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WO2002007714A3 - Utilisation de dihydropyridines annelees pour la preparation d'agents destines au traitement de douleurs chroniques - Google Patents

Utilisation de dihydropyridines annelees pour la preparation d'agents destines au traitement de douleurs chroniques Download PDF

Info

Publication number
WO2002007714A3
WO2002007714A3 PCT/EP2001/008453 EP0108453W WO0207714A3 WO 2002007714 A3 WO2002007714 A3 WO 2002007714A3 EP 0108453 W EP0108453 W EP 0108453W WO 0207714 A3 WO0207714 A3 WO 0207714A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
chronic pain
preparation
pharmaceutical compositions
anellated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/008453
Other languages
English (en)
Other versions
WO2002007714A2 (fr
Inventor
Walter Loesel
Dietrich Arndts
Wolfram Gaida
Klaus Klinder
Stefan Matthias Blech
Henning Draheim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to AU2001289719A priority Critical patent/AU2001289719A1/en
Publication of WO2002007714A2 publication Critical patent/WO2002007714A2/fr
Publication of WO2002007714A3 publication Critical patent/WO2002007714A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4747—Quinolines; Isoquinolines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne l'utilisation de dihydropyridines annellées et de sels de ces produits avec des acides physiologiquement acceptables pour la préparation d'agents destinés au traitement de douleurs chroniques, conformes à la formule générale (I), où A désigne un benzo ou un thiéno et Z, R?1, R2, R3, R4, R5 et R6¿ sont tels que définis dans la description. L'invention concerne également de nouveaux composés de formule (I).
PCT/EP2001/008453 2000-07-25 2001-07-21 Utilisation de dihydropyridines annelees pour la preparation d'agents destines au traitement de douleurs chroniques Ceased WO2002007714A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001289719A AU2001289719A1 (en) 2000-07-25 2001-07-21 Use of anellated dihydropyridines for the preparation of pharmaceutical compositions for the treatment of chronic pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035997.3 2000-07-25
DE10035997A DE10035997A1 (de) 2000-07-25 2000-07-25 Verwendung von anellierten Dihydropyridinen zur Herstellung von Mitteln für die Behandlung von chronischen Schmerzen

Publications (2)

Publication Number Publication Date
WO2002007714A2 WO2002007714A2 (fr) 2002-01-31
WO2002007714A3 true WO2002007714A3 (fr) 2002-09-06

Family

ID=7650021

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008453 Ceased WO2002007714A2 (fr) 2000-07-25 2001-07-21 Utilisation de dihydropyridines annelees pour la preparation d'agents destines au traitement de douleurs chroniques

Country Status (5)

Country Link
AR (1) AR029981A1 (fr)
AU (1) AU2001289719A1 (fr)
DE (1) DE10035997A1 (fr)
UY (1) UY26852A1 (fr)
WO (1) WO2002007714A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014089A1 (fr) * 2001-07-31 2003-02-20 Virginia Commonwealth University Derives d'aminotetrahydroisoquinoleines en tant qu'analgesiques
RU2711646C1 (ru) * 2019-04-08 2020-01-17 Федеральное государственное бюджетное учреждение науки Институт молекулярной генетики Российской академии наук Синтез меченного тритием 6,7-диметокси-4,4-диметил-1-[4-(4-трифторметилфенокси)фенил]-3Н-изохинолина

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3823148A (en) * 1971-06-03 1974-07-09 A Jansen 4-biphenylyl isoquinoline derivatives
EP0251361A1 (fr) * 1986-05-21 1988-01-07 Duphar International Research B.V Dérivés de la di- et tétrahydroisoquinoléine
GB2236674A (en) * 1989-09-20 1991-04-17 Wyeth John & Brother Ltd Pharmaceutical composition containing gaba autoreceptor antagonists
EP0491441A1 (fr) * 1990-12-17 1992-06-24 Shell Internationale Researchmaatschappij B.V. Dérivés d'isoquinolinefongicides
WO2000044725A1 (fr) * 1999-01-28 2000-08-03 Boehringer Ingelheim Pharma Kg Dihydropyridines annelees et utilisation de dihydropyridines annelees pour preparer des agents utilises dans le traitement de l'epilepsie

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3823148A (en) * 1971-06-03 1974-07-09 A Jansen 4-biphenylyl isoquinoline derivatives
EP0251361A1 (fr) * 1986-05-21 1988-01-07 Duphar International Research B.V Dérivés de la di- et tétrahydroisoquinoléine
GB2236674A (en) * 1989-09-20 1991-04-17 Wyeth John & Brother Ltd Pharmaceutical composition containing gaba autoreceptor antagonists
EP0491441A1 (fr) * 1990-12-17 1992-06-24 Shell Internationale Researchmaatschappij B.V. Dérivés d'isoquinolinefongicides
WO2000044725A1 (fr) * 1999-01-28 2000-08-03 Boehringer Ingelheim Pharma Kg Dihydropyridines annelees et utilisation de dihydropyridines annelees pour preparer des agents utilises dans le traitement de l'epilepsie

Also Published As

Publication number Publication date
AU2001289719A1 (en) 2002-02-05
AR029981A1 (es) 2003-07-23
WO2002007714A2 (fr) 2002-01-31
DE10035997A1 (de) 2002-02-07
UY26852A1 (es) 2002-02-28

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