2005517927A (en) 2005-06-16
GB0203768D0 (en) 2002-04-03
AU2003210267B2 (en) 2008-01-31
EP1476759A2 (en) 2004-11-17
CA2474670A1 (en) 2003-08-21
AU2003210267A1 (en) 2003-09-04
WO2003069346A2 (en) 2003-08-21
JP4287282B2 (en) 2009-07-01

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