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WO2002014862A8 - Verfahren und vorrichtung zur charakterisierung und/oder zum nachweis eines bindungskomplexes - Google Patents

Verfahren und vorrichtung zur charakterisierung und/oder zum nachweis eines bindungskomplexes

Info

Publication number
WO2002014862A8
WO2002014862A8 PCT/EP2001/009206 EP0109206W WO0214862A8 WO 2002014862 A8 WO2002014862 A8 WO 2002014862A8 EP 0109206 W EP0109206 W EP 0109206W WO 0214862 A8 WO0214862 A8 WO 0214862A8
Authority
WO
WIPO (PCT)
Prior art keywords
bonding
complex
characterising
detecting
partner
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/009206
Other languages
English (en)
French (fr)
Other versions
WO2002014862A3 (de
WO2002014862A2 (de
Inventor
Hermann Gaub
Christian Albrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NANOTYPE GmbH
Original Assignee
NANOTYPE GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10051143A external-priority patent/DE10051143C2/de
Priority claimed from DE10117866A external-priority patent/DE10117866A1/de
Priority to EP01974149A priority Critical patent/EP1350107A2/de
Priority to US10/344,212 priority patent/US20040086883A1/en
Priority to JP2002519940A priority patent/JP2004525341A/ja
Priority to AU2001293747A priority patent/AU2001293747A1/en
Application filed by NANOTYPE GmbH filed Critical NANOTYPE GmbH
Priority to CA002418861A priority patent/CA2418861A1/en
Priority to IL15406901A priority patent/IL154069A0/xx
Publication of WO2002014862A2 publication Critical patent/WO2002014862A2/de
Anticipated expiration legal-status Critical
Publication of WO2002014862A3 publication Critical patent/WO2002014862A3/de
Publication of WO2002014862A8 publication Critical patent/WO2002014862A8/de
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Ein Verfahren zur Charakterisierung und/oder zum Nachweis eines Bindungskomplexes weist folgende Shritte auf: Bereitstellen eines ersten Bindungspartners und eines Konjugats aus einem zweiten und einem dritten Bindungspartner und Bereitstellen eines vierten Bindungspartners, Bilden einer Verkettung der Bindungspartner, wobei der erste Bindungspartner mit dem zweiten Bindungspartner einen Probenkomplex und der dritte Bindungspartner mit dem vierten Bindungspartner eine Referenzkomplex ausbildet, Aufbringen einer Kraft an die Verkettung, die zur Trennung des Probenkomplexes oder des Referenzkomplexes führt und Bestimmen welcher der beiden Bindungskomplexe getrennt wurde.
PCT/EP2001/009206 2000-08-11 2001-08-09 Verfahren und vorrichtung zur charakterisierung und/oder zum nachweis eines bindungskomplexes Ceased WO2002014862A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IL15406901A IL154069A0 (en) 2000-08-11 2001-08-09 Method and device for characterising and/or for detecting a bonding complex
CA002418861A CA2418861A1 (en) 2000-08-11 2001-08-09 Method and device for characterising and/or for detecting a bonding complex
US10/344,212 US20040086883A1 (en) 2000-08-11 2001-08-09 Method and device for characterising and/or for detecting a bonding complex
JP2002519940A JP2004525341A (ja) 2000-08-11 2001-08-09 結合複合体を特徴付けおよび／または同定するための方法および装置
AU2001293747A AU2001293747A1 (en) 2000-08-11 2001-08-09 Method and device for characterising and/or for detecting a bonding complex
EP01974149A EP1350107A2 (de) 2000-08-11 2001-08-09 Verfahren und vorrichtung zur charakterisierung und/oder zum nachweis eines bindungskomplexes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE10039393 2000-08-11
DE10039393.4 2000-08-11
DE10051143A DE10051143C2 (de) 2000-08-11 2000-10-16 Verfahren und Vorrichtung zur Charakterisierung und/oder zum Nachweis eines Bindungskomplexes
DE10051143.0 2000-10-16
DE10117866.2 2001-04-10
DE10117866A DE10117866A1 (de) 2001-04-10 2001-04-10 Verfahren und Vorrichtung zur Charakterisierung und/oder zum Nachweis eines Bindungskomplexes

Publications (3)

Publication Number Publication Date
WO2002014862A2 WO2002014862A2 (de) 2002-02-21
WO2002014862A3 WO2002014862A3 (de) 2003-05-30
WO2002014862A8 true WO2002014862A8 (de) 2004-03-25

Family

ID=27213999

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/009206 Ceased WO2002014862A2 (de) 2000-08-11 2001-08-09 Verfahren und vorrichtung zur charakterisierung und/oder zum nachweis eines bindungskomplexes

Country Status (7)

Country Link
US (1) US20040086883A1 (de)
EP (1) EP1350107A2 (de)
JP (1) JP2004525341A (de)
AU (1) AU2001293747A1 (de)
CA (1) CA2418861A1 (de)
IL (1) IL154069A0 (de)
WO (1) WO2002014862A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10126798A1 (de) 2001-06-01 2002-12-19 Nanotype Gmbh Verfahren zur Bestimmung einer Probe
DE50210214D1 (de) * 2001-12-24 2007-07-05 Arrowhead Res Corp Verfahren zur in-vitro selektion von bindern
EP1565569A2 (de) * 2002-02-09 2005-08-24 Nanotype GmbH Verfahren zum nachweis von mutationen
DE10207918A1 (de) * 2002-02-23 2003-09-11 Nanotype Gmbh Verfahren zum Nachweis von Mutationen
US7858386B2 (en) * 2006-03-07 2010-12-28 The United States Of America As Represented By The Secretary Of The Navy Method of controlling quantum dot photoluminescence and other intrinsic properties through biological specificity
EP2060637A1 (de) * 2007-11-14 2009-05-20 Koninklijke Philips Electronics N.V. Mittel und Verfahren zum Erkennen von Nukleinsäuren
NL2010960C2 (en) * 2013-06-12 2014-12-15 Stichting Vu Vumc Molecular manipulation system and method.
JP6949595B2 (ja) * 2017-07-19 2021-10-13 シスメックス株式会社 被検物質を検出する方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3539215A1 (de) * 1985-11-05 1987-05-07 Boehringer Mannheim Gmbh Verfahren zur bestimmung eines immunologisch bindefaehigen analyten
WO1993019371A1 (en) * 1992-03-20 1993-09-30 Abbott Laboratories Determination of binding affinity using magneticaly-labeled binding members
US5445970A (en) * 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5395754A (en) * 1992-07-31 1995-03-07 Hybritech Incorporated Membrane-based immunoassay method
FR2703693B1 (fr) * 1993-04-06 1995-07-13 Pasteur Institut Procédé rapide de détermination d'une séquence d'ADN et application au séquençage et au diagnostic.
US5620857A (en) * 1995-06-07 1997-04-15 United States Of America, As Represented By The Secretary Of Commerce Optical trap for detection and quantitation of subzeptomolar quantities of analytes
US5726913A (en) * 1995-10-24 1998-03-10 Intel Corporation Method and apparatus for analyzing interactions between workloads and locality dependent subsystems
JP3377215B2 (ja) * 1996-09-06 2003-02-17 インターナショナル・ビジネス・マシーンズ・コーポレーション 化学的に定義されたボディを配向析出する方法
US5861954A (en) * 1996-10-10 1999-01-19 Israelachvili; Jacob N. Instrument for measuring static and dynamic forces between surfaces in three dimensions
US6051372A (en) * 1997-09-09 2000-04-18 Nimbus Biotechnologie Gmbh Template induced patterning of surfaces and their reversible stabilization using phase transitions of the patterned material
US6094971A (en) * 1997-09-24 2000-08-01 Texas Instruments Incorporated Scanning-probe microscope including non-optical means for detecting normal tip-sample interactions
US6348322B1 (en) * 1997-10-17 2002-02-19 Duke University Method of screening for specific binding interactions
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6180418B1 (en) * 1998-01-20 2001-01-30 The United States Of America As Represented By The Secretary Of The Navy Force discrimination assay
DE19808884A1 (de) * 1998-03-03 1999-09-16 November Ag Molekulare Medizin Vorrichtung und Verfahren zum Nachweis chemischer Substanzen
CA2323638A1 (en) * 1998-04-03 1999-10-14 Phylos, Inc. Addressable protein arrays
US5992226A (en) * 1998-05-08 1999-11-30 The United States Of America As Represented By The Secretary Of The Navy Apparatus and method for measuring intermolecular interactions by atomic force microscopy
US5958701A (en) * 1999-01-27 1999-09-28 The United States Of America As Represented By The Secretary Of The Navy Method for measuring intramolecular forces by atomic force
US6086821A (en) * 1999-03-29 2000-07-11 The United States Of America As Represented By The Secretary Of The Navy Ultrasonic force differentiation assay

Also Published As

Publication number Publication date
WO2002014862A3 (de) 2003-05-30
IL154069A0 (en) 2003-07-31
EP1350107A2 (de) 2003-10-08
US20040086883A1 (en) 2004-05-06
WO2002014862A2 (de) 2002-02-21
AU2001293747A1 (en) 2002-02-25
CA2418861A1 (en) 2002-02-21
JP2004525341A (ja) 2004-08-19

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