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WO2003047558A3 - Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase inhibitors - Google Patents

Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase inhibitors Download PDF

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Publication number
WO2003047558A3
WO2003047558A3 PCT/IB2002/004805 IB0204805W WO03047558A3 WO 2003047558 A3 WO2003047558 A3 WO 2003047558A3 IB 0204805 W IB0204805 W IB 0204805W WO 03047558 A3 WO03047558 A3 WO 03047558A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxidase
amino acid
inhibitors
treatment
cns disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2002/004805
Other languages
French (fr)
Other versions
WO2003047558A2 (en
Inventor
Paul Moser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Biodevelopment SAS
Original Assignee
Genset SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genset SA filed Critical Genset SA
Priority to AU2002339696A priority Critical patent/AU2002339696A1/en
Publication of WO2003047558A2 publication Critical patent/WO2003047558A2/en
Publication of WO2003047558A3 publication Critical patent/WO2003047558A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to compounds that are inhibitors of D-amino acid oxidase, D-aspartate oxidase, or g34872; methods of treating CNS disorders including spinocerebellar ataxia, CAG repeat disorders, and other ataxic disorders using the compounds; and pharmaceutically acceptable compositions that contain the inhibitors are disclosed.
PCT/IB2002/004805 2001-12-03 2002-10-29 Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase inhibitors Ceased WO2003047558A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002339696A AU2002339696A1 (en) 2001-12-03 2002-10-29 Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33658301P 2001-12-03 2001-12-03
US60/336,583 2001-12-03

Publications (2)

Publication Number Publication Date
WO2003047558A2 WO2003047558A2 (en) 2003-06-12
WO2003047558A3 true WO2003047558A3 (en) 2004-03-25

Family

ID=23316743

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/004805 Ceased WO2003047558A2 (en) 2001-12-03 2002-10-29 Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase inhibitors

Country Status (2)

Country Link
AU (1) AU2002339696A1 (en)
WO (1) WO2003047558A2 (en)

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WO2004110339A2 (en) * 2003-06-18 2004-12-23 Nst Neurosurvival Technologies Ltd. Method for selective targeting of apoptotic cells and small molecule ligands used thereof
CA2472806A1 (en) 2004-05-18 2005-11-18 Petro-Canada Compositions and methods for treating turf insect pests and diseases such as fungal infestations
US20060111442A1 (en) * 2004-11-20 2006-05-25 Mr. Stanley Antosh Use of methyl pyruvate to increase cellular energy production downstream of glycolysis for the PARP-1 ablation of HIV without necrotic cell death caused by continuous, chronic PARP-1 activation through the concomitant depletion of ATP and NAD.
US20100048713A1 (en) * 2006-01-06 2010-02-25 Aarhus Universitet Compounds acting on the serotonin transporter
US9357768B2 (en) 2006-10-05 2016-06-07 Suncor Energy Inc. Herbicidal composition with increased herbicidal efficacy
FR2929115B1 (en) * 2008-03-31 2010-06-04 Exsymol Sa COSMETIC USE OF CONJUGATED COMPOUNDS OF INDOLIC AUXINS.
WO2009155693A1 (en) 2008-06-26 2009-12-30 Petro-Canada Improved turfgrass fungicide formulation with pigment
HRP20170089T1 (en) 2009-01-20 2017-03-24 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical
CA2810578C (en) 2010-09-09 2016-08-30 Suncor Energy Inc. Synergistic paraffinic oil and boscalid fungicides
JO3115B1 (en) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co Pyridazinone Compounds and Their Use as DAAO Inhibitors
US9889222B2 (en) 2011-11-09 2018-02-13 Kimberly-Clark Worldwide, Inc. Aqueous medium-sensitive coating compositions for triggered release of active ingredients and visual indication for wetness
US8791045B2 (en) 2011-11-09 2014-07-29 Kimberly-Clark Worldwide, Inc. Non-tacky wetness indicator composition for application on a polymeric substrate
US9212147B2 (en) 2011-11-15 2015-12-15 Takeda Pharmaceutical Company Limited Dihydroxy aromatic heterocyclic compound
EP2858503B1 (en) 2012-06-04 2020-06-03 Suncor Energy Inc. Formulations containing paraffinic oil and anti-settling agent
US9585826B2 (en) 2012-11-07 2017-03-07 Kimberly-Clark Worldwide, Inc. Triggerable compositions for two-stage, controlled release of active chemistry
GB201222711D0 (en) 2012-12-17 2013-01-30 Takeda Pharmaceutical Novel compounds
US9119780B2 (en) 2013-10-30 2015-09-01 Kimberly-Clark Worldwide, Inc. Triggerable compositions for two-stage, controlled release of proactive chemistry
GB201403944D0 (en) * 2014-03-06 2014-04-23 Takeda Pharmaceutical New use
WO2016191468A1 (en) * 2015-05-28 2016-12-01 Baylor College Of Medicine Benefits of supplementation with n-acetylcysteine and glycine to improve glutathione levels
CA2938096C (en) 2016-08-04 2019-02-26 Suncor Energy Inc. Stabilized emulsions
CN108420810A (en) * 2018-02-11 2018-08-21 华南农业大学 Phenylpyruvic acid is preparing the application in alleviating or improving the product of anxiety and Depressive behavior
US12207655B2 (en) 2019-02-15 2025-01-28 Nutrien Ag Solutions (Canada) Inc. Protoporphyrin IX derivatives and use thereof to improve the health of plants
RU2751003C1 (en) * 2020-07-29 2021-07-07 Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный университет имени М.В.Ломоносова» (МГУ) Use of sulfonates for inhibiting human lactate dehydrogenase a
CN115745848A (en) * 2022-12-07 2023-03-07 上海优合生物科技有限公司 Processing and synthesizing process of aminoguanidine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0950406A2 (en) * 1998-01-26 1999-10-20 Niigata University Remedy for CAG repeat expansion diseases
WO1999065516A1 (en) * 1998-06-17 1999-12-23 Yeda Research And Development Co. Ltd. Methods and compositions for treating diseases mediated by transglutaminase activity
WO2000011952A1 (en) * 1998-08-31 2000-03-09 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
WO2001009118A2 (en) * 1999-07-29 2001-02-08 Patrick T Prendergast Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement
WO2002066672A2 (en) * 2001-01-16 2002-08-29 Genset S.A. Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase antagonists

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0950406A2 (en) * 1998-01-26 1999-10-20 Niigata University Remedy for CAG repeat expansion diseases
WO1999065516A1 (en) * 1998-06-17 1999-12-23 Yeda Research And Development Co. Ltd. Methods and compositions for treating diseases mediated by transglutaminase activity
WO2000011952A1 (en) * 1998-08-31 2000-03-09 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
WO2001009118A2 (en) * 1999-07-29 2001-02-08 Patrick T Prendergast Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement
WO2002066672A2 (en) * 2001-01-16 2002-08-29 Genset S.A. Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase antagonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BEERS M H ET AL.: "The Merck Manual, 17th ed.", 1999, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION, N.J., XP002246495 *
GISPERT S ET AL: "Localization of the candidate gene D-amino acid oxidase outside the refined I-cM region of spinocerebellar ataxia 2.", AMERICAN JOURNAL OF HUMAN GENETICS. UNITED STATES OCT 1995, vol. 57, no. 4, October 1995 (1995-10-01), pages 972 - 975, XP009013160, ISSN: 0002-9297 *
LARSON JEFFREY L ET AL: "The toxicity of repeated exposures to rolipram, a type IV phosphodiesterase inhibitor, in rats.", PHARMACOLOGY & TOXICOLOGY, vol. 78, no. 1, 1996, pages 44 - 49, XP009013100, ISSN: 0901-9928 *
PHANJOO A L ET AL: "Double-blind comparative multicentre study of fluvoxamine and mianserin in the treatment of major depressive episode in elderly people", ACTA PSYCHIATRICA SCANDINAVICA 1991 DENMARK, vol. 83, no. 6, 1991, pages 476 - 479, XP009013266, ISSN: 0001-690X *

Also Published As

Publication number Publication date
WO2003047558A2 (en) 2003-06-12
AU2002339696A1 (en) 2003-06-17
AU2002339696A8 (en) 2003-06-17

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