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WO2003060121A3 - Compositions and methods relating to gastric specific genes and proteins - Google Patents

Compositions and methods relating to gastric specific genes and proteins Download PDF

Info

Publication number
WO2003060121A3
WO2003060121A3 PCT/US2002/041160 US0241160W WO03060121A3 WO 2003060121 A3 WO2003060121 A3 WO 2003060121A3 US 0241160 W US0241160 W US 0241160W WO 03060121 A3 WO03060121 A3 WO 03060121A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
gastric
compositions
antagonists
agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/041160
Other languages
French (fr)
Other versions
WO2003060121A2 (en
WO2003060121A9 (en
Inventor
Yongming Sun
Chenghua Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diadexus Inc
Original Assignee
Diadexus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diadexus Inc filed Critical Diadexus Inc
Priority to AU2002359817A priority Critical patent/AU2002359817A1/en
Publication of WO2003060121A2 publication Critical patent/WO2003060121A2/en
Publication of WO2003060121A3 publication Critical patent/WO2003060121A3/en
Publication of WO2003060121A9 publication Critical patent/WO2003060121A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic gastric cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating gastric cancer and non-cancerous disease states in gastric, identifying gastric tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered gastric tissue for treatment and research.
PCT/US2002/041160 2001-12-21 2002-12-20 Compositions and methods relating to gastric specific genes and proteins Ceased WO2003060121A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002359817A AU2002359817A1 (en) 2001-12-21 2002-12-20 Compositions and methods relating to gastric specific genes and proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34313801P 2001-12-21 2001-12-21
US60/343,138 2001-12-21

Publications (3)

Publication Number Publication Date
WO2003060121A2 WO2003060121A2 (en) 2003-07-24
WO2003060121A3 true WO2003060121A3 (en) 2003-08-28
WO2003060121A9 WO2003060121A9 (en) 2003-10-02

Family

ID=23344857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/041160 Ceased WO2003060121A2 (en) 2001-12-21 2002-12-20 Compositions and methods relating to gastric specific genes and proteins

Country Status (2)

Country Link
AU (1) AU2002359817A1 (en)
WO (1) WO2003060121A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5773979B2 (en) 2010-03-03 2015-09-02 東レ株式会社 Gastric cancer detection marker and gastric cancer detection method
KR20120137386A (en) 2010-03-03 2012-12-20 고쿠리츠 다이가쿠 호진 교토 다이가쿠 Gastric cancer marker, and method for detecting gastric cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024946A (en) * 1985-09-30 1991-06-18 Asahi Kasei Kabushiki Kaisha Human monoclonal antibody to antigen of gastric cancer and B-cell line for producing this antibody, method for preparing this B-cell line and antibody, antigen and method of preparation of this antigen
US5051355A (en) * 1986-07-15 1991-09-24 Kyowa Hakko Kogyo Co., Ltd. Anti-human gastric cancer monoclonal antibody
US6153390A (en) * 1992-10-13 2000-11-28 Vanderbilt University TagA gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma
US6416961B1 (en) * 1997-03-18 2002-07-09 Biohit Oyj Diagnosis of early gastric cancer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024946A (en) * 1985-09-30 1991-06-18 Asahi Kasei Kabushiki Kaisha Human monoclonal antibody to antigen of gastric cancer and B-cell line for producing this antibody, method for preparing this B-cell line and antibody, antigen and method of preparation of this antigen
US5051355A (en) * 1986-07-15 1991-09-24 Kyowa Hakko Kogyo Co., Ltd. Anti-human gastric cancer monoclonal antibody
US6153390A (en) * 1992-10-13 2000-11-28 Vanderbilt University TagA gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma
US6416961B1 (en) * 1997-03-18 2002-07-09 Biohit Oyj Diagnosis of early gastric cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GENEMBL [online] DOE JOINT GENOME INSTITUTE AND STANFORD HUMAN GENOME CENTER; 1 May 2001 (2001-05-01), "Homo sapiens chromosome 5 clone CTD-2353F22", XP002964894, Database accession no. (AC008957) *
DATABASE GENEMBL [online] DOE JOINT GENOME INSTITUTE AND STANFORD HUMAN GENOME CENTER; 18 April 2000 (2000-04-18), "Homo sapiens chromosome 5 clone CTD-2074B5", XP002964895, Database accession no. (AC010386) *
GIBCO B.R.L.: "Random primers DNA labeling system", LIFE TECHNOLOGIES, INC. (CATALOGUE AND REFERENCE GUIDE), 2000, pages 404, XP002965029 *

Also Published As

Publication number Publication date
WO2003060121A2 (en) 2003-07-24
AU2002359817A1 (en) 2003-07-30
WO2003060121A9 (en) 2003-10-02

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