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WO2002008190A3 - Neue heteroaryl-derivate und deren verwendung als antitumormittel - Google Patents

Neue heteroaryl-derivate und deren verwendung als antitumormittel Download PDF

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Publication number
WO2002008190A3
WO2002008190A3 PCT/EP2001/008262 EP0108262W WO0208190A3 WO 2002008190 A3 WO2002008190 A3 WO 2002008190A3 EP 0108262 W EP0108262 W EP 0108262W WO 0208190 A3 WO0208190 A3 WO 0208190A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumour agents
heteroaryl derivatives
novel heteroaryl
novel
derivatives
Prior art date
Application number
PCT/EP2001/008262
Other languages
English (en)
French (fr)
Other versions
WO2002008190A2 (de
Inventor
Peter Emig
Eckhard Guenther
Juergen Schmidt
Bernhard Kutscher
Bernd Nickel
Anita Storch
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP01960509A priority Critical patent/EP1305289A2/de
Priority to AU8198901A priority patent/AU8198901A/xx
Priority to NZ524156A priority patent/NZ524156A/en
Priority to KR10-2003-7000880A priority patent/KR20030015894A/ko
Priority to SK194-2003A priority patent/SK1942003A3/sk
Priority to PL36135401A priority patent/PL361354A1/xx
Priority to IL15393101A priority patent/IL153931A0/xx
Priority to JP2002514097A priority patent/JP2004516243A/ja
Priority to AU2001281989A priority patent/AU2001281989B2/en
Priority to BR0112711-0A priority patent/BR0112711A/pt
Application filed by Zentaris Ag filed Critical Zentaris Ag
Priority to MXPA03000596A priority patent/MXPA03000596A/es
Priority to HU0300743A priority patent/HUP0300743A2/hu
Publication of WO2002008190A2 publication Critical patent/WO2002008190A2/de
Publication of WO2002008190A3 publication Critical patent/WO2002008190A3/de
Priority to NO20030302A priority patent/NO20030302L/no
Priority to BG107506A priority patent/BG107506A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Die Erfindung betrifft neue Pyridin-Derivate der allgemeinen Formel (1), deren Herstellung und Verwendung als Arzneimittel, insbesondere zur Behandlung von Tumoren.
PCT/EP2001/008262 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel WO2002008190A2 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
AU2001281989A AU2001281989B2 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
NZ524156A NZ524156A (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and their use as medicaments
KR10-2003-7000880A KR20030015894A (ko) 2000-07-21 2001-07-18 신규한 헤테로아릴 유도체 및 약물로서의 이의 용도
SK194-2003A SK1942003A3 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
PL36135401A PL361354A1 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
IL15393101A IL153931A0 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
JP2002514097A JP2004516243A (ja) 2000-07-21 2001-07-18 新規のヘテロアリール誘導体および該化合物の医薬品としての使用
EP01960509A EP1305289A2 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel
AU8198901A AU8198901A (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as medicaments
BR0112711-0A BR0112711A (pt) 2000-07-21 2001-07-18 Derivados de heteroarila e seus usos como medicamentos
MXPA03000596A MXPA03000596A (es) 2000-07-21 2001-07-18 Nuevos derivasdos de heteroarilo y su uso como agentes antitumorales.
HU0300743A HUP0300743A2 (hu) 2000-07-21 2001-07-18 Heteroarilszármazékok és alkalmazásuk gyógyszerként
NO20030302A NO20030302L (no) 2000-07-21 2003-01-20 Nye heteroarylderivater og deres anvendelse som medikamenter
BG107506A BG107506A (bg) 2000-07-21 2003-01-30 Нови хетероарилови производни и тяхното използване като лекарствени средства

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035908.6 2000-07-21
DE10035908A DE10035908A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel

Publications (2)

Publication Number Publication Date
WO2002008190A2 WO2002008190A2 (de) 2002-01-31
WO2002008190A3 true WO2002008190A3 (de) 2002-08-01

Family

ID=7649970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008262 WO2002008190A2 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel

Country Status (21)

Country Link
US (1) US6638935B2 (de)
EP (1) EP1305289A2 (de)
JP (1) JP2004516243A (de)
KR (1) KR20030015894A (de)
CN (1) CN1447796A (de)
AR (1) AR032467A1 (de)
AU (2) AU2001281989B2 (de)
BG (1) BG107506A (de)
BR (1) BR0112711A (de)
CA (1) CA2353353A1 (de)
DE (1) DE10035908A1 (de)
HU (1) HUP0300743A2 (de)
IL (1) IL153931A0 (de)
MX (1) MXPA03000596A (de)
NO (1) NO20030302L (de)
NZ (1) NZ524156A (de)
PL (1) PL361354A1 (de)
RU (1) RU2003105238A (de)
SK (1) SK1942003A3 (de)
WO (1) WO2002008190A2 (de)
ZA (1) ZA200300545B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014744A1 (en) * 2002-04-05 2004-01-22 Fortuna Haviv Substituted pyridines having antiangiogenic activity
CN100509790C (zh) * 2002-06-29 2009-07-08 赞塔里斯有限公司 芳基羰基哌嗪和杂芳基羰基哌嗪及其治疗良性和恶性肿瘤疾病的用途
MXPA05008099A (es) * 2003-01-28 2005-09-21 Aventis Pharma Sa Productos n-aril-heteroaromaticos, composiciones que los contienen y su utilizacion.
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
PE20050226A1 (es) * 2003-06-04 2005-05-18 Aventis Pharma Sa Productos aril-heteroaromaticos y composiciones que los contienen
US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
FR2871157A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Produits biaryl aromatiques, compositions les contenant et utilisation
EP1645556A1 (de) * 2004-10-07 2006-04-12 Boehringer Ingelheim International GmbH Arylpiperazin-Benzoylamidderivate geeignet als Arzneimittelwirkstoffe
EP2778155A1 (de) 2007-01-31 2014-09-17 Vertex Pharmaceuticals Incorporated 2-Aminopyridinderivate als Kinaseinhibitoren
WO2008106128A2 (en) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
US8329897B2 (en) * 2007-07-26 2012-12-11 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
WO2009073300A1 (en) 2007-11-02 2009-06-11 Vertex Pharmaceuticals Incorporated [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
EP2229368A1 (de) 2007-12-11 2010-09-22 Vitae Pharmaceuticals, Inc. Cyclische harnstoffe als inhibitoren von 11beta-hydroxysteroiddehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5734666B2 (ja) * 2008-02-11 2015-06-17 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の１，３−オキサアゼパン−２−オン及び１，３−ジアゼパン−２−オン阻害剤
WO2009102460A2 (en) * 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5538356B2 (ja) * 2008-03-18 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
US8242111B2 (en) * 2008-05-01 2012-08-14 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
CL2009001058A1 (es) 2008-05-01 2010-09-10 Vitae Pharmaceuticals Inc Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras.
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TW200946520A (en) 2008-05-01 2009-11-16 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN102131809A (zh) 2008-07-23 2011-07-20 沃泰克斯药物股份有限公司 三环吡唑并吡啶激酶抑制剂
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
CA2731451A1 (en) 2008-07-23 2010-01-28 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
CA2730499A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MX2011001319A (es) * 2008-08-06 2011-04-05 Vertex Pharma Inhibidores de aminopiridina cinasa.
JP5679997B2 (ja) 2009-02-04 2015-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
KR20120061771A (ko) * 2009-04-30 2012-06-13 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
JP5627675B2 (ja) 2009-05-06 2014-11-19 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ ピラゾロピリジン
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
WO2011002910A1 (en) 2009-07-01 2011-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2011094288A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrazine kinase inhibitors
EP2582702A1 (de) 2010-01-27 2013-04-24 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidinkinasehemmer
MX2012008644A (es) 2010-01-27 2012-11-23 Vertex Pharma Inhibidores de cinasa de pirazolopiridinas.
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
MX2013004699A (es) 2010-11-02 2013-05-22 Boehringer Ingelheim Int Combinaciones farmaceuticas para el tratamiento de trastornos metabolicos.

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2215545A1 (de) * 1971-03-31 1972-10-12 Egyt Gyogyszervegyeszeti Gyar, Budapest Pyridinderivate und ihre Salze sowie ihre Verwendung und Verfahren zur Herstellung derselben
DE2240665A1 (de) * 1971-11-19 1974-03-07 Albert Ag Chem Werke Verfahren zur herstellung von n,n'disubstituierten cyclischen diaminen
JPS50151886A (de) * 1974-05-29 1975-12-06
DE2828888A1 (de) * 1977-06-30 1979-01-18 Egyt Gyogyszervegyeszeti Gyar Verfahren zur herstellung von pyridincarbonsaeureamiden
EP0040793A1 (de) * 1980-05-22 1981-12-02 Masayuki Ishikawa Chinazolindion-Verbindungen, Verfahren zu deren Herstellung und deren pharmazeutische Verwendung
EP0318235A2 (de) * 1987-11-25 1989-05-31 Takeda Chemical Industries, Ltd. PAF-Antagonist, 1,4-disubstituierte Piperazin-Verbindungen und deren Herstellung
EP0350448A1 (de) * 1988-07-07 1990-01-10 Ciba-Geigy Ag Biarylverbindungen
WO1995000497A1 (en) * 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1996021648A1 (en) * 1995-01-11 1996-07-18 Samjin Pharmaceutical Co., Ltd. New piperazine derivatives and methods for the preparation thereof and compositions containing the same
WO1996028427A1 (en) * 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
WO1998000402A1 (en) * 1996-06-29 1998-01-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
WO1999043682A1 (en) * 1998-02-26 1999-09-02 Neurogen Corporation 2-(het-)aryl-4-(cyclic amino substituted) heteroaryl fused pyridine derivatives, their preparation and their use as (ant-)agonists for gaba (a) brain receptors
EP1006110A1 (de) * 1997-07-21 2000-06-07 Laboratorios Del Dr. Esteve, S.A. Derivate von acyl-piperazinil-pyrimidinen, ihre herstellung und verwendung als medikament
WO2000052001A1 (en) * 1999-03-03 2000-09-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
WO2000076521A1 (en) * 1999-06-15 2000-12-21 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
WO2001044201A1 (en) * 1999-12-16 2001-06-21 Schering Corporation Substituted imidazole neuropeptide y y5 receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU772477B2 (en) * 1998-08-28 2004-04-29 Scios Inc. Inhibitors of p38-alpha kinase

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2215545A1 (de) * 1971-03-31 1972-10-12 Egyt Gyogyszervegyeszeti Gyar, Budapest Pyridinderivate und ihre Salze sowie ihre Verwendung und Verfahren zur Herstellung derselben
DE2240665A1 (de) * 1971-11-19 1974-03-07 Albert Ag Chem Werke Verfahren zur herstellung von n,n'disubstituierten cyclischen diaminen
JPS50151886A (de) * 1974-05-29 1975-12-06
DE2828888A1 (de) * 1977-06-30 1979-01-18 Egyt Gyogyszervegyeszeti Gyar Verfahren zur herstellung von pyridincarbonsaeureamiden
EP0040793A1 (de) * 1980-05-22 1981-12-02 Masayuki Ishikawa Chinazolindion-Verbindungen, Verfahren zu deren Herstellung und deren pharmazeutische Verwendung
EP0318235A2 (de) * 1987-11-25 1989-05-31 Takeda Chemical Industries, Ltd. PAF-Antagonist, 1,4-disubstituierte Piperazin-Verbindungen und deren Herstellung
EP0350448A1 (de) * 1988-07-07 1990-01-10 Ciba-Geigy Ag Biarylverbindungen
WO1995000497A1 (en) * 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1996021648A1 (en) * 1995-01-11 1996-07-18 Samjin Pharmaceutical Co., Ltd. New piperazine derivatives and methods for the preparation thereof and compositions containing the same
WO1996028427A1 (en) * 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
WO1998000402A1 (en) * 1996-06-29 1998-01-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
EP1006110A1 (de) * 1997-07-21 2000-06-07 Laboratorios Del Dr. Esteve, S.A. Derivate von acyl-piperazinil-pyrimidinen, ihre herstellung und verwendung als medikament
WO1999043682A1 (en) * 1998-02-26 1999-09-02 Neurogen Corporation 2-(het-)aryl-4-(cyclic amino substituted) heteroaryl fused pyridine derivatives, their preparation and their use as (ant-)agonists for gaba (a) brain receptors
WO2000052001A1 (en) * 1999-03-03 2000-09-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
WO2000076521A1 (en) * 1999-06-15 2000-12-21 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
WO2001044201A1 (en) * 1999-12-16 2001-06-21 Schering Corporation Substituted imidazole neuropeptide y y5 receptor antagonists

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ACTA CHIM. ACAD. SCI. HUNG. (1980), 105(4), 241-6 *
ACTA POL. PHARM. (1967), 24(3), 225-9 *
BIOORG. MED. CHEM. LETT. (2000), 10(24), 2819-2823 *
CHEMICAL ABSTRACTS, vol. 104, Columbus, Ohio, US; abstract no. 142076, TRUBITSYNA, T. K. ET AL: "Comparative anorexic activity and other pharmacological properties of quipazine and its N-acyl derivatives" XP002185956 *
CHEMICAL ABSTRACTS, vol. 134, Columbus, Ohio, US; abstract no. 207791, KANOJIA, R. M. ET AL: "Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines" XP002185955 *
CHEMICAL ABSTRACTS, vol. 68, Columbus, Ohio, US; abstract no. 59531, BINIECKI, STANISLAW ET AL: "Synthesis of 1,4-bis(pyridylcarbonyl)piperazines" XP002185958 *
CHEMICAL ABSTRACTS, vol. 84, no. 25, 21 June 1976, Columbus, Ohio, US; abstract no. 180288, IRIKURA, TSUTOMU: "1-(3-Phenylpropyl)-4-pyridinecarbonyl-piperazine derivatives" XP002185954 *
CHEMICAL ABSTRACTS, vol. 94, Columbus, Ohio, US; abstract no. 192275, BUDAI, ZOLTAN ET AL: "A novel synthesis of pyridinecarboxylic acid piperazides" XP002185959 *
CHEMICAL ABSTRACTS, vol. 95, Columbus, Ohio, US; abstract no. 42145, BENASSI, ROIS ET AL: "Proton dynamic nuclear magnetic resonance study of hindered internal rotation in N-aroyl- and N-thioaroyl-N'-piperonylpiperazines" XP002185957 *
FARMAKOL. TOKSIKOL. (MOSCOW) (1986), 49(1), 44-9 *
ORG. MAGN. RESON. (1981), 15(1), 25-8 *

Also Published As

Publication number Publication date
BR0112711A (pt) 2003-05-20
US6638935B2 (en) 2003-10-28
NO20030302D0 (no) 2003-01-20
AU2001281989B2 (en) 2005-05-12
ZA200300545B (en) 2003-02-12
RU2003105238A (ru) 2004-08-10
CN1447796A (zh) 2003-10-08
SK1942003A3 (en) 2003-12-02
CA2353353A1 (en) 2002-01-21
MXPA03000596A (es) 2003-05-14
PL361354A1 (en) 2004-10-04
HUP0300743A2 (hu) 2003-10-28
NO20030302L (no) 2003-02-07
DE10035908A1 (de) 2002-03-07
US20020111354A1 (en) 2002-08-15
NZ524156A (en) 2005-10-28
EP1305289A2 (de) 2003-05-02
WO2002008190A2 (de) 2002-01-31
KR20030015894A (ko) 2003-02-25
IL153931A0 (en) 2003-07-31
BG107506A (bg) 2003-09-30
AU8198901A (en) 2002-02-05
AR032467A1 (es) 2003-11-12
JP2004516243A (ja) 2004-06-03

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