WO2003068184A1 - Use of low molecular protein hydrolysates as anti-inflammable active substances - Google Patents

Abstract

The invention relates to the use of low molecular protein hydrolysates as anti-inflammable active substances for producing sun-protecting agents, after-sun-preparations and/or scalp soothing preparations.

Description

 USE OF LOW MOLECULAR PROTEIN HYDROLYSATES AS AN ANTI-FLAMMABLE ACTIVE SUBSTANCES

Field of the Invention

The invention is in the field of cosmetic and pharmaceutical preparations and relates to the use of low molecular weight protein hydrolyzates as anti-inflammatory agents.

State of the art

Proteins and their derivatives have been used successfully for more than 50 years as care components in cosmetic products, made from a variety of natural sources of animal or vegetable origin. However, they can not only be differentiated according to origin, amino acid composition or derivatization, but in particular the molecular weight plays a decisive role in the cosmetic properties of the protein products.

The object of the present patent application was to find new effects of already known active substances and to enable their use in cosmetic and / or dermopharmaceutical agents which are also well tolerated by sensitive skin and which also have good physico-chemical stability ,

Description of the invention

The present invention relates to the use of low molecular weight protein hydrolyzates as anti-inflammatory active substances, in particular for the inhibition of inflammatory processes induced by UV radiation. This also results in the use of low molecular weight protein hydrolyzates for the manufacture of sunscreens and / or after-sun preparations and for the manufacture of scalp soothing agents. It has surprisingly been found that low molecular weight protein hydrolyzates, in particular of vegetable origin and especially low molecular weight wheat protein hydrolyzates, have a pronounced anti-inflammatory effect.

More and more consumers complain about sensitive, sensitive or even irritated skin. For protein hydrolyzates, the anti-inflammatory effect is another interesting property. This effect usually not only has a beneficial and calming effect on the skin and hair, but is also able to effectively remove irritation on the skin. Low molecular weight wheat protein hydrolyzates even show better efficacy than acetylsaiicylic acid in in vitro tests. In this way, they can help the skin regain balance. Therefore, the use of low molecular weight wheat peptides e.g. in formulations for irritated, stressed skin or after-sun formulations.

When used in hair care products, the protein hydrolyzates could e.g. contribute to the stabilization and relaxation of sensitive scalp. A positive influence on the usual symptoms of tense scalp can also be expected, e.g. the widespread itching, so that it has a calming effect on (scalp) skin and hair.

Low molecular weight protein hydrolyzates

Low molecular weight protein active ingredients in the sense of the present invention essentially consist of oligopeptides which are formed from up to 10 amino acids, predominantly up to 6 and preferably predominantly 2 to 4 amino acids. They have an average molecular weight of 50 to 3,000 daltons, preferably 100 to 1,000 daltons and particularly preferably 200 to 600 daltons.

Commercial products include Gluadin ^® WLM (Cognis, Düsseldorf). As a result, low molecular weight protein hydrolyzates have such a small molecular size that these "microprotein active ingredients" are even able to penetrate deep into the hair fiber and repair, strengthen and protect it from the inside.

In the amino acid composition of the low molecular weight protein hydrolyzates according to the invention, the high content of glutamic acid and proline is particularly noteworthy. Glutamic acid is generally widespread in nature and therefore in almost all To find proteins. Wheat protein, however, has the highest content, usually with more than 30% glutamic acid. The name of this protein component is therefore derived from gluten, the protein of wheat gluten from which glutamic acid was first obtained. Although this is not an essential amino acid, glutamic acid plays an important role in various metabolic processes. It also forms the preliminary stage for proline. The second dominant amino acid proline is also referred to as a "helix breaker" due to its extensive structure (with pyrrole ring), since its frequent occurrence prevents the formation of a superordinate secondary structure, eg α-helix or β-sheet structures. This proline position also acts like a swivel around which the rest of the protein chain can move almost freely. This gives the wheat protein molecule an extremely flexible structure and is able to intercept kinetic energy, for example in the form of heat, very effectively. In this way, denaturation of the wheat protein can be counteracted for a long time.

The amount of the low molecular weight protein hydrolyzates can be 0.1 to 10, preferably 0.2 to 5 and in particular 0.5 to 2% by weight of active substance, based on the final formulation.

Industrial applicability

Due to the proven effects, low molecular weight products are ideal for hair and skin care. - - - -

The protein hydrolyzates according to the invention can be used to produce cosmetic and / or pharmaceutical preparations, such as, for example, hair shampoos, hair lotions, hair balms, hair rinses, sunscreen and after-sun creams, gels, lotions or emulsions. These agents can also be used as further auxiliaries and additives, mild surfactants, oil bodies, emulsifiers, pearlescent waxes, consistency agents, thickeners, superfatting agents, stabilizers, polymers, silicone compounds, fats, waxes, lecithins, phospholipids, biogenic active ingredients, UV light protection factors, antioxidants Contain dantien, anti-dandruff agents, film formers, swelling agents, insect repellents, hydrotropes, solubilizers, preservatives, perfume oils, dyes and the like. surfactants

Anionic, nonionic, cationic and / or amphoteric or amphoteric surfactants may be present as surface-active substances, the proportion of which in the compositions is usually about 1 to 70, preferably 5 to 50 and in particular 10 to 30% by weight. Typical examples of anionic surfactants are soaps, alkylbenzenesulfonates, alkanesulfonates, olefin sulfonates, alkyl ether sulfonates, glycerol ether sulfonates, α-methyl ester sulfonates, sulfo fatty acids, alkyl sulfates, fatty alcohol ether sulfates, glycerin ether sulfates, fatty acid ether sulfates, hydroxymate ether ether sulfates, sulfymate ether sulfates, hydroxymate ether ether sulfates, monomers , Mono- and dialkylsulfosuccinates, mono- and dialkylsulfosuccinamates, sulfotriglycerides, amide soaps, ether carboxylic acids and their salts, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurides, N-acylamino acids, such as acyl lactamate acid and acyl glucosolate acidates, acyl glucosolate acidate, acyl glucosolate acidate, Wheat base) and alkyl (ether) phosphates. If the anionic surfactants contain polyglycol ether chains, they can have a conventional, but preferably a narrow, homolog distribution. Typical examples of nonionic surfactants are fatty alcohol polyglycol ethers, alkylphenol polyglycol ethers, fatty acid polyglycol esters, fatty acid amide polyglycol ethers, fatty amine polyglycol ethers, alkoxylated triglycerides, mixed ethers or mixed formals, optionally partially oxidized alk (en) yl oligoglycosides or especially glucoronic acid protein derivatives, and glucoronic acid protein derivatives Wheat base), polyol fatty acid esters, sugar esters, sorbitan esters, polysorbates and amine oxides. If the nonionic surfactants contain polyglycol ether chains, they can have a conventional, but preferably a narrow, homolog distribution. Typical examples of cationic surfactants are quaternary ammonium compounds, such as, for example, dimethyldistearylammonium chloride, and esterquats, in particular quaternized fatty acid trialkanolamine ester salts. Typical examples of amphoteric or zwitterionic surfactants are alkyl betaines, alkyl amidobetaines, aminopropionates, aminoglycinates, imidazolinium betaines and sulfobetaines. The surfactants mentioned are exclusively known compounds. With regard to the structure and manufacture of these substances, reference is made to relevant reviews, for example J.Falbe (ed.), "Surfactants in Consumer Products", Springer Verlag, Berlin, 1987, pp. 54-124 or J.Falbe (ed.) _/ "Catalysts, Tenside und Mineralöladditive ", Thieme Verlag, Stuttgart, 1978, pp. 123-217. Typical examples of particularly suitable mild, ie particularly skin-compatible, surfactants are fatty alcohol polyglycol ether sulfates, monoglyceride sulfates, mono- and / or dialkyl sulfosuccinates, fatty acid isethionates, fatty acid sarcosinates, fatty acid dew ride, fatty acid glutamates, α-olefin sulfonates, ether carboxylic acids, alkyl oligoglucosides, fatty acid glucamides, alkyl amido betaines, amphoacetals and / or protein fatty acid condensates, the latter preferably based on wheat proteins.

oil body

und/oder Guerbetalkoholen mit aromatischen Carbonsäuren, insbesondere Benzoesäure, Ester von C₂-Cι₂-Dicarbonsäuren mit linearen oder verzweigten Alkoholen mit 1 bis 22 Kohlenstoffatomen oder Polyolen mit 2 bis 10 Kohlenstoffatomen und 2 bis 6 Hydroxylgruppen, pflanzliche Öle, verzweigte primäre Alkohole, substituierte Cyclohexane, lineare und verzweigte C₆-C₂₂-Fettalkoholcarbonate, wie z.B. Dicaprylyl Carbonate (Cetiol® CC), Guerbetcarbonate auf Basis von Fettalkoholen mit 6 bis 18, vorzugsweise 8 bis 10 C Atomen, Ester der Benzoesäure mit linearen und/oder verzweigten C₆-C₂₂-Alkoholen (z.B. Finsolv® TN), lineare oder verzweigte, symmetrische oder unsymmetrische Dialkylether mit 6 bis 22 Kohlenstoffatomen pro Alkylgruppe, wie z.B. Dicaprylyl Ether (Cetiol® OE), Ringöffnungsprodukte von epoxi- dierten Fettsäureestern mit Polyolen, Siliconöle (Cydomethicone, Siliciummethicontypen u.a.) und/oder aliphatische bzw. naphthenische Kohlenwasserstoffe, wie z.B. wie Squalan, Squalen oder Dialkylcyclohexane in Betracht.Suitable oil bodies are, for example, Guerbet alcohols preferably containing 8 to 10 carbon atoms, esters of linear C ₆ -C come based on fatty alcohols having 6 to 18, ₂₂ fatty acids with linear or branched C ₆ -C ₂₂ -fatty alcohols or esters of branched Cs-Cι ₃ - Carboxylic acids with linear or branched Cs-C ₂₂ fatty alcohols, such as myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl stearate, cetyl stearate, cetyl stearate, , Stearyli- sostearat, stearyl oleate, stearyl behenate, Stearylerucat, isostearyl, Isostearylpal- palmitate, Isostearylstearat, isostearyl isostearate, Isostearyloleat, isostearyl behenate, Isostearyloleat, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, Oleylbe- tribehenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl , Behenyl isostearate, behen yloleate, behenyl behenate, behenyl erucate, erucyl myristate, erucyl palmitate, erucyl stearate, erucyl isostearate, erucyl oleate, erucyl behenate and erucyl erucate. In addition, esters of linear C _δ -C∑ _∑ fatty acids with branched alcohols, in particular 2-ethylhexanol, esters of Ci ₈ -C ₃₈ alkylhydroxycarboxylic acids with linear or branched C _δ -C ₂₂ fatty alcohols (cf. DE 19756377 AI) , in particular dioctyl malates, esters of linear and / or branched fatty acids with polyhydric alcohols (such as propylene glycol, dimer diol or trimer triol) and / or Guerbet alcohols, triglycerides based on Ce-Cio fatty acids, liquid mono- / di- / triglyceride mixtures Base of Ce-Cis fatty acids, esters of

and / or Guerbet alcohols with aromatic carboxylic acids, in particular benzoic acid, esters of C ₂ -C ₂ -dicarboxylic acids with linear or branched alcohols with 1 to 22 carbon atoms or polyols with 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, Substituted cyclohexanes, linear and branched C ₆ -C ₂₂ fatty alcohol carbonates, such as dicaprylyl carbonates (Cetiol® CC), Guerbet carbonates based on fatty alcohols with 6 to 18, preferably 8 to 10 C atoms, esters of benzoic acid with linear and / or branched C ₆ -C ₂₂ alcohols (eg Finsolv® TN), linear or branched, symmetrical or unsymmetrical dialkyl ethers with 6 to 22 carbon atoms per alkyl group, such as dicaprylyl ether (Cetiol® OE), ring opening products of epoxidized fatty acid esters with polyols, silicone oils (Cydomethicone, silicon methicone types inter alia) and / or aliphatic or naphthenic hydrocarbons, such as, for example, squalane, squalene or dialkylcyclohexanes.

emulsifiers

Examples of suitable emulsifiers are nonionic surfactants from at least one of the following groups:

> Adducts of 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide with linear fatty alcohols with 8 to 22 carbon atoms, with fatty acids with 12 to 22 carbon atoms, with alkylphenols with 8 to 15 carbon atoms in the Alkyl group and alkylamines with 8 to 22 carbon atoms in the alkyl radical;

> Alkyl and / or alkenyl oligoglycosides with 8 to 22 carbon atoms in the alk (en) yl radical and their ethoxylated analogs;

> Addition products of 1 to 15 moles of ethylene oxide with castor oil and / or hydrogenated

castor oil;

> Adducts of 15 to 60 moles of ethylene oxide with castor oil and / or hardened castor oil;

> Partial esters of glycerol and / or sorbitan with unsaturated, linear or saturated, branched fatty acids with 12 to 22 carbon atoms and / or hydroxycarboxylic acids with 3 to 18 carbon atoms and their adducts with 1 to 30 mol ethylene oxide;

-> ^~ partial esters of polyglycerol (average degree of self-condensation 2 to 8), polyethylene glycol (molecular weight 400 to 5000), trimethylolpropane, pentaerythritol, sugar alcohols (e.g. sorbitol), alkyl glucosides (e.g. methyl glucoside, butylglucoside, lauryl glucoside) and polyglucosides (e.g. cellulose with saturated and / or unsaturated, linear or branched fatty acids with 12 to 22 carbon atoms and / or hydroxycarboxylic acids with 3 to 18 carbon atoms and their adducts with 1 to 30 mol ethylene oxide;

> Mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohol according to DE

1165574 PS and / or mixed esters of fatty acids with 6 to 22 carbon atoms, methyl glucose and polyols, preferably glycerol or polyglycerol.

> Mono-, di- and trialkyl phosphates and mono-, di- and / or tri-PEG-alkyl phosphates and their salts;

> Wool wax alcohols;

> Polysiloxane-polyalkyl-polyether copolymers or corresponding derivatives; > Block copolymers, for example polyethylene glycol 30 dipolyhydroxystearate;

> Polymer emulsifiers, e.g. Pemulen types (TR-1, TR-2) from Goodrich;

> Polyalkylene glycols as well

> Glycerine carbonate.

> Ethylene oxide investment products

The adducts of ethylene oxide and / or of propylene oxide with fatty alcohols, fatty acids, alkylphenols or with castor oil are known, commercially available products. These are mixtures of homologs whose average degree of alkoxylation is the ratio of the amounts of ethylene oxide and / or propylene oxide and substrate, with which the addition reaction is carried out. Cι _{2 /} i ₈ fatty acid monoesters and diesters of adducts of ethylene oxide with glycerol are known from DE 2024051 PS as refatting agents for cosmetic preparations.

Alkyl and / or alkenyl ologoglycosides

Alkyl and / or alkenyl oligoglycosides, their preparation and their use are known from the prior art. They are produced in particular by reacting glucose or oligosaccharides with primary alcohols with 8 to 18 carbon atoms. Regarding the glycoside residue, both monoglycosides in which a cyclic sugar residue is glycosidically bonded to the fatty alcohol and oligomeric glycosides with a degree of oligomerization of up to about 8 are suitable. The degree of oligomerization is a statistical mean value which is based on a homolog distribution customary for such technical products.

Partialqlyceride

Typical examples of suitable partial glycerides are säurediglycerid Hydroxystearinsäuremonogly- cerid, hydroxystearic acid diglyceride, isostearic acid, Isostearinsäure- diglyceride, oleic acid monoglyceride, oleic acid diglyceride, Ricinolsäuremoglycerid, ricinoleic, Linolsäuremonoglycerid, Linolsäurediglycerid, Linolensäuremonogly- cerid, inolensäurediglycerid, Erucasäuremonoglycerid, Erucasäurediglycerid, tartaric Acid monoglyceride, tartaric acid diglyceride, citric acid monoglyceride, citric diglyceride, malic acid monoglyceride, malic acid diglyceride and their technical mixtures, which may still contain small amounts of triglyceride from the manufacturing process. Addition products of 1 to 30, preferably 5 to 10, mol of ethylene oxide onto the partial glycerides mentioned are also suitable.

sorbitan

As sorbitan sorbitan, sorbitan sesquiisostearate, sorbitan diisostearate, sorbitan triisostearate, sorbitan monooleate, sorbitan dioleate, trioleate, Sorbitanmonoerucat, Sorbitansesquierucat, sorbitan come dierucat, Sorbitantrierucat, Sorbitanmonoricinoleat, Sorbitansesquiricinoleat, sorbitan tandiricinoleat, Sorbitantriricinoleat, Sorbitanmonohydroxystearat, sorbitan - sesquihydroxystearate, sorbitan dihydroxystearate, sorbitan trihydroxystearate, sorbitan monotartrate, sorbitan sesqui-tartrate, sorbitan ditartrate, sorbitan tritanartrate, sorbitan monocitrate, sorbitan squitrate, sorbitan tritanate, sorbitan tritone Addition products of 1 to 30, preferably 5 to 10, mol of ethylene oxide onto the sorbitan esters mentioned are also suitable.

polyglycerol

Typical examples of suitable polyglycerol esters are polyglyceryl-2 dipolyhydroxystearate (Dehymuls® PGPH), polyglycerol-3-diisostearate (Lameform® TGI), polyglycerol-4 isostearate (Isolan® GI 34), polyglyceryl-3 oleate, diisostearoyl po- lyglyceryl-3 diisostearate (Isolan® PDI), polyglyceryl-3 methylglucose distearate (Tego Care® 450), polyglyceryl-3 beeswax (Cera Bellina®), polyglyceryl-4 caprate (polyglycerol caprate T2010 / 90), polyglyceryl-3 cetyl ether ( Chimexane® NL), Polyglyceryl-3 Distearate (Cremophor® GS 32) and Polyglyceryl Polyricinoleate (Admul® WOL 1403) Polyglyceryl Dimerate Isostearate and their mixtures. Examples of other suitable polyol esters are the mono-, di- and triesters of trimethylolpropane or pentaerythritol which are optionally reacted with 1 to 30 mol of ethylene oxide with lauric acid, coconut fatty acid, tallow fatty acid, palmitic acid, stearic acid, oleic acid, behenic acid and the like. Anionic emulsifiers

Typical anionic emulsifiers are aliphatic fatty acids with 12 to 22 carbon atoms, such as, for example, palmitic acid, stearic acid or behenic acid, and dicarboxylic acids with 12 to 22 carbon atoms, such as, for example, azelaic acid or sebacic acid.

Amphoteric and cationic emulsifiers

Zwitterionic surfactants can also be used as emulsifiers. Zwitterionic surfactants are surface-active compounds that contain at least one quaternary ammonium group and at least one carboxylate and one sulfonate group in the molecule. Particularly suitable zwitterionic surfactants are the so-called betaines such as the N-alkyl-N, N-dimethylammonium glycinate, for example coconut alkyldimethylammonium glycinate, N-acylaminopropyl-N, N-dimethylammonium glycinate, for example coconutacylaminopropyldimethylammoniumglycinate, and 2 -Alkyl-3-carboxylmethyl-3-hydroxyethylimidazolines each having 8 to 18 carbon atoms in the alkyl or acyl group and the cocoacylaminoethylhydroxyethylcarboxymethylglycinate. The fatty acid amide derivative known under the CTFA name Cocamidopropyl Betaine is particularly preferred. Suitable emulsifiers are ampholytic surfactants. Under ämpholytischen Tensiden- such surface active compounds werden- understood, in addition to a _{C8 /} ι ₈ alkyl or acyl group, contain at least one free amino group and at least one -COOH or _-SO3H group and are capable of forming inner salts are. Examples of suitable ampholytic surfactants are N-alkylglycine, N-alkylpropionic acid, N-alkylaminobutyric acid, N- alkyliminodipropionic acid, N-hydroxyethyl-N-alkylamidopropylglycine, N-

Alkyl taurines, N-alkyl sarcosines, 2-alkyl aminopropionic acids and alkyl amino acetic acids, each with about 8 to 18 carbon atoms in the alkyl group. Particularly preferred ampholytic surfactants are the N-coconut alkyl aminopropionate, the coconut acylaminoethyl aminopropionate and the C _{2 2} acyl sarcosine. Finally, cationic surfactants are also suitable as emulsifiers, those of the esterquat type, preferably methylquaternized difatty acid triethanolamine ester salts, being particularly preferred. Fats and waxes

Typical examples of fats are glycerides, i.e. Solid or liquid vegetable or animal products, which consist essentially of mixed glycerol esters of higher fatty acids, come as waxes, among others. natural waxes, e.g. Candelilla wax, Carnauba wax, Japanese wax, esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugar cane wax, ouricury wax, montan wax, beeswax, shellac wax, walnut, lanolin (wool wax), pretzel fat, ceresin, ozokerite (earth wax), petrolatum, paraffin wax microcrystalline waxes; chemically modified waxes (hard waxes), e.g. Montanester waxes, Sasol waxes, hydrogenated jojoba waxes and synthetic waxes, such as Polyalkylene waxes and polyethylene glycol waxes in question. In addition to fats, fat-like substances such as lecithins and phospholipids can also be used as additives. The skilled worker understands the term lecithins to mean those glycerophospholipids which are formed from fatty acids, glycerol, phosphoric acid and choline by esterification. Lecithins are therefore often used in the professional world as phosphatidylcholines (PC). Examples of natural lecithins are the cephalins, which are also referred to as phosphatidic acids and are derivatives of 1,2-diacyl-sn-glycerol-3-phosphoric acids. In contrast, phospholipids are usually understood to be mono- and preferably diesters of phosphoric acid with glycerol (glycerol phosphates), which are generally classed as fats. In addition, sphingosines or sphingolipids are also suitable.

pearlescent

Pearlescent waxes that can be used are, for example: alkylene glycol esters, especially ethylene glycol distearate; Fatty acid alkanolamides, especially coconut fatty acid diethanolamide; Partial glycerides, especially stearic acid monoglyceride; Esters of polyvalent, optionally hydroxy-substituted carboxylic acids with fatty alcohols having 6 to 22 carbon atoms, especially long-chain esters of tartaric acid; Fatty substances, such as, for example, fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates, which have a total of at least 24 carbon atoms, especially lauron and distearyl ether; Fatty acids such as stearic acid, hydroxystearic acid or behenic acid, ring opening products of olefin epoxides with 12 to 22 carbon atoms with fatty alcohols with 12 to 22 carbon atoms and / or polyols with 2 to 15 carbon atoms and 2 to 10 hydroxyl groups and mixtures thereof. Consistency feeders and thickeners

Suitable consistency agents are primarily fatty alcohols or hydroxy fatty alcohols with 12 to 22 and preferably 16 to 18 carbon atoms and, in addition, partial glycerides, fatty acids or hydroxy fatty acids. A combination of these substances with alkyl oligoglucosides and / or fatty acid N-methylglucamides of the same chain length and / or polyglycerol poly-12-hydroxystearates is preferred. Suitable thickeners are, for example, Aerosil types (hydrophilic silicas), polysaccharides, in particular xanthan gum, guar guar, agar agar, alginates and tyloses, carboxymethyl cellulose and hydroxyethyl and hydroxypropyl cellulose, and also higher molecular weight polyethylene glycol mono- and diesters of fatty acids, Polyacrylates, (eg Carbopole® and Pemulen types from Goodrich; Synthalene® from Sigma; Keltrol types from Kelco; Sepigel types from Seppic; Salcare types from Allied Colloids), polyacrylamides, polymers, polyvinyl alcohol and polyvinylpyrrolidone. Bentonites, such as e.g. Bentone® Gel VS-5PC (Rheox) has been proven, which is a mixture of cyclopentasiloxane, disteardimonium hectorite and propylene carbonate. Surfactants such as, for example, ethoxylated fatty acid glycerides, esters of fatty acids with polyols such as, for example, pentaerythritol or trimethylolpropane, fatty alcohol ethoxylates with a narrow homolog distribution or alkyl oligoglucosides and electrolytes such as sodium chloride and ammonium chloride are also suitable.

Überfettunosmittel

Substances such as, for example, lanolin and lecithin and polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, monoglycerides and fatty acid alkanolamides can be used as superfatting agents, the latter simultaneously serving as foam stabilizers.

stabilizers

Metal salts of fatty acids such as magnesium, aluminum and / or zinc stearate or ricinoleate can be used as stabilizers. polymers

Suitable cationic polymers are, for example, cationic cellulose derivatives, e.g. a quaternized hydroxyethyl cellulose available under the name Polymer JR 400® from Amerchol, cationic starch, copolymers of diallylammonium salts and acrylamides, quaternized vinylpyrrolidone / vinylimidazole polymers such as e.g. Luviquat® (BASF), condensation products of polyglycols and amines, quaternized collagen polypeptides, such as, for example, lauryldimonium hydroxypropyl hydrolyzed collagen (Lamequat®L / Grünau), quaternized wheat polypeptides, polyethyleneimine, cationic silicone polymers, such as e.g. Amodimethicones, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine (Cartaretine® / Sandoz), copolymers of acrylic acid with dimethyldiallylammonium chloride (Merquat® 550 / Chemviron), polyamino polyamides, e.g. described in FR 2252840 A and its crosslinked water-soluble polymers, cationic chitin derivatives such as quaternized chitosan, optionally microcrystalline, condensation products of dihaloalkylene, such as e.g. Dibromobutane with bisdialkylamines, e.g. Bis-dimethylamino-1,3-propane, cationic guar gum, e.g. Jaguar® CBS, Jaguar® C-17, Jaguar® C-16 from Celanes, quaternized ammonium salt polymers, such as e.g. Mirapol® A-15, Mirapol® AD-1, Mirapol® AZ-1 from Miraπol.

Suitable anionic, zwitterionic, amphoteric and nonionic polymers are, for example, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone / vinyl acrylate copolymers, vinyl acetate / butyl maleate / isobornyl acrylate copolymers, methyl vinyl ether / maleic anhydride copolymers and esters thereof, uncrosslinked and polyol-crosslinked polyacrylic acids, acrylamidopropyl / Acrylate copolymers, octylacrylamide / methyl methacrylate / tert.butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymers, polyvinyl pyrrolidone, vinyl pyrrolidone / vinyl acetate copolymers, vinyl pyrrolidone / dimethylaminoethyl methacrylate / vinyl caprolactam and also derivatized terpolymers in question. Other suitable polymers and thickeners are in Cosm.Toil. 108, 95 (1993).

silicone compounds

Suitable silicone compounds are, for example, dimethylpolysiloxanes, methylphenylpolysiloxanes, cydic silicones and amino-, fatty acid-, alcohol-, polyether-, epoxy-, fluorine-, glycoside- and / or alkyl-modified silicone compounds which are used at room temperature can be both liquid and resinous. Simethicones, which are mixtures of dimethicones with an average chain length of 200 to 300 dimethylsiloxane units and hydrogenated silicates, are also suitable. A detailed overview of suitable volatile silicones can also be found by Todd et al. in Cosm.Toil. £ 1.27 (1976).

UV light protection filters and antioxidants

UV light protection factors are understood to mean, for example, organic substances (light protection filters) which are liquid or crystalline at room temperature and which are able to absorb ultraviolet rays and absorb the energy absorbed in the form of longer-wave radiation, e.g. To give off heat again. UVB filters can be oil-soluble or water-soluble. As oil-soluble substances e.g. to call:

3-benzylidene camphor or 3-benzylidene norcampher and its derivatives, e.g. 3- (4-methylbenzylidene) camphor as described in EP 0693471 B1;

> 4-aminobenzoic acid derivatives, preferably 2-ethyl-hexyl 4- (dimethylamino) benzoate, 2-octyl 4- (dimethylamino) benzoate and amyl 4- (dimethylamino) benzoate;

> Esters of cinnamic acid, preferably 2-ethylhexyl 4-methoxycinnamate, propyl 4-methoxycinnamate, isoamyl 4-methoxycinnamate, 2-ethylhexyl 2-cyano-3,3-phenylcinnamate (octocrylene);

> Esters of salicylic acid, preferably salicylic acid 2-ethylhexyl ester, salicylic acid 4-iso-propylbenzyl ester, salicylic acid homomethyl ester;

> Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4 ^, methylbenzophenone, 2.2 ^λ- dihydroxy-4-methoxybenzophenone;

> Esters of benzalmalonic acid, preferably 4-methoxybenzmalonic acid di-2-ethylhexyl ester;

> Triazine derivatives, such as 2,4,6-trianilino- (p-carbo-2 ^, -ethyl-r-hexyloxy) -l, 3,5-triazine and octyl triazone, as described in EP 0818450 AI or dioctyl butamido triazone (Uvasorb® HEB);

> Propane-1,3-diones, such as 1- (4-tert-butylphenyl) -3- (4 ^, methoxyphenyl) propane-1,3-dione;

> Ketotricyclo (5.2.1.0) decane derivatives, as described in EP 0694521 B1. Possible water-soluble substances are:

> 2-phenylbenzimidazole-5-sulfonic acid and its alkali, alkaline earth, ammonium, alkylammonium, alkanolammonium and glucammonium salts;

> Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts;

> Sulfonic acid derivatives of 3-benzylidene camphor, e.g. 4- (2-oxo-3-bornylidene methyl) benzenesulfonic acid and 2-methyl-5- (2-oxo-3-bornylidene) sulfonic acid and their salts.

Typical UV-A filters are, in particular, derivatives of benzoyl methane such as l- ^(4, -tert.Butylphenyl) -3- ^{(4-methoxyphenyl)} propan-l, 3-dione, 4-tert-butyl -4 ^x -methoxydibenzoylmethan (Parsol® 1789), l-phenyl-3- (4 ^Λ -isopropylphenyl) propane-l, 3-dione and enamine compounds, as described in DE 19712033 AI (BASF). The UV-A and UV-B filters can of course also be used in mixtures. Particularly favorable combinations consist of the derivatives of benzoylmethane, for example 4-tert-butyl-4 ^, methoxydibenzoylmethane (Parsol® 1789) and 2-cyano-3,3-phenylcinnamic acid 2-ethyl-hexyl ester (octocrylene) in combination with Esters of cinnamic acid, preferably 4-methoxycinnamic acid-2-ethyl! Hexyl ester and / or 4-methoxycinnamic acid propyl ester and / or 4-methoxycinnamic acid isoamyl ester. Such combinations are advantageously combined with water-soluble filters such as, for example, 2-phenylbenzimidazole-5-sulfonic acid and its alkali metal, alkaline earth metal, ammonium, alkylammonium, alkanolammonium and glucammonium salts.

In addition to the soluble substances mentioned, insoluble light protection pigments, namely finely dispersed metal oxides or salts, are also suitable for this purpose. Examples of suitable metal oxides are, in particular, zinc oxide and titanium dioxide and, in addition, oxides of iron, zirconium, silicon, manganese, aluminum and cerium and mixtures thereof. Silicates (talc), barium sulfate or zinc stearate can be used as salts. The oxides and salts are used in the form of the pigments for skin-care and skin-protecting emulsions and decorative cosmetics. The particles should have an average diameter of less than 100 nm, preferably between 5 and 50 nm and in particular between 15 and 30 nm. They can have a spherical shape, but it is also possible to use particles which have an ellipsoidal shape or shape which differs from the spherical shape in some other way. The pigments can also be surface-treated, ie hydrophilized or hydrophobicized. Typical examples are coated titanium dioxide, such as titanium dioxide T 805 (Degussa) or Eusolex® T2000 (Merck). Silicones, and in particular trialkoxyoctylsilanes or simethicones, are particularly suitable as hydrophobic coating agents. So-called micro- or nanopigments are preferably used in sunscreens. Micronized zinc oxide is preferably used. Other suitable UV light protection filters can be found in the overview by P.Finkel in SÖFW-Journal 122, 543 (1996) and Parf.Kosm. 3, 11 (1999).

In addition to the two aforementioned groups of primary light stabilizers, secondary light stabilizers of the antioxidant type can also be used, which interrupt the photochemical reaction chain which is triggered when UV radiation penetrates the skin. Typical examples are amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anse- rin), carotenoids, carotenes (e.g. α-carotene, ß-carotene, lycopene) and their derivatives, chlorogenic acid and their derivatives, lipoic acid and their derivatives (e.g. dihydroliponic acid), aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, Cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropioπat, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (eg buthioninsulfoximines, homocysteine sulfoximine, Butioninsulfone, penta-, hexa-, Himinathion in very) compatible doses (e.g. pmol to μmol / kg), (metal) chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin , Biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. ascorbyl palmitate, Mg-ascorbyl phosphate, Ascorbylacetate), tocopherols and derivatives (eg vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) as well as coniferyl benzoate of benzoin, rutinic acid and its derivatives, α-glycosylrutin, ferulic acid, furfurylidene glucitol, carnosine, Butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguajakarzarzäure, nordihydroguajaretic acid, trihydroxy-butyrophenon, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, Zi nk and its derivatives (e.g. ZnO, ZnSO ₄ ) selenium and its derivatives (e.g. selenium-methionine), stilbenes and their derivatives (e.g. stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, Nucleosides, peptides and lipids) of these active ingredients. Biogenic agents

Examples of biogenic active ingredients include tocopherol, tocopherol acetate, tocopherol palmitate, ascorbic acid, (deoxy) ribonucleic acid and its fragmentation products, β-glucans, retinol, bisabolol, allantoin, phytantriol, panthenol, AHA acids, amino acids, ceramides, essentil oils, pseudoceramides To understand plant extracts and vitamin complexes.

film formers

Common film formers are, for example, chitosan, microcrystalline chitosan, quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone-vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives, collagen, hyaluronic acid or its salts and similar compounds.

Antidandruff agents

Piroctone olamine (l-hydroxy-4-methyl-6- (2,4,4-trimythylpentyl) -2- (lH) -pyridinone monoethanolamine salt), Baypival® (Climbazole), Keto-conazol®, (4-AcetyM - {- 4- [2- (2.4-dichlorophenyl) r-2- (lH-imidazol-l-ylmethyl) -l, 3-dioxylan-c-4-ylmethoxyphenyl} piperazine, ketoconazole, elubiol, selenium disulfide, sulfur colloidal, Schwefelpolyehtylenglykolsorbitanmonooleat, Schwefelrizinolpolyehtoxylat, Schwfel tar distillate, salicylic acid (or in combination with hexachlorophene), Undexy- lensäure monoethanolamide sulfosuccinate Na salt, Lamepon® UD (protein undecylenic acid condensate), zinc pyrithione, magnesium pyrithione Aluminiumpyrithion and / dipyrithione magnesium sulfate.

Ouellmittel

Montmorillonites, clay minerals, pemulene and alkyl-modified carbopol types (Goodrich) can serve as swelling agents for aqueous phases. Further suitable polymers or swelling agents can be found in the overview by R. Lochhead in Cosm.Toil. 108, 95 (1993). hydrotropes

Hydrotropes, such as, for example, ethanol, isopropyl alcohol or polyols, can also be used to improve the flow behavior. Polyols that come into consideration here preferably have 2 to 15 carbon atoms and at least two hydroxyl groups. The polyols can also contain further functional groups, in particular amino groups, or be modified with nitrogen. Typical examples are

> Glycerin;

> Alkylene glycols, such as, for example, ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol and polyethylene glycols with an average molecular weight of 100 to 1,000 daltons;

> technical oligoglycerol mixtures with a degree of self-condensation of 1.5 to 10 such as technical diglycerol mixtures with a diglycerol content of 40 to 50% by weight; Methyl compounds, such as in particular trimethylolethane, trimethylolpropane, trimethylolbutane, pentaerythritol and dipentaerythritol; Lower alkyl glucosides, especially those with 1 to 8 carbons in the alkyl radical, such as methyl and butyl glucoside;

> Sugar alcohols with 5 to 12 carbon atoms, such as sorbitol or mannitol,

> Sugar with 5 to 12 carbon atoms, such as glucose or sucrose;

> Aminosugars such as glucamine;

> Dialcohol amines, such as diethanolamine or 2-amino-l, 3-propanediol.

preservative

Suitable preservatives are, for example, phenoxyethanol, formaldehyde solution, parabens, pentanediol or sorbic acid, and the silver complexes known under the name Surfacine® and the other classes of substances listed in Appendix 6, Parts A and B of the Cosmetics Ordinance. Perfume oils and flavors

Perfume oils include mixtures of natural and synthetic fragrances. Natural fragrances are extracts of flowers (lily, lavender, roses, jasmine, neroli, ylang-ylang), stems and leaves (geranium, patchouli, petitgrain), fruits (anise, coriander, caraway, juniper), fruit peel (bergamot, lemon, Oranges), roots (mace, angelica, celery, cardamom, costus, iris, calmus), wood (pine, sandal, guaiac, cedar, rosewood), herbs and grasses (tarragon, lemongrass, sage, thyme), Needles and twigs (spruce, fir, pine, mountain pine), resins and balms (galbanum, elemi, benzoin, myrrh, olibanum, opoponax). Animal raw materials, such as civet and castoreum, are also suitable. Typical synthetic fragrance compounds are products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type. Fragrance compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinylacetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethyl methylphenyl glycinate, allylcyclohexyl benzylatepylpropylate, stylate propionate, stylate propionate. The ethers include, for example, benzyl ethyl ether, the aldehydes include, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonal, and the ketones include, for example, the joonons, α-isomethylionone and methylcedrγl ketone the alcohols anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol, the hydrocarbons mainly include the terpenes and balsams. However, preference is given to using mixtures of different fragrances which together produce an appealing fragrance. Essential oils of lower volatility, which are mostly used as aroma components, are also suitable as perfume oils, for example sage oil, chamomile oil, clove oil, lemon balm oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiver oil, oliban oil, galbanum oil, labolanum oil and lavandin oil. Bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, α-hexylcinnamaldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, boisambrene forte, ambroxan, indole, hedione, sandelice, lemon oil, mandarin oil, lavenderlyl oil, orange oil alaline oil, orange oil oil, orange oil oil, orange oil oil , Muscatel sage oil, ß-Damascone, geranium oil bourbon, cyclohexyl salicylate, Vertofix Coeur, Iso-E-Super, Fixolide NP, Evernyl, Iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilllate, irotyl and floramate, used alone or in mixtures. Suitable flavors are, for example, peppermint oil, spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, lemon oil, wintergreen oil, clove oil, menthol and the like.

dyes

The dyes which can be used are those substances which are suitable and approved for cosmetic purposes, as compiled, for example, in the publication "Cosmetic Dyes" by the Dye Commission of the German Research Foundation, Verlag Chemie, Weinheim, 1984, pp. 81-106. Examples are culinary red A (CI 16255), patent blue V (CI42051), indigotine (CI73015), chlorophyllin (CI75810), quinoline yellow (CI47005), titanium dioxide (CI77891), indanthrene blue RS (CI 69800) and madder varnish (CI58000). Luminol may also be present as the luminescent dye. These dyes are usually used in concentrations of 0.001 to 0.1% by weight, based on the mixture as a whole.

Proof of effectiveness

The anti-inflammatory effects of low molecular weight protein hydrolyzates could be increased by several

Studies are proven. During the first proof of effectiveness, the activity of low molecular weight protein hydrolyzates against inflammatory processes after UV-B radiation on skin cultures was demonstrated in vitro. In the last two studies, acetylsaiicylic acid, which inhibits cyclooxygenase, was selected as the reference substance.

The test design is based on epidermal inflammation induction using UV-B radiation (280 to 320 nm). This is essentially due to the activation of the enzyme phospholipase A2 or PLA2, which releases arachidonic acid from the cell membrane. Then other specific enzymes, so-called cyclooxygenases, convert the arachidonic acid into prostaglandins (PG), which are excreted by the cell. The attachment of certain prostaglandins such as PGE2 to specific receptors is then associated with reddening and swelling as after sunburn on the skin. In cell cultures, these UV-B effects on the cell membrane are associated with the release of a cytoplasmic enzyme, lactate dehydrogenase (LDH). Ultimately, UV-damaged cells can be eliminated by apoptosis, the biological process by which living organisms get rid of defective cells. In apoptotic cells, cytoplasmic DNA fragments are separated from nuclear DNA by the endonuclease.

The enzymes and parameters described above can be determined quantitatively after application of low molecular weight protein hydrolyzates (0.1 and 0.3% original product Gluadin® WLM) to the cell cultures and thus allow conclusions to be drawn about its excellent anti-inflammatory effect in this test system.

Method: The effect of UVB radiation was investigated on keratinocytes in vitro by determining the release of the cytoplasmic enzyme LDH (lactate dehydrogenase). This enzyme serves as a marker for cell damage. To perform the tests, a defined medium containing fetal calf serum was inoculated with the keratinocytes and low molecular weight wheat protein hydrolyzate was added 72 hours after the inoculation.

The keratinocytes were then irradiated with a UVB dose (50 mJ / cm ² - tubes: DUKE GL40E).

After a further 1 day incubation at 37 ° C. and 5% CO ₂ , the LDH and PGE2 content in the supernatant were determined. The content of LDH- (lactate dehydrogenase) was determined by means of an enzyme reaction (kit used to investigate the LDH content from the company Röche). The content of PGE2 was determined using an EUSA test (ELISA kit from the company Röche). To determine the DNA content in the cytoplasm of the keratinocytes, bromodeoxyuridine (BrDU) was added to the growth medium. After the trypsin treatment, the cells were centrifuged and counted. The BrdU content in DNA fragments from the cytoplasm was then determined using the ELISA test. The number of adherent keratinocytes is determined (after trypsin treatment) with a particle counter.

Table 1: Evidence of anti-inflammatory activity [% versus control]

About 57% of the keratinocytes present were destroyed by UV-B radiation. By using low molecular weight protein hydrolyzates, however, this toxic effect could be reduced by more than 50%. The content of released lactate dehydrogenase, on the other hand, was greatly increased by UV-B radiation. Here, too, our low molecular weight wheat peptides led to a reduction of this characteristic UV-B effect by more than 50%. UV-B radiation also caused a sharp increase in the content of released prostaglandins (here PGE2), even in the cell culture which was treated with Aspirin ^® as reference substance (control; 0.002% AS). By using low molecular weight protein hydrolyzates, however, the release of PGE2 was reduced by approx. 66%.

The content of DNA fragments in the cytoplasm of the keratinocytes increased to a similar extent as a result of UV-B radiation. In contrast to the Aspirin ^® (Control; 0.002%), a significant reduction of these fragments by approx. 46% could be achieved with low molecular weight protein hydrolyzates.

Based on these studies, it has been demonstrated that low-molecular-weight protein hydrolyzates are clearly able to build up effective protection against the consequences of UV-B radiation on keratinocytes in cell cultures. The low-molecular-weight protein hydrolyzates thus showed such a good anti-inflammatory effect that they were even better than acetylsaiicylic acid in these studies.

Another proof of efficacy that proves the positive effect of low molecular weight protein hydrolyzates on inflammatory processes is its influence on the inhibition of the "respiratory burst" in cell cultures in vitro.

During the epidermal inflammatory process, leukocytes are attracted, e.g. PMN (polymorphonuclear neutrophil granulocytes) and stimulated by cytokines and other messenger substances such as leukotrienes, which are released by activated or necrotic epidermal cells. These activated PMNs not only release pro-inflammatory cytokines, leukotrienes and proteases, but also ROS (reactive oxygen species) such as superoxide and hypochlorite anions to kill pathogenic bacteria or fungi. PMN activity during inflammation is known as a "respiratory burst" and can mediate tissue damage through the release of ROS and lysosomal enzymes.

For this reason, the anti-inflammatory efficacy of low molecular weight protein hydrolyzates was checked to see if it respiratory the PMN, which is triggered by a yeast extract ("Zymosan"). For this purpose, the content of released active oxygen compounds (ROS) without and with zymosan and the number of cells present were quantified in cell cultures [GM Pieper, GJ Gross: EMD 52692 (bimakalim), a new potassium channel opener, attenuates luminol-enhanced chemimuminescence and Superoxide anion radical formation by zymosan-activated polymorphonuclear leucocytes. Immunopharmacology, 23, 191-197 (1992)], in the same way the Influence of 0.03%, 0.1% and 0.3% of low molecular weight protein hydrolyzates on these parameters.

Table 2:

Proof of anti-inflammatory activity - Zymosan test [% versus control]

The results clearly show the inducing influence of the yeast extract on the respiratory burst of the granulocytes (measured in RLU - relative luminiscence units): the addition of the zymosan increases the content of active oxygen compounds (ROS) by approximately ten times. However, this increase can be considerably reduced by using low-molecular-weight protein hydrolyzates, with an application concentration of 0.3% even by approx. 75%. Accordingly, low-molecular protein hydrolyzates are characterized by an effective inhibition of the "respiratory burst" on granulocytes with a constant cell number and consequently an excellent anti-inflammatory effect. This detection approach confirms the results of the first series of tests and thus effectively demonstrates the anti-inflammatory effects of low molecular weight protein hydrolyzates in vitro.

Claims

claims 1. Use of low molecular weight protein hydrolyzates as anti-inflammatory agents. 2. Use of low molecular weight protein hydrolyzates for the inhibition of inflammatory processes induced by UV radiation. 3. Use of low molecular weight protein hydrolyzates for the production of sunscreens and / or after-sun preparations. 4. Use of low molecular weight protein hydrolyzates for the manufacture of scalp soothing agents. 5. Use according to at least one of claims 1 to 4, characterized in that vegetable protein hydrolyzates are used. 6. Use according to at least one of claims 1 to 5, characterized in that low-molecular wheat protein hydrolyzates are used. 7. Use according to at least one of claims 1 to 6, characterized in that low molecular weight protein hydrolyzates are used which - based on the protein content - have an average molecular weight of 50 to 3,000 daltons. 8. Use according to at least one of claims 1 to 7, characterized in that low molecular weight protein hydrolyzates are used which - based on the protein content - have an average molecular weight of 100 to 1,000 daltons. 9. Use according to at least one of claims 1 to 8, characterized in that low molecular weight protein hydrolyzates are used which - based on the protein content - have an average molecular weight of 200 to 600 daltons. 0. Use according to at least one of claims 1 to 9, characterized in that the low molecular weight protein hydrolyzates are used in amounts of 0.1 to 10% by weight, based on the final formulation.