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WO2002006522A3 - Estrogen receptor gene polymorphisms as markers for determining a predisposition for low bone density - Google Patents

Estrogen receptor gene polymorphisms as markers for determining a predisposition for low bone density Download PDF

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Publication number
WO2002006522A3
WO2002006522A3 PCT/CA2001/000898 CA0100898W WO0206522A3 WO 2002006522 A3 WO2002006522 A3 WO 2002006522A3 CA 0100898 W CA0100898 W CA 0100898W WO 0206522 A3 WO0206522 A3 WO 0206522A3
Authority
WO
WIPO (PCT)
Prior art keywords
estrogen receptor
predisposition
determining
markers
osteoporosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2001/000898
Other languages
French (fr)
Other versions
WO2002006522A2 (en
Inventor
Francois Rousseau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Signalgene Inc
Original Assignee
Signalgene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signalgene Inc filed Critical Signalgene Inc
Publication of WO2002006522A2 publication Critical patent/WO2002006522A2/en
Anticipated expiration legal-status Critical
Publication of WO2002006522A3 publication Critical patent/WO2002006522A3/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a method of determining genetic predisposition to low or high bone mineral density of a patient, wherein low beone density is indicative of a predisposition to esteoporosis, esteopenia or bone fracture and high bone density is indicative of resistance to osteoporosis, osteopenia or bone fracture. The invention further relates to a marker at the estrogen receptor or equivalents thereof to prognose a response to esteoporosis therapy. As well, the invention relates to a method for determining osteoporosis susceptibility, prognosis and response to therapy based on a determination of the combination of the genotype at the estrogen receptor or at markers in linkage disequilibrium therewith, alone or together with other parameters such as age, or a therapeutic regimen. The invention further relates to screening assays to identify and select agents which can be used in the treatment of osteoporosis.
PCT/CA2001/000898 2000-07-15 2001-06-15 Estrogen receptor gene polymorphisms as markers for determining a predisposition for low bone density Ceased WO2002006522A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59437100A 2000-07-15 2000-07-15
US09/594,371 2000-07-15

Publications (2)

Publication Number Publication Date
WO2002006522A2 WO2002006522A2 (en) 2002-01-24
WO2002006522A3 true WO2002006522A3 (en) 2003-03-06

Family

ID=24378600

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000898 Ceased WO2002006522A2 (en) 2000-07-15 2001-06-15 Estrogen receptor gene polymorphisms as markers for determining a predisposition for low bone density

Country Status (1)

Country Link
WO (1) WO2002006522A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006084937A1 (en) * 2005-02-14 2006-08-17 Leskelae Hannu-Ville Method for diagnosing and treating women with increased response to hormonal replacement therapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022387A1 (en) * 1995-01-16 1996-07-25 Garvan Institute Of Medical Research Diagnostic method using estrogen receptor gene polymorphisms
WO1997027321A1 (en) * 1996-01-25 1997-07-31 Universite Laval Marker at the estrogen receptor gene for determination of osteoporosis predisposition
WO2000015836A2 (en) * 1998-09-15 2000-03-23 Signalgene Inc. Combination of markers at the estrogen- and vitamin d-receptor genes or equivalents thereof to prognose a response to osteoporosis therapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022387A1 (en) * 1995-01-16 1996-07-25 Garvan Institute Of Medical Research Diagnostic method using estrogen receptor gene polymorphisms
WO1997027321A1 (en) * 1996-01-25 1997-07-31 Universite Laval Marker at the estrogen receptor gene for determination of osteoporosis predisposition
WO2000015836A2 (en) * 1998-09-15 2000-03-23 Signalgene Inc. Combination of markers at the estrogen- and vitamin d-receptor genes or equivalents thereof to prognose a response to osteoporosis therapy

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ALBAGHA O ET AL: "ESTROGEN RECEPTOR -ALPHA AND -BETA GENE POLYMORPHISMS AND OSTEOPOROSIS: A POPULATION BASED STUDY", CALCIFIED TISSUE INTERNATIONAL, NEW YORK, NY, US, vol. 64, no. SUPPL 1, 1999, pages S86, XP001023177, ISSN: 0171-967X *
BLANCHET C ET AL: "Association between bone mineral density, physical activity, vitamin D and estrogen receptors polymorphisms in postmenopausal women.", MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, vol. 30, no. 5 SUPPL., May 1998 (1998-05-01), 45th Annual Meeting of the American College of Sports Medicine;Orlando, Florida, USA; June 3-6, 1998, pages S228, XP001106246, ISSN: 0195-9131 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2000, JULKUNEN HEIKKI: "Hormone replacement therapy in women with rheumatic diseases.", XP002216183, Database accession no. PREV200000351945 *
GENNARI LUIGI ET AL: "Vitamin D and estrogen receptor allelic variants in Italian postmenopausal women: Evidence of multiple gene contribution to bone mineral density.", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 83, no. 3, March 1998 (1998-03-01), pages 939 - 944, XP002216180, ISSN: 0021-972X *
GIGUERE Y ET AL: "Common polymorphisms in vitamin D receptor and estrogen receptor in the prediction of bone mineral density and stiffness index in a cohort of postmenopausal women.", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 61, no. 4 SUPPL., October 1997 (1997-10-01), 47th Annual Meeting of the American Society of Human Genetics;Baltimore, Maryland, USA; October 28-November 1, 1997, pages A199, XP001106248, ISSN: 0002-9297 *
GIGUERE YVES ET AL: "The association between heel ultrasound and hormone replacement therapy is modulated by a two-locus vitamin D and estrogen receptor genotype.", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 15, no. 6, June 2000 (2000-06-01), pages 1076 - 1084, XP001106669, ISSN: 0884-0431 *
KOBAYASHI S ET AL: "ASSOCIATION OF BONE MINERAL DENSITY WITH POLYMORPHISM OF THE ESTROGEN RECEPTOR GENE", JOURNAL OF BONE AND MINERAL RESEARCH, NEW YORK, NY, US, vol. 11, no. 3, 1 March 1996 (1996-03-01), pages 306 - 311, XP000671392, ISSN: 0884-0431 *
SAMBROOK P N: "Corticosteroid osteoporosis.", ZEITSCHRIFT FUER RHEUMATOLOGIE, vol. 59, no. 1 Suppl. 1, 2000, pages 45 - 47, XP002216181, ISSN: 0340-1855 *
SANO M ET AL: "ASSOCIATION OF ESTROGEN RECEPTOR DINUCLEOTIDE REPEAT POLYMORPHISM WITH OSTEOPOROSIS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 217, no. 1, 5 December 1995 (1995-12-05), pages 378 - 383, XP002030082, ISSN: 0006-291X *
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, vol. 29, no. 3, 2000, pages 146 - 153, ISSN: 0300-9742 *
WILLING M ET AL: "BONE MINERAL DENSITY AND ITS CHANGE IN WHITE WOMEN: ESTROGEN AND VITAMIN D RECEPTOR GENOTYPES AND THEIR INTERACTION", JOURNAL OF BONE AND MINERAL RESEARCH, NEW YORK, NY, US, vol. 13, no. 4, 1998, pages 695 - 705, XP000915461, ISSN: 0884-0431 *
YAICH L ET AL: "ANALYSIS OF THE PVUII RESTRICTION FRAGMENT-LENGTH POLYMORPHISM AND EXON STRUCTURE OF THE ESTROGEN RECEPTOR GENE IN BREAST CANCER AND PERIPHERAL BLOOD", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 52, 1992, pages 77 - 83, XP002030083, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
WO2002006522A2 (en) 2002-01-24

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