[go: up one dir, main page]

WO2003066808A3 - Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells - Google Patents

Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells Download PDF

Info

Publication number
WO2003066808A3
WO2003066808A3 PCT/US2003/002047 US0302047W WO03066808A3 WO 2003066808 A3 WO2003066808 A3 WO 2003066808A3 US 0302047 W US0302047 W US 0302047W WO 03066808 A3 WO03066808 A3 WO 03066808A3
Authority
WO
WIPO (PCT)
Prior art keywords
migration
inhibiting
subject
mammalian
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/002047
Other languages
French (fr)
Other versions
WO2003066808A2 (en
Inventor
Suzanne J Lindsey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas Tech University TTU
Original Assignee
Texas Tech University TTU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas Tech University TTU filed Critical Texas Tech University TTU
Priority to AU2003219679A priority Critical patent/AU2003219679B2/en
Priority to US10/502,163 priority patent/US20050124800A1/en
Priority to CA 2473853 priority patent/CA2473853A1/en
Priority to EP03715948A priority patent/EP1578921A4/en
Publication of WO2003066808A2 publication Critical patent/WO2003066808A2/en
Anticipated expiration legal-status Critical
Publication of WO2003066808A3 publication Critical patent/WO2003066808A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to isolated nucleic acid molecules conferring on mammalian carcinoma cells an ability to undergo cell migration. Recombinant DNA expression systems and host cells containing the subject nucleic acid molecule, as well as antisense oligonucleotides, are also described. Also disclosed are methods of inhibiting expresssion of the subject nucleic acid molecule, inhibiting production of the encoded protein or polypeptide, inhibiting metastasis of a carcinoma cell in a subject (including in humans), inhibiting migration of carcinoma cell in a subject, detecting the presence of a migrating carcinoma cell in a sample of a subject's tissue or body fluids, and inhibiting the migration of a placental cell into the blood stream of a female mammal.
PCT/US2003/002047 2002-01-23 2003-01-23 Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells Ceased WO2003066808A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003219679A AU2003219679B2 (en) 2002-01-23 2003-01-23 Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells
US10/502,163 US20050124800A1 (en) 2002-01-23 2003-01-23 Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells
CA 2473853 CA2473853A1 (en) 2002-01-23 2003-01-23 Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells
EP03715948A EP1578921A4 (en) 2002-01-23 2003-01-23 MAMMALIAN CELL MIGRATION INDUCTION GENE AND METHODS OF DETECTING AND INHIBITING MUMMING TUMOR CELLS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35107302P 2002-01-23 2002-01-23
US60/351,073 2002-01-23

Publications (2)

Publication Number Publication Date
WO2003066808A2 WO2003066808A2 (en) 2003-08-14
WO2003066808A3 true WO2003066808A3 (en) 2006-07-20

Family

ID=27734263

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/002047 Ceased WO2003066808A2 (en) 2002-01-23 2003-01-23 Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells

Country Status (5)

Country Link
US (1) US20050124800A1 (en)
EP (1) EP1578921A4 (en)
AU (1) AU2003219679B2 (en)
CA (1) CA2473853A1 (en)
WO (1) WO2003066808A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232285B2 (en) 2007-06-22 2012-07-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1846406T5 (en) 2005-02-09 2011-10-31 Arqule Inc Maleimide derivatives, pharmaceutical compositions and methods for the treatment of cancer
WO2007131071A2 (en) * 2006-05-02 2007-11-15 Washington State University Mig-7 as a specific anticancer target
EP2173748B1 (en) 2007-06-22 2011-08-31 ArQule, Inc. Indolyl pyrrolidines for the treatment of cancer
CA2690799C (en) 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
WO2009055498A2 (en) * 2007-10-22 2009-04-30 Washington State University Research Foundation Mig-7 as a specific anticancer target

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
US20030054985A1 (en) * 2000-02-22 2003-03-20 Stuart Aaronson N-cadherin modulated migration, invasion, and metastasis
WO2001072781A2 (en) * 2000-03-28 2001-10-04 Chiron Corporation Human genes and expression products

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CROUCH S. ET AL: "HGF and ligation of alpha5beta5 integrin induce a novel, cancer cell-specific gene expression required for cell scattering", EXPERIMENTAL CELL RESEARCH, vol. 292, 2004, pages 274 - 287, XP003001871 *
PHILLIPS T. M. ET AL: "Carcinoma cell-specific Mig-7: A new potential marker for circulating and migrating cells", ONCOLOGY REPORTS, vol. 13, 2005, pages 37 - 44, XP008070968 *
See also references of EP1578921A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232285B2 (en) 2007-06-22 2012-07-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof

Also Published As

Publication number Publication date
AU2003219679A1 (en) 2003-09-02
US20050124800A1 (en) 2005-06-09
CA2473853A1 (en) 2003-08-14
WO2003066808A2 (en) 2003-08-14
EP1578921A4 (en) 2007-05-30
EP1578921A2 (en) 2005-09-28
AU2003219679B2 (en) 2009-02-26

Similar Documents

Publication Publication Date Title
Bravo et al. Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ
WO2001053349A3 (en) Small cell lung cancer associated antigens and uses therefor
AU2262197A (en) Fhit proteins and nucleic acids and methods based thereon
ATE464391T1 (en) HYALURONIDASE FROM HUMAN PLASMA
WO2000073801A3 (en) Breast, gastric and prostate cancer associated antigens and uses therefor
WO1997006255A3 (en) Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
CA2488404A1 (en) Genes and polypeptides relating to human colon cancers
EP1005540A4 (en) Ikk-beta proteins, nucleic acids and methods
WO2002082075A3 (en) Method for detecting chronic dementia diseases, and corresponding peptides and detection reagents
WO2002032953A3 (en) Pregnancy-associated plasma protein-a2 (papp-a2)
WO2000020587A3 (en) Cancer associated antigens and uses therefor
CA2362527A1 (en) A novel, prostate-specific gene for diagnosis, prognosis and management of prostate cancer
Kim et al. Bovine seminal ribonuclease produced from a synthetic gene
WO2002086071A3 (en) Cancer-testis antigens
WO2002078526A3 (en) Cancer-testis antigens
WO2003066808A3 (en) Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells
Yamakawa et al. cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells
Miele et al. Gene organization and nucleotide sequence of the primase region of IncP plasmids RP4 and R751
WO1997014797A3 (en) Cystatin m, a novel cysteine proteinase inhibitor
WO2003062826A3 (en) Materials and methods for examining and treating nasopharyngeal carcinoma
WO2007131071A8 (en) Mig-7 as a specific anticancer target
WO1999037764A3 (en) New members of the glypican gene family
Borukhov et al. Escherichia coli transcript cleavage factors GreA and GreB: functions and mechanisms of action
CA2446197A1 (en) Use of alpha 1-antichymotrypsin polypeptides, or nucleic acids encoding them, or of a cell which is expressing an act polypeptide, or a nucleic acid encoding it, for treatment and/or prevention of diabetes-associated and/or arterial poorly healing wounds and for identifying pharmacologically active substances
MX9701596A (en) A human map kinase homolog.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2473853

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003219679

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2003715948

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10502163

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2003715948

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP