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WO2002005616A8 - Novel 6-phenylphenanthridines - Google Patents

Novel 6-phenylphenanthridines

Info

Publication number
WO2002005616A8
WO2002005616A8 PCT/EP2001/007829 EP0107829W WO0205616A8 WO 2002005616 A8 WO2002005616 A8 WO 2002005616A8 EP 0107829 W EP0107829 W EP 0107829W WO 0205616 A8 WO0205616 A8 WO 0205616A8
Authority
WO
WIPO (PCT)
Prior art keywords
phenylphenanthridines
novel
salts
oxide
coor9
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/007829
Other languages
French (fr)
Other versions
WO2002005616A1 (en
Inventor
Daniela Bundschuh
Dieter Flockerzi
Gerhard Grundler
Armin Hatzelmann
Hans-Peter Kley
Beate Gutterer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Priority to AU2001281965A priority Critical patent/AU2001281965A1/en
Publication of WO2002005616A1 publication Critical patent/WO2002005616A1/en
Publication of WO2002005616A8 publication Critical patent/WO2002005616A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the formula I, in which R6 is SO2N(R7)R8, COOR9, CON(R10)R11 or a R15-substituted tetrazol-5-yl radical, R18 is hydroxyl, halogen, nitro, amino, 1-4C-alkyl or 1-4C-alkoxy, or the salts, the N-oxide and the salts of the N-oxide of this compound, are active PDE4 inhibitors.
PCT/EP2001/007829 2000-07-14 2001-07-07 Novel 6-phenylphenanthridines Ceased WO2002005616A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281965A AU2001281965A1 (en) 2000-07-14 2001-07-07 Novel 6-phenylphenanthridines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00115278 2000-07-14
EP00115278.4 2000-07-14

Publications (2)

Publication Number Publication Date
WO2002005616A1 WO2002005616A1 (en) 2002-01-24
WO2002005616A8 true WO2002005616A8 (en) 2002-02-14

Family

ID=8169260

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007829 Ceased WO2002005616A1 (en) 2000-07-14 2001-07-07 Novel 6-phenylphenanthridines

Country Status (2)

Country Link
AU (1) AU2001281965A1 (en)
WO (1) WO2002005616A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4587294B2 (en) * 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 2-hydroxy-6-phenylphenanthridine as PDE4 inhibitor
WO2004019945A1 (en) * 2002-08-29 2004-03-11 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
US6894061B2 (en) 2002-12-04 2005-05-17 Wyeth Substituted dihydrophenanthridinesulfonamides
WO2004072046A2 (en) * 2003-02-12 2004-08-26 Carex S.A. Quinoline derivatives and their use for modulation of lxr activity
EP1658270A1 (en) * 2003-07-31 2006-05-24 ALTANA Pharma AG Novel 6-phenylphenantridines
WO2005012253A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenanthridines
AU2005212857B2 (en) 2004-02-18 2011-04-28 Takeda Gmbh Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors
JP4801039B2 (en) 2004-03-03 2011-10-26 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors
CA2578933A1 (en) 2004-09-02 2006-03-16 Wyeth Phenanthridine carbonyl phenols as cytokine modulators
DE602005027866D1 (en) 2004-09-08 2011-06-16 Nycomed Gmbh 3-OXA-10-AZA-PHENANTHRENE AS PDE4 OR PDE3 / 4 INHIBITORS
WO2006027345A2 (en) * 2004-09-08 2006-03-16 Altana Pharma Ag Novel 3-thia-10-aza-phenanthrene derivatives
MX2007010400A (en) * 2005-03-02 2008-01-11 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives.
JP2008532980A (en) * 2005-03-09 2008-08-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Amide-substituted 6-phenylphenanthridine
CN101815512B (en) 2007-10-04 2013-04-24 弗·哈夫曼-拉罗切有限公司 Cyclopropyl aryl amide derivatives and uses thereof
AR079451A1 (en) 2009-12-18 2012-01-25 Nycomed Gmbh COMPOUNDS 3,4,4A, 10B-TETRAHIDRO-1H-TIOPIRANO [4,3-C] ISOQUINOLINA
NO340563B1 (en) * 2016-09-05 2017-05-15 Takeda Gmbh New salts of 6-heterocyclyl-substituted hexahydrophenanthridine derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191138B1 (en) * 1996-01-31 2001-02-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines
AU718752B2 (en) * 1996-03-26 2000-04-20 Altana Pharma Ag Novel phenanthridines substituted in the 6 position
SI1000034T1 (en) * 1997-07-25 2003-04-30 Altana Pharma Ag Substituted 6-alkylphenanthridines
US6410551B1 (en) * 1997-07-25 2002-06-25 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrazole derivatives
AU756349B2 (en) * 1997-07-25 2003-01-09 Altana Pharma Ag Substituted 6-phenylphenanthridines

Also Published As

Publication number Publication date
WO2002005616A1 (en) 2002-01-24
AU2001281965A1 (en) 2002-01-30

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