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WO2003059386A3 - Conjuges-vecteurs de proteines prion - Google Patents

Conjuges-vecteurs de proteines prion Download PDF

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Publication number
WO2003059386A3
WO2003059386A3 PCT/EP2003/000460 EP0300460W WO03059386A3 WO 2003059386 A3 WO2003059386 A3 WO 2003059386A3 EP 0300460 W EP0300460 W EP 0300460W WO 03059386 A3 WO03059386 A3 WO 03059386A3
Authority
WO
WIPO (PCT)
Prior art keywords
prion
provides
prion protein
conjugates
ordered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/000460
Other languages
English (en)
Other versions
WO2003059386A2 (fr
Inventor
Martin Bachmann
Patrick Maurer
Erica Pellicioli
Wolfgang A Renner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytos Biotechnology AG
Original Assignee
Cytos Biotechnology AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/050,902 external-priority patent/US7264810B2/en
Application filed by Cytos Biotechnology AG filed Critical Cytos Biotechnology AG
Priority to AU2003205623A priority Critical patent/AU2003205623A1/en
Publication of WO2003059386A2 publication Critical patent/WO2003059386A2/fr
Publication of WO2003059386A3 publication Critical patent/WO2003059386A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5409—IL-5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5437—IL-13
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne les domaines de la biologie moléculaire, de la virologie, de l'immunologie et de la médecine. L'invention concerne également une composition contenant un antigène ordonné et répétitif ou un jeu ordonné de déterminants antigènes, et en particulier, un peptide de prion ou un jeu de particules du type virus et des protéines prions. L'invention concerne plus spécifiquement une composition contenant une particule du type virus et au moins une protéine prion (PrP) ou un dimère de celle-ci ou un peptide PrP lié à celle-ci. L'invention concerne, en outre, une méthode de production de conjugués et de jeux ordonnés et répétitifs respectifs. On utilise lesdites compositions pour produire des vaccins destinés à traiter des maladies à prion et en tant que pharmaccins (vaccins thérapeutiques) permettant de prévenir ou de traiter des maladies à prion et d'induire efficacement des réponses immunitaires, en particulier des réponses d'anticorps. Ces compositions sont particulièrement utiles pour induire des réponses immunitaires auto-spécifiques dans le contexte indiqué.
PCT/EP2003/000460 2002-01-18 2003-01-17 Conjuges-vecteurs de proteines prion Ceased WO2003059386A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003205623A AU2003205623A1 (en) 2002-01-18 2003-01-17 Prion protein carrier-conjugates

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US10/050,902 2002-01-18
US10/050,902 US7264810B2 (en) 2001-01-19 2002-01-18 Molecular antigen array
IBPCT/IB02/00166 2002-01-21
PCT/IB2002/000166 WO2002056905A2 (fr) 2001-01-19 2002-01-21 Jeu ordonne d'echantillons d'antigenes moleculaires
US39372502P 2002-07-08 2002-07-08
US60/393,725 2002-07-08
US39659002P 2002-07-18 2002-07-18
US60/396,590 2002-07-18

Publications (2)

Publication Number Publication Date
WO2003059386A2 WO2003059386A2 (fr) 2003-07-24
WO2003059386A3 true WO2003059386A3 (fr) 2004-03-11

Family

ID=27452011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000460 Ceased WO2003059386A2 (fr) 2002-01-18 2003-01-17 Conjuges-vecteurs de proteines prion

Country Status (2)

Country Link
AU (1) AU2003205623A1 (fr)
WO (1) WO2003059386A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9404126B2 (en) 2006-06-12 2016-08-02 Kuros Biosciences Ag Processes for packaging aggregated oligonucleotides into virus-like particles of RNA bacteriophages

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2196217A1 (fr) 2001-09-14 2010-06-16 Cytos Biotechnology AG Emballage de substances immunostimulantes dans des particules similaires aux virus: procédés de production et utilisations
NZ542323A (en) 2003-03-26 2008-07-31 Cytos Biotechnology Ag Melan-A peptide analogue-virus-like-particle conjugates
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
US7867487B2 (en) 2005-02-01 2011-01-11 Ramot At Tel-Aviv University Ltd. Method for treating inflammation associated with amyloid deposits and brain inflammation involving activated microglia
JP5484732B2 (ja) 2005-12-14 2014-05-07 サイトス バイオテクノロジー アーゲー 過敏症の治療のための免疫賦活性核酸パッケージ粒子
SG11201501191XA (en) * 2012-09-17 2015-04-29 Hoffmann La Roche Method for the production of polypeptides in the periplasm of prokaryotic cells
AU2016207099C1 (en) 2015-01-15 2021-02-04 University Of Copenhagen Virus-like particle with efficient epitope display
DK3368068T3 (da) 2015-10-30 2021-02-22 Univ Copenhagen Viruslignende partikler med effektiv epitopdisplay

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032227A2 (fr) * 1998-11-30 2000-06-08 Cytos Biotechnology Ag Presentation moleculaire ordonnee d'antigenes, procede de preparation et utilisation
WO2000078344A1 (fr) * 1999-06-23 2000-12-28 Caprion Pharmaceuticals, Inc. Peptides proteiniques du prion et utilisations associees
WO2001053457A2 (fr) * 2000-01-21 2001-07-26 University Of Connecticut Health Center Vaccins contre certains troubles neurodegeneratifs
WO2001085208A2 (fr) * 2000-05-05 2001-11-15 Cytos Biotechnology Ag Jeu ordonne d'antigenes moleculaires
EP1158003A1 (fr) * 2000-05-23 2001-11-28 Blood Transfusion Centre of Slovenia Anticorps pour la détection d'isoformes du prion PrP Sc

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032227A2 (fr) * 1998-11-30 2000-06-08 Cytos Biotechnology Ag Presentation moleculaire ordonnee d'antigenes, procede de preparation et utilisation
WO2000078344A1 (fr) * 1999-06-23 2000-12-28 Caprion Pharmaceuticals, Inc. Peptides proteiniques du prion et utilisations associees
WO2001053457A2 (fr) * 2000-01-21 2001-07-26 University Of Connecticut Health Center Vaccins contre certains troubles neurodegeneratifs
WO2001085208A2 (fr) * 2000-05-05 2001-11-15 Cytos Biotechnology Ag Jeu ordonne d'antigenes moleculaires
EP1158003A1 (fr) * 2000-05-23 2001-11-28 Blood Transfusion Centre of Slovenia Anticorps pour la détection d'isoformes du prion PrP Sc

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VASILJEVA I ET AL: "Mosaic Qbeta coats as a new presentation model", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 431, no. 1, 10 July 1998 (1998-07-10), pages 7 - 11, XP004258931, ISSN: 0014-5793 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9404126B2 (en) 2006-06-12 2016-08-02 Kuros Biosciences Ag Processes for packaging aggregated oligonucleotides into virus-like particles of RNA bacteriophages

Also Published As

Publication number Publication date
AU2003205623A1 (en) 2003-07-30
AU2003205623A8 (en) 2003-07-30
WO2003059386A2 (fr) 2003-07-24

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