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WO2003045985A3 - Nouveaux polypeptides purifies impliques dans le metabolisme coenzymatique et glucidique - Google Patents

Nouveaux polypeptides purifies impliques dans le metabolisme coenzymatique et glucidique Download PDF

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Publication number
WO2003045985A3
WO2003045985A3 PCT/CA2002/001784 CA0201784W WO03045985A3 WO 2003045985 A3 WO2003045985 A3 WO 2003045985A3 CA 0201784 W CA0201784 W CA 0201784W WO 03045985 A3 WO03045985 A3 WO 03045985A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbohydrate
purified polypeptides
polypeptides involved
coenzyme metabolism
coenzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2002/001784
Other languages
English (en)
Other versions
WO2003045985A2 (fr
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Ivy Ng
Muhammad Zahoor Alam
Donald Awrey
Bryan Beattie
Megan Domagala
Kamran Mansoury
Benjamin Pinder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affinium Pharmaceuticals Inc
Original Assignee
Affinium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharmaceuticals Inc filed Critical Affinium Pharmaceuticals Inc
Priority to AU2002364770A priority Critical patent/AU2002364770A1/en
Publication of WO2003045985A2 publication Critical patent/WO2003045985A2/fr
Publication of WO2003045985A3 publication Critical patent/WO2003045985A3/fr
Priority to US10/806,062 priority patent/US20050214773A1/en
Anticipated expiration legal-status Critical
Priority to US10/922,802 priority patent/US20050187718A1/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01026—Riboflavin kinase (2.7.1.26)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02003—Phosphoglycerate kinase (2.7.2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07003—Pantetheine-phosphate adenylyltransferase (2.7.7.3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La présente invention concerne des cibles de polypeptides destinées à des bactéries pathogènes. Cette invention a également trait à des caractéristiques biochimiques et biophysiques de ces polypeptides.
PCT/CA2002/001784 2001-09-21 2002-11-26 Nouveaux polypeptides purifies impliques dans le metabolisme coenzymatique et glucidique Ceased WO2003045985A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002364770A AU2002364770A1 (en) 2001-11-26 2002-11-26 Purified polypeptides involved in carbohydrate and coenzyme metabolism
US10/806,062 US20050214773A1 (en) 2001-09-21 2004-03-22 Novel purified polypeptides from bacteria
US10/922,802 US20050187718A1 (en) 2001-09-21 2004-08-20 Novel purified polypeptides from Streptococcus pneumoniae

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US33334901P 2001-11-26 2001-11-26
US33342001P 2001-11-26 2001-11-26
US60/333,420 2001-11-26
US60/333,349 2001-11-26
US34195001P 2001-12-19 2001-12-19
US60/341,950 2001-12-19
US34364301P 2001-12-28 2001-12-28
US60/343,643 2001-12-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/806,062 Continuation-In-Part US20050214773A1 (en) 2001-09-21 2004-03-22 Novel purified polypeptides from bacteria
US10/922,802 Continuation-In-Part US20050187718A1 (en) 2001-09-21 2004-08-20 Novel purified polypeptides from Streptococcus pneumoniae

Publications (2)

Publication Number Publication Date
WO2003045985A2 WO2003045985A2 (fr) 2003-06-05
WO2003045985A3 true WO2003045985A3 (fr) 2004-03-11

Family

ID=27502480

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001784 Ceased WO2003045985A2 (fr) 2001-09-21 2002-11-26 Nouveaux polypeptides purifies impliques dans le metabolisme coenzymatique et glucidique

Country Status (2)

Country Link
AU (1) AU2002364770A1 (fr)
WO (1) WO2003045985A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070955A2 (fr) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification de genes esentiels dans des procaryotes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070955A2 (fr) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification de genes esentiels dans des procaryotes

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ABOLA E ET AL: "AUTOMATION OF X-RAY CRYSTALLOGRAPHY", NATURE STRUCTURAL BIOLOGY, NEW YORK, NY, US, vol. 7, no. SUPPL, November 2000 (2000-11-01), pages 973 - 977, XP001062873, ISSN: 1072-8368 *
BAGBY S ET AL: "Optimization of protein solubility and stability for protein nuclear magnetic resonance.", METHODS IN ENZYMOLOGY. UNITED STATES 2001, vol. 339, 2001, pages 20 - 41, XP001152932, ISSN: 0076-6879 *
DATABASE EMBL [online] 11 January 2003 (2003-01-11), "Staphylococcus aureus subsp. aureus N315", XP002247044, Database accession no. BAB41960 *
DATABASE EMBL [online] 11 March 1999 (1999-03-11), "Staphylococcus aureus gap operon (gapR, gap, pgk and tpi genes)", XP002247043, Database accession no. AJ133520 *
DATABASE GSN [online] 13 February 2002 (2002-02-13), "Staphylococcus aureus DNA for cellular proliferation protein #1118", XP002247041, Database accession no. AAS54806 *
DATABASE GSP [online] 14 February 2002 (2002-02-14), "Staphylococcus aureus cellular proliferation protein #1118", XP002247040, Database accession no. AAU36948 *
DATABASE SWALL [online] "Phosphoglycerate kinase (EC 2.7.2.3)", XP002247042, Database accession no. Q9Z5C4 *
KAY L E: "Nuclear magnetic resonance methods for high molecular weight proteins: a study involving a complex of maltose binding protein and beta-cyclodextrin.", METHODS IN ENZYMOLOGY. UNITED STATES 2001, vol. 339, 2001, pages 174 - 203, XP001152928, ISSN: 0076-6879 *
KRAFT P ET AL: "Infrared, surface-assisted laser desorption ionization mass spectrometry on frozen aqueous solutions of proteins and peptides using suspensions of organic solids", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, ELSEVIER SCIENCE INC., NEW YORK, NY, US, vol. 9, no. 9, September 1998 (1998-09-01), pages 912 - 924, XP004149186, ISSN: 1044-0305 *
KURODA M ET AL: "Whole genome sequencing of meticillin-resistant Staphylococcus aureus", LANCET THE, LANCET LIMITED. LONDON, GB, vol. 357, no. 9264, Q9Z5C4, 21 April 2001 (2001-04-21), pages 1225 - 1240, XP004246103, ISSN: 0140-6736 *
THOMA R ET AL: "Efficient expression, purification and crystallisation of two hyperthermostable enzymes of histidine biosynthesis", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 454, no. 1-2, 2 July 1999 (1999-07-02), pages 1 - 6, XP004259914, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
AU2002364770A8 (en) 2003-06-10
AU2002364770A1 (en) 2003-06-10
WO2003045985A2 (fr) 2003-06-05

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