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WO2002013967A3 - Microarray alignment mechanism - Google Patents

Microarray alignment mechanism Download PDF

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Publication number
WO2002013967A3
WO2002013967A3 PCT/US2001/024844 US0124844W WO0213967A3 WO 2002013967 A3 WO2002013967 A3 WO 2002013967A3 US 0124844 W US0124844 W US 0124844W WO 0213967 A3 WO0213967 A3 WO 0213967A3
Authority
WO
WIPO (PCT)
Prior art keywords
registration
workpiece
arm
roller
alignment mechanism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/024844
Other languages
French (fr)
Other versions
WO2002013967A2 (en
Inventor
Eric J Rollins
Joeben Bevirt
Joshua N Guyot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc filed Critical Incyte Genomics Inc
Priority to AU2001281179A priority Critical patent/AU2001281179A1/en
Publication of WO2002013967A2 publication Critical patent/WO2002013967A2/en
Publication of WO2002013967A3 publication Critical patent/WO2002013967A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00533—Sheets essentially rectangular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0491—Position sensing, encoding; closed-loop control
    • G01N2035/0494—Detecting or compensating piositioning errors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Materials Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Composite Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Jigs For Machine Tools (AREA)
  • Specific Conveyance Elements (AREA)

Abstract

The present invention provides an alignment mechanism for aligning a workpiece such as a microscope slide for a microarray processing machine. The alignment mechanism includes a stationary support base, an actuator arm and a roller support member. The actuator arm is slidably attached to the support base and has an actuator and a registration arm. The registration arm has a first registration surface and a second registration surface. The roller support member is also slidably attached to the support base and has a main body portion, a first roller and a second roller. The actuator arm is capable of sliding the registration arm and the roller support member toward the workpiece such that the first roller presses the first edge of the workpiece against the first registration surface of the registration arm and the second roller presses the second edge of the workpiece against the second registration surface of the registration arm. To further align the workpiece in a third dimension, the workpiece has a bottom surface and the registration arm has a third registration surface and a plurality of springs. The present invention is also a method within a microarray processing device for aligning a workpiece.
PCT/US2001/024844 2000-08-11 2001-08-08 Microarray alignment mechanism Ceased WO2002013967A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281179A AU2001281179A1 (en) 2000-08-11 2001-08-08 Microarray alignment mechanism

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US22433500P 2000-08-11 2000-08-11
US22433600P 2000-08-11 2000-08-11
US22433700P 2000-08-11 2000-08-11
US22433800P 2000-08-11 2000-08-11
US60/224,337 2000-08-11
US60/224,335 2000-08-11
US60/224,338 2000-08-11
US60/224,336 2000-08-11
US63973400A 2000-08-15 2000-08-15
US63973200A 2000-08-15 2000-08-15
US63973100A 2000-08-15 2000-08-15
US63973300A 2000-08-15 2000-08-15
US09/639,731 2000-08-15
US09/639,734 2000-08-15
US09/638,733 2000-08-15
US09/639,732 2000-08-15

Publications (2)

Publication Number Publication Date
WO2002013967A2 WO2002013967A2 (en) 2002-02-21
WO2002013967A3 true WO2002013967A3 (en) 2002-08-08

Family

ID=27575221

Family Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2001/024844 Ceased WO2002013967A2 (en) 2000-08-11 2001-08-08 Microarray alignment mechanism
PCT/US2001/024850 Ceased WO2002014877A2 (en) 2000-08-11 2001-08-08 Microarray retrieval unit
PCT/US2001/024994 Ceased WO2002014531A2 (en) 2000-08-11 2001-08-09 Microarray platen
PCT/US2001/024996 Ceased WO2002013968A2 (en) 2000-08-11 2001-08-09 Microarray placer unit

Family Applications After (3)

Application Number Title Priority Date Filing Date
PCT/US2001/024850 Ceased WO2002014877A2 (en) 2000-08-11 2001-08-08 Microarray retrieval unit
PCT/US2001/024994 Ceased WO2002014531A2 (en) 2000-08-11 2001-08-09 Microarray platen
PCT/US2001/024996 Ceased WO2002013968A2 (en) 2000-08-11 2001-08-09 Microarray placer unit

Country Status (2)

Country Link
AU (4) AU2001281182A1 (en)
WO (4) WO2002013967A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6955788B2 (en) 2001-09-07 2005-10-18 Affymetrix, Inc. Apparatus and method for aligning microarray printing head
DE10261533A1 (en) * 2002-12-23 2004-07-15 BioChip Technologies GmbH Gesellschaft für Entwicklung und Produktion von Detektionssystemen Holder for slide onto which droplet array is deposited, includes locating stops on long side of slide support surface, used in conjunction with clamping system
CA2524964A1 (en) * 2004-10-29 2006-04-29 Affymetrix, Inc. Automated method of manufacturing polymer arrays
HUP0700404A2 (en) * 2007-06-08 2009-03-30 3D Histech Kft Catch frame for slide and slide feeding unit
US10509216B2 (en) 2012-12-26 2019-12-17 Ventana Medical Systems, Inc. Specimen processing systems and methods for aligning slides
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
CN102010817B (en) * 2010-08-06 2013-05-22 博奥生物有限公司 A chip automatic loading device for a microarray chip scanner
CN104053995B (en) * 2011-11-16 2017-06-13 莱卡生物系统墨尔本私人有限公司 The automatic system and method for the tissue samples on treatment slide
CN104053979B (en) 2011-11-16 2018-03-27 莱卡生物系统墨尔本私人有限公司 For handling the equipment and automated process of the biological specimen being arranged on substrate
US11274998B2 (en) 2012-12-26 2022-03-15 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
AU2013369398B2 (en) * 2012-12-26 2017-04-20 Ventana Medical Systems, Inc. Specimen processing systems and methods for aligning slides
US9989448B2 (en) 2012-12-26 2018-06-05 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
CN104007274B (en) * 2014-06-04 2016-02-03 上海宏莘科技发展有限公司 Folder off-type digital-code type fully-automatic intelligent sampler
DE102016125691B4 (en) * 2016-12-23 2018-10-25 Leica Microsystems Cms Gmbh Holder for microscope slide, microscope and method for controlling a microscope
JP7126809B2 (en) 2017-04-13 2022-08-29 浜松ホトニクス株式会社 Image acquisition device and image acquisition method

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US5592289A (en) * 1995-01-09 1997-01-07 Molecular Dynamics Self-aligning mechanism for positioning analyte receptacles
US5659421A (en) * 1995-07-05 1997-08-19 Neuromedical Systems, Inc. Slide positioning and holding device
US5658802A (en) * 1995-09-07 1997-08-19 Microfab Technologies, Inc. Method and apparatus for making miniaturized diagnostic arrays
DE19906422A1 (en) * 1998-11-20 2000-05-31 Leica Microsystems Holder used for carrying a glass object used in microscope investigations has a pressed part contacting the object carrier at two pressing points

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Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
WO1992004651A1 (en) * 1990-09-12 1992-03-19 Medical Research Council Microscope slide clip
US5592289A (en) * 1995-01-09 1997-01-07 Molecular Dynamics Self-aligning mechanism for positioning analyte receptacles
US5659421A (en) * 1995-07-05 1997-08-19 Neuromedical Systems, Inc. Slide positioning and holding device
US5658802A (en) * 1995-09-07 1997-08-19 Microfab Technologies, Inc. Method and apparatus for making miniaturized diagnostic arrays
DE19906422A1 (en) * 1998-11-20 2000-05-31 Leica Microsystems Holder used for carrying a glass object used in microscope investigations has a pressed part contacting the object carrier at two pressing points

Also Published As

Publication number Publication date
WO2002013968A2 (en) 2002-02-21
WO2002013967A2 (en) 2002-02-21
WO2002014877A2 (en) 2002-02-21
AU2001279251A1 (en) 2002-02-25
AU2001281217A1 (en) 2002-02-25
AU2001281182A1 (en) 2002-02-25
WO2002014531A3 (en) 2003-01-16
WO2002014877A3 (en) 2003-01-03
WO2002014531A2 (en) 2002-02-21
WO2002013968A3 (en) 2003-01-16
AU2001281179A1 (en) 2002-02-25

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