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WO2003047610A1 - Composition permettant d'augmenter la libido et d'ameliorer la satisfaction sexuelle, et procede associe - Google Patents

Composition permettant d'augmenter la libido et d'ameliorer la satisfaction sexuelle, et procede associe Download PDF

Info

Publication number
WO2003047610A1
WO2003047610A1 PCT/US2001/046497 US0146497W WO03047610A1 WO 2003047610 A1 WO2003047610 A1 WO 2003047610A1 US 0146497 W US0146497 W US 0146497W WO 03047610 A1 WO03047610 A1 WO 03047610A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
arginine
pregnelone
histidine
sexual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/046497
Other languages
English (en)
Inventor
Don Perry Haygood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HERTURN LLC
Original Assignee
HERTURN LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HERTURN LLC filed Critical HERTURN LLC
Priority to PCT/US2001/046497 priority Critical patent/WO2003047610A1/fr
Priority to AU2002227225A priority patent/AU2002227225A1/en
Publication of WO2003047610A1 publication Critical patent/WO2003047610A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal

Definitions

  • This invention relates generally to sexual enhancers. More specifically, this invention relates to a composition and method for increasing female sexual desire and satisfaction.
  • Proper sexual performance is one of the hallmarks for a full and enriching lifestyle.
  • Sexual responsiveness in women involves libido, arousal and orgasm.
  • Libido in women is defined as a woman's desire or interest in having a sexual experience.
  • Arousal is the physical response of a woman's sexual anatomy to odors, thoughts, visual images, kissing, rubbing, touching and direct genital stimulation.
  • Arousal includes vaginal lubrication and clitoral erection — clitoral rigidity, enlargement and increased sensitivity.
  • Orgasm is a woman's ultimate pleasurable experience when the pelvic muscles contract and relax in rhythmic waves or spasms. Clitoral stimulation and tumescence
  • FSD Female Sexual Dysfunction
  • Sexual responsiveness can be increased in women with and without FSD.
  • Aphrodisiacs have long been reputed to enhance libido and contribute to sexual excitement.
  • Sexual stimulants as distinguished from aphrodisiacs, provide a physiological boost that may in turn make it possible to have better sex or even sex at all.
  • VIAGRA® With the advent of the male sexual stimulant VIAGRA®, there has been an increased awareness of a similar need to increase sexual desire and sexual satisfaction in women.
  • Yohimbine has previously been available to increase sexual responsiveness but is not very effective alone. As with all drugs, there are side effects and some women do not or cannot take medication.
  • Non-pharmaceutical options for treating organically based FSD have included a clitoral therapy device called the EROS-CTD. This device creates a gentle suction over the clitoris and the surrounding tissue, with the intention of increasing blood flow to the area and enhancing lubrication and sensation. Unfortunately, this device is intrusive and available by prescription only.
  • the present invention relates to a natural composition and method of increasing female sexual desire and sexual satisfaction by oral and/or topical administration of a composition comprising in the range of :
  • Topical in two ounces
  • the composition comprises about:
  • Topical in two ounces
  • Maca Extract 6 1 50 mg —
  • At least one cooling agent may also be included in the topical composition in an amount not to exceed 3 mg, and preferably less than 1 mg.
  • Exemplary cooling agents include menthol and peppermint oil but other known cooling agents may be used.
  • the method of the invention comprises administering one capsule two times per
  • compositions may be delivered topically to the clitoris approximately 30 minutes before sexual contact, not necessarily on a daily basis, but as neeed.
  • ingredients in the cream have a more rapid delivery system because of the menthol being a carrier transdermally.
  • the present invention is concerned with a composition and method for increasing female sexual desire and sexual satisfaction.
  • the method of the invention the
  • composition may be delivered orally and/or topically.
  • composition comprises in each oral dose in a size 1 gel capsule, in the range of: Oral L-Arginine 75-150 mg
  • composition in each capsule comprises about: Oral (per size 1 capsule)
  • the composition in two ounces of topical cream comprises, in the range of:
  • composition in two ounces of topical cream comprises about:
  • At least one cooling agent may also be included in the topical composition.
  • Exemplary cooling agents include menthol and peppermint oil. They may be added in an amount not to exceed 3 mg and preferably about less than 1 mg.
  • the cooling agent may be blended with aloe vera gel and deionized water.
  • the cooling agent may also provide a pleasing odor to the topical composition.
  • the topical composition may alternatively be in a lotion or gel form.
  • compositions utilize the L-Arginine - nitric oxide synthase pathway with L-Arginine as the substrate.
  • composition is manufactured according to good manufacturing practices
  • Glycerin 6.43 Kgs. or 14.45 Lbs. Menthol .00117 Kgs. or .0026 Lbs.
  • Each raw material component is subjected to an identity test (typically thin layer chromatography) and scaled up individually and upon completion of that task, all materials are transferred to a planetary blender (capacity approximately 500 Kilograms) to blend all components. The blending process lasts for approximately 1 hour at room temperature at which time the ingredients are removed and taken to an encapsulation room for encapsulation.
  • the raw materials are available from such suppliers as Sabinsa Corp., 121 Ethel
  • the suggested oral dose schedule is one size 1 capsule two times per day, morning and evening, or as directed by a health care professional.
  • the oral composition is to be taken for a minimum of 30-60 days in order to assimilate the composition into the system.
  • the capsules may be used on a routine daily basis for overall female sexual health.
  • the topical cream may be applied to the clitoris area approximately 30 minutes before sexual activity.
  • the topical cream may be used alone or with the oral composition. After topical application of the composition, the woman may experience arousal in less than four minutes. Cases of arousal and desire have been reported in under one minute. Once applied, the effects are prolonged. Median lasting time of arousal is between 60 to 90 minutes (1-1.5 hours).
  • the topical composition may be applied as needed.
  • composition and method are effective in increasing sexual desire and sexual satisfaction in women with and without FSD.
  • the composition is believed to stimulate clitoral tissue, which results in increased blood flow and dilation of the blood vessels in the clitoral area, resulting in intense sexual arousal and lubrication. There is a shorter time to orgasm with more intense and frequent orgasms.
  • the composition and method may be substantially less expensive, less intrusive,

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une composition naturelle et un procédé associé, permettant d'augmenter la libido et la satisfaction sexuelle chez les femmes. Cette composition contient une quantité efficace de L-Arginine, de L-Histidine, de feuilles de Damiana, de racines de Cimicaire, de Pregnelone, et de la Maca ou de la progestérone. Le procédé consiste à administrer la composition par voie orale et/ou de manière topique.
PCT/US2001/046497 2001-12-03 2001-12-03 Composition permettant d'augmenter la libido et d'ameliorer la satisfaction sexuelle, et procede associe Ceased WO2003047610A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/US2001/046497 WO2003047610A1 (fr) 2001-12-03 2001-12-03 Composition permettant d'augmenter la libido et d'ameliorer la satisfaction sexuelle, et procede associe
AU2002227225A AU2002227225A1 (en) 2001-12-03 2001-12-03 Composition and method to increase female sexual desire and sexual satisfaction

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2001/046497 WO2003047610A1 (fr) 2001-12-03 2001-12-03 Composition permettant d'augmenter la libido et d'ameliorer la satisfaction sexuelle, et procede associe

Publications (1)

Publication Number Publication Date
WO2003047610A1 true WO2003047610A1 (fr) 2003-06-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046497 Ceased WO2003047610A1 (fr) 2001-12-03 2001-12-03 Composition permettant d'augmenter la libido et d'ameliorer la satisfaction sexuelle, et procede associe

Country Status (2)

Country Link
AU (1) AU2002227225A1 (fr)
WO (1) WO2003047610A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006021930A3 (fr) * 2004-08-25 2006-05-26 Femi X As Composition aux herbes aphrodisiaques pour les femmes, comprimes ou capsules comprenant cette composition et procede d'auto-administration de ladite composition
WO2009045505A3 (fr) * 2007-10-03 2009-10-22 Libidinol Llc Composition de prohormone et méthode d'utilisation
FR2936953A1 (fr) * 2008-10-09 2010-04-16 Holymark Composition orale, en particulier complement alimentaire comprenant de la l-arginine et des extraits secs de racines de mace et de feuilles de damiana
US20130023505A1 (en) * 2010-03-09 2013-01-24 Dignity Health Methods for inhibiting preterm labor and uterine contractility disorders and preventing cervical ripening
WO2012006107A3 (fr) * 2010-06-28 2014-05-15 Stemtide, Inc. Compositions de soins de la peau
CN104208444A (zh) * 2014-09-15 2014-12-17 龚定军 一种补肾壮阳的药茶
US9271991B2 (en) 2010-10-27 2016-03-01 Dignity Health Trimegestone (TMG) for treatment of preterm birth
US10226418B2 (en) 2014-05-12 2019-03-12 Susie Q, Ltd. Arginine-containing topical composition

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010744A1 (fr) * 1996-09-12 1998-03-19 Simon Everard Barton Composition comportant un agent antiviral ou antibacterien destinee a empecher la transmission de maladies
JP2000086504A (ja) * 1998-09-07 2000-03-28 Suzuki Yushi Kogyo Kk インポテンツおよび精力減退治療用の貼付剤
US6242012B1 (en) * 1999-10-19 2001-06-05 Thomas Newmark Herbal composition for promoting hormonal balance in women and methods of using same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010744A1 (fr) * 1996-09-12 1998-03-19 Simon Everard Barton Composition comportant un agent antiviral ou antibacterien destinee a empecher la transmission de maladies
JP2000086504A (ja) * 1998-09-07 2000-03-28 Suzuki Yushi Kogyo Kk インポテンツおよび精力減退治療用の貼付剤
US6242012B1 (en) * 1999-10-19 2001-06-05 Thomas Newmark Herbal composition for promoting hormonal balance in women and methods of using same

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
ALEXANDER ET AL.: "Testosterone and sexual behavior in oral contraceptive users and nonusers: a prospective study", HOM. BEHAV., vol. 24, no. 3, 1990, pages 388 - 402 *
BARTON ET AL.: "Composition comprising an antiviral or antibacterial agent for preventing transmission of diseases", PCT INT. APPL., 19 March 1998 (1998-03-19), pages 13 *
DATABASE CAPLUS [online] XP002908642, accession no. STN Database accession no. 1966:103240 *
DATABASE CAPLUS [online] XP002908643, accession no. STN Database accession no. 1972:538655 *
DATABASE CAPLUS [online] XP002908644, accession no. STN Database accession no. 114:136188 *
DATABASE CAPLUS [online] XP002908645, accession no. STN Database accession no. 1998:180748 *
DATABASE CAPLUS [online] XP002908646, accession no. STN Database accession no. 2000:197970 *
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DATABASE CAPLUS [online] XP002908648, accession no. STN Database accession no. 2000:793155 *
FEIGELSON, MURIEL: "Estrogenic regulation of hepatic histidase during postnatal development and adulthood", J. BIOL. CHEM., vol. 243, no. 19, 1968, pages 5088 - 5093, XP002908647 *
FRYER, F.A.: "Chemical investigation of damiana (turnera diffusa)", SPECIALTIES, vol. 1, no. 12, 1995, pages 21 - 23 *
IWAKURA, TAIICHIRO: "Patches containing skin irritants and olfactory sense stimulants to treat impotence and to boost stamina", 28 March 2000 (2000-03-28), JPN. KOKAI TOKKYO KOHO, pages 10 *
PARINA ET AL.: "Changes in concentration of free amino acids in the blood serum of albino rats related to age of animals and protein content of food", ZH. EVOL. BIOKHIM. FIZIOL., vol. 8, no. 4, 1972, pages 363 - 368 *
ZHENG, QUN YI: "Bioactivity guided standardization for a maca extract", AMERICAN CHEMICAL SOCIETY, MEETING ABSTRACT, 220TH, AGFD-123, 2000 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006021930A3 (fr) * 2004-08-25 2006-05-26 Femi X As Composition aux herbes aphrodisiaques pour les femmes, comprimes ou capsules comprenant cette composition et procede d'auto-administration de ladite composition
WO2009045505A3 (fr) * 2007-10-03 2009-10-22 Libidinol Llc Composition de prohormone et méthode d'utilisation
FR2936953A1 (fr) * 2008-10-09 2010-04-16 Holymark Composition orale, en particulier complement alimentaire comprenant de la l-arginine et des extraits secs de racines de mace et de feuilles de damiana
US20130023505A1 (en) * 2010-03-09 2013-01-24 Dignity Health Methods for inhibiting preterm labor and uterine contractility disorders and preventing cervical ripening
WO2012006107A3 (fr) * 2010-06-28 2014-05-15 Stemtide, Inc. Compositions de soins de la peau
US9271991B2 (en) 2010-10-27 2016-03-01 Dignity Health Trimegestone (TMG) for treatment of preterm birth
US10226418B2 (en) 2014-05-12 2019-03-12 Susie Q, Ltd. Arginine-containing topical composition
CN104208444A (zh) * 2014-09-15 2014-12-17 龚定军 一种补肾壮阳的药茶

Also Published As

Publication number Publication date
AU2002227225A1 (en) 2003-06-17

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