WO2002098505A1 - Digestive organ stimulator - Google Patents
Digestive organ stimulator Download PDFInfo
- Publication number
- WO2002098505A1 WO2002098505A1 PCT/KR2001/000968 KR0100968W WO02098505A1 WO 2002098505 A1 WO2002098505 A1 WO 2002098505A1 KR 0100968 W KR0100968 W KR 0100968W WO 02098505 A1 WO02098505 A1 WO 02098505A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stimulator
- porous material
- digestive organ
- insulator
- bodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37205—Microstimulators, e.g. implantable through a cannula
Definitions
- the invention relates to a digestive organ stimulator in capsule type for oral administration, more specifically, to digestive organ stimulators for enabling activation of digestive function of the digestive organ or curing the digestive organ by administrating the curing agent into the affected part.
- a medical agent is prescribed into the digestive organ for helping digestion of the food in each digestive organ, to cure digestive disorders.
- the medicine may bring about serious side effects, tolerance to radioactivity, resistant bacteria or anergy if taken for a long period.
- the digestive organ stimulator in a capsule-shape has been suggested to solve these problems and administered to patients which is made to generate the low frequency in the process of passing through the digestive organ.
- Fig. 1 shows a conventional digestive organ stimulator and
- Fig. 2 shows a sectional view of Fig. 1.
- the digestive organ stimulator comprises a couple of hollow bodies 110' in a semi-sphere, insulator 120' disposed between the 5 bodies for insulation, and a low frequency generator 130' disposed within the insulator 120' for generating impulse of a predetermined frequency as two poles connected to the bodies in opposite contact with the humors.
- the low frequency generator 130' in the bodies 110' is insulated by the insulator 120' and do not operate out of contact with the humors .
- the stimulator 100' moves in the digestive organ 15 to cure the affected part and is discharged from the patient body approximately after 48 hours.
- the low frequency generator 130' disposed within the insulator 120' begins to 20 actuate and stimulate the affected part such as stomach, duodenum, liver, pancreas, colon, rectum or other blood vessel, so that the organ cells are activated to cure the disease .
- the conventional digestive organ stimulator 25100' merely depends on activation of the organ cell by vibrations from the low frequency generator 130' in passing through in the stomach. In a case that the inflammation exists in the organ, it becomes difficult to expect the sufficient curing effect by one stimulator and more stimulators need to be administered.
- the present invention is derived to solve the above disadvantage and has an object to provide an improved digestive organ stimulator to activate the organ cells by stimulation from the low frequency generator and to dissolve the curing agent from the stimulator, so as to increase curing effect .
- a digestive organ stimulator comprising a couple of hollow bodies in a semi-sphere, insulator disposed between the bodies for insulation, and a low frequency generator disposed within the insulator for generating impulse of a predetermined frequency as two poles connected to the bodies in opposite contact with the humors, wherein permeable porous material on the outer surface of the stimulator and the curing agent is impregnated into the porous material .
- Fig. 1 shows a conventional digestive organ stimulator
- Fig. 2 is a longitudinal sectional view of Fig. 1;
- Fig. 3 is a perspective view of a preferred embodiment of the present invention.
- Fig. 4 is a longitudinal sectional view of Fig. 3 ;
- Fig. 5 is a sectional view of the second embodiment of the present invention.
- Fig. 6 is a longitudinal sectional view of the third embodiment of the present invention.
- the present invention is in detail described with reference to Figs. 3 to 6.
- the invention shows the configuration that the permeable porous material 140 having curing agent 150 therein is disposed on the outer surface of the stimulator 100 and the curing agent 150 in the porous material 140 become dissolved in the process of passing through in the organ of affected part.
- Fig. 3 is a perspective view of the first embodiment of the invention
- Fig. 4 is a sectional view of Fig. 3.
- An insulator 120 for insulating the body no combines the body 110 in a hollow semi-sphere shape in opposite.
- the low frequency generator 130 for generating impulse of a predetermined frequency is fixed as two poles are in contact with the humors .
- An insert groove 160 is formed on the insulator of the stimulator, so as to fix the porous material 140 in the insulator.
- the curing agent 150 ⁇ is impregnated.
- An insert groove 160 may be formed in a specific shape in the insulator 120 to fix the porous material 140 in the insert groove.
- a plurality of insert grooves 160 in a cylindrical shape are formed with a predetermined interval to have the porous material 140 inserted in the insulator 120.
- Fig. 5 is a sectional view of the second embodiment of the invention in which the porous material 140 is inserted into the outer surface of the bodies 110.
- the insert groove 170 is formed on the bodies 110 in a ring shape along the outer surface to insert the porous material 140 in the insert groove 170.
- the porous material 140 having curing agent 150 may be formed on either body 110.
- the invention shows the porous material 140 formed on each bodies 110, for better curing effect .
- the other embodiment of the invention enables the insert grooves in a cylindrical shape to be formed on the bodies 110 to fix the porous material in the insert grooves as well as in the preferred embodiment.
- the porous materials 140 are formed either on the insulator 120 or on the bodies 110 as in the first embodiment or in the second embodiment, it is important for form the height corresponding to the porous materials on the stimulator 100, so as to prevent cut of the organ by the stimulator 100 in the process of passing through in the digestive organ.
- Fig. 6 shows the third embodiment of the invention.
- the porous material 140 are fixed throughout the surface of the bodies 110. This is especially designed for the patient who needs concentrated cares.
- the porous material 140 of the invention include a plurality of pores to impregnate the curing agent 150 and any harmless type material to men may be used for the porous material.
- TiNi alloy is used for the embodiments.
- TiNi alloy serves to keep the curing agent 150 to be dissoluble in a very slow speed in the organ although contact of the stimulator 100 and the digestive organ is made.
- the present invention is in detail explained hereinbelow.
- the stimulator 100 having curing agent 150 in the porous material 140 is administered to the person who is experiencing disorder of the digestive organ or some digestion disease, the stimulator 100 is moved along the water into the organ. As the stimulator 100 contacts with the humors, acid and alkali, the low frequency generator 130 begins to operate.
- the interval between the poles of the low frequency generator 130 keeps insulated by insulator 120 between the bodies 110 and contents in the intestines.
- the low frequency generator 130 generates and converts impulse, so that the electric impulse field effects on the walls and reacts the peristaltic wave.
- the stimulator 100 moves in a normal speed in the intestines by peristaltic wave of the low frequency generator 130.
- the stimulator 100 when the stimulator 100 reaches the low pathological diminution part, e.g. imperfect paralysis, movement of the stimulator 100 becomes slow, as motion of the intestines is slow. While the stimulator 100 stays at the part, the curing agent 150 in the porous material 140 becomes dissoluble with a low speed, to promote recovery of the intestines.
- the low pathological diminution part e.g. imperfect paralysis
- a 47-year-old man being in confirmed pancreatitis and gradual weak gastroptosis with inveterate stomachache and swollen intestines has taken a stimulator 100 of the preferred embodiment .
- Disinfected and dried stimulator 100 is sunk in 2% Novocaine solution to absorb in the porous material 140. This clinical test is not advised of the client and the stimulator 100 is administered with a lot of waters.
- the stimulator 100 reaches the stomach to react with the humors.
- the electric stimulation from the low frequency generator activates the organ cells, and as a result, ache of intestines begins to deterge .
- low frequency generator 130 treats the ache
- curing solution from the porous material 140 acts to promote curing of the inflammation. Swelling of the intestines subsides in about two or three hours. After 24 hours, confirmed pancreatitis is clinically improved.
- the stimulator 100 is discharged out of the patient's body.
- a 50-year-old man being in pains due to intestine inflammation has taken a stimulator 100 of the preferred embodiment.
- the curing solution is absorbed by porous material 140 of the stimulator 100.
- Example 2 shows similar to that of the Example 1.
- the digestive organ stimulator of the invention serves to cure the affected part by making activation of the organ cell by electric stimulation from the low frequency generator in contact with the humors in stomach and dissoluble in the porous material in the process of passing through the affected part in case that the normal digestive function does not work or digestive disease occurs .
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Digestive organ stimulator of the invention accomplishes activation of the organ cells by electric stimulus from the low frequency generator during passing through the stomach and maximizes curing effect by curing agent wherein the porous material (140) of permeable type is disposed on the outer surface of the stimulator (100) with curing agent (150) impregnating in the porous material (140), to allow the curing agent in the porous material (140) to be dissolved in passing through the organ, thereby promoting curing effect on the affected part.
Description
DIGESTIVE ORGAN STIMULATOR
TECHNICAL FIELD
The invention relates to a digestive organ stimulator in capsule type for oral administration, more specifically, to digestive organ stimulators for enabling activation of digestive function of the digestive organ or curing the digestive organ by administrating the curing agent into the affected part.
BACKGROUND ART
In general, in a case that low digestive function or abnormal digestion in the digestive organ occurs with symptoms such as stomachache, heartburn, inappetence or abdominal inflation, digestion of the food is not sufficiently accomplished.
In this case, a medical agent is prescribed into the digestive organ for helping digestion of the food in each digestive organ, to cure digestive disorders. However, the medicine may bring about serious side effects, tolerance to radioactivity, resistant bacteria or anergy if taken for a long period.
The digestive organ stimulator in a capsule-shape has been suggested to solve these problems and administered to patients which is made to generate the low frequency in the process of passing through the digestive organ.
Fig. 1 shows a conventional digestive organ stimulator and Fig. 2 shows a sectional view of Fig. 1. The digestive organ stimulator comprises a couple of hollow bodies 110' in a semi-sphere, insulator 120' disposed between the 5 bodies for insulation, and a low frequency generator 130' disposed within the insulator 120' for generating impulse of a predetermined frequency as two poles connected to the bodies in opposite contact with the humors.
Referring to the conventional stimulator 100' of Fig. 102, the low frequency generator 130' in the bodies 110' is insulated by the insulator 120' and do not operate out of contact with the humors .
When the patient takes a stimulator 100' along with the water, the stimulator 100' moves in the digestive organ 15 to cure the affected part and is discharged from the patient body approximately after 48 hours.
When the stimulator 100' taken with the water reaches the stomach and contact with the humors, the low frequency generator 130' disposed within the insulator 120' begins to 20 actuate and stimulate the affected part such as stomach, duodenum, liver, pancreas, colon, rectum or other blood vessel, so that the organ cells are activated to cure the disease .
However, the conventional digestive organ stimulator 25100' merely depends on activation of the organ cell by vibrations from the low frequency generator 130' in passing
through in the stomach. In a case that the inflammation exists in the organ, it becomes difficult to expect the sufficient curing effect by one stimulator and more stimulators need to be administered.
DISCLOSURE OF THE INVENTION
The present invention is derived to solve the above disadvantage and has an object to provide an improved digestive organ stimulator to activate the organ cells by stimulation from the low frequency generator and to dissolve the curing agent from the stimulator, so as to increase curing effect .
To achieve the object and in accordance with the purpose of the invention, there is provided a digestive organ stimulator comprising a couple of hollow bodies in a semi-sphere, insulator disposed between the bodies for insulation, and a low frequency generator disposed within the insulator for generating impulse of a predetermined frequency as two poles connected to the bodies in opposite contact with the humors, wherein permeable porous material on the outer surface of the stimulator and the curing agent is impregnated into the porous material .
BRIEF DESCRIPTION OF THE DRAWINGS The present invention will be described in detail through use of the accompanying drawings in which:
Fig. 1 shows a conventional digestive organ stimulator;
Fig. 2 is a longitudinal sectional view of Fig. 1;
Fig. 3 is a perspective view of a preferred embodiment of the present invention;
Fig. 4 is a longitudinal sectional view of Fig. 3 ;
Fig. 5 is a sectional view of the second embodiment of the present invention; and
Fig. 6 is a longitudinal sectional view of the third embodiment of the present invention.
BEST MODE FOR CARRYING OUT THE INVENTION The present invention is in detail described with reference to Figs. 3 to 6. The invention shows the configuration that the permeable porous material 140 having curing agent 150 therein is disposed on the outer surface of the stimulator 100 and the curing agent 150 in the porous material 140 become dissolved in the process of passing through in the organ of affected part.
Fig. 3 is a perspective view of the first embodiment of the invention, and Fig. 4 is a sectional view of Fig. 3.
An insulator 120 for insulating the body no combines the body 110 in a hollow semi-sphere shape in opposite. At the insulator the low frequency generator 130 for generating impulse of a predetermined frequency is fixed as
two poles are in contact with the humors .
An insert groove 160 is formed on the insulator of the stimulator, so as to fix the porous material 140 in the insulator. In the porous material 140 the curing agent 150~ is impregnated.
An insert groove 160 may be formed in a specific shape in the insulator 120 to fix the porous material 140 in the insert groove. In an embodiment of the invention, a plurality of insert grooves 160 in a cylindrical shape are formed with a predetermined interval to have the porous material 140 inserted in the insulator 120.
Fig. 5 is a sectional view of the second embodiment of the invention in which the porous material 140 is inserted into the outer surface of the bodies 110. The insert groove 170 is formed on the bodies 110 in a ring shape along the outer surface to insert the porous material 140 in the insert groove 170.
The porous material 140 having curing agent 150 may be formed on either body 110. However, the invention shows the porous material 140 formed on each bodies 110, for better curing effect .
The other embodiment of the invention enables the insert grooves in a cylindrical shape to be formed on the bodies 110 to fix the porous material in the insert grooves as well as in the preferred embodiment.
In case that the porous materials 140 are formed
either on the insulator 120 or on the bodies 110 as in the first embodiment or in the second embodiment, it is important for form the height corresponding to the porous materials on the stimulator 100, so as to prevent cut of the organ by the stimulator 100 in the process of passing through in the digestive organ.
Fig. 6 shows the third embodiment of the invention. The porous material 140 are fixed throughout the surface of the bodies 110. This is especially designed for the patient who needs concentrated cares.
The porous material 140 of the invention include a plurality of pores to impregnate the curing agent 150 and any harmless type material to men may be used for the porous material. In the invention, TiNi alloy is used for the embodiments.
TiNi alloy serves to keep the curing agent 150 to be dissoluble in a very slow speed in the organ although contact of the stimulator 100 and the digestive organ is made. The present invention is in detail explained hereinbelow.
Once the stimulator 100 having curing agent 150 in the porous material 140 is administered to the person who is experiencing disorder of the digestive organ or some digestion disease, the stimulator 100 is moved along the water into the organ. As the stimulator 100 contacts with
the humors, acid and alkali, the low frequency generator 130 begins to operate.
The interval between the poles of the low frequency generator 130 keeps insulated by insulator 120 between the bodies 110 and contents in the intestines.
The low frequency generator 130 generates and converts impulse, so that the electric impulse field effects on the walls and reacts the peristaltic wave.
The stimulator 100 moves in a normal speed in the intestines by peristaltic wave of the low frequency generator 130.
On the contrary, when the stimulator 100 reaches the low pathological diminution part, e.g. imperfect paralysis, movement of the stimulator 100 becomes slow, as motion of the intestines is slow. While the stimulator 100 stays at the part, the curing agent 150 in the porous material 140 becomes dissoluble with a low speed, to promote recovery of the intestines.
Curing results are shown in the Examples hereinbelow. <Example 1>
A 47-year-old man being in confirmed pancreatitis and gradual weak gastroptosis with inveterate stomachache and swollen intestines has taken a stimulator 100 of the preferred embodiment . Disinfected and dried stimulator 100 is sunk in 2% Novocaine solution to absorb in the porous material 140.
This clinical test is not advised of the client and the stimulator 100 is administered with a lot of waters.
15-30 minutes have elapsed. The stimulator 100 reaches the stomach to react with the humors. The electric stimulation from the low frequency generator activates the organ cells, and as a result, ache of intestines begins to deterge .
While low frequency generator 130 treats the ache, curing solution from the porous material 140 acts to promote curing of the inflammation. Swelling of the intestines subsides in about two or three hours. After 24 hours, confirmed pancreatitis is clinically improved.
After completing the treatment, the stimulator 100 is discharged out of the patient's body.
<Example 2>
A 50-year-old man being in pains due to intestine inflammation has taken a stimulator 100 of the preferred embodiment. The curing solution is absorbed by porous material 140 of the stimulator 100.
Result of the Example 2 shows similar to that of the Example 1.
INDUSTRIAL APPLICABILITY The digestive organ stimulator of the invention serves to cure the affected part by making activation of
the organ cell by electric stimulation from the low frequency generator in contact with the humors in stomach and dissoluble in the porous material in the process of passing through the affected part in case that the normal digestive function does not work or digestive disease occurs .
Claims
1. A digestive organ stimulator including a couple of hollow bodies in a semi-sphere, insulator disposed between the bodies for insulation, and a low frequency generator disposed within the insulator for generating impulse of a predetermined frequency as two poles connected to the bodies in opposite contact with the humors, characterized in that permeable porous material on the outer surface of the stimulator and the curing agent is impregnated into the porous material .
2. The digestive organ stimulator as claimed in Claim 1, wherein an insert groove is formed on the insulator of the stimulator, so as to fix the porous material in the insulator.
3. The digestive organ stimulator as claimed in Claim 2, wherein a plurality of insert grooves is formed on the insulator with a predetermined interval.
4. The digestive organ stimulator as claimed in Claim 1, wherein the porous material is inserted into the outer surface of the bodies .
5. The digestive organ stimulator as claimed in Claim 4, wherein the porous materials are disposed on the outer surface of the separated bodies .
6. The digestive organ stimulator as claimed in Claim 1, wherein the porous material is inserted into the outer surface of the bodies.
7. The digestive organ stimulator as one of Claims 1 to 6, wherein the porous material is formed to correspond to the outer surface of the insulator.
8. The digestive organ stimulator as one of Claims 1 to 6, wherein the porous material is TiNi alloy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2001/000968 WO2002098505A1 (en) | 2001-06-07 | 2001-06-07 | Digestive organ stimulator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2001/000968 WO2002098505A1 (en) | 2001-06-07 | 2001-06-07 | Digestive organ stimulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2002098505A1 true WO2002098505A1 (en) | 2002-12-12 |
Family
ID=19198403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2001/000968 Ceased WO2002098505A1 (en) | 2001-06-07 | 2001-06-07 | Digestive organ stimulator |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2002098505A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014528757A (en) * | 2011-08-09 | 2014-10-30 | フランクリン・アール・レイシー | System for gastrointestinal and vascular degeneration engineering to restore normal youthful human function |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58135808A (en) * | 1982-02-08 | 1983-08-12 | Funakubo Hiroyasu | Capsule |
| RU2097073C1 (en) * | 1995-02-14 | 1997-11-27 | Сергей Федорович Глущук | Electrostimulation device for treating gastrointestinal tract |
| RU2121381C1 (en) * | 1996-05-05 | 1998-11-10 | Виктор Филиппович Агафонников | Electrostimulator of gastroenteric tract |
| RU2128059C1 (en) * | 1996-09-27 | 1999-03-27 | Глущук Сергей Федорович | Electric stimulator of gastrointestinal tract |
-
2001
- 2001-06-07 WO PCT/KR2001/000968 patent/WO2002098505A1/en not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58135808A (en) * | 1982-02-08 | 1983-08-12 | Funakubo Hiroyasu | Capsule |
| RU2097073C1 (en) * | 1995-02-14 | 1997-11-27 | Сергей Федорович Глущук | Electrostimulation device for treating gastrointestinal tract |
| RU2121381C1 (en) * | 1996-05-05 | 1998-11-10 | Виктор Филиппович Агафонников | Electrostimulator of gastroenteric tract |
| RU2128059C1 (en) * | 1996-09-27 | 1999-03-27 | Глущук Сергей Федорович | Electric stimulator of gastrointestinal tract |
Non-Patent Citations (4)
| Title |
|---|
| DATABASE WPI Week 198338, Derwent World Patents Index; AN 1983-767939 * |
| DATABASE WPI Week 199831, Derwent World Patents Index; AN 1998-360624 * |
| DATABASE WPI Week 200013, Derwent World Patents Index; AN 2000-146099 * |
| DATABASE WPI Week 200026, Derwent World Patents Index; AN 2000-301375 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014528757A (en) * | 2011-08-09 | 2014-10-30 | フランクリン・アール・レイシー | System for gastrointestinal and vascular degeneration engineering to restore normal youthful human function |
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