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WO2002018430A3 - Sequences nucleotidiques codant les genes metr et metz - Google Patents

Sequences nucleotidiques codant les genes metr et metz Download PDF

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Publication number
WO2002018430A3
WO2002018430A3 PCT/EP2001/008221 EP0108221W WO0218430A3 WO 2002018430 A3 WO2002018430 A3 WO 2002018430A3 EP 0108221 W EP0108221 W EP 0108221W WO 0218430 A3 WO0218430 A3 WO 0218430A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotide
acid sequence
amino acid
metr
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/008221
Other languages
English (en)
Other versions
WO2002018430A2 (fr
WO2002018430A8 (fr
Inventor
Brigitte Bathe
Walter Pfefferle
Klaus Huthmacher
Christian Rueckert
Joern Kalinowski
Alfred Puehler
Michael Binder
Dieter Greissinger
Georg Thierbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10109688A external-priority patent/DE10109688A1/de
Application filed by Degussa GmbH filed Critical Degussa GmbH
Priority to AU8198401A priority Critical patent/AU8198401A/xx
Priority to EP01960503A priority patent/EP1313757A2/fr
Publication of WO2002018430A2 publication Critical patent/WO2002018430A2/fr
Publication of WO2002018430A3 publication Critical patent/WO2002018430A3/fr
Anticipated expiration legal-status Critical
Publication of WO2002018430A8 publication Critical patent/WO2002018430A8/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des polynucléotides issus de bactéries corynéformes codant les gènes mdhR et mdhZ et renfermant des séquences polynucléotidiques choisis dans le groupe comprenant: a) un polynucléotide identique au moins à 70 % à un polynucléotide codant un polypeptide contenant la séquence d'acides aminés SEQ ID No. 2; b) un polynucléotide identique au moins à 70 % à un polynucléotide codant un polypeptide contenant la séquence d'acides aminés SEQ ID No. 3; c) un polynucléotide codant un polypeptide contenant une séquence d'acides aminés identique à au moins 70 % à la séquence d'acides aminés SEQ ID No 2; d) un polynucléotide codant un polypeptide contenant une séquence d'acides aminés identique au moins à 70 % à la séquence d'acides aminés SEQ ID No 3; e) un polynucléotide complémentaire des polynucléotides susmentionnés aux points a), b), c) ou d); et un polynucléotide comprenant au moins 15 nucléotides successifs des séquences polynucléotidiques décrites aux points a), b), c), d) ou e). L'invention concerne également un procédé de préparation par fermentation d'acides aminés L à l'aide de bactéries corynéformes dans lesquelles au moins les gènes metR et/ou metZ sont présents sous forme atténuée; ainsi que l'utilisation des polynucléotides comprenant les séquences selon l'invention comme sondes d'hybridation.
PCT/EP2001/008221 2000-09-02 2001-07-17 Sequences nucleotidiques codant les genes metr et metz Ceased WO2002018430A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU8198401A AU8198401A (en) 2000-09-02 2001-07-17 Nucleotide sequences which code for the metr and metz genes
EP01960503A EP1313757A2 (fr) 2000-09-02 2001-07-17 Sequences nucleotidiques codant les genes metr et metz

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10043335 2000-09-02
DE10043335.9 2000-09-02
DE10109688.7 2001-02-28
DE10109688A DE10109688A1 (de) 2000-09-02 2001-02-28 Neue für die Gene metR und metZ kodierende Nukleotidsequenzen

Publications (3)

Publication Number Publication Date
WO2002018430A2 WO2002018430A2 (fr) 2002-03-07
WO2002018430A3 true WO2002018430A3 (fr) 2002-07-04
WO2002018430A8 WO2002018430A8 (fr) 2004-03-04

Family

ID=26006908

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008221 Ceased WO2002018430A2 (fr) 2000-09-02 2001-07-17 Sequences nucleotidiques codant les genes metr et metz

Country Status (3)

Country Link
EP (1) EP1313757A2 (fr)
AU (1) AU8198401A (fr)
WO (1) WO2002018430A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000842A2 (fr) * 1999-06-25 2001-01-04 Basf Aktiengesellschaft Genes de corynebacterium glutamicum codant des proteines impliquees dans l'homeostase et adaptation
WO2001000843A2 (fr) * 1999-06-25 2001-01-04 Basf Aktiengesellschaft Genes de corynebacterum glutamicum codant pour des proteines de voie metabolique
EP1108790A2 (fr) * 1999-12-16 2001-06-20 Kyowa Hakko Kogyo Co., Ltd. Nouveaux polynuclétides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000842A2 (fr) * 1999-06-25 2001-01-04 Basf Aktiengesellschaft Genes de corynebacterium glutamicum codant des proteines impliquees dans l'homeostase et adaptation
WO2001000843A2 (fr) * 1999-06-25 2001-01-04 Basf Aktiengesellschaft Genes de corynebacterum glutamicum codant pour des proteines de voie metabolique
EP1108790A2 (fr) * 1999-12-16 2001-06-20 Kyowa Hakko Kogyo Co., Ltd. Nouveaux polynuclétides

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE EBI [online] EMBL; 24 January 2001 (2001-01-24), POMPEJUS M. ET AL.: "Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaption", XP002185890, Database accession no. Ac: AX065835 *
DATABASE EMBL [online] EBI; 24 January 2001 (2001-01-24), POMPEJUS M. ET AL.: "Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaption", XP002203339, Database accession no. Ac:AX063913 *
FOGLINO M ET AL: "A DIRECT SULFHYDRYLATION PATHWAY IS USED FOR METHIONINE BIOSYNTHESIS IN PSEUDOMONAS AERUGINOSA", MICROBIOLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 141, no. 2, 1 February 1995 (1995-02-01), pages 431 - 439, XP002054742, ISSN: 1350-0872 *
FRITSCH PAULA S ET AL: "Role of the RNA polymerase alpha subunits in MetR-dependent activation of metE and metH: Important residues in the C-terminal domain and orientation requirements within RNA polymerase.", JOURNAL OF BACTERIOLOGY, vol. 182, no. 19, October 2000 (2000-10-01), pages 5539 - 5550, XP002185889, ISSN: 0021-9193 *
HWANG B-J ET AL.: "ANALYSIS OF CORYNEBACTERIUM GLUTAMICUM METHIONINE BIOSYNTHETIC PATHWAY: ISOLATION AND ANALSYSIS OF metB ENCODING CYSTATHIONINE gamma-SYNTHASE", MOL. CELLS, vol. 9, no. 3, 3 February 1999 (1999-02-03), pages 300 - 308, XP001037229 *
LORENZ EVA ET AL: "MetR-mediated repression of the glyA gene in Escherichia coli.", FEMS MICROBIOLOGY LETTERS, vol. 144, no. 2-3, 1996, pages 229 - 233, XP001038523, ISSN: 0378-1097 *
PARK S-D ET AL: "ISOLATION AND ANALYSIS OF META, A METHIONINE BIOSYNTHETIC GENE ENCODING HOMOSERINE ACETYLTRANSFERASE IN CORYNEBACTERIUM GLUTAMICUM", MOLECULAR AND CELLS, KOREAN SOCIETY FOR MOLECULAR SOCIETY, KR, vol. 8, no. 3, 30 June 1998 (1998-06-30), pages 286 - 294, XP001002218 *
TATE R ET AL: "THE RHIZOBIUM ETLI METZ GENE IS ESSENTIAL FOR METHIONINE BIOSYNTHESIS AND NODULATION OF PHASEOLUS VULGARIS", MOLECULAR PLANT-MICROBE INTERACTIONS, APS PRESS, ST. PAUL, MN, US, vol. 12, no. 1, January 1999 (1999-01-01), pages 24 - 34, XP001038478, ISSN: 0894-0282 *

Also Published As

Publication number Publication date
EP1313757A2 (fr) 2003-05-28
WO2002018430A2 (fr) 2002-03-07
AU8198401A (en) 2002-03-13
WO2002018430A8 (fr) 2004-03-04

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