[go: up one dir, main page]

WO2003064999A3 - Methods for identifying modulators of receptor tyrosine kinases - Google Patents

Methods for identifying modulators of receptor tyrosine kinases Download PDF

Info

Publication number
WO2003064999A3
WO2003064999A3 PCT/US2003/002192 US0302192W WO03064999A3 WO 2003064999 A3 WO2003064999 A3 WO 2003064999A3 US 0302192 W US0302192 W US 0302192W WO 03064999 A3 WO03064999 A3 WO 03064999A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
receptor tyrosine
jki
tyrosine kinases
site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/002192
Other languages
French (fr)
Other versions
WO2003064999A2 (en
Inventor
Stevan Hubbard
Jeffrey H Till
Shiqing Li
Evan Stein
Nicole Covino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University NYU
Original Assignee
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York University NYU filed Critical New York University NYU
Priority to AU2003217247A priority Critical patent/AU2003217247A1/en
Publication of WO2003064999A2 publication Critical patent/WO2003064999A2/en
Publication of WO2003064999A3 publication Critical patent/WO2003064999A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Screening methods for identifying small molecules capable of binding to the juxtamembrane-kinase interaction (JKI) site of the tyrosine kinase domain of the insulin receptor (IRK) to prevent or lessen constitutive inhibition of kinase activity. More generally, the invention relates to screening methods for identifying small molecules capable of binding to the JKI site of a tyrosine kinase domain, to modulate kinase activity in a receptor molecule comprising a JKI site.
PCT/US2003/002192 2002-01-25 2003-01-24 Methods for identifying modulators of receptor tyrosine kinases Ceased WO2003064999A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003217247A AU2003217247A1 (en) 2002-01-25 2003-01-24 Methods for identifying modulators of receptor tyrosine kinases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35192402P 2002-01-25 2002-01-25
US60/351,924 2002-01-25

Publications (2)

Publication Number Publication Date
WO2003064999A2 WO2003064999A2 (en) 2003-08-07
WO2003064999A3 true WO2003064999A3 (en) 2004-02-26

Family

ID=27663036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/002192 Ceased WO2003064999A2 (en) 2002-01-25 2003-01-24 Methods for identifying modulators of receptor tyrosine kinases

Country Status (2)

Country Link
AU (1) AU2003217247A1 (en)
WO (1) WO2003064999A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2047252B1 (en) * 2006-06-22 2013-01-23 Walter and Eliza Hall Institute of Medical Research Structure of the insulin receptor ectodomain

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514981B1 (en) * 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514981B1 (en) * 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds

Also Published As

Publication number Publication date
AU2003217247A1 (en) 2003-09-02
WO2003064999A2 (en) 2003-08-07

Similar Documents

Publication Publication Date Title
WO2008061236A3 (en) Sulfoximines as kinase inhibitors
AU9158498A (en) Benzylidene-1,3-dihydro-indol-2-one derivatives as receptor tyrosine kinase inhibitors, particularly of raf kinases
WO2005113596A3 (en) Cell surface receptor isoforms and methods of identifying and using the same
WO1999048868A3 (en) Heterocyclic classes of compounds for the modulating tyrosine protein kinase
AU2003245773A1 (en) Vanilloid receptor modulators
DK1409459T3 (en) ECL labels which have improved, non-specific binding properties, methods of using them, and kits containing the same.
WO2004010929A3 (en) METHODS FOR IMPROVEMENT OF LUNG FUNCTION USING TGF-β INHIBITORS
AU2001288374A1 (en) Substituted oxindole derivatives as tyrosine kinase inhibitors
AU2003249369A1 (en) Certain amino-substituted monocycles as kinase modulators
EE200200398A (en) Indazole compounds, pharmaceutical compositions and methods for mediating or inhibiting cell proliferation
WO2005023824A3 (en) Methods for inhibiting tumor cell proliferation
HK1040745A1 (en) Crystal structure of cpla2, and methods of identifying agonists and antagonists using same
WO1998024432A3 (en) Use of indolinone compounds as modulators of protein kinases
AU2003233455A1 (en) Novel fused quinazoline derivatives useful as tyrosine kinase inhibitors
DK1866433T3 (en) Method for identifying LRRK-2 interacting molecules and for purifying LRRK2
AU5215700A (en) Substituted indolinone as tyrosine kinase inhibitors
AU2001229350A1 (en) Low color, aromatic modified c5 hydrocarbon resins
WO2007121147A3 (en) Disheveled pdz modulators
WO2004046317A3 (en) Products and processes for modulating peptide-peptide binding domain interactions
PL375033A1 (en) Her-2 receptor tyrosine kinase molecules and uses thereof
WO2003064999A3 (en) Methods for identifying modulators of receptor tyrosine kinases
WO2004029583A3 (en) Methods of secretory vimentin detection and modulation
AU2003222022A1 (en) Methods for treating deodorizer distillate
WO2006017522A3 (en) Use of antisense oligonucleotides to effect translation modulation
NO20006026D0 (en) Methods and Compositions Useful for Modulating Angiogenesis Using Tyrosine Kinase SRC

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP