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WO2002100448A1 - Matiere antibacterienne - Google Patents

Matiere antibacterienne Download PDF

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Publication number
WO2002100448A1
WO2002100448A1 PCT/AU2002/000772 AU0200772W WO02100448A1 WO 2002100448 A1 WO2002100448 A1 WO 2002100448A1 AU 0200772 W AU0200772 W AU 0200772W WO 02100448 A1 WO02100448 A1 WO 02100448A1
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WO
WIPO (PCT)
Prior art keywords
antibacterial material
material according
biocide
carrier
antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2002/000772
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English (en)
Inventor
Barrie David Cooper
Harry Knowles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP02727047A priority Critical patent/EP1401509A4/fr
Priority to US10/480,537 priority patent/US20050008840A1/en
Priority to JP2003503267A priority patent/JP2005501016A/ja
Publication of WO2002100448A1 publication Critical patent/WO2002100448A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M23/00—Treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, characterised by the process
    • D06M23/12—Processes in which the treating agent is incorporated in microcapsules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
    • A61L2/232—Solid substances, e.g. granules, powders, blocks, tablets layered or coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/01—Deodorant compositions
    • A61L9/014—Deodorant compositions containing sorbent material, e.g. activated carbon
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
    • D06M13/152—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen having a hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • D06M13/156—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen having a hydroxy group bound to a carbon atom of a six-membered aromatic ring containing halogen atoms
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
    • D—TEXTILES; PAPER
    • D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
    • D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
    • D21H21/00—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties
    • D21H21/14—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties characterised by function or properties in or on the paper
    • D21H21/36—Biocidal agents, e.g. fungicidal, bactericidal, insecticidal agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
    • D06M2101/02—Natural fibres, other than mineral fibres
    • D06M2101/04—Vegetal fibres
    • D06M2101/06—Vegetal fibres cellulosic
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F8/00—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying
    • F24F8/10—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering
    • F24F8/15—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering by chemical means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249924—Noninterengaged fiber-containing paper-free web or sheet which is not of specified porosity

Definitions

  • the present invention relates to antibacterial material and in particular to material suitable as a dressing for wounds such as ulcerated or burned tissue.
  • Ulcers are a particularly painful form of slow healing wound and are often difficult to treat due to underlying circulatory problems and the continuous risk of infection. Ulcers are secreting skin wounds which produce exudates such as blood, pus and other wound fluids. These fluids can accumulate in the wound cavity and form a rich pool of nutrients which promotes bacterial growth. This, in turn, delays or prevents the healing process, or in some cases leads to further tissue damage or even the possibility of systemic life threatening infection. It is would be desirable to allow such wounds to heal in a slightly moist environment provided infection can be controlled and excess wound exudates can be removed to prevent blisters forming under the dressing or the dressing becoming embedded in the woimd. Examples of conventional dressings used to protect open wounds and promote the healing process include traditional cloth, cotton or lint pads, non-adherent latex dressings and synthetic-algin coatings.
  • Non-adherent latex dressings have a high rate of allergic reaction. Along with some other types of conventional dressings, they are unable to absorb exuded fluids at a rate commensurate with the rate of fluid production by the wound or alternatively, their fluid holding capacity is not significant to allow long periods of time in contact with the wound. The progressive build up of bacteria then delays healing and may also produce unpleasant odours.
  • Algin type dressings are designed to avoid adhering to healing wounds and for easy removal. They present the appearance of being coated with jelly-like substance. While these may avoid adhering to a healing wound, they have a propensity to go mouldy when exposed to bacteria filled fluids for extended periods.
  • the present invention relates to an antibacterial material, a method of producing an antibacterial material and methods of inhibiting infection during the treatment of wounds using the antibacterial material of the present invention.
  • the present invention provides an antibacterial material including: a fibrous substrate impregnated with a carrier; and a controlled release biocide dispersed through said carrier.
  • the present invention provides a process for making an antibacterial material according to the first aspect, said process including: dispersing a controlled release biocide within a carrier to provide an active carrier mixture; and impregnating a fibrous substrate with said active carrier mixture.
  • the present invention provides a method of inhibiting infection during the treatment of wounds by applying an antibacterial material according to the first aspect to an affected skin area on a patient.
  • the present invention provides use of an antibacterial material according to the first- aspect in the manufacture of a dressing for inhibiting infection during the treatment of wounds.
  • wound includes tissue injury such as flesh wounds, mechanical injuries, ulcers, burns, open surgical wounds and lesions and also skin conditions such as acne.
  • the substrate is paper.
  • the carrier is preferably propylene glycol, although other glycols may be used as carriers. Other suitable carriers include alcohols. Water based carriers may also be used.
  • the biocide is preferably triclosan, mobile within the carrier. Other suitable biocides may also be employed. Detailed Description of the Invention
  • the antibacterial material includes a fibrous substrate impregnated with a carrier having a controlled release biocide dispersed therethrough. Once the controlled release takes place, the biocide is mobile within the carrier so that it can travel to the site of action.
  • the substrate is a substantially cotton cellulose fibre blend, most preferably a soft sheet of open weave paper.
  • the substrate may be creped paper which has a high surface area and increased stretch and flexibility. This enables the material in use to adapt readily to various configurations of the patient.
  • the preferred paper substrate has sufficient wet strength to be pulled intact from a wound. However, in some embodiments the paper strength may be selected to be disintegrable or dissolvable such that it can be washed out of a wound if necessary.
  • the weight of the substrate may vary. Depending on particular requirements, the weight may be in the range of 50 to 200 gsm, more preferably in the range of 80 to 150 gsm, and most preferably in the range of 100 to 120 gsm.
  • the biocide of the present invention is a controlled release biocide.
  • the biocide is encapsulated so as to be in a latent state capable of being activated by external stimuli.
  • the encapsulation for example, may be by means of polypropylene microspheres for instance.
  • the external stimuli may include pressure or light, in particular ultraviolet light.
  • the level of antibacterial effect may be varied by increasing or decreasing the amount of biocide.
  • the biocide When the biocide is released from encapsulation, it is taken up in the carrier and dissolves therethrough.
  • the biocide itself is preferably triclosan.
  • triclosan is that known under the trademark CANSAN ® TCH.
  • Triclosan is non-toxic and non-allergenic to humans and inhibits the growth of bacteria such as E. coli, Legionella or Staphylococcus and low titre viruses for example HIV.
  • the biocide is deactivated by blood serum such that it is effective in killing bacteria but has no effect on humans.
  • the biocide is present in an amount of 10 to 10,000 ppm of the carrier, depending upon the intended use.
  • use for dressings for non-serious wounds is 10-1,000 ppm biocide, or 10-200 ppm biocide in even less serious cases.
  • concentration of biocide in the carrier is anywhere up to about 3,000-6,000ppm.
  • an amount of 10-100 ppm is found to be appropriate.
  • a concentration of about 100-500ppm biocide in carrier is an appropriate concentration. These concentrations are those which would be used when the carrier is applied at its preferred rate of 100 ml/m , or 1 litre of carrier per 10m 2 . Appropriate adjustments to the concentration and rate of application to the substrate can be made to provide equivalent amounts of active if required.
  • the encapsulated biocide is dispersed through a carrier which is preferably a glycol and most preferably propylene glycol.
  • the carrier is applied to the substrate at a rate of between 80 and 120 ml per square metre, and more preferably around 100ml of the carrier is used per square metre of the substrate.
  • the humectant properties of propylene glycol keep the dressing damp and enable it to be easily removed from the wound.
  • the preferred method of adjusting the total amount of active in a dressing or other article of the present invention is through varying the concentration of active in the carrier, rather than by the alternative procedure of varying the amount of carrier applied to the substrate.
  • the fibrous substrate further includes strengthening material, such as a nylon resin and most preferably a Kymene resin.
  • the strengthening resin is present in an amount of around 0.01% to 0.06% by weight of the paper.
  • the amount of Kymene resin is around 0.03%. The higher the amount of Kymene, the harder the paper.
  • air conditioning filters will have an amount of Kymene near the high end of the range as they require high strength.
  • the antibacterial material of the present invention has a wide range of possible applications in the medical, dental and veterinary fields.
  • the material is most suitable as a wound dressing. Unlike conventional dressings, which are changed daily, in its preferred form the material of the present invention can be left on the wound for extended periods of time, for example 3 to 4 days in some cases. By minimising the number of dressing changes the wound has a better chance of healing over a shorter period of total treatment time.
  • the controlled release of active biocide kills bacteria or maintains a low bacterial population throughout this time, thus inhibiting infection and reducing odour. It will be appreciated that the material is particularly applicable to the treatment of sensitive skin wounds such as burns and ulcers.
  • the material of the present invention may be adapted for use to inhibit infection during treatment of animal wounds such as injuries to the front forelegs of horses.
  • the skin in this area is particularly thin and prone to injury.
  • Such injuries behave like ulcers in that they are open and slow healing.
  • the antibacterial material of the present invention can be used to accelerate the healing time of such wounds and thus return the horse more quickly to an active state.
  • the antibacterial material of the present invention has other uses in the field of infection control.
  • Triclosan can be applied to the buccal mucosa without adverse effects.
  • Another use is as a surgical barrier, such as a bib for the protection of surgeons, or as a sheet to protect patients. Any disruption to the surgical barrier would result in immediate release of the antibacterial agent from the antibacterial material of the present invention.
  • the antibacterial material of the present invention may also be used to wrap autoclaved instruments.
  • the controlled release of active biocide ensures sterility for longer periods of time than wrapping with standard plastic material which is susceptible to bacterial infection.
  • the material of the present invention may be employed as a wipe, including surface wipe to sterilise surfaces or a hand cleansing wipe to reduce the hand transfer of bacteria. It is well-known that hand to mouth transfer of bacteria is a major cause of bacterial infection.
  • the material of the present invention may also be useful in the treatment of acne. It will be appreciated that the biocidal material of the present invention may be used with, for example, waterproof backing materials or elastic backed sticking plasters.
  • the material of the present invention may be used to combat airborne pathogens. Examples of this include production of medical or other microbiologically protective masks formed from the antibacterial material.
  • the antibacterial material of the present invention may also be adapted for use as an air conditioning filter to combat Legionella or other bacteria in the recirculated air within air conditioning ducts. Breakdown of the encapsulated biocide is proportional to the air flow velocity through the filter. Thus, when air flow (and consequently bacterial flux through the filter) is high, the amount of triclosan released is also high. When the air flow is off, there is not a significant increase of airborne bacteria, and nor is there significant further release of triclosan. Thus, the biocide is delivered when it is needed, and is not overproduced during times of low demand.
  • the antibacterial material of the present invention can be easily cut to any size, contributing to its wide range of applications.
  • the preferred material of the present invention is inherently sterile in its packaged form and is not fully activated until placed in use. This avoids the necessity for complex autoclaving procedures.
  • the packaged material of the present invention can be treated with gamma radiation in order to verify that the material is sterile. Should any damage occur to the packaged material the damage itself releases the biocide to inhibit bacterial contamination.
  • Manufacture of the preferred material includes the step of producing an open weave paper by conventional methods. However, before the final drying stage, the paper is sprayed with the carrier, which may be an aqueous carrier, an alcohol or a glycol, such as propylene glycol containing a dispersion of encapsulated triclosan at the requisite concentration for the intended purpose and then drying the paper with heat.
  • the carrier which may be an aqueous carrier, an alcohol or a glycol, such as propylene glycol containing a dispersion of encapsulated triclosan at the requisite concentration for the intended purpose and then drying the paper with heat.
  • roller drying is not used after the encapsulated biocide has been applied.
  • the mechanical effect of packaging the dressing in a sealed package means that the paper of the present invention is self-sterilising when packaged.
  • the material of the present invention thus avoids the need for expensive and complex autoclaving.
  • Test 1 the antimicrobial activity of the different antibacterial Paper Sheets, treated with Cansan TCH has been determined under agar diffusion test conditions.
  • Test 2 the remaining antibacterial effect on hands after usage of the Cansan
  • Microbiological evaluation 1 Determination of the bacteriostatic activity according to the bacterial growth inhibition test.
  • Discs with a diameter of 2cm were punched out from the hand Sheets.
  • the discs were applied on the top layer of the solidified agar containing the bacteria.
  • a 1 : 100 (Staphyloccocus aureus and Micrococcus luteus) and a 1:1000 (Escherichia coli) dilution were made and 3.5 ml of the dilutions were added to 500 ml agar.
  • Test bacteria Staphylococcus aureus ATCC 9144
  • Escherichia coli NCTC 8196 Nutrient medium Casein soy meal pepton agar (two layers of agar: 15 ml bottom layer without germs and 5 ml top layer with bacteria)
  • Test 2 Finger print test
  • Test bacteria Staphylococcus aureus ATCC 9144
  • Filter paper discs (2 cm diameter) soaked with ethanol were placed in sterile plates. The fingertips were applied on the filter paper discs for 30 sec. in order to allow a migration of Cansan due to the excellent adsorption of ethanol. After 1 minute contact time, the filter discs were dried in the plates and then placed in the middle of agar plates containing the test germs (placebo sample).
  • the hands were rinsed under running lukewarm tap water and subsequently washed with the placebo soaps for 60 seconds. Subsequently the later was washed off under running lukewarm tap water. The hands have been dried with the test Paper Sheets for 1 minute.
  • Ethanol soaked filter paper disks (2 cm diameter) were placed in sterile plates and the same procedure as described under 3. has been performed. 6. The procedure after application of the test Sheets in order to determine the activity of Cansan ® TCH on the skin. 7. The plates were incubated under optimal conditions according to the germ's requirements on temperature and media.
  • the Paper Sheets with Cansan ® TCH showed good antibacterial effects against gram-positive and gram-negative test bacteria under agar diffusion test conditions where the Paper Sheets were in direct contact with the contaminated agar.
  • Example 6 Preliminary Patient Test A patient with a leg ulcer had the ulcer dressed with the antibacterial material of the present invention. The dressing was changed after 3 days, and the condition of the wound was observed after one week.
  • the natural healing of the wound was scored by a registered nurse as being 8/10.
  • a normal natural healing score for a leg ulcer dressed with a conventional dressing is expected to be around 4/10. While there is a degree of subjectivity in the scores, the preliminary test result is believed by the present applicants to be significant.
  • the dressing was readily removed, and did not adhere to the wound. Conventional dressings would be expected to adhere to the wound to varying degrees after only about one day, which is the life span of the dressing.
  • the condition of the dressing was also examined and triclosan was determined to be present. It was estimated that the dressing could be used for a further.period, possibly being allowed to remain untouched on the wound for as long as 4-5 days.
  • Example 7 Preliminary Patient Test
  • a medical practitioner applied a dressing according to the present invention on the skin ulcers of six patients.
  • the dressings of the present invention maintained a high standard of cleanliness of the wounds. After 2-3 weeks, the wounds exhibited accelerated healing relative to comparable ulcers dressed with conventional dressings.
  • a medical practitioner applied a dressing of the present invention to a minor burn as a result of scalding.
  • the dressing contained lOOppm Cansan TCH in propylene glycol (applied at 100ml per square metre) impregnated onto 120gsm paper. After five days, the bum was almost completely healed, with only slight signs of scarring.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pest Control & Pesticides (AREA)
  • Textile Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Combustion & Propulsion (AREA)
  • Materials For Medical Uses (AREA)
  • Filtering Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Paper (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une matière antibactérienne, un procédé permettant la production d'une matière antibactérienne, et un procédé destiné à inhiber l'infection au cours du traitement de plaies par utilisation d'une matière antibactérienne. La matière antibactérienne comprend un substrat fibreux imprégné d'un excipient et d'un biocide à libération contrôlée dispersé dans l'excipient.
PCT/AU2002/000772 2001-06-13 2002-06-13 Matiere antibacterienne Ceased WO2002100448A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02727047A EP1401509A4 (fr) 2001-06-13 2002-06-13 Matiere antibacterienne
US10/480,537 US20050008840A1 (en) 2001-06-13 2002-06-13 Antibacterial material
JP2003503267A JP2005501016A (ja) 2001-06-13 2002-06-13 抗菌性材料

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR5643A AUPR564301A0 (en) 2001-06-13 2001-06-13 Antibacterial material
AUPR5643 2001-06-13

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WO2006113967A1 (fr) * 2005-04-27 2006-11-02 Novapharm Research (Australia) Pty Ltd Filtre biostatique et formulation biocide insoluble dans l’eau pour celui-ci
WO2016055839A1 (fr) 2014-10-10 2016-04-14 Uab "Biocentras" Extraction de complexes enzymatiques à partir de streptomyces gougerotii 101, préparation de biopréparations multienzymatiques, et leur application
GB2548994A (en) * 2016-03-31 2017-10-04 Riaz Sajid An absorbent sheet material product

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US20080008865A1 (en) * 2006-06-23 2008-01-10 Georgia-Pacific Consumer Products Lp Antimicrobial hand towel for touchless automatic dispensers
WO2009105760A2 (fr) * 2008-02-22 2009-08-27 Musculoskeletal Transplant Foundation Matrices biologiques comprenant un anti-infectieux, et procédés et compositions associées
US8152785B2 (en) 2008-03-13 2012-04-10 Tyco Healthcare Group Lp Vacuum port for vacuum wound therapy
US20190160199A1 (en) * 2014-10-21 2019-05-30 Auburn University N-halamine containing fibrous compositions and uses thereof
CN116497592A (zh) * 2023-03-30 2023-07-28 湖州创塑新材科技有限公司 一种抗菌增生无纺布及其制作方法

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Publication number Priority date Publication date Assignee Title
WO2006113967A1 (fr) * 2005-04-27 2006-11-02 Novapharm Research (Australia) Pty Ltd Filtre biostatique et formulation biocide insoluble dans l’eau pour celui-ci
WO2016055839A1 (fr) 2014-10-10 2016-04-14 Uab "Biocentras" Extraction de complexes enzymatiques à partir de streptomyces gougerotii 101, préparation de biopréparations multienzymatiques, et leur application
GB2548994A (en) * 2016-03-31 2017-10-04 Riaz Sajid An absorbent sheet material product
GB2548994B (en) * 2016-03-31 2021-06-23 Riaz Sajid An absorbent sheet material product

Also Published As

Publication number Publication date
EP1401509A4 (fr) 2006-12-20
AUPR564301A0 (en) 2001-07-12
US20050008840A1 (en) 2005-01-13
JP2005501016A (ja) 2005-01-13
EP1401509A1 (fr) 2004-03-31
CN1527728A (zh) 2004-09-08

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