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WO2002008282A3 - Bstp-ras/rerg protein and related reagents and methods of use thereof - Google Patents

Bstp-ras/rerg protein and related reagents and methods of use thereof Download PDF

Info

Publication number
WO2002008282A3
WO2002008282A3 PCT/US2001/023574 US0123574W WO0208282A3 WO 2002008282 A3 WO2002008282 A3 WO 2002008282A3 US 0123574 W US0123574 W US 0123574W WO 0208282 A3 WO0208282 A3 WO 0208282A3
Authority
WO
WIPO (PCT)
Prior art keywords
ras
bstp
rerg
provides
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/023574
Other languages
French (fr)
Other versions
WO2002008282A2 (en
Inventor
David Botstein
Patrick O Brown
Channing Der
Chuck Perou
Douglas Ross
Douglas Seitz
Fuyu Tamanoi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Applied Genomics Inc
University of California Berkeley
University of California San Diego UCSD
Leland Stanford Junior University
Original Assignee
University of North Carolina at Chapel Hill
Applied Genomics Inc
University of California Berkeley
University of California San Diego UCSD
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, Applied Genomics Inc, University of California Berkeley, University of California San Diego UCSD, Leland Stanford Junior University filed Critical University of North Carolina at Chapel Hill
Priority to AU2001277202A priority Critical patent/AU2001277202A1/en
Publication of WO2002008282A2 publication Critical patent/WO2002008282A2/en
Anticipated expiration legal-status Critical
Publication of WO2002008282A3 publication Critical patent/WO2002008282A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides a protein (BSTP-Ras/Rerg) and polynucleotides which identify and encode BSTP-Ras. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. In addition, the invention provides methods for treating or preventing disorders of cell proliferation, particularly breast cancer, by administering a pharmaceutical composition comprising a polypeptide, polynucleotide, or antibody of the invention. The invention also provides methods of classifying diseases, particularly breast cancer, by detecting expression of BSTP-Ras or of a polynucleotide encoding BSTP-Ras, and of providing diagnostic, prognostic, and/or predictive information for a patient based on the detection and/or measurement of BSTP-Ras or of a gene that encodes BSTP-Ras or of a mutation in the BST-RAS/Rerg gene.
PCT/US2001/023574 2000-07-26 2001-07-26 Bstp-ras/rerg protein and related reagents and methods of use thereof Ceased WO2002008282A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001277202A AU2001277202A1 (en) 2000-07-26 2001-07-26 Bstp-ras/rerg protein and related reagents and methods of use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22096700P 2000-07-26 2000-07-26
US60/220,967 2000-07-26
US23781900P 2000-10-03 2000-10-03
US60/237,819 2000-10-03

Publications (2)

Publication Number Publication Date
WO2002008282A2 WO2002008282A2 (en) 2002-01-31
WO2002008282A3 true WO2002008282A3 (en) 2003-09-25

Family

ID=26915368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/023574 Ceased WO2002008282A2 (en) 2000-07-26 2001-07-26 Bstp-ras/rerg protein and related reagents and methods of use thereof

Country Status (2)

Country Link
AU (1) AU2001277202A1 (en)
WO (1) WO2002008282A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003078662A1 (en) 2002-03-13 2003-09-25 Genomic Health Gene expression profiling in biopsied tumor tissues
JP4606879B2 (en) 2002-11-15 2011-01-05 ジェノミック ヘルス， インコーポレイテッド Gene expression profiling of EGFR positive cancer
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
ATE412779T1 (en) 2003-02-20 2008-11-15 Genomic Health Inc USE OF INTRONIC RNA SEQUENCES TO QUANTIFY GENE EXPRESSION
WO2005039382A2 (en) 2003-06-24 2005-05-06 Genomic Health Prediction of likelihood of cancer recurrence
ES2651849T3 (en) 2003-07-10 2018-01-30 Genomic Health, Inc. Expression profile and test algorithm for cancer prognosis
ES2360113T3 (en) 2003-12-23 2011-06-01 Genomic Health, Inc. UNIVERSAL AMPLIFICATION OF FRAGMENTED RNA.
US7871769B2 (en) 2004-04-09 2011-01-18 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
US7587279B2 (en) 2004-07-06 2009-09-08 Genomic Health Method for quantitative PCR data analysis system (QDAS)
WO2006052862A1 (en) 2004-11-05 2006-05-18 Genomic Health, Inc. Predicting response to chemotherapy using gene expression markers
EP1815014B1 (en) 2004-11-05 2012-03-21 Genomic Health, Inc. Molecular indicators of breast cancer prognosis and prediction of treatment response

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998049194A2 (en) * 1997-04-30 1998-11-05 Incyte Pharmaceuticals, Inc. Ras-like protein
WO1999058677A1 (en) * 1998-05-13 1999-11-18 Axys Pharmaceuticals, Inc. Raq genes and their uses
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001054733A1 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins and antibodies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998049194A2 (en) * 1997-04-30 1998-11-05 Incyte Pharmaceuticals, Inc. Ras-like protein
WO1999058677A1 (en) * 1998-05-13 1999-11-18 Axys Pharmaceuticals, Inc. Raq genes and their uses
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001054733A1 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins and antibodies

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FINLIN B. ET AL.: "RERG is a Novel ras-related, Estrogen-regulated and Growth-inhibitory Gene in Breast Cancer", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC., vol. 276, no. 45, 31 August 2001 (2001-08-31), US, pages 42259 - 42267, XP002220234 *
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658, ISSN: 0036-8075 *
MARTIN K J ET AL: "LINKING GENE EXPRESSION PATTERNS TO THERAPEUTIC GROUPS IN BREAST CANCER", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 60, no. 8, 15 April 2000 (2000-04-15), pages 2232 - 2238, XP001026395, ISSN: 0008-5472 *
MENDOZA L G ET AL: "HIGH-THROUGHPUT MICROARRAY-BASED ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)", BIOTECHNIQUES, EATON PUBLISHING, NATICK, US, vol. 27, no. 4, October 1999 (1999-10-01), pages 778,780,782 - 786,788, XP000992893, ISSN: 0736-6205 *
MOSCOW J A ET AL: "Utilization of multiple polyadenylation signals in the human RHOA protooncogene.", GENE. NETHERLANDS 8 JUL 1994, vol. 144, no. 2, 8 July 1994 (1994-07-08), pages 229 - 236, XP002220233, ISSN: 0378-1119 *

Also Published As

Publication number Publication date
WO2002008282A2 (en) 2002-01-31
AU2001277202A1 (en) 2002-02-05

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