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WO2002097440A3 - Method for determining peptides or proteins, mass spectrometry for metals and determination of conductivity capacity - Google Patents

Method for determining peptides or proteins, mass spectrometry for metals and determination of conductivity capacity Download PDF

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Publication number
WO2002097440A3
WO2002097440A3 PCT/DE2002/001966 DE0201966W WO02097440A3 WO 2002097440 A3 WO2002097440 A3 WO 2002097440A3 DE 0201966 W DE0201966 W DE 0201966W WO 02097440 A3 WO02097440 A3 WO 02097440A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
mass spectrometry
peptides
metals
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2002/001966
Other languages
German (de)
French (fr)
Other versions
WO2002097440A2 (en
Inventor
Reinhold Kiehl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2001126697 external-priority patent/DE10126697A1/en
Application filed by Individual filed Critical Individual
Priority to EP02750770A priority Critical patent/EP1397687A2/en
Priority to AU2002344245A priority patent/AU2002344245A1/en
Publication of WO2002097440A2 publication Critical patent/WO2002097440A2/en
Publication of WO2002097440A3 publication Critical patent/WO2002097440A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6866—Interferon

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a method for determining peptides or proteins. Said method is characterised in that peptides or proteins are measured at their C-end, N-end and/or their modified parts, in addition to in their entirety using specific antibodies, which are labelled in such a way that subsequent measurement is possible. The invention also relates to a mass spectrometry method and device, in which a carrier gas source, in particular a CO source is provided, in order to bombard a sample with a carrier gas, in particular CO, or in which an enzyme-solution container is provided with/for an enzyme solution for reaction with at least one metal. The invention also relates to a method and device for the measurement of conductivity capacity, in which a blood sample is introduced into a measuring tube, which is surrounded by a number of electrodes, said electrodes being controlled crosswise according to a predetermined pattern by means of a frequency generator.
PCT/DE2002/001966 2001-05-29 2002-05-28 Method for determining peptides or proteins, mass spectrometry for metals and determination of conductivity capacity Ceased WO2002097440A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02750770A EP1397687A2 (en) 2001-05-29 2002-05-28 Method for determining peptides or proteins, mass spectrometry for metals and determination of conductivity capacity
AU2002344245A AU2002344245A1 (en) 2001-05-29 2002-05-28 Method for determining peptides or proteins, mass spectrometry for metals and determination of conductivity capacity

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE10126697.9 2001-05-29
DE2001126697 DE10126697A1 (en) 2001-05-29 2001-05-29 Detecting peptides and proteins by reaction with labeled antibodies, useful e.g. for diagnosing allergies, and a mass spectrometer and conductivity meter for carrying out the test
DE10126696.0 2001-05-29
DE10126695.2 2001-05-29
DE10126696 2001-05-29
DE10126695 2001-05-29

Publications (2)

Publication Number Publication Date
WO2002097440A2 WO2002097440A2 (en) 2002-12-05
WO2002097440A3 true WO2002097440A3 (en) 2003-11-06

Family

ID=27214451

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/001966 Ceased WO2002097440A2 (en) 2001-05-29 2002-05-28 Method for determining peptides or proteins, mass spectrometry for metals and determination of conductivity capacity

Country Status (3)

Country Link
EP (1) EP1397687A2 (en)
AU (1) AU2002344245A1 (en)
WO (1) WO2002097440A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666865A (en) * 1984-01-13 1987-05-19 Centocor, Inc. Immunoassay for biologically active human interferon-gamma employing unique monoclonal antibodies
US4792521A (en) * 1985-08-15 1988-12-20 Immunomedics, Inc. Non-enzymatic immunohistochemical staining system and reagents
US5910418A (en) * 1993-03-19 1999-06-08 The Johns Hopkins University Antibodies and assay for detecting mutant APC proteins
DE19918141A1 (en) * 1999-04-21 2000-10-26 Boehringer Ingelheim Vetmed Diagnosing transmissible spongiform encephalopathy, particularly before appearance of clinical symptoms, by detecting specific markers in blood cells
WO2001004158A1 (en) * 1999-07-12 2001-01-18 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method for determining dna double-stranded breaks

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666865A (en) * 1984-01-13 1987-05-19 Centocor, Inc. Immunoassay for biologically active human interferon-gamma employing unique monoclonal antibodies
US4792521A (en) * 1985-08-15 1988-12-20 Immunomedics, Inc. Non-enzymatic immunohistochemical staining system and reagents
US5910418A (en) * 1993-03-19 1999-06-08 The Johns Hopkins University Antibodies and assay for detecting mutant APC proteins
DE19918141A1 (en) * 1999-04-21 2000-10-26 Boehringer Ingelheim Vetmed Diagnosing transmissible spongiform encephalopathy, particularly before appearance of clinical symptoms, by detecting specific markers in blood cells
WO2001004158A1 (en) * 1999-07-12 2001-01-18 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method for determining dna double-stranded breaks

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Bioanalytik", 1998, LOTTSPEICH / SORBAS, SPEKTRUM LEHRBUCH, HEIDELBERG, BERLIN, XP002229189 *
AKDIS A C ET AL: "Cytokine immunotrapping: an assay to study the kinetics of production and consumption or degradation of human interferon-gamma", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 182, no. 2, 9 June 1995 (1995-06-09), pages 251 - 261, XP004021173, ISSN: 0022-1759 *

Also Published As

Publication number Publication date
WO2002097440A2 (en) 2002-12-05
EP1397687A2 (en) 2004-03-17
AU2002344245A1 (en) 2002-12-09

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