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WO2002026768A3 - Haplotypes du gene por - Google Patents

Haplotypes du gene por Download PDF

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Publication number
WO2002026768A3
WO2002026768A3 PCT/US2001/030877 US0130877W WO0226768A3 WO 2002026768 A3 WO2002026768 A3 WO 2002026768A3 US 0130877 W US0130877 W US 0130877W WO 0226768 A3 WO0226768 A3 WO 0226768A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
por
gene
disclosed
por gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/030877
Other languages
English (en)
Other versions
WO2002026768A2 (fr
Inventor
Amir Kazemi
Stefanie E Kliem
Elizabeth M Lanz
Chad Messer
Debra A Tanguay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2002211373A priority Critical patent/AU2002211373A1/en
Publication of WO2002026768A2 publication Critical patent/WO2002026768A2/fr
Publication of WO2002026768A3 publication Critical patent/WO2002026768A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des nouveaux allèles génétiques du gène P450 (Cytochrome) Oxydoréductase (POR) ; divers génotypes, haplotypes et paires d'haplotypes présents en général dans la population des Etats-Unis pour le gène POR ; des compositions et des méthodes d'haplotypage et/ou de génotypage du gène POR chez un individu ; enfin, les polynucléotides définis par les haplotypes selon l'invention.
PCT/US2001/030877 2000-09-29 2001-10-01 Haplotypes du gene por Ceased WO2002026768A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002211373A AU2002211373A1 (en) 2000-09-29 2001-10-01 Haplotypes of the por gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23644900P 2000-09-29 2000-09-29
US60/236,449 2000-09-29

Publications (2)

Publication Number Publication Date
WO2002026768A2 WO2002026768A2 (fr) 2002-04-04
WO2002026768A3 true WO2002026768A3 (fr) 2002-06-13

Family

ID=22889546

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/030877 Ceased WO2002026768A2 (fr) 2000-09-29 2001-10-01 Haplotypes du gene por

Country Status (2)

Country Link
AU (1) AU2002211373A1 (fr)
WO (1) WO2002026768A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888324B2 (en) 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US7511131B2 (en) * 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US20050287558A1 (en) 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
EP2023940B1 (fr) 2006-05-05 2011-06-22 Isis Pharmaceuticals, Inc. Composés et procédés de modulation de l'expression de sglt2
KR20090128494A (ko) 2007-03-24 2009-12-15 겐자임 코포레이션 인간 아포리포프로틴 ｂ에 상보적인 안티센스 올리고뉴클레오타이드 투여
EP2141250A1 (fr) * 2008-07-02 2010-01-06 Institut National De La Recherche Agronomique (Inra) Procédé de diagnostic et de prédiction d'ataxie cérébelleuse
WO2010107838A1 (fr) 2009-03-16 2010-09-23 Isis Pharmaceuticals, Inc. Ciblage de l'apolipoprotéine b pour la réduction de l'apolipoprotéine c-iii

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 2 September 2000 (2000-09-02), CZERWINSKI ET AL.: "Polymorphism of human CYPOR: Expression of new allele", XP002908410, accession no. NCBI Database accession no. AF258341 *
O'LEARY K.A. ET AL.: "Molecular basis for cell-specific regulation of the NADPH-cytochrome p450 oxidoreductase gene", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 379, 1 July 2000 (2000-07-01), pages 97 - 108, XP002908409 *
YAMANO S. ET AL.: "Human NADPH-P450 oxidoreductase: Complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7", MOLECULAR PHARMACOLOGY, vol. 35, 1989, pages 83 - 88, XP002908411 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888324B2 (en) 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression

Also Published As

Publication number Publication date
WO2002026768A2 (fr) 2002-04-04
AU2002211373A1 (en) 2002-04-08

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