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WO2002010450A3 - Replicable probe array - Google Patents

Replicable probe array Download PDF

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Publication number
WO2002010450A3
WO2002010450A3 PCT/US2001/021607 US0121607W WO0210450A3 WO 2002010450 A3 WO2002010450 A3 WO 2002010450A3 US 0121607 W US0121607 W US 0121607W WO 0210450 A3 WO0210450 A3 WO 0210450A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligand
address
array
complementary
probe array
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/021607
Other languages
French (fr)
Other versions
WO2002010450A2 (en
Inventor
Patrick E Guire
Melvin J Swanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surmodics Inc
Original Assignee
Surmodics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics Inc filed Critical Surmodics Inc
Priority to AU2001278886A priority Critical patent/AU2001278886A1/en
Priority to MXPA03000962A priority patent/MXPA03000962A/en
Priority to EP01957111A priority patent/EP1349956A2/en
Priority to JP2002516366A priority patent/JP2004509323A/en
Priority to CA002417903A priority patent/CA2417903A1/en
Publication of WO2002010450A2 publication Critical patent/WO2002010450A2/en
Anticipated expiration legal-status Critical
Publication of WO2002010450A3 publication Critical patent/WO2002010450A3/en
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00378—Piezoelectric or ink jet dispensers
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    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/0061—The surface being organic
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
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    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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    • B01J2219/00709—Type of synthesis
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    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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    • C—CHEMISTRY; METALLURGY
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    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)

Abstract

A system for producing substantially identical specific binding ligand probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address ligands immobilized thereon, b) a multi-ligand conjugate having a binding domain complementary to an address ligand, a binding domain complementary to a target ligand, and a third ligand for use in transferring the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary ligands.
PCT/US2001/021607 2000-08-02 2001-07-09 Replicable probe array Ceased WO2002010450A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001278886A AU2001278886A1 (en) 2000-08-02 2001-07-09 Replicable probe array
MXPA03000962A MXPA03000962A (en) 2000-08-02 2001-07-09 Replicable probe array.
EP01957111A EP1349956A2 (en) 2000-08-02 2001-07-09 Replicable probe array
JP2002516366A JP2004509323A (en) 2000-08-02 2001-07-09 Replicatable probe array
CA002417903A CA2417903A1 (en) 2000-08-02 2001-07-09 Replicable probe array

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63113900A 2000-08-02 2000-08-02
US09/631,139 2000-08-02

Publications (2)

Publication Number Publication Date
WO2002010450A2 WO2002010450A2 (en) 2002-02-07
WO2002010450A3 true WO2002010450A3 (en) 2003-07-31

Family

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Application Number Title Priority Date Filing Date
PCT/US2001/021607 Ceased WO2002010450A2 (en) 2000-08-02 2001-07-09 Replicable probe array

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EP (1) EP1349956A2 (en)
JP (1) JP2004509323A (en)
AU (1) AU2001278886A1 (en)
CA (1) CA2417903A1 (en)
MX (1) MXPA03000962A (en)
WO (1) WO2002010450A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0302058D0 (en) * 2003-01-29 2003-02-26 Univ Cranfield Replication of nucleic acid arrays
US20070254376A1 (en) * 2004-10-01 2007-11-01 Koninklijke Philips Electronics, N.V. Method and apparatus for the detection of labeling elements in a sample
DE102007062154A1 (en) * 2007-12-21 2009-06-25 Emc Microcollections Gmbh Process for the preparation and use of stochastically arranged arrays of test substances
WO2019069372A1 (en) * 2017-10-03 2019-04-11 株式会社ニコン Detection target measurement method, capture probe-anchoring carrier, detection kit, and fluid device
CA3154609A1 (en) 2019-09-16 2021-03-25 Regeneron Pharmaceuticals, Inc. Lc-ms methods for antibody isotyping and quantification
WO2025249499A1 (en) * 2024-05-30 2025-12-04 株式会社ダイセル Separation agent

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001836A1 (en) * 1994-07-07 1996-01-25 Nanogen, Inc. Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics
US6007987A (en) * 1993-08-23 1999-12-28 The Trustees Of Boston University Positional sequencing by hybridization
WO2000027521A1 (en) * 1998-11-06 2000-05-18 Solexa Ltd. A method for reproducing molecular arrays
WO2000044939A1 (en) * 1999-01-29 2000-08-03 Surmodics, Inc. Replicable probe array

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007987A (en) * 1993-08-23 1999-12-28 The Trustees Of Boston University Positional sequencing by hybridization
WO1996001836A1 (en) * 1994-07-07 1996-01-25 Nanogen, Inc. Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics
WO2000027521A1 (en) * 1998-11-06 2000-05-18 Solexa Ltd. A method for reproducing molecular arrays
WO2000044939A1 (en) * 1999-01-29 2000-08-03 Surmodics, Inc. Replicable probe array

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CA2417903A1 (en) 2002-02-07
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JP2004509323A (en) 2004-03-25
WO2002010450A2 (en) 2002-02-07
EP1349956A2 (en) 2003-10-08

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