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WO2002093143A3 - Procede et appareil pour determiner la profondeur, la brillance et la dimension d'une cible dans une zone du corps humain - Google Patents

Procede et appareil pour determiner la profondeur, la brillance et la dimension d'une cible dans une zone du corps humain Download PDF

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Publication number
WO2002093143A3
WO2002093143A3 PCT/US2002/016006 US0216006W WO02093143A3 WO 2002093143 A3 WO2002093143 A3 WO 2002093143A3 US 0216006 W US0216006 W US 0216006W WO 02093143 A3 WO02093143 A3 WO 02093143A3
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WO
WIPO (PCT)
Prior art keywords
size
subject
light
intensity profile
brightness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/016006
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English (en)
Other versions
WO2002093143A2 (fr
Inventor
Bradley W Rice
Daniel G Stearns
Tamara L Troy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenogen Corp
Original Assignee
Xenogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenogen Corp filed Critical Xenogen Corp
Priority to DE60213993T priority Critical patent/DE60213993T2/de
Priority to CA002447262A priority patent/CA2447262A1/fr
Priority to EP02731879A priority patent/EP1402243B1/fr
Priority to KR10-2003-7014990A priority patent/KR20040012844A/ko
Priority to JP2002589773A priority patent/JP4259879B2/ja
Priority to AU2002303819A priority patent/AU2002303819B2/en
Publication of WO2002093143A2 publication Critical patent/WO2002093143A2/fr
Anticipated expiration legal-status Critical
Publication of WO2002093143A3 publication Critical patent/WO2002093143A3/fr
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un procédé d'investigation pour déterminer la localisation et la dimension d'une source lumineuse chez un sujet. Selon ce procédé, on obtient d'abord un profil d'intensité lumineuse, à partir d'une première perspective au moyen d'un dispositif de photodétection, en mesurant des photons qui (i) proviennent de la source lumineuse, (ii) traversent le tissu biologique trouble du sujet, et (iii) sont émis par une première zone superficielle d'intérêt du sujet. Le profil d'intensité lumineuse est mis en regard d'une fonction biophotonique à base paramétrique pour estimer des paramètres de fonction tels que la profondeur et la dimension. Les paramètres ainsi déterminés sont affinés au moyen de données différentes du premier profil d'intensité lumineuse mesuré, pour obtenir une profondeur et une dimension approximatives de la source lumineuse chez le sujet. La présente invention porte également sur un appareil servant à réaliser ledit procédé.
PCT/US2002/016006 2001-05-17 2002-05-17 Procede et appareil pour determiner la profondeur, la brillance et la dimension d'une cible dans une zone du corps humain Ceased WO2002093143A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE60213993T DE60213993T2 (de) 2001-05-17 2002-05-17 Verfahren und vorrichtung zur feststellung von zieltiefe, helligkeit und grösse in einer körperregion
CA002447262A CA2447262A1 (fr) 2001-05-17 2002-05-17 Procede et appareil pour determiner la profondeur, la brillance et la dimension d'une cible dans une zone du corps humain
EP02731879A EP1402243B1 (fr) 2001-05-17 2002-05-17 Procede et appareil pour determiner la profondeur, la brillance et la dimension d'une cible dans une zone du corps humain
KR10-2003-7014990A KR20040012844A (ko) 2001-05-17 2002-05-17 신체영역내의 표적 깊이, 휘도 및 크기의 결정 방법 및 장치
JP2002589773A JP4259879B2 (ja) 2001-05-17 2002-05-17 身体領域内の標的の深さ、輝度およびサイズを決定するための方法および装置
AU2002303819A AU2002303819B2 (en) 2001-05-17 2002-05-17 Method and apparatus for determining target depth, brightness and size within a body region

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29179401P 2001-05-17 2001-05-17
US60/291,794 2001-05-17

Publications (2)

Publication Number Publication Date
WO2002093143A2 WO2002093143A2 (fr) 2002-11-21
WO2002093143A3 true WO2002093143A3 (fr) 2004-01-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/016006 Ceased WO2002093143A2 (fr) 2001-05-17 2002-05-17 Procede et appareil pour determiner la profondeur, la brillance et la dimension d'une cible dans une zone du corps humain

Country Status (9)

Country Link
US (4) US7403812B2 (fr)
EP (1) EP1402243B1 (fr)
JP (1) JP4259879B2 (fr)
KR (1) KR20040012844A (fr)
AT (1) ATE336717T1 (fr)
AU (1) AU2002303819B2 (fr)
CA (1) CA2447262A1 (fr)
DE (1) DE60213993T2 (fr)
WO (1) WO2002093143A2 (fr)

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US20030002028A1 (en) 2003-01-02
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