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WO2002002146A3 - Dextrin-amphotericin conjugates and their methods of preparation - Google Patents

Dextrin-amphotericin conjugates and their methods of preparation Download PDF

Info

Publication number
WO2002002146A3
WO2002002146A3 PCT/GB2001/002886 GB0102886W WO0202146A3 WO 2002002146 A3 WO2002002146 A3 WO 2002002146A3 GB 0102886 W GB0102886 W GB 0102886W WO 0202146 A3 WO0202146 A3 WO 0202146A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
amphotericin
dextrin
conjugates
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/002886
Other languages
French (fr)
Other versions
WO2002002146A2 (en
Inventor
Sunil Shaunak
Ruth Duncan
Lisa German
Dale Hreczuk-Hirst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovata Ltd
Original Assignee
ML Laboratories PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0016134A external-priority patent/GB0016134D0/en
Priority claimed from GB0022156A external-priority patent/GB0022156D0/en
Application filed by ML Laboratories PLC filed Critical ML Laboratories PLC
Priority to AU2001266201A priority Critical patent/AU2001266201A1/en
Priority to EP01943663A priority patent/EP1296719A2/en
Publication of WO2002002146A2 publication Critical patent/WO2002002146A2/en
Publication of WO2002002146A3 publication Critical patent/WO2002002146A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

There is described a compound of the general formula (I): wherein GP is a glucose polymer, or a mixture of glucose polymers, and optionally salts thereof; AF is an antifungal agent; and n is an integer from 1 to 12. There is also described compositions containing this compound and methods of treatment relating thereto.
PCT/GB2001/002886 2000-07-01 2001-07-02 Dextrin-amphotericin conjugates and their methods of preparation Ceased WO2002002146A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001266201A AU2001266201A1 (en) 2000-07-01 2001-07-02 Medicaments
EP01943663A EP1296719A2 (en) 2000-07-01 2001-07-02 Dextrin - amphotericin conjugates and their methods of preparation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0016134A GB0016134D0 (en) 2000-07-01 2000-07-01 Medicaments
GB0016134.9 2000-07-01
GB0022156.4 2000-09-09
GB0022156A GB0022156D0 (en) 2000-09-09 2000-09-09 Medicaments

Publications (2)

Publication Number Publication Date
WO2002002146A2 WO2002002146A2 (en) 2002-01-10
WO2002002146A3 true WO2002002146A3 (en) 2002-06-13

Family

ID=26244576

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/002886 Ceased WO2002002146A2 (en) 2000-07-01 2001-07-02 Dextrin-amphotericin conjugates and their methods of preparation

Country Status (3)

Country Link
EP (1) EP1296719A2 (en)
AU (1) AU2001266201A1 (en)
WO (1) WO2002002146A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220414B2 (en) 2000-09-06 2007-05-22 A.P. Pharma, Inc. Degradable polyacetal polymers

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10129369C1 (en) * 2001-06-21 2003-03-06 Fresenius Kabi De Gmbh Water soluble antibiotic in the form of a polysaccharide conjugate containing an aminosugar
DE10324710A1 (en) * 2003-05-30 2004-12-16 Supramol Parenteral Colloids Gmbh Starch derivative Complex

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015628A1 (en) * 1989-06-14 1990-12-27 Cetus Corporation Polymer/antibiotic conjugate
EP0466038A1 (en) * 1990-07-12 1992-01-15 E.R. SQUIBB & SONS, INC. Water-dispersible polyene antifungal complexes
WO1998056424A1 (en) * 1997-06-12 1998-12-17 Ml Laboratories Plc Biologically active materials

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015628A1 (en) * 1989-06-14 1990-12-27 Cetus Corporation Polymer/antibiotic conjugate
EP0466038A1 (en) * 1990-07-12 1992-01-15 E.R. SQUIBB & SONS, INC. Water-dispersible polyene antifungal complexes
WO1998056424A1 (en) * 1997-06-12 1998-12-17 Ml Laboratories Plc Biologically active materials

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DUNCAN R ET AL: "Dextrins as Carriers of Anticancer Agents", PROCEEDINGS OF THE 24TH. INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS. STOCKHOLM, JUNE 15 - 19, 1997, PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, DEERFIELD, IL., CONTROLLED RELEASE, vol. SYMP. 24, 15 June 1997 (1997-06-15), pages 771 - 772, XP002078115, ISSN: 1022-0178 *
FALK RAMA ET AL: "A novel injectable water-soluble amphotericin B-arabinogalactan conjugate.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 43, no. 8, August 1999 (1999-08-01), pages 1975 - 1981, XP002182534, ISSN: 0066-4804 *
GERMAN L A ET AL: "Dextrin-amphotericin B: A potential polymeric anti-infective or antiparasitic agent.", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 52, no. Supplement, September 2000 (2000-09-01), 137th British Pharmaceutical Conference;Birmingham, England, UK; September 10-13, 2000, pages 37, XP001022489, ISSN: 0022-3573 *
YOUNG D H ET AL: "ANTIFUNGAL PROPERTIES OF TAXOL AND VARIOUS ANALOGUES", EXPERIENTIA, BIRKHAUSER VERLAG. BASEL, CH, vol. 48, no. 9, 1992, pages 882 - 885, XP000929422, ISSN: 0014-4754 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220414B2 (en) 2000-09-06 2007-05-22 A.P. Pharma, Inc. Degradable polyacetal polymers

Also Published As

Publication number Publication date
AU2001266201A1 (en) 2002-01-14
WO2002002146A2 (en) 2002-01-10
EP1296719A2 (en) 2003-04-02

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