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WO2002092613A3 - Acide nucleique se liant a la gnrh - Google Patents

Acide nucleique se liant a la gnrh Download PDF

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Publication number
WO2002092613A3
WO2002092613A3 PCT/EP2002/005246 EP0205246W WO02092613A3 WO 2002092613 A3 WO2002092613 A3 WO 2002092613A3 EP 0205246 W EP0205246 W EP 0205246W WO 02092613 A3 WO02092613 A3 WO 02092613A3
Authority
WO
WIPO (PCT)
Prior art keywords
gnrh
nucleic acid
nucleic acids
binds
target molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/005246
Other languages
German (de)
English (en)
Other versions
WO2002092613A2 (fr
Inventor
Sven Klussmann
Susanne Leva
Andrea Lichte
Jens Burmeister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TME Pharma AG
Original Assignee
Noxxon Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noxxon Pharma AG filed Critical Noxxon Pharma AG
Priority to AU2002312906A priority Critical patent/AU2002312906A1/en
Publication of WO2002092613A2 publication Critical patent/WO2002092613A2/fr
Anticipated expiration legal-status Critical
Publication of WO2002092613A3 publication Critical patent/WO2002092613A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un acide nucléique se liant à la GnRH ainsi qu'un procédé de production et/ou d'identification d'acides nucléiques se liant à une molécule cible, en particulier d'un acide nucléique de la présente invention. Selon ledit procédé, a) une population hétérogène d'acides nucléiques est créée, b) la population obtenue à l'étape a) est mise en contact, c) les acides nucléiques n'entrant pas en interaction avec la molécule cible sont séparés, d) les acides nucléiques entrant en interaction avec cette molécule cible sont éventuellement séparés et e) les acides nucléiques qui sont entrés en interaction avec ladite molécule sont éventuellement séquencés. Ce procédé est caractérisé en ce que la molécule cible est la GnRH.
PCT/EP2002/005246 2001-05-11 2002-05-13 Acide nucleique se liant a la gnrh Ceased WO2002092613A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002312906A AU2002312906A1 (en) 2001-05-11 2002-05-13 Nucleic acid, which binds to gnrh

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10122862.7 2001-05-11
DE2001122862 DE10122862A1 (de) 2001-05-11 2001-05-11 GnRH bindende Nukleinsäure

Publications (2)

Publication Number Publication Date
WO2002092613A2 WO2002092613A2 (fr) 2002-11-21
WO2002092613A3 true WO2002092613A3 (fr) 2003-12-18

Family

ID=7684375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/005246 Ceased WO2002092613A2 (fr) 2001-05-11 2002-05-13 Acide nucleique se liant a la gnrh

Country Status (3)

Country Link
AU (1) AU2002312906A1 (fr)
DE (1) DE10122862A1 (fr)
WO (1) WO2002092613A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10233704A1 (de) * 2002-07-24 2004-02-12 Heraeus Noblelight Gmbh Entladungslampe mit einem rohrförmigen, transparenten Entladungsgefäß sowie deren Verwendung

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008856A2 (fr) * 1996-08-30 1998-03-05 Fuerste Jens Peter Selection et evolution speculaires d'acides nucleiques
WO1999044987A1 (fr) * 1998-03-05 1999-09-10 Agouron Pharmaceuticals, Inc. AGENTS NON-PEPTIDIQUES ANTI-GnRH
WO2001092566A2 (fr) * 2000-05-26 2001-12-06 Noxxon Pharma Ag Acides nucleiques immobilises et leur utilisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008856A2 (fr) * 1996-08-30 1998-03-05 Fuerste Jens Peter Selection et evolution speculaires d'acides nucleiques
WO1999044987A1 (fr) * 1998-03-05 1999-09-10 Agouron Pharmaceuticals, Inc. AGENTS NON-PEPTIDIQUES ANTI-GnRH
WO2001092566A2 (fr) * 2000-05-26 2001-12-06 Noxxon Pharma Ag Acides nucleiques immobilises et leur utilisation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FAMULOK M ET AL: "Nucleic acid aptamers-from selection in vitro to applications in vivo", ACCOUNTS OF CHEMICAL RESEARCH, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, no. 9, September 2000 (2000-09-01), pages 591 - 599, XP002221277, ISSN: 0001-4842 *
LEVA SUSANNE ET AL: "GnRH binding RNA and DNA Spiegelmers: A novel approach toward GnRH antagonism.", CHEMISTRY & BIOLOGY (LONDON), vol. 9, no. 3, March 2002 (2002-03-01), March, 2002, pages 351 - 359, XP002234826, ISSN: 1074-5521 *
NOLTE A ET AL: "MIRROR-DESIGN OF L-OLIGONUCLEOTIDE LIGANDS BINDING TO L-ARGININE", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 14, 1 September 1996 (1996-09-01), pages 1116 - 1119, XP002039162, ISSN: 1087-0156 *
PATEL D J ET AL: "STRUCTURE, RECOGNITION AND ADAPTIVE BINDING IN RNA APTAMER COMPLEXES", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 272, 1997, pages 645 - 664, XP002952170, ISSN: 0022-2836 *
WILLIAMS KELLY P ET AL: "Bioactive and nuclease-resistant L-DNA ligand of vasopressin", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 94, no. 21, 1997, pages 11285 - 11290, XP002185340, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU2002312906A1 (en) 2002-11-25
DE10122862A1 (de) 2002-11-21
WO2002092613A2 (fr) 2002-11-21

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