[go: up one dir, main page]

WO2002010404A3 - Regulation of human masp-like serine protease - Google Patents

Regulation of human masp-like serine protease Download PDF

Info

Publication number
WO2002010404A3
WO2002010404A3 PCT/EP2001/008181 EP0108181W WO0210404A3 WO 2002010404 A3 WO2002010404 A3 WO 2002010404A3 EP 0108181 W EP0108181 W EP 0108181W WO 0210404 A3 WO0210404 A3 WO 0210404A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
human masp
regulation
reagents
regulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/008181
Other languages
French (fr)
Other versions
WO2002010404A2 (en
Inventor
Yonghong Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001279752A priority Critical patent/AU2001279752A1/en
Publication of WO2002010404A2 publication Critical patent/WO2002010404A2/en
Publication of WO2002010404A3 publication Critical patent/WO2002010404A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human MASP-like serine protease activity and reagents which bind to human MASP-like serine protease gene products can be used to regulate extracellular matrix degradation. Such regulation is particularly useful for defending against pathogens, such as viruses, bacteria, mycoplasma, fungi, protozoa, helminths, rikettsia, chloamydiae, parasites, prions, and the like.
PCT/EP2001/008181 2000-07-27 2001-07-16 Regulation of human masp-like serine protease Ceased WO2002010404A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001279752A AU2001279752A1 (en) 2000-07-27 2001-07-16 Regulation of human masp-like serine protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22121100P 2000-07-27 2000-07-27
US60/221,211 2000-07-27

Publications (2)

Publication Number Publication Date
WO2002010404A2 WO2002010404A2 (en) 2002-02-07
WO2002010404A3 true WO2002010404A3 (en) 2002-06-13

Family

ID=22826843

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008181 Ceased WO2002010404A2 (en) 2000-07-27 2001-07-16 Regulation of human masp-like serine protease

Country Status (2)

Country Link
AU (1) AU2001279752A1 (en)
WO (1) WO2002010404A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001247483A1 (en) * 2000-03-17 2001-10-03 Incyte Genomics, Inc. Proteases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038501A2 (en) * 1999-11-23 2001-05-31 Zymogenetics, Inc. Human serine protease
WO2001040451A2 (en) * 1999-12-02 2001-06-07 Jens Christian Jensenius Masp-3, a complement-fixing enzyme, and uses for it
WO2001071004A2 (en) * 2000-03-17 2001-09-27 Incyte Genomics, Inc. Proteases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038501A2 (en) * 1999-11-23 2001-05-31 Zymogenetics, Inc. Human serine protease
WO2001040451A2 (en) * 1999-12-02 2001-06-07 Jens Christian Jensenius Masp-3, a complement-fixing enzyme, and uses for it
WO2001071004A2 (en) * 2000-03-17 2001-09-27 Incyte Genomics, Inc. Proteases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DAHL MADS R ET AL: "MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway.", IMMUNITY, vol. 15, no. 1, July 2001 (2001-07-01), pages 127 - 135, XP002195186, ISSN: 1074-7613 *
DATABASE EMBL SEQUENCE DATABASE Hinxton, UK; 10 October 2001 (2001-10-10), H. YUE ET AL.: "Sequences 1 and 2 from patent WO0171004", XP002195189 *
DATABASE EMBL SEQUENCE DATABASE Hinxton, UK; 22 June 2001 (2001-06-22), J.C. JENSENIUS AND S. THIEL: "Sequences 1 and 2 from patent WO0140451", XP002195188 *
DATABASE EMBL SEQUENCE DATABASE Hinxton, UK; 22 June 2001 (2001-06-22), J.L. HOLLOWAY: "Sequence 1 and 2 from patent Wo0138501", XP002195187 *
DATABASE EMBL SEQUENCE DATABASE Hinxton, UK; 23 May 2000 (2000-05-23), D.M. MUZNY ET AL.: "Homo sapiens 3 BAC RP11-460F1 (Roswell Park Cancer Institute HUman BAC Library) complete Sequence", XP002195190 *

Also Published As

Publication number Publication date
AU2001279752A1 (en) 2002-02-13
WO2002010404A2 (en) 2002-02-07

Similar Documents

Publication Publication Date Title
WO2002098210A3 (en) Chromosome doubling method
MXPA04000622A (en) Pyrazolylcarboxanilides as fungicides.
UA93384C2 (en) Process for manufacture of sterilized powder pancreatin
EA200201012A1 (en) METHODS OF STERILIZATION OF BIOLOGICAL MATERIALS
BR9407138A (en) Method for sterilizing products
NZ583686A (en) Combinations comprising a fungicidal bacillus strain and an carboxamide
EP1719410A4 (en) Method of controlling plant disease damage by using bacillus and controlling agent
ATE441670T1 (en) FRACTIONATION OF GRAIN AND RESULTING PRODUCTS
WO2002026968A3 (en) Antisense iap nucleic acids and uses thereof
WO2007136640A3 (en) Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
WO2003025781A3 (en) Router
MY128138A (en) Method for fighting against arthropods destructive of crops and compositions therefor
WO2002060914A3 (en) Identification of small rnas and orfs form e. coli as mediators of cell and intercell regulation
WO2002005643A3 (en) Biocide compositions and methods and systems employing same
WO2005108565A3 (en) Modified xylanase, methods of making and use thereof
WO2004082366A3 (en) Methods to confer enhanced floral properties to plants
ATE307498T1 (en) ANTIMICROBIAL COMPOSITION
EA200600778A1 (en) 1,3-DIMETHYLBUTYLKARBOXANILES TO COMBAT AGAINST UNDESIRABLE MICROORANISMS
MXPA05009449A (en) Pyridinium salts, compounds and methods of use.
WO2007074303A3 (en) Protection of plants against their pathogenic agents
DE60107718D1 (en) PRESERVATION OF CELLS
MXPA03010120A (en) Substituted arylketones.
WO2002010404A3 (en) Regulation of human masp-like serine protease
TNSN01111A1 (en) FUNGICIDAL COMPOSITION COMPRISING IN PARTICULAR A VEGETABLE OIL OF HIGH SICCATIVE POWER
WO2005092924A3 (en) Rab9a, rab11a, and modulators thereof related to infectious disease

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP