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WO2003064651A3 - Regulation de la serine protease humaine du type membrane - Google Patents

Regulation de la serine protease humaine du type membrane Download PDF

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Publication number
WO2003064651A3
WO2003064651A3 PCT/EP2003/000812 EP0300812W WO03064651A3 WO 2003064651 A3 WO2003064651 A3 WO 2003064651A3 EP 0300812 W EP0300812 W EP 0300812W WO 03064651 A3 WO03064651 A3 WO 03064651A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
human membrane
regulation
disorders
type serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/000812
Other languages
English (en)
Other versions
WO2003064651A2 (fr
Inventor
Yonghong Xiao
Annette J Russel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Priority to AU2003238359A priority Critical patent/AU2003238359A1/en
Publication of WO2003064651A2 publication Critical patent/WO2003064651A2/fr
Publication of WO2003064651A3 publication Critical patent/WO2003064651A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Selon l'invention, des réactifs qui régulent la sérine protéase humaine du type membrane ainsi que des réactifs qui se lient à des produits géniques de sérine protéase humaine du type membrane peuvent jouer un rôle dans la prévention, l'amélioration ou la correction de dysfonctionnements ou de maladies telles que, notamment, le cancer, la bronchopneumopathie chronique obstructive, l'ostéoporose, les troubles du SNC, les troubles cardiovasculaires, les troubles génito-urinaires et les troubles gastro-intestinaux.
PCT/EP2003/000812 2002-01-28 2003-01-28 Regulation de la serine protease humaine du type membrane Ceased WO2003064651A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003238359A AU2003238359A1 (en) 2002-01-28 2003-01-28 Regulation of human membrane-type serine protease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35137602P 2002-01-28 2002-01-28
US60/351,376 2002-01-28
US40529902P 2002-08-23 2002-08-23
US60/405,299 2002-08-23

Publications (2)

Publication Number Publication Date
WO2003064651A2 WO2003064651A2 (fr) 2003-08-07
WO2003064651A3 true WO2003064651A3 (fr) 2004-05-13

Family

ID=27669026

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000812 Ceased WO2003064651A2 (fr) 2002-01-28 2003-01-28 Regulation de la serine protease humaine du type membrane

Country Status (2)

Country Link
AU (1) AU2003238359A1 (fr)
WO (1) WO2003064651A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001098468A2 (fr) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases
WO2002012461A2 (fr) * 2000-08-07 2002-02-14 Bayer Aktiengesellschaft Regulation de la serine protease membranaire humaine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001098468A2 (fr) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases
WO2002012461A2 (fr) * 2000-08-07 2002-02-14 Bayer Aktiengesellschaft Regulation de la serine protease membranaire humaine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
INOUE M ET AL: "CLONING AND TISSUE DISTRIBUTION OF A NOVEL SERINE PROTEASE ESP-1 FROM HUMAN EOSINOPHILS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 252, 1998, pages 307 - 312, XP002925663, ISSN: 0006-291X *
TAKEUCHI TOSHIHIKO ET AL: "Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 20, 28 September 1999 (1999-09-28), pages 11054 - 11061, XP002169835, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2003064651A2 (fr) 2003-08-07
AU2003238359A1 (en) 2003-09-02

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