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WO2003041645A3 - Method of vaccinating a human patient to prevent metastatic tumors - Google Patents

Method of vaccinating a human patient to prevent metastatic tumors Download PDF

Info

Publication number
WO2003041645A3
WO2003041645A3 PCT/US2002/035957 US0235957W WO03041645A3 WO 2003041645 A3 WO2003041645 A3 WO 2003041645A3 US 0235957 W US0235957 W US 0235957W WO 03041645 A3 WO03041645 A3 WO 03041645A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumors
human patient
vaccinating
methods
metastatic tumors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/035957
Other languages
French (fr)
Other versions
WO2003041645A2 (en
Inventor
Ning Y Yu
Jian-Min Lin
Robert J Tressler
Richard E Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to EP02778802A priority Critical patent/EP1453468A4/en
Priority to AU2002340439A priority patent/AU2002340439A1/en
Publication of WO2003041645A2 publication Critical patent/WO2003041645A2/en
Publication of WO2003041645A3 publication Critical patent/WO2003041645A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Methods of preventing or inhibiting metastatic tumors in an immunocompetent human patient are provided. Specifically, methods of this invention involved identifying one or more solid tumors in a human patient wherein said tumors are accessible by injection techniques. A first does of a pharmaceutical composition is administered to said solid, accessible tumor or tumors in an amount effective to initiate an immune response to the tumor or tumors. The immune response initiated by the methods of this invention may also exhibit immunological memory.
PCT/US2002/035957 2001-11-09 2002-11-08 Method of vaccinating a human patient to prevent metastatic tumors Ceased WO2003041645A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02778802A EP1453468A4 (en) 2001-11-09 2002-11-08 Method of vaccinating a human patient to prevent metastatic tumors
AU2002340439A AU2002340439A1 (en) 2001-11-09 2002-11-08 Method of vaccinating a human patient to prevent metastatic tumors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33798401P 2001-11-09 2001-11-09
US60/337,984 2001-11-09

Publications (2)

Publication Number Publication Date
WO2003041645A2 WO2003041645A2 (en) 2003-05-22
WO2003041645A3 true WO2003041645A3 (en) 2003-07-24

Family

ID=23322894

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/035957 Ceased WO2003041645A2 (en) 2001-11-09 2002-11-08 Method of vaccinating a human patient to prevent metastatic tumors

Country Status (3)

Country Link
EP (1) EP1453468A4 (en)
AU (1) AU2002340439A1 (en)
WO (1) WO2003041645A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
CN113993522A (en) 2019-04-17 2022-01-28 指南针探路者有限公司 Method for treating anxiety disorders, headache disorders and eating disorders with siloxibin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09507233A (en) * 1993-12-29 1997-07-22 マトリクス ファーマスーティカル，インコーポレイティド Method for treating host with cell proliferative disorder and composition for treatment
US5478556A (en) * 1994-02-28 1995-12-26 Elliott; Robert L. Vaccination of cancer patients using tumor-associated antigens mixed with interleukin-2 and granulocyte-macrophage colony stimulating factor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GRIMM E.A. ET AL.: "Unexprected cytokines in serum of malignant melanoma patients during sequential biochemotherapy", CLIN. CANCER RES., vol. 6, no. 10, October 2000 (2000-10-01), pages 3895 - 3903, XP002963858 *
MUGINOVA S.: "Inhibition of peroxidase, trypsin and alpha-chymotrypsin by platinum(II) and platinum(IV) complexes", BIOCHEMISTRY (MOSC), vol. 64, no. 4, April 1999 (1999-04-01), pages 399 - 404 *
PAVIA M.B.: "Laser and cisplatinum for treatment of human squamous cell carcinoma", LARYNGOSCOPE, vol. 108, no. 9, September 1998 (1998-09-01), pages 1269 - 1276 *

Also Published As

Publication number Publication date
EP1453468A4 (en) 2005-11-23
EP1453468A2 (en) 2004-09-08
WO2003041645A2 (en) 2003-05-22
AU2002340439A1 (en) 2003-05-26

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