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WO2002014359A3 - Serpine humaine zserp15 - Google Patents

Serpine humaine zserp15 Download PDF

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Publication number
WO2002014359A3
WO2002014359A3 PCT/US2001/024650 US0124650W WO0214359A3 WO 2002014359 A3 WO2002014359 A3 WO 2002014359A3 US 0124650 W US0124650 W US 0124650W WO 0214359 A3 WO0214359 A3 WO 0214359A3
Authority
WO
WIPO (PCT)
Prior art keywords
zserp15
serine protease
serpin
serine
human serpin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/024650
Other languages
English (en)
Other versions
WO2002014359A2 (fr
Inventor
James L Holloway
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU2001281116A priority Critical patent/AU2001281116A1/en
Publication of WO2002014359A2 publication Critical patent/WO2002014359A2/fr
Publication of WO2002014359A3 publication Critical patent/WO2002014359A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Les membres de la famille des sérine protéases jouent un rôle dans des procédés contrôlés avec soin, tels que la coagulation sanguine, la fibrinolyse, l'activation de compléments, la fertilisation et la production d'hormones. L'activité enzymatique des sérine protéases est partiellement régulée par les serpines, qui sont des inhibiteurs de sérine protéase. La dysfonction des serpines est associée à divers troubles, y compris l'emphysème, les troubles de la coagulation sanguine, la cirrhose, la maladie d'Alzheimer et la maladie de Parkinson. Zserp15 est un nouveau membre de la famille des inhibiteurs de sérine protéase.
PCT/US2001/024650 2000-08-10 2001-08-06 Serpine humaine zserp15 Ceased WO2002014359A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281116A AU2001281116A1 (en) 2000-08-10 2001-08-06 Human serpin zserp15

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22445000P 2000-08-10 2000-08-10
US60/224,450 2000-08-10

Publications (2)

Publication Number Publication Date
WO2002014359A2 WO2002014359A2 (fr) 2002-02-21
WO2002014359A3 true WO2002014359A3 (fr) 2002-08-01

Family

ID=22840738

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024650 Ceased WO2002014359A2 (fr) 2000-08-10 2001-08-06 Serpine humaine zserp15

Country Status (2)

Country Link
AU (1) AU2001281116A1 (fr)
WO (1) WO2002014359A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003046006A1 (fr) * 2001-11-27 2003-06-05 Bayer Healthcare Ag Polynucleotides codant pour l'inhibiteur d'une serine protease parente de la nexine
FR2842534B1 (fr) * 2002-07-19 2006-01-20 Inst Nat Sante Rech Med Amplification multiplex quantitative a l'echelle d'un genome, et applications a la detection de remaniements genomiques

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041381A1 (fr) * 1998-02-13 1999-08-19 Peter Sonderegger Neuroserpine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041381A1 (fr) * 1998-02-13 1999-08-19 Peter Sonderegger Neuroserpine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EBI, Hinxton, UK; 19 May 1993 (1993-05-19), VASSALLI ET AL.: "M. musculus PN-1 mRNA for protease-nexin 1", XP002199160, Database accession no. X70296 *
WHISSTOCK JAMES ET AL: "An atlas of serpin conformations.", TRENDS IN BIOCHEMICAL SCIENCES, vol. 23, no. 2, February 1998 (1998-02-01), pages 63 - 67, XP002199159, ISSN: 0968-0004 *
WORRALL D M ET AL: "The expanding superfamily of serpins: Searching for the real targets.", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 27, no. 4, August 1999 (1999-08-01), Meeting of the Biochemical Society, Irish Area Section;Dublin, Ireland; September 9-10, 1998, pages 746 - 750, XP001076869, ISSN: 0300-5127 *

Also Published As

Publication number Publication date
AU2001281116A1 (en) 2002-02-25
WO2002014359A2 (fr) 2002-02-21

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