[go: up one dir, main page]

WO2002024752A3 - Anticorps monoclonaux diriges contre des structures lipidiques differentes de la bicouche de membranes cellulaires afin de definir des etats physiologiques dans differents types cellulaires et afin de detecter des anticorps diriges contre des particules lipidiques presents chez des individus et/ou des animaux - Google Patents

Anticorps monoclonaux diriges contre des structures lipidiques differentes de la bicouche de membranes cellulaires afin de definir des etats physiologiques dans differents types cellulaires et afin de detecter des anticorps diriges contre des particules lipidiques presents chez des individus et/ou des animaux Download PDF

Info

Publication number
WO2002024752A3
WO2002024752A3 PCT/MX2001/000069 MX0100069W WO0224752A3 WO 2002024752 A3 WO2002024752 A3 WO 2002024752A3 MX 0100069 W MX0100069 W MX 0100069W WO 0224752 A3 WO0224752 A3 WO 0224752A3
Authority
WO
WIPO (PCT)
Prior art keywords
different
monoclonal antibodies
double layer
antibodies
certain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/MX2001/000069
Other languages
English (en)
Spanish (es)
Other versions
WO2002024752A2 (fr
Inventor
Pierres Maria Guadalupe Ortega
Linan Sara Rocio Fonseca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional
Original Assignee
Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from MXPA/A/2000/008567A external-priority patent/MXPA00008567A/xx
Application filed by Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional filed Critical Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional
Priority to AU2001288136A priority Critical patent/AU2001288136A1/en
Publication of WO2002024752A2 publication Critical patent/WO2002024752A2/fr
Publication of WO2002024752A3 publication Critical patent/WO2002024752A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne l'obtention d'hybridomes murins qui produisent des anticorps monoclonaux dirigés contre des particules lipidiques sans bicouche, également appelées particules lipidiques dans des liposomes. Les anticorps monoclonaux, qui sont de l'isotype IgM, ont été obtenus par fusion des cellules de rate de souris BALB/c femelles qui ont été immunisées avec des liposomes de phosphatidilcoline:phosphatidate (2:1) unilamellaires qui comportent des particules lipidiques induites par Mn+2 et des cellules de myélome de la lignée P3X63AGBU.1. Dans cette invention, on a essayé ces anticorps dans des essais de ELISA afin de détecter des associations lipidiques sans bicouche, aussi bien dans des cellules animales que dans des plantes. D'où leur utilisation potentielle pour la prévention et le traitement de maladies associées à la production d'anticorps anti-phospholipidiques.
PCT/MX2001/000069 2000-09-01 2001-08-31 Anticorps monoclonaux diriges contre des structures lipidiques differentes de la bicouche de membranes cellulaires afin de definir des etats physiologiques dans differents types cellulaires et afin de detecter des anticorps diriges contre des particules lipidiques presents chez des individus et/ou des animaux Ceased WO2002024752A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001288136A AU2001288136A1 (en) 2000-09-01 2001-08-31 Monoclonal antibodies against lipid structures different from the double layer of cell membranes for defining physiological states in different cell types and detecting anti lipid particle antibodies in human beings and/or animals suffering from certain antiphospholipid antibody-related diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXPA/A/2000/008567A MXPA00008567A (en) 2000-09-01 Monoclonal antibodies against lipid structures different from the two-layer of cellular membranes to define phsycological states in different cellular types and for the detection of antiparticles antibodies
MX008567 2000-09-01

Publications (2)

Publication Number Publication Date
WO2002024752A2 WO2002024752A2 (fr) 2002-03-28
WO2002024752A3 true WO2002024752A3 (fr) 2002-07-18

Family

ID=34101929

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2001/000069 Ceased WO2002024752A2 (fr) 2000-09-01 2001-08-31 Anticorps monoclonaux diriges contre des structures lipidiques differentes de la bicouche de membranes cellulaires afin de definir des etats physiologiques dans differents types cellulaires et afin de detecter des anticorps diriges contre des particules lipidiques presents chez des individus et/ou des animaux

Country Status (2)

Country Link
AU (1) AU2001288136A1 (fr)
WO (1) WO2002024752A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104155451B (zh) * 2014-08-20 2016-01-06 厦门大学附属中山医院 梅毒螺旋体IgM抗体生物素亲和素酶联免疫检测试剂盒及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002672A1 (fr) * 1982-02-02 1983-08-04 Hana Biolog Inc Analyse immunologique permettant de determiner la presence d'un phospholipide dans un fluide biologique
US4666831A (en) * 1985-02-19 1987-05-19 The Liposome Company, Inc. Lipid-dependent diagnostic assays
US4698299A (en) * 1985-02-19 1987-10-06 The Liposome Company, Inc. Lipid-dependent diagnostic assays
WO1997039736A1 (fr) * 1996-04-19 1997-10-30 Pasteur Sanofi Diagnostics, S.A. Reactifs a base de liposomes pour dosages immunologiques
WO1997040387A1 (fr) * 1996-04-19 1997-10-30 Pasteur Sanofi Diagnostics, S.A. Dosages immunologiques de detection d'anticorps antiphospholipides
WO1999002992A1 (fr) * 1997-07-11 1999-01-21 The Mount Sinai School Of Medicine Of The City University Of New York Tests pour le diagnostic de thrombophilie

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002672A1 (fr) * 1982-02-02 1983-08-04 Hana Biolog Inc Analyse immunologique permettant de determiner la presence d'un phospholipide dans un fluide biologique
US4666831A (en) * 1985-02-19 1987-05-19 The Liposome Company, Inc. Lipid-dependent diagnostic assays
US4698299A (en) * 1985-02-19 1987-10-06 The Liposome Company, Inc. Lipid-dependent diagnostic assays
WO1997039736A1 (fr) * 1996-04-19 1997-10-30 Pasteur Sanofi Diagnostics, S.A. Reactifs a base de liposomes pour dosages immunologiques
WO1997040387A1 (fr) * 1996-04-19 1997-10-30 Pasteur Sanofi Diagnostics, S.A. Dosages immunologiques de detection d'anticorps antiphospholipides
WO1999002992A1 (fr) * 1997-07-11 1999-01-21 The Mount Sinai School Of Medicine Of The City University Of New York Tests pour le diagnostic de thrombophilie

Also Published As

Publication number Publication date
AU2001288136A1 (en) 2002-04-02
WO2002024752A2 (fr) 2002-03-28

Similar Documents

Publication Publication Date Title
CN104254544B (zh) Cdim结合蛋白及其用途
US10858446B2 (en) Anti-PCSK9 antibodies and uses thereof
Zuo et al. IgG4 autoantibodies are inhibitory in the autoimmune disease bullous pemphigoid
WO1998057994A3 (fr) Anticorps opsoniques, monoclonaux protecteurs, et chimeres specifiques a l'acide lipoteichoique des bacteries gram positif
DE69126607T2 (de) Extrazelluläre teilstücke humaner ige-immunoglobulin-ankerpeptide und dafür spezifische antikörper
JP2018520991A (ja) 抗ｃｄ７１抗体、活性化可能抗ｃｄ７１抗体、およびその使用方法
WO2004045512A3 (fr) Anticorps monoclonaux humains contre cd25
EA038470B1 (ru) СВЯЗЫВАЮЩЕЕСЯ С FcRn АНТИТЕЛО ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ ЗАБОЛЕВАНИЙ
WO2004043989A3 (fr) Anticorps monoclonaux humains diriges contre l'heparanase
JP2003534781A5 (fr)
IL147638A0 (en) Human monoclonal antibodies to prostate specific membrane antigen
CA2225852A1 (fr) Anticorps anti-ligand fas et methode de dosage le faisant intervenir
JP2016513682A (ja) 抗血漿カリクレイン抗体
US20040101909A1 (en) Purification of polyreactive autoantibodies and uses thereof
EP0585224A1 (fr) ANTICORPS MONOCLONAUX QUI SE LIENT A L'IgE SECRETEE ET LIEE AUX MEMBRANES MAIS QUI NE SE LIENT PAS A L'IgE SE TROUVANT SUR LES LEUCOCYTES BASOPHILES
CN113853388A (zh) 抗-egfrviii抗体及其抗原结合片段
PT2432804E (pt) Anticorpos ou seus fragmentos direcionados contra um epítopo de staphylococcus aureus de isaa ou isab
US9718891B2 (en) Antibodies specific to a novel epitope on CεMX of human membrane-bound IgE and uses thereof in treating IgE-mediated diseases
AT503297B1 (de) Allergen-spezifische antikörper
WO2002024752A3 (fr) Anticorps monoclonaux diriges contre des structures lipidiques differentes de la bicouche de membranes cellulaires afin de definir des etats physiologiques dans differents types cellulaires et afin de detecter des anticorps diriges contre des particules lipidiques presents chez des individus et/ou des animaux
Lamoureux et al. Autoantibodies purified from therapeutic preparations of intravenous immunoglobulins (IVIg) induce the formation of autoimmune complexes in normal human serum: a role in the in vivo mechanisms of action of IVIg?
US20040081649A1 (en) Treating Atopic dermatitis with IgE antagonists
KR890016165A (ko) 수도모나스 아에루기노사(Pseudomonas aeruginosa)에 대한 모노클로날 항체, 이의 제조방법 및 용도
Spira et al. Generation of biologically active anti‐Cryptococcus neoformans IgG, IgE and IgA isotype switch variant antibodies by acridine orange mutagenesis
WO2006004950A3 (fr) Anticorps monoclonal 31.1 humanise utilise en tant qu'agent anticancereux

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP