[go: up one dir, main page]

WO2002092466A1 - Distributeur - Google Patents

Distributeur Download PDF

Info

Publication number
WO2002092466A1
WO2002092466A1 PCT/EP2002/003327 EP0203327W WO02092466A1 WO 2002092466 A1 WO2002092466 A1 WO 2002092466A1 EP 0203327 W EP0203327 W EP 0203327W WO 02092466 A1 WO02092466 A1 WO 02092466A1
Authority
WO
WIPO (PCT)
Prior art keywords
ferrule
weld
closure
flange
laser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/003327
Other languages
English (en)
Inventor
Karl Edward Robinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of WO2002092466A1 publication Critical patent/WO2002092466A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/38—Details of the container body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/20—Bonding
    • B23K26/206—Laser sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/20—Bonding
    • B23K26/21—Bonding by welding
    • B23K26/24—Seam welding
    • B23K26/242—Fillet welding, i.e. involving a weld of substantially triangular cross section joining two parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/20—Bonding
    • B23K26/21—Bonding by welding
    • B23K26/24—Seam welding
    • B23K26/244—Overlap seam welding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/20—Bonding
    • B23K26/21—Bonding by welding
    • B23K26/24—Seam welding
    • B23K26/28—Seam welding of curved planar seams
    • B23K26/282—Seam welding of curved planar seams of tube sections
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K33/00—Specially-profiled edge portions of workpieces for making soldering or welding connections; Filling the seams formed thereby
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/141—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant specially adapted for specific contents or propellants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K2101/00—Articles made by soldering, welding or cutting
    • B23K2101/04—Tubular or hollow articles
    • B23K2101/12—Vessels
    • B23K2101/125—Cans

Definitions

  • This invention relates to an aerosol dispenser, in particular to a medicament dispenser for dispensing metered doses of medicament.
  • the invention also relates to a method for assembling aerosol dispensers using laser welding to hermetically seal the dispenser.
  • Medicinal aerosol dispensers typically comprise a metal container enclosing a pressurised medicament formulation and a valve arrangement for dispensing metered drug doses.
  • the valve arrangement is generally attached to the dispenser by crimping a ferrule against the body of the container.
  • An elastomeric gasket or O-ring, compressed between the body and the ferrule, is frequently used to seal the container.
  • the aerosol dispenser is as leak-proof as possible.
  • gaskets perform well in this respect, they do offer a potential leakage path extending circumferentially around the container. For that reason also, it would be desirable to eliminate the need for a gasket and provide a hermetic seal between the body and closure which offered no such potential leakage path.
  • French Patent Application No. 2543923 describes an aerosol dispenser comprising a dome shaped upper closure laser welded to a body portion.
  • this arrangement does not produce a hermetic seal and a gasket is required to improve the sealing properties of the dispenser.
  • an aerosol dispenser comprising a body and a closure sealed to the body; the closure comprises an annular metal ferrule extending circumferentially around the axis of the closure and provided with a valve arrangement for dispensing material from the interior of the dispenser, characterised in that the closure welds directly to the body by an overlapping metal-to-metal laser weld extending around the body to produce a double weld in the region of overlap and provide a hermetic seal between the mating sur aces of the body and the ferrule.
  • the overlapping weld is a continuous weld which extends from 365 to 720 degrees around the axis of the body and the closure, giving a double weld which overlaps by 5 to 360 degrees.
  • the weld extends from 380 to 540 degrees around the axis and gives a double weld which overlaps by 20 to 180 degrees.
  • the mating surfaces of the ferrule or the body comprise one or more dimples or indents to enable release of purging gases during the welding process.
  • gases used to purge the weld area during the welding process are the inert gases such as Helium or Argon.
  • the overlapping weld is between the ferrule and an annular flange forming part of the body, the flange being axially directed and cylindrical.
  • the overlapping weld is between the ferrule and an annular flange forming part of the body, the ferrule and flange being outwardly directed and flat.
  • the dispenser is charged with an aerosol suspension.
  • the aerosol suspension comprises a medicament and a propellant.
  • the medicament is selected from the group consisting of albuterol, salmeterol, fluticasone propionate and beclomethasone dipropionate and salts or solvates thereof and any mixtures thereof.
  • the propellant is selected from the group consisting of 1,1 ,1 ,2-tetrafluoroethane and 1 ,1 ,1 ,2,3,3,3-heptafluoropropane.
  • an aerosol dispenser comprising a metal body and a closure, the closure comprising an annular ferrule extending circumferentially around the axis of the closure and provided with a valve arrangement for dispensing material from the interior of the dispenser, characterised by applying laser energy to the mating surfaces of the ferrule and the body to produce an overlapping metal-to-metal laser weld extending around the body to form a double weld in the region of overlap and provide a hermetic seal between the body and the ferrule.
  • the ferrule is positioned at the open end of and co-axially with the body such that the mating surfaces are in contact with each other.
  • the weld is a continuous weld extending from 365 to 720 degrees about the axis of the body and the closure, giving a double weld which overlaps by 5 to 360 degrees.
  • the weld extends from 380 to 540 degrees about the axis to give a double weld which overlaps by 20 to 180 degrees.
  • the mating surfaces comprise one or more dimples or indents to enable release of purging gases which expand on heating during the welding process.
  • the mating surfaces comprise one or more dimples or indents to enable release of purging gases which expand on heating during the welding process.
  • three dimples or indents, spaced at 120 degree intervals around the circumference of the ferrule or the body, may be employed to facilitate release of the inert purging gases (such as Helium or Argon).
  • the laser energy is applicable at an angle of from 10 to
  • the angle is from 20 to 40 degrees.
  • the angle is selected to equilibrate and slow heating of the ferrule relative to the container body (which can dissipate heat more effectively) otherwise the ferrule melts too rapidly for an effective weld.
  • the closure is positioned at the open end of and co-axially with the body, the body comprising a complementary annular flange extending circumferentially about its axis such that the ferrule and the flange are parallel and in contact with each other.
  • the ferrule and the flange are outwardly directed and flat. More preferably, the ferrule and the flange are bent to lie in a substantially axial direction after the ferrule and the flange have been welded together. More preferably, the ferrule and flange are axially directed and cylindrical.
  • ferrule and the flange are first welded together then rolled and crimped together.
  • ferrule and flange are first rolled and crimped together then laser welded to each other.
  • the laser welding is conducted by means of a laser source having a maximum average power of from 10W to 200W, and a maximum peak power of from 1kW to 10kW.
  • the laser source can be any source suitable for laser welding, including carbon dioxide, diode, fibre and copper vapour laser sources.
  • the laser beam can also be generated by a Q- switched Neodymium Yttrium Aluminium Garnate laser source.
  • An AM 183 (1.8 kW) Yttrium Aluminium Garnate laser source is particularly useful in this respect.
  • the laser source has a pulse width of from 0.5 to 20 microseconds and a maximum pulse energy of from 10 to 100 Joules. More preferably, the laser source utilises a square wave modulated beam.
  • the width of the weld produced is in the range of 0.4 to 0.8 millimetres. Preferably, the width of the weld produced is 0.6 millimetres.
  • Figure 1 is a section perspective of a prior art aerosol dispenser
  • Figure 2 is a sectional perspective of an embodiment of the invention
  • Figure 3 is a sectional perspective of the embodiment of Figure 2 illustrating welding of the ferrule to an annular, planar flange.
  • Figure 4 is a sectional perspective of the embodiment of Figure 2 illustrating welding of the ferrule to an annular, axial flange.
  • Figure 5 shows a detail of a modification of the embodiment of Figure 3
  • Figure 6 shows a further embodiment of the invention.
  • Figures 7a to 7c show successive steps in assembling the embodiment of Figure 6.
  • Figure 8 shows a schematic representation of another embodiment of the invention.
  • Figure 9a - 9c show the closure and ferrule arrangement of the dispenser of Figure 8. Detailed Description of the Drawings
  • FIG. 1 of the accompanying drawings The upper portion of a known medicament dispenser is shown in cross section in Figure 1 of the accompanying drawings.
  • This comprises a metal can body 10 and a metal closure 20 having a ferrule 22 the lower end of which is crimped around an upper wall portion 12 of the can body 10.
  • the closure 20 has a downwardly opening annular channel 25 within which is received a sealing gasket 30.
  • the upper edge of the ferrule 22 of the can body 10 is in sealing engagement with the gasket 30.
  • the medicament dispenser is provided with a valve arrangement 40, the purpose of which is to enable metered doses of a material held under pressure within the can body 10 to be dispensed.
  • the valve arrangement 40 includes a metering chamber 41 , within which a dose of medicament is held prior to being dispensed, and a hollow stem 42 which is longitudinally movable with respect to the chamber 41.
  • the stem 42 has a transfer port 44 and an outlet 45. When the stem is depressed from the position shown, the dose passes from the chamber 41 through the port 44 into the stem, and from there it passes out through the outlet 45.
  • the stem 42 is in slidably sealing engagement with an aperture formed in the centre of a sealing ring 35.
  • FIG. 2 shows a cross sectional view of a dispenser according to the invention.
  • the principal components of the dispenser are identical to those shown in Figure 1 except that the gasket 30 (of Figure 1) is now redundant due to the presence of laser weld 150.
  • the body 110 is attached to closure 120 by means of laser weld 150 between ferrule 122 and upper body wall portion 112.
  • Laser source 160 directs beam 162 at the mating surfaces of ferrule 122 and wall portion 112 to form weld 150.
  • the laser beam 162 is directed at an angle of approximately 30 degrees to the vertical of body portion 112 to equilibrate heating rates of the ferrule 122 and portion 112 which can dissipate heat more effectively.
  • the beam 162 is angled more towards the body portion 112 than the ferrule 122.
  • the welding operation may be carried out when the dispenser components are in an upright (as shown) or inverted position.
  • a 390 degree overlapping weld is produced around the body 110 of the dispenser by relative movement of laser beam 162 with respect to the mating surfaces of the ferrule 122 and upper wall portion 112.
  • a double weld (not shown) will be produced in the 30 degree region of overlap.
  • Laser welding enables only very localised heating to be produced in the region of the weld itself. This may enable the can to be filled before the closure is secured thereto (the alternative being to fill the can through the valve arrangement) since it reduces the risk of the medicament being undesirably heated.
  • the metal containers are typically composed of aluminium or stainless steel and the interior surfaces may be coated with materials, such as fluoropolymers, which reduce the tendency of medicament to adhere thereto.
  • the ferrule and flanges may also be composed of aluminium or stainless steel.
  • the laser source can be any source suitable for laser welding.
  • the maximum average power is from 10W to 200W, preferably from 25W to 100W and the maximum peak power is from 1kW to 10kW, preferably from 1kW to 3kW.
  • the pulse width is typically from 0.5 to 20 microseconds, and the maximum pulse energy from 10 to 100 Joules, preferably from 25 to 50 Joules.
  • the laser welds are furthermore clean and produce welds which are hermetic in nature. Also, since laser output is typically very stable it is possible to achieve consistent weld repeatability.
  • laser welding offers the additional benefits ;of speed over contact based welding methods such as ultrasonic welding.
  • the dispenser of Figure 3 is essentially identical to that of Figure 2 but differs in the orientation of the ferrule and a flange structure on the container body.
  • Figure 3 illustrates laser welding of the ferrule 222 to annular, planar flange 212, forming part of the body 210, which are both outwardly directed in relation to the orientation of the body 210 and the closure 220.
  • Laser weld 250 is produced by a laser beam 262, emanating from source 260.
  • the beam 262 is angled at approximately 30 degrees in relation to the mating surfaces of ferrule 222 and flange 212 to equilibrate heating rates of the two surfaces.
  • a 30 degree overlapping double weld (not shown) is effected by revolving the beam 262 or the mating surface of the ferrule 222 and flange 214 through 390 degrees.
  • the contents of the dispenser exert a peel force on the weld between the flanges.
  • a welded joint is relatively weak under a peel force, though nevertheless strong enough to withstand any force to which it is reasonably likely to be exposed.
  • the flange and ferrule can alternatively have the shape in Figure 4 wherein they are axially directed and cylindrical. To achieve this, either the flange and ferrule may be welded in the form shown in Figure 3, and then bent through 90 degrees, or they may be bent first and welded afterwards.
  • the ferrule 322 is slightly splayed to aid alignment and to promote an interference (or at least a transition) fit at the top periphery.
  • This fit between the flange 312 and ferrule 322 at the top is necessary because the presence of any gap therebetween will undesirably permit the laser beam 362 to irradiate the contents of the container body 310 rather than contacting and heating the mating surfaces of the flange 312 and ferrule 322.
  • the laser beam 362 can be angled to prevent entry into the container body 310 and equilibrate heating rates of the mating surfaces.
  • a laser beam 362 is directed at the peripheral joint of the body 310 and ferrule 322.
  • the body 310 and ferrule 322 assembly can be spun in the presence of a stationary laser beam 362, or alternatively, the laser beam may be rotated around a stationary assembly. Welding continues until a continuous overlapping peripheral weld 350 is produced.
  • the extent of overlap may vary, an overlap of 30 degrees producing a partial double weld which provides a reproducible, hermetic seal.
  • FIG. 5 An alternative to the flange shape of Figure 4 as a way of avoiding subjecting the weld joint to a shear force is shown in Figure 5, in which the flange 412 of the body 410 and the ferrule 422 are welded in the shape shown in Figure 3, and then bent downwardly.
  • FIG 8 depicts another embodiment of an aerosol dispenser of the present invention.
  • the container body 710 is cylindrical in nature, is composed of aluminium and has a raised base 715 and narrowed neck 717.
  • a valve arrangement 740 (shown in simplified fashion) is seated in the open end of the container body 710 and is used to dispense a measured dose of medicament from the interior of the container body 710 via hollow stem 742.
  • the valve arrangement is seated in position by means of closure 720.
  • the closure comprises a ferrule 722 which can be welded with the upper wall portion 712 with laser energy.
  • a laser beam 762 angled at approximately 30 degrees to the vertical of body 710, is generated from source 760 onto the mating surfaces of the ferrule 722 and wall portion 712.
  • a series of indents or dimples are pre-formed in the mating surfaces of the ferrule 722 and/or wall portion 712. These dimples allow gaseous escape during the initial stages of the welding process.
  • An overlapping, continuous laser weld 750 is formed between the mating surfaces of the ferrule 722 and wall 712 which extends more than 360 degrees around the circumference of the container neck 717.
  • the weld 750 is produced by rotating the dispenser through, for example, 390 degrees whilst the laser source 760 remains stationary, or the laser source 760 is rotated around the stationary dispenser. In this way, a double weld (not shown) is produced in the 30 degree region of overlap around the neck 717 of the container.
  • Figures 9a - 9c are schematic diagrams of the closure 820 of Figure 8 and illustrate the dimples or indents 827 described above.
  • a sectional view of the cylindrical closure 820 is seen in Figure 9a to comprise top 823 and ferrule 822.
  • the ferrule has three dimples or indents 827 cut into its interior surface which forms the mating surface with the body of the container (not shown). Only three dimples 827 are shown in the diagram, equispaced at approximately 120 degrees to each other, although more dimples can be used to effect gaseous release during the laser welding process.
  • An enlarged view of the highlighted area of the ferrule 827, graphically illustrating the nature of the dimple 827, is shown in Figure 9b.
  • a plan view of the closure 820 is seen in Figure 9c.
  • Figures 1 to 9c describe particular embodiments in which a valved ferrule is weldable to a metal can body other variations are possible.
  • a valved can body is weldable to a base ferrule.
  • the base ferrule may be either dome shaped or essentially flat.
  • any of the parts of the dispenser or actuator which contact the medicament suspension may be coated with materials such as fluoropolymer materials (e.g. PTFE or FEP) which reduce the tendency of medicament to adhere thereto.
  • fluoropolymer materials e.g. PTFE or FEP
  • Any movable parts may also have coatings applied thereto which enhance their desired movement characteristics. Frictional coatings may therefore be applied to enhance frictional contact and lubricants (e.g. silicone oil) used to reduce frictional contact as necessary.
  • the medicament dispenser of the invention is suitable for dispensing medicament, particularly for the treatment of respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD).
  • respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD).
  • COPD chronic obstructive pulmonary disease
  • Appropriate medicaments may thus be selected from, for example, analgesics, e.g., codeine, dihydromorphine, ergotamine, fentanyl or morphine; anginal preparations, e.g., diltiazem; antiallergics, e.g., cromoglycate (eg s the sodium salt), ketotifen or nedocromil (e.g.
  • analgesics e.g., codeine, dihydromorphine, ergotamine, fentanyl or morphine
  • anginal preparations e.g., diltiazem
  • antiallergics e.g., cromoglycate (eg s the sodium salt), ketotifen or nedocromil (e.g.
  • antiinfectives e.g., cephalosporins, penicillins, streptomycin, sulphonamides, tetracyclines and pentamidine
  • antihistamines e.g., methapyrilene
  • anti- inflammatories e.g., beclomethasone (e.g. as the dipropionate ester), fluticasone (e.g. as the propionate ester), flunisolide, budesonide, rofleponide, mometasone e.g. as the furcate ester), ciclesonide, triamcinolone (e.g.!
  • antitussives e.g., noscapine
  • bronchodilators e.g., albuterol (e.g. as free base or sulphate), salmeterol (e.g. as xinafoate), ephedrine, adrenaline, fenoterol (e.g. as hydrobromide), formoterol (e.g.
  • bromide as bromide
  • tiotropium as bromide
  • atropine or oxitropium hormones, e.g., cortisone, hydrocortisone or prednisolone
  • xanthines e.g., aminophylline, choline theophyllinate, lysine theophyllinate or theophylline
  • therapeutic proteins and peptides e.g., insulin or glucagon
  • vaccines, diagnostics, and gene therapies as bromide
  • hormones e.g., cortisone, hydrocortisone or prednisolone
  • xanthines e.g., aminophylline, choline theophyllinate, lysine theophyllinate or theophylline
  • therapeutic proteins and peptides e.g., insulin or glucagon
  • vaccines diagnostics, and gene therapies.
  • the medicaments may be used in the form of salts, (e.g., as alkali metal or amine salts or as acid addition salts) or as esters (e.g., lower alkyl esters) or as solvates (e.g., hydrates) to optimise the activity and/or stability of the medicament.
  • Preferred medicaments are selected from albuterol, salmeterol, fluticasone propionate and beclomethasone dipropionate and salts or solvates thereof, e.g., the sulphate of albuterol and the xinafoate of salmeterol.
  • Medicaments can also be delivered in combinations.
  • Preferred formulations containing combinations of active ingredients contain salbutamol (e.g., as the free base or the sulphate salt) or salmeterol (e.g., as the xinafoate salt) or formoterol (e.g. as the fumarate salt) in combination with an antiinflammatory steroid such as a beclomethasone ester (e.g., the dipropionate) or a fluticasone ester (e.g., the propionate) or budesonide.
  • a particularly preferred combination is a combination of fluticasone propionate and salmeterol, or a salt thereof (particularly the xinafoate salt).
  • a further combination of particular interest is budesonide and formoterol (e.g. as the fumarate salt).

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Mechanical Engineering (AREA)
  • Plasma & Fusion (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un distributeur d'aérosol comprenant un corps (210) et une fermeture (220) scellée sur le corps (210). La fermeture (220) comprend une virole métallique annulaire (222) s'étendant périphériquement autour de l'axe de la fermeture (220), ainsi qu'un ensemble soupape (40) servant à distribuer la substance se trouvant à l'intérieur du distributeur. Le distributeur selon l'invention est caractérisé en ce que la fermeture (220) est directement soudée sur le corps (210) par une soudure laser métal sur métal chevauchante (250) qui s'étend autour du corps afin de produire une soudure double dans la zone de chevauchement et de fournir un scellement hermétique entre les surfaces de contact du corps (210) et de la virole (222).
PCT/EP2002/003327 2001-05-12 2002-03-25 Distributeur Ceased WO2002092466A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0111702.7A GB0111702D0 (en) 2001-05-12 2001-05-12 Dispenser
GB0111702.7 2001-05-12

Publications (1)

Publication Number Publication Date
WO2002092466A1 true WO2002092466A1 (fr) 2002-11-21

Family

ID=9914572

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/003327 Ceased WO2002092466A1 (fr) 2001-05-12 2002-03-25 Distributeur

Country Status (2)

Country Link
GB (1) GB0111702D0 (fr)
WO (1) WO2002092466A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068127A3 (fr) * 2004-01-15 2005-12-15 Crebocan Ag Procede et dispositif pour produire un corps de boite, et corps de boite
EP2014407A1 (fr) * 2007-07-13 2009-01-14 FLEXIDER S.r.l. Appareil et procédé pour la fermeture de colliers de soufflets à double paroi et soufflets à double paroi ainsi obtenus qui peuvent être équipés d'une surveillance des craquelures
US7584639B2 (en) 2003-06-27 2009-09-08 Crebocan Ag Method and device for the production of a can body, and can body
US7777153B2 (en) * 2004-10-19 2010-08-17 Medtronic, Inc. Connection between two components
US8362385B2 (en) 2009-08-07 2013-01-29 Flexider S.R.L. Apparatus and method for sealing collars of double-wall bellows and double-wall bellows so obtained that can be fitted with crack monitoring

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330699A (en) * 1979-07-27 1982-05-18 The United States Of America As Represented By The Secretary Of The Navy Laser/ultrasonic welding technique
EP0200098A2 (fr) * 1985-04-22 1986-11-05 Karl Huber Verpackungswerke GmbH + Co. Procédé de fabrication de récipient en tôle mince comme de la tôle mince fine ou très fine
JPH01299787A (ja) * 1988-02-27 1989-12-04 Masayuki Matsushita 溶接缶並びにその製造方法
US4905858A (en) * 1987-08-28 1990-03-06 Buedenbender Bernd Sheetmetal container with attached end closures
US5186592A (en) * 1991-03-22 1993-02-16 Buedenbender Bernd Sheet metal container with attached end closures
WO2000035772A1 (fr) * 1998-12-16 2000-06-22 Glaxo Group Limited Diffuseur d'aerosols et procede de fabrication associe

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330699A (en) * 1979-07-27 1982-05-18 The United States Of America As Represented By The Secretary Of The Navy Laser/ultrasonic welding technique
EP0200098A2 (fr) * 1985-04-22 1986-11-05 Karl Huber Verpackungswerke GmbH + Co. Procédé de fabrication de récipient en tôle mince comme de la tôle mince fine ou très fine
US4905858A (en) * 1987-08-28 1990-03-06 Buedenbender Bernd Sheetmetal container with attached end closures
JPH01299787A (ja) * 1988-02-27 1989-12-04 Masayuki Matsushita 溶接缶並びにその製造方法
US5186592A (en) * 1991-03-22 1993-02-16 Buedenbender Bernd Sheet metal container with attached end closures
WO2000035772A1 (fr) * 1998-12-16 2000-06-22 Glaxo Group Limited Diffuseur d'aerosols et procede de fabrication associe

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 014, no. 087 (M - 0937) 19 February 1990 (1990-02-19) *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7584639B2 (en) 2003-06-27 2009-09-08 Crebocan Ag Method and device for the production of a can body, and can body
WO2005068127A3 (fr) * 2004-01-15 2005-12-15 Crebocan Ag Procede et dispositif pour produire un corps de boite, et corps de boite
EA008857B1 (ru) * 2004-01-15 2007-08-31 Кребокан Аг Способ и устройство для изготовления корпуса банки, а также корпус банки
US7670094B2 (en) 2004-01-15 2010-03-02 Crebocan Ag Method and device for producing a can body and can body
US7777153B2 (en) * 2004-10-19 2010-08-17 Medtronic, Inc. Connection between two components
EP2014407A1 (fr) * 2007-07-13 2009-01-14 FLEXIDER S.r.l. Appareil et procédé pour la fermeture de colliers de soufflets à double paroi et soufflets à double paroi ainsi obtenus qui peuvent être équipés d'une surveillance des craquelures
US8362385B2 (en) 2009-08-07 2013-01-29 Flexider S.R.L. Apparatus and method for sealing collars of double-wall bellows and double-wall bellows so obtained that can be fitted with crack monitoring

Also Published As

Publication number Publication date
GB0111702D0 (en) 2001-07-04

Similar Documents

Publication Publication Date Title
CN1144744C (zh) 用于气雾剂容器的装置壳体
AU755977B2 (en) Metered dose inhaler for fluticasone propionate
EP1379305B1 (fr) Distributeur de medicament
WO2001010742A1 (fr) Valve de distribution possedant un systeme d'essuyage de la tige
EP1439877B1 (fr) Procédé de fabrication d'un distributeur de medicaments
WO2002092466A1 (fr) Distributeur
US20050143685A1 (en) Drug dispensing components
CA2297983A1 (fr) Soupape pour recipient aerosol
MXPA04009718A (es) Metodo y aparato para cargar un contenedor con un producto.
AU3656200A (en) Valve
EP1318952A2 (fr) Recipient d'aerosol doseur recouvert deux fois ou plus de polymeres de fluorocarbure
EP1590574B1 (fr) Dispositif de fixation
US20040129737A1 (en) Valves for use in containers having valve stems slidably movable within round-edged sealing rings
JP2009521285A (ja) 水分障壁特性が改善されたポリマーフィルムを用いたエアロゾルキャニスター
ZA200102876B (en) Aerosol dispenser and method for its manufacture.
MXPA01005899A (en) Aerosol dispenser and method for its manufacture
US20060210481A1 (en) Medicament dispenser
AU2002339061A1 (en) Medicament dispenser
HK1026407B (en) Aerosol container comprising a valve
JPH06209983A (ja) ガラスからなる多成分混合カプセルの製造方法

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP