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WO2002028351A3 - Recombinant mucin binding proteins from steptococcus pneumoniae - Google Patents

Recombinant mucin binding proteins from steptococcus pneumoniae Download PDF

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Publication number
WO2002028351A3
WO2002028351A3 PCT/US2001/031269 US0131269W WO0228351A3 WO 2002028351 A3 WO2002028351 A3 WO 2002028351A3 US 0131269 W US0131269 W US 0131269W WO 0228351 A3 WO0228351 A3 WO 0228351A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding proteins
proteins
mucin binding
recombinant mucin
steptococcus pneumoniae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/031269
Other languages
French (fr)
Other versions
WO2002028351A2 (en
WO2002028351A9 (en
Inventor
Bruce A Green
Amy W Masi
Molakala S Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Research Foundation of the State University of New York
Original Assignee
Wyeth LLC
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC, Research Foundation of the State University of New York filed Critical Wyeth LLC
Priority to AU2002213037A priority Critical patent/AU2002213037A1/en
Publication of WO2002028351A2 publication Critical patent/WO2002028351A2/en
Publication of WO2002028351A3 publication Critical patent/WO2002028351A3/en
Publication of WO2002028351A9 publication Critical patent/WO2002028351A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56944—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides for amino acid and nucleic acid sequences of isolated mucin-binding proteins from pneumococcal bacteria and fragments thereof. Expression vectors, transfected host cells, methods for producing recombinant mucin-binding proteins, compositions comprising the proteins, and antibodies to the proteins also are contemplated. A method of inducing an immune response is described by the present invention. Screening and diagnosing methods are also discussed.
PCT/US2001/031269 2000-10-04 2001-10-04 Recombinant mucin binding proteins from steptococcus pneumoniae Ceased WO2002028351A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002213037A AU2002213037A1 (en) 2000-10-04 2001-10-04 Recombinant mucin binding proteins from steptococcus pneumoniae

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23788800P 2000-10-04 2000-10-04
US60/237,888 2000-10-04
US26710401P 2001-02-07 2001-02-07
US60/267,104 2001-02-07

Publications (3)

Publication Number Publication Date
WO2002028351A2 WO2002028351A2 (en) 2002-04-11
WO2002028351A3 true WO2002028351A3 (en) 2002-07-18
WO2002028351A9 WO2002028351A9 (en) 2002-12-05

Family

ID=26931135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031269 Ceased WO2002028351A2 (en) 2000-10-04 2001-10-04 Recombinant mucin binding proteins from steptococcus pneumoniae

Country Status (2)

Country Link
AU (1) AU2002213037A1 (en)
WO (1) WO2002028351A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1382970A1 (en) * 2002-07-15 2004-01-21 Societe Des Produits Nestle S.A. Novel mucin binding polypeptides
EP1394176A1 (en) * 2002-08-27 2004-03-03 Nestec S.A. Novel mucin binding polypeptides derived from Lactobacillus johnsonii
CN109553662B (en) * 2018-11-02 2021-07-13 宁波大学 Expression and purification of a functional Lactobacillus acidophilus mucus-binding protein and its application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006734A1 (en) * 1996-08-16 1998-02-19 Smithkline Beecham Corporation Novel prokaryotic polynucleotides, polypeptides and their uses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006734A1 (en) * 1996-08-16 1998-02-19 Smithkline Beecham Corporation Novel prokaryotic polynucleotides, polypeptides and their uses

Also Published As

Publication number Publication date
WO2002028351A2 (en) 2002-04-11
WO2002028351A9 (en) 2002-12-05
AU2002213037A1 (en) 2002-04-15

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