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WO2002010164A3 - Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers - Google Patents

Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers Download PDF

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Publication number
WO2002010164A3
WO2002010164A3 PCT/US2001/023804 US0123804W WO0210164A3 WO 2002010164 A3 WO2002010164 A3 WO 2002010164A3 US 0123804 W US0123804 W US 0123804W WO 0210164 A3 WO0210164 A3 WO 0210164A3
Authority
WO
WIPO (PCT)
Prior art keywords
dihydropyrrolopyridine
dihydronaphthyridine
derivated
compounds
potassium channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/023804
Other versions
WO2002010164A2 (en
Inventor
Konstantinos Agrios
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to CA002385908A priority Critical patent/CA2385908A1/en
Priority to JP2002515893A priority patent/JP2004505081A/en
Priority to EP01963751A priority patent/EP1307453A2/en
Publication of WO2002010164A2 publication Critical patent/WO2002010164A2/en
Publication of WO2002010164A3 publication Critical patent/WO2002010164A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PCT/US2001/023804 2000-08-02 2001-07-27 Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers Ceased WO2002010164A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002385908A CA2385908A1 (en) 2000-08-02 2001-07-27 Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers
JP2002515893A JP2004505081A (en) 2000-08-02 2001-07-27 Dihydronaphthyridine potassium channel opener
EP01963751A EP1307453A2 (en) 2000-08-02 2001-07-27 Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63119300A 2000-08-02 2000-08-02
US09/631,193 2000-08-02

Publications (2)

Publication Number Publication Date
WO2002010164A2 WO2002010164A2 (en) 2002-02-07
WO2002010164A3 true WO2002010164A3 (en) 2002-04-25

Family

ID=24530165

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/023804 Ceased WO2002010164A2 (en) 2000-08-02 2001-07-27 Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers

Country Status (4)

Country Link
EP (1) EP1307453A2 (en)
JP (1) JP2004505081A (en)
CA (1) CA2385908A1 (en)
WO (1) WO2002010164A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060128710A1 (en) * 2004-12-09 2006-06-15 Chih-Hung Lee Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
JP2006232819A (en) * 2005-01-25 2006-09-07 Takeda Chem Ind Ltd Method for producing cyanodihydropyridine compound
DE102006026583A1 (en) 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Aryl-substituted hetero-bicyclic compounds and their use
DE102006026585A1 (en) * 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Substituted 4-aryl-1,4-dihydro-1,6-naphthyridines and their use
DE102007009494A1 (en) 2007-02-27 2008-08-28 Bayer Healthcare Ag New 1,6-naphthyridine or 8-azaquinazoline derivatives useful for treating aldosteronism, hypertension, cardiac insufficiency, myocardial infarct sequelae, liver cirrhosis, renal insufficiency and stroke
CN101619041B (en) * 2008-07-02 2012-07-04 重庆华邦制药股份有限公司 A kind of synthetic method and its intermediate of diketo nitrogen-containing ring compound
EP2398790B1 (en) 2009-02-18 2013-07-03 Bayer Intellectual Property GmbH Bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives and uses thereof
CN109721536B (en) * 2017-10-27 2020-11-24 广东东阳光药业有限公司 Phenyl-substituted fused tricyclic compounds and their uses

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3130041A1 (en) * 1981-07-30 1983-02-17 Bayer Ag, 5090 Leverkusen Dihydropyridines having a positive inotropic effect, novel compounds, their use in medicaments, and processes for their preparation
EP0111453A1 (en) * 1982-12-10 1984-06-20 Ciba-Geigy Ag Amide derivatives
EP0111455A2 (en) * 1982-12-10 1984-06-20 Ciba-Geigy Ag Unsaturated lactones
EP0133530A2 (en) * 1983-07-30 1985-02-27 Gödecke Aktiengesellschaft 1,6-Naphthyridinone derivatives, process for their preparation, and medicaments containing them
US4567268A (en) * 1984-04-03 1986-01-28 Merck & Co., Inc. Process for preparation of certain tetrahydrofuro[3,4-b]pyridines

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3130041A1 (en) * 1981-07-30 1983-02-17 Bayer Ag, 5090 Leverkusen Dihydropyridines having a positive inotropic effect, novel compounds, their use in medicaments, and processes for their preparation
EP0111453A1 (en) * 1982-12-10 1984-06-20 Ciba-Geigy Ag Amide derivatives
EP0111455A2 (en) * 1982-12-10 1984-06-20 Ciba-Geigy Ag Unsaturated lactones
EP0133530A2 (en) * 1983-07-30 1985-02-27 Gödecke Aktiengesellschaft 1,6-Naphthyridinone derivatives, process for their preparation, and medicaments containing them
US4567268A (en) * 1984-04-03 1986-01-28 Merck & Co., Inc. Process for preparation of certain tetrahydrofuro[3,4-b]pyridines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. D. MAYA ET AL.: "Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY PART C, vol. 125, no. 1, 2000, pages 103 - 109, XP002188922 *

Also Published As

Publication number Publication date
CA2385908A1 (en) 2002-02-07
JP2004505081A (en) 2004-02-19
EP1307453A2 (en) 2003-05-07
WO2002010164A2 (en) 2002-02-07

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