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WO2003040298A3 - Zell- und gewebezüchtung mit hilfe reversibel sauerstoff bindender substanzen - Google Patents

Zell- und gewebezüchtung mit hilfe reversibel sauerstoff bindender substanzen Download PDF

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Publication number
WO2003040298A3
WO2003040298A3 PCT/EP2002/008370 EP0208370W WO03040298A3 WO 2003040298 A3 WO2003040298 A3 WO 2003040298A3 EP 0208370 W EP0208370 W EP 0208370W WO 03040298 A3 WO03040298 A3 WO 03040298A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxygen
cultures
substances
utilized
reversibly bind
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/008370
Other languages
English (en)
French (fr)
Other versions
WO2003040298A2 (de
WO2003040298B1 (de
Inventor
Wolfgang Fege
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU2002363454A priority Critical patent/AU2002363454A1/en
Priority to EP02799039A priority patent/EP1451298A2/de
Publication of WO2003040298A2 publication Critical patent/WO2003040298A2/de
Publication of WO2003040298A3 publication Critical patent/WO2003040298A3/de
Publication of WO2003040298B1 publication Critical patent/WO2003040298B1/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Die Erfindung betrifft die Verwendung von Substanzen, welche Sauerstoff reversibel binden zum Transport, zur Weiterleitung und zur Speicherung von Sauerstoff zur Sauerstoffversorgung bei der Züchtung von Organen, organähnlichen Strukturen, von Gewebekulturen, Kulturen von menschlichen oder tierischen Zellen oder Kulturen von Mikroorganismen. Hierbei können mehrere mögliche Eigenschaften solcher Substanzen genutzt werden. Zum einen die Eigenschaft, Sauerstoff bei höherem Partialdruck zu binden und bei niedrigem Partialdruck der Umgebung wieder abzugeben, so dass ein Sauerstofftransport möglich ist. Desweiteren wird die Fähigkeit genutzt, Sauerstoff zu speichern und nur bei sehr niedrigen Partialdrücken wieder abzugeben. Auch wird die Fähigkeit einiger solcher Substanzen genutzt, Sauerstoff unterschiedlich gut weiterzuleiten. Durch das Zugeben von reversibel Sauerstoff bindenden Substanzen zu Organ-, Organoid-, Gewebs-, Zell- oder Mikroorganismen-Kulturen kann eine ausreichende Sauerstoffversorgung auch in den Bereichen erzielt werden, wo ohne diese Stoffe unter sonst gleichen Bedingungen keine für das Überleben oder eine gute Funktion von Zellen oder sauerstoffbenötigenden Mikroorganismen ausreichende Sauerstoffversorgung möglich wäre.
PCT/EP2002/008370 2001-07-30 2002-07-26 Zell- und gewebezüchtung mit hilfe reversibel sauerstoff bindender substanzen Ceased WO2003040298A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002363454A AU2002363454A1 (en) 2001-07-30 2002-07-26 Cell and tissue growth using substances that reversibly bind oxygen
EP02799039A EP1451298A2 (de) 2001-07-30 2002-07-26 Zell- und gewebezüchtung mit hilfe reversibel sauerstoff bindender substanzen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10136912A DE10136912A1 (de) 2001-07-30 2001-07-30 Verfahren zur Sauerstoffversorgung von Mikroorganismenkulturen, Kulturen von tierischen oder menschlichen Körperzellen und von Gewebekulturen, Organoiden, Organen
DE10136912.3 2001-07-30

Publications (3)

Publication Number Publication Date
WO2003040298A2 WO2003040298A2 (de) 2003-05-15
WO2003040298A3 true WO2003040298A3 (de) 2003-10-16
WO2003040298B1 WO2003040298B1 (de) 2003-12-04

Family

ID=7693473

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008370 Ceased WO2003040298A2 (de) 2001-07-30 2002-07-26 Zell- und gewebezüchtung mit hilfe reversibel sauerstoff bindender substanzen

Country Status (4)

Country Link
EP (1) EP1451298A2 (de)
AU (1) AU2002363454A1 (de)
DE (1) DE10136912A1 (de)
WO (1) WO2003040298A2 (de)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006641A1 (en) * 1989-10-30 1991-05-16 California Institute Of Technology Enhancement of cell growth by expression of a cloned hemoglobin gene
WO1995027040A1 (en) * 1994-04-01 1995-10-12 Unisyn Technologies, Inc. Culture media additives for hollow fiber bioreactors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006641A1 (en) * 1989-10-30 1991-05-16 California Institute Of Technology Enhancement of cell growth by expression of a cloned hemoglobin gene
WO1995027040A1 (en) * 1994-04-01 1995-10-12 Unisyn Technologies, Inc. Culture media additives for hollow fiber bioreactors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHAE S Y ET AL: "Bioactive polymers for biohybrid artificial pancreas.", JOURNAL OF DRUG TARGETING. SWITZERLAND 2001, vol. 9, no. 6, 2001, pages 473 - 484, XP009013685, ISSN: 1061-186X *
KIMURA T ET AL: "Oxygen carrying capacity and oxygen supply rate of artificial oxygen carrier, Neo Red Cell (NRC).", ARTIFICIAL CELLS, BLOOD SUBSTITUTES, AND IMMOBILIZATION BIOTECHNOLOGY. UNITED STATES NOV 1998, vol. 26, no. 5-6, November 1998 (1998-11-01), pages 455 - 464, XP009013683, ISSN: 1073-1199 *
MANO T ET AL: "Comparison of oxygen supply methods for cultures of shear-stress sensitive organisms including animal cell culture.", JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (OXFORD, OXFORDSHIRE: 1986) ENGLAND 1990, vol. 47, no. 3, 1990, pages 259 - 271, XP009013684, ISSN: 0268-2575 *
NOVÁKOVÁ V: "The evaluation of synthetic oxygen carriers by perfusion of isolated rat liver.", ACTA PHYSIOLOGICA SCANDINAVICA. SWEDEN DEC 1976, vol. 98, no. 4, December 1976 (1976-12-01), pages 433 - 439, XP009013686, ISSN: 0001-6772 *

Also Published As

Publication number Publication date
WO2003040298A2 (de) 2003-05-15
AU2002363454A1 (en) 2003-05-19
WO2003040298B1 (de) 2003-12-04
EP1451298A2 (de) 2004-09-01
DE10136912A1 (de) 2003-02-20

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