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WO2002032408A3 - Combinations of a thyromimetic compound and a statin - Google Patents

Combinations of a thyromimetic compound and a statin Download PDF

Info

Publication number
WO2002032408A3
WO2002032408A3 PCT/EP2001/012075 EP0112075W WO0232408A3 WO 2002032408 A3 WO2002032408 A3 WO 2002032408A3 EP 0112075 W EP0112075 W EP 0112075W WO 0232408 A3 WO0232408 A3 WO 0232408A3
Authority
WO
WIPO (PCT)
Prior art keywords
statin
combinations
thyromimetic compound
thyromimetic
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/012075
Other languages
French (fr)
Other versions
WO2002032408A2 (en
Inventor
Ronald Edward Steele
Beatriz N Dardik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH Austria
Novartis AG
Original Assignee
Novartis Pharma GmbH Austria
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma GmbH Austria, Novartis AG filed Critical Novartis Pharma GmbH Austria
Priority to AU2002223626A priority Critical patent/AU2002223626A1/en
Publication of WO2002032408A2 publication Critical patent/WO2002032408A2/en
Anticipated expiration legal-status Critical
Publication of WO2002032408A3 publication Critical patent/WO2002032408A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Disclosed are methods for the treatment of conditions associated with elevated levels of Lp(a), such as CHD, ischaemic stroke, restenosis after angioplasty, peripheral vascular disease, intermittent claudication, reduction in necrosis after myocardial infarction, dyslipidemia and post-prandial lipemia. The methods include administration of a therapeutically effective amount of a pharmaceutical combination of a thyromimetic compound and a statin.
PCT/EP2001/012075 2000-10-20 2001-10-18 Combinations of a thyromimetic compound and a statin Ceased WO2002032408A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002223626A AU2002223626A1 (en) 2000-10-20 2001-10-18 Combinations of a thyromimetic compound and a statin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24203600P 2000-10-20 2000-10-20
US60/242,036 2000-10-20

Publications (2)

Publication Number Publication Date
WO2002032408A2 WO2002032408A2 (en) 2002-04-25
WO2002032408A3 true WO2002032408A3 (en) 2003-10-02

Family

ID=22913212

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/012075 Ceased WO2002032408A2 (en) 2000-10-20 2001-10-18 Combinations of a thyromimetic compound and a statin

Country Status (2)

Country Link
AU (1) AU2002223626A1 (en)
WO (1) WO2002032408A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8933083B2 (en) 2003-01-14 2015-01-13 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1262177B1 (en) * 2001-05-31 2006-08-23 Pfizer Products Inc. Medical use of thyromimetic compounds to treat hair loss and compositions
AR045697A1 (en) 2003-07-14 2005-11-09 Arena Pharm Inc ARIL AND HETEROARIL FUSIONATED DERIVATIVES AS MODULATORS OF METABOLISM AND THE PREVENTION AND TREATMENT OF DISORDERS RELATED TO THE SAME
WO2005051298A2 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
BRPI0514150A (en) 2004-08-06 2007-11-27 Otsuka Pharma Co Ltd aromatic compound or a salt thereof, method for producing the same, and pharmaceutical composition for treating fibrosis
JP2008542301A (en) 2005-05-26 2008-11-27 メタバシス・セラピューティクス・インコーポレイテッド Thyroid hormone-like drug for the treatment of fatty liver disease
US8236826B2 (en) 2005-12-05 2012-08-07 Otsuka Pharmaceutical Co., Ltd. Diarylether derivatives as antitumor agents
CN100371709C (en) * 2005-12-12 2008-02-27 重庆医药工业研究院有限责任公司 Method for separating and determining pitavastatin and its optical isomer by means of liquid chromatography
UA95978C2 (en) 2006-10-02 2011-09-26 Оцука Фармас'Ютікел Ко., Лтд. Stat3/5 activation inhibitor
SG188548A1 (en) 2010-09-22 2013-04-30 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
CA3002551A1 (en) 2015-06-22 2016-12-29 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders
EP3541395A4 (en) 2016-11-21 2020-07-01 Viking Therapeutics, Inc. Method of treating glycogen storage disease
CA3053418A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
EP3634426A4 (en) 2017-06-05 2021-04-07 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis
KR20200138283A (en) 2018-03-22 2020-12-09 바이킹 테라퓨틱스 인코포레이티드 Crystalline forms, and methods of preparing compounds in crystalline form
CA3102136A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
US12102646B2 (en) 2018-12-05 2024-10-01 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000051971A1 (en) * 1999-03-01 2000-09-08 Pfizer Products Inc. Oxamic acids and derivatives as thyroid receptor ligands
WO2000058279A1 (en) * 1999-03-29 2000-10-05 Novartis Ag Diaryl derivatives and their use as medicaments

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000051971A1 (en) * 1999-03-01 2000-09-08 Pfizer Products Inc. Oxamic acids and derivatives as thyroid receptor ligands
WO2000058279A1 (en) * 1999-03-29 2000-10-05 Novartis Ag Diaryl derivatives and their use as medicaments

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HARWOOD H J ET AL: "MODULATORS OF DYSLIPIDAEMIA", EMERGING DRUGS, ASHLEY PUBLICATIONS, LONDON, GB, 1998, pages 147 - 172, XP008002918, ISSN: 1361-9195 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8933083B2 (en) 2003-01-14 2015-01-13 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia

Also Published As

Publication number Publication date
AU2002223626A1 (en) 2002-04-29
WO2002032408A2 (en) 2002-04-25

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