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WO2003062410A3 - Proteine torero - Google Patents

Proteine torero Download PDF

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Publication number
WO2003062410A3
WO2003062410A3 PCT/GB2003/000317 GB0300317W WO03062410A3 WO 2003062410 A3 WO2003062410 A3 WO 2003062410A3 GB 0300317 W GB0300317 W GB 0300317W WO 03062410 A3 WO03062410 A3 WO 03062410A3
Authority
WO
WIPO (PCT)
Prior art keywords
torero
activity
protein
loss
shape
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/000317
Other languages
English (en)
Other versions
WO2003062410A2 (fr
Inventor
Stephen Cohen
Arellano Antonio Giraldez
Richard Copley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Europaisches Laboratorium fuer Molekularbiologie EMBL
Original Assignee
Europaisches Laboratorium fuer Molekularbiologie EMBL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Europaisches Laboratorium fuer Molekularbiologie EMBL filed Critical Europaisches Laboratorium fuer Molekularbiologie EMBL
Priority to AU2003202694A priority Critical patent/AU2003202694A1/en
Publication of WO2003062410A2 publication Critical patent/WO2003062410A2/fr
Publication of WO2003062410A3 publication Critical patent/WO2003062410A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

La présente invention concerne un nouveau mécanisme par lequel une signalisation Wg régule la forme du gradient de protéine Wg. Des niveaux élevés de signalisation Wg induisent l'expression d'une protéine avec une similarité avec des acétylestérases de pectine prédites de plantes ou d'agents pathogènes de plante. Nous avons appelé ce gène Torero du fait de son phénotype mutant à perte de fonction (andalou pour la libellule). Lorsqu'il est surexprimé, le gène Torero bloque l'activité Wg. La perte de la fonction Torero conduit à augmenter l'activité Wg par la modification de la forme du gradient de protéine Wg. L'activité Torero est requise dans l'embryon et dans les disques imaginaux pour limiter l'activité Wg.
PCT/GB2003/000317 2002-01-25 2003-01-27 Proteine torero Ceased WO2003062410A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003202694A AU2003202694A1 (en) 2002-01-25 2003-01-27 Torero protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0201808.3 2002-01-25
GBGB0201808.3A GB0201808D0 (en) 2002-01-25 2002-01-25 Protein

Publications (2)

Publication Number Publication Date
WO2003062410A2 WO2003062410A2 (fr) 2003-07-31
WO2003062410A3 true WO2003062410A3 (fr) 2004-03-11

Family

ID=9929803

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/000317 Ceased WO2003062410A2 (fr) 2002-01-25 2003-01-27 Proteine torero

Country Status (3)

Country Link
AU (1) AU2003202694A1 (fr)
GB (1) GB0201808D0 (fr)
WO (1) WO2003062410A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130224191A1 (en) * 2010-08-27 2013-08-29 Robert A. Stull Notum protein modulators and methods of use
PT2643019T (pt) * 2010-11-24 2019-04-23 Lexicon Pharmaceuticals Inc Anticorpos para notum pectinacetilesterase
US8802365B2 (en) 2011-03-22 2014-08-12 Whitehead Institute For Biomedical Research Methods for identifying candidate modulators of NOTUM activity
CN110862975B (zh) * 2019-12-18 2021-08-31 西南大学 柑橘果胶乙酰酯酶CsPAE及其编码基因和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001018547A1 (fr) * 1999-09-07 2001-03-15 The University Court Of The University Of Glasgow Genes essentiels et recherches relatives a ceux-ci
WO2001071042A2 (fr) * 2000-03-23 2001-09-27 Pe Corporation (Ny) Necessaires de detection, tels que des jeux ordonnes d'echantillons d'acide nucleique, servant a detecter l'expression d'au moins 10.000 genes de drosophila et leur utilisation
WO2001094641A2 (fr) * 2000-06-09 2001-12-13 Idec Pharmaceuticals Corporation Nouvelles cibles geniques et ligands se fixant a celles-ci pour le traitement et le diagnostic de carcinomes ovariens
WO2002002759A2 (fr) * 2000-06-29 2002-01-10 Millennium Pharmaceuticals, Inc. 32225, un nouveau membre de la famille des $g(a)/$g(b)-hydrolases humaines, et utilisations correspondantes
WO2002062841A2 (fr) * 2001-02-02 2002-08-15 Incyte Genomics, Inc. Proteines secretees

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001018547A1 (fr) * 1999-09-07 2001-03-15 The University Court Of The University Of Glasgow Genes essentiels et recherches relatives a ceux-ci
WO2001071042A2 (fr) * 2000-03-23 2001-09-27 Pe Corporation (Ny) Necessaires de detection, tels que des jeux ordonnes d'echantillons d'acide nucleique, servant a detecter l'expression d'au moins 10.000 genes de drosophila et leur utilisation
WO2001094641A2 (fr) * 2000-06-09 2001-12-13 Idec Pharmaceuticals Corporation Nouvelles cibles geniques et ligands se fixant a celles-ci pour le traitement et le diagnostic de carcinomes ovariens
WO2002002759A2 (fr) * 2000-06-29 2002-01-10 Millennium Pharmaceuticals, Inc. 32225, un nouveau membre de la famille des $g(a)/$g(b)-hydrolases humaines, et utilisations correspondantes
WO2002062841A2 (fr) * 2001-02-02 2002-08-15 Incyte Genomics, Inc. Proteines secretees

Non-Patent Citations (20)

* Cited by examiner, † Cited by third party
Title
ADAMS MARK D ET AL: "The genome sequence of Drosophila melanogaster.", SCIENCE (WASHINGTON D C), vol. 287, no. 5461, 24 March 2000 (2000-03-24), pages 2185 - 2195, XP002169943 *
BRETON C ET AL: "PCR cloning and expression analysis of a cDNA encoding a pectinacetylesterase from Vigna radiata L", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 388, 1996, pages 139 - 142, XP002129460, ISSN: 0014-5793 *
DATABASE EMBL [online] 1 February 2000 (2000-02-01), STRAUSBERG R: "hc98f06.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone IMAGE:2908067 3' similar to TR:O80731 O80731 PUTATIVE PECTINACETYLESTERASE PRECURSOR, mRNA sequence.", XP002262866, Database accession no. AW340565 *
DATABASE EMBL [online] 24 November 2000 (2000-11-24), STRAUSBERG, R: "maa34h03.y1 NCI_CGAP_Li10 Mus musculus cDNA clone IMAGE:3812981 5' similar to TR:Q9VUX3 Q9VUX3 CG13076 PROTEIN, mRNA sequence.", XP002262868, Database accession no. BF322230 *
DATABASE EMBL [online] 29 August 2002 (2002-08-29), STRAUSBERG R.L., ET AL.: "Homo sapiens hypothetical protein LOC147111, mRNA (cDNA clone IMAGE:5225889), partial cds.", XP002262869, Database accession no. BC036872 *
DATABASE EMBL [online] 4 September 2001 (2001-09-04), MUZNY D., ET AL.: "Drosophila melanogaster 3L BAC RP98-18K24 (Roswell Park Cancer Institute Drosophila BAC Library) complete sequence.", XP002250860, Database accession no. AC093499 *
DATABASE EMBL [online] 9 February 2001 (2001-02-09), ADACHI J, ET AL: "Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730593N15 product:hypothetical protein, full insert sequence.", XP002262867, Database accession no. AK019987 *
DATABASE GENESEQ [online] 17 July 2001 (2001-07-17), DAVIES RW, ET AL.: "Drosophila melanogaster essential gene fragment, SEQ ID NO: 482.", XP002250861, Database accession no. AAH29293 *
DATABASE GENESEQ [online] 26 March 2002 (2002-03-26), VENTER JC, ET AL.: "Drosophila melanogaster genomic polynucleotide SEQ ID NO 17104", XP002250863, Database accession no. ABL21877 *
DATABASE GENESEQ [online] 26 March 2002 (2002-03-26), VENTER JC, ET AL.: "Drosophila melanogaster polypeptide SEQ ID NO 30057", XP002250862, Database accession no. ABB67755 *
DATABASE SWALL [online] 1 May 2000 (2000-05-01), ADAMS M.D., ET AL.: "CG13076 protein", XP002250859, Database accession no. Q9VUX3 *
DATABASE SWALL [online] 1 October 2002 (2002-10-01), STRAUSBERG R.: "Hypothetical protein (Fragment)", XP002262870, Database accession no. Q8N410 *
GERLITZ OFFER ET AL: "Wingful, an extracellular feedback inhibitor of wingless.", GENES & DEVELOPMENT, vol. 16, no. 9, 1 May 2002 (2002-05-01), May 1, 2002, pages 1055 - 1059, XP002250858, ISSN: 0890-9369 *
GIRALDEZ ANTONIO J ET AL: "HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient.", DEVELOPMENTAL CELL, vol. 2, no. 5, May 2002 (2002-05-01), May, 2002, pages 667 - 676, XP009014916, ISSN: 1534-5807 *
KAWAIJ ET AL: "Functional annotation of a full-length mouse cDNA collection", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 409, no. 6821, 8 February 2001 (2001-02-08), pages 685 - 690, XP002952962 *
MATA JUAN ET AL: "Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis.", CELL, vol. 101, no. 5, 26 May 2000 (2000-05-26), pages 511 - 522, XP002250857, ISSN: 0092-8674 *
NARDINI MARCO ET AL: "alpha/beta Hydrolase fold enzymes: The family keeps growing.", CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 9, no. 6, December 1999 (1999-12-01), pages 732 - 737, XP002250856, ISSN: 0959-440X *
OLLIS D L ET AL: "THE ALPHA/BETA HYDROLASE FOLD", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 5, no. 3, 1992, pages 197 - 211, XP002057138, ISSN: 0269-2139 *
STRAUSBERG R L ET AL: "Generation and initial analysis of more than 15,000 full -length human and mouse cDNA sequences", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 99, no. 26, 24 December 2002 (2002-12-24), pages 16899 - 16903, XP002245220 *
ZENG W ET AL: "NAKED CUTICLE ENCODES AN INDUCIBLE ANTAGONIST OF WNT SIGNALLING", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 403, no. 6771, 17 February 2000 (2000-02-17), pages 789 - 795, XP000934072, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
GB0201808D0 (en) 2002-03-13
WO2003062410A2 (fr) 2003-07-31
AU2003202694A1 (en) 2003-09-02

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