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WO2002014275A3 - Derives sulfonamides heterocycliques - Google Patents

Derives sulfonamides heterocycliques Download PDF

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Publication number
WO2002014275A3
WO2002014275A3 PCT/US2001/021122 US0121122W WO0214275A3 WO 2002014275 A3 WO2002014275 A3 WO 2002014275A3 US 0121122 W US0121122 W US 0121122W WO 0214275 A3 WO0214275 A3 WO 0214275A3
Authority
WO
WIPO (PCT)
Prior art keywords
glutamate receptor
receptor function
sulfonamide derivatives
heterocyclic sulfonamide
potentiating glutamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/021122
Other languages
English (en)
Other versions
WO2002014275A2 (fr
Inventor
Scott Louis Forman
Winton Dennis Jones
Daryl Lynn Smith
Hamideh Zarrinmayeh
Dennis Michael Zimmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to AU2001280470A priority Critical patent/AU2001280470A1/en
Priority to US10/332,941 priority patent/US20030220369A1/en
Priority to EP01958860A priority patent/EP1313719A2/fr
Publication of WO2002014275A2 publication Critical patent/WO2002014275A2/fr
Publication of WO2002014275A3 publication Critical patent/WO2002014275A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne certains dérivés sulfonamides hétérocycliques représentés par la formule (I) qui permettent de potentialiser la fonction de récepteur du glutamate chez un patient et qui conviennent bien pour le traitement de diverses pathologies, dont des troubles psychiatriques et neurologiques.
PCT/US2001/021122 2000-08-11 2001-07-27 Derives sulfonamides heterocycliques Ceased WO2002014275A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001280470A AU2001280470A1 (en) 2000-08-11 2001-07-27 Heterocyclic sulfonamide derivatives
US10/332,941 US20030220369A1 (en) 2001-07-27 2001-07-27 Heterocyclic sulfonamide derivatives and their use for potentiating glutamate receptor function
EP01958860A EP1313719A2 (fr) 2000-08-11 2001-07-27 Derives sulfonamides heterocycliques et leur utilisation pour accroitre la fonction du recepteur glutaminique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22449700P 2000-08-11 2000-08-11
US60/224,497 2000-08-11

Publications (2)

Publication Number Publication Date
WO2002014275A2 WO2002014275A2 (fr) 2002-02-21
WO2002014275A3 true WO2002014275A3 (fr) 2002-05-30

Family

ID=22840959

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021122 Ceased WO2002014275A2 (fr) 2000-08-11 2001-07-27 Derives sulfonamides heterocycliques

Country Status (3)

Country Link
EP (1) EP1313719A2 (fr)
AU (1) AU2001280470A1 (fr)
WO (1) WO2002014275A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
US20080207659A1 (en) 2007-02-15 2008-08-28 Asit Kumar Chakraborti Inhibitors of phosphodiesterase type 4
US20120302546A1 (en) * 2010-02-04 2012-11-29 Fox Chase Chemical Diversity Center, Inc. Novel sulfamides exhibiting neuroprotective action and methods for use thereof
JP2013521290A (ja) 2010-03-04 2013-06-10 メルク・シャープ・エンド・ドーム・コーポレイション Ｍｇｌｕｒ２の正のアロステリックモジュレータ
US8765784B2 (en) * 2010-06-09 2014-07-01 Merck Sharp & Dohme Corp. Positive allosteric modulators of MGLUR2
US8993779B2 (en) 2010-08-12 2015-03-31 Merck Sharp & Dohme Corp. Positive allosteric modulators of MGLUR2
WO2012020424A1 (fr) 2010-08-12 2012-02-16 Arch Pharmalabs Limited Procédé court pour la préparation de ziprasidone et de ses intermédiaires
US8609849B1 (en) 2010-11-30 2013-12-17 Fox Chase Chemical Diversity Center, Inc. Hydroxylated sulfamides exhibiting neuroprotective action and their method of use
WO2013016411A1 (fr) * 2011-07-28 2013-01-31 Garry Robert Smith Nouveaux sulfamides cycliques fluorés présentant une action neuroprotectrice et leur procédé d'utilisation
WO2013093928A1 (fr) 2011-12-20 2013-06-27 Arch Pharmalabs Limited Procédé amélioré de préparation de 2-oxindoles de formule i, une matière première clé pour la fabrication de médicaments et de leurs intermédiaires
MX2015017253A (es) 2013-06-13 2016-04-19 Veroscience Llc Composiciones y metodos para tratar trastornos metabolicos.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0976744A1 (fr) * 1998-07-31 2000-02-02 Eli Lilly And Company Dérivés amides, de carbamates et de l'urée ayant une activité stimulatrice de la fonction des récepteurs de glutamate
WO2000066546A2 (fr) * 1999-04-30 2000-11-09 Eli Lilly And Company Derives de monofluoralkyle

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0976744A1 (fr) * 1998-07-31 2000-02-02 Eli Lilly And Company Dérivés amides, de carbamates et de l'urée ayant une activité stimulatrice de la fonction des récepteurs de glutamate
WO2000066546A2 (fr) * 1999-04-30 2000-11-09 Eli Lilly And Company Derives de monofluoralkyle

Also Published As

Publication number Publication date
EP1313719A2 (fr) 2003-05-28
WO2002014275A2 (fr) 2002-02-21
AU2001280470A1 (en) 2002-02-25

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