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WO2002088345A3 - Murine dnasex, medicament containing the same and non-human mammal comprising modified dnasex gene - Google Patents

Murine dnasex, medicament containing the same and non-human mammal comprising modified dnasex gene Download PDF

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Publication number
WO2002088345A3
WO2002088345A3 PCT/EP2002/004003 EP0204003W WO02088345A3 WO 2002088345 A3 WO2002088345 A3 WO 2002088345A3 EP 0204003 W EP0204003 W EP 0204003W WO 02088345 A3 WO02088345 A3 WO 02088345A3
Authority
WO
WIPO (PCT)
Prior art keywords
dnasex
murine
gene
modified
human mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/004003
Other languages
French (fr)
Other versions
WO2002088345A2 (en
Inventor
Annemarie Poustka
Johannes Coy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Priority to AU2002338549A priority Critical patent/AU2002338549A1/en
Publication of WO2002088345A2 publication Critical patent/WO2002088345A2/en
Publication of WO2002088345A3 publication Critical patent/WO2002088345A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a DNA sequence coding for murine DNAseX, the murine DNaseX protein and anti-DNaseX antibodies. The invention also relates to medicaments containing the above compounds, used preferably for preventing and/or treating diseases where apoptosis plays a role, and to diagnostic methods and kits, all based on these compounds. In addition, the invention relates to a non-human mammal in which the DNaseX gene is modified, preferably inactivated.
PCT/EP2002/004003 2001-04-11 2002-04-10 Murine dnasex, medicament containing the same and non-human mammal comprising modified dnasex gene Ceased WO2002088345A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002338549A AU2002338549A1 (en) 2001-04-11 2002-04-10 Murine dnasex, medicament containing the same and non-human mammal comprising modified dnasex gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01109024A EP1249495A1 (en) 2001-04-11 2001-04-11 Murine DNase X, pharmaceuticals containing thereof and non-human mammal with modified DNase X-gene
EP01109024.8 2001-04-11

Publications (2)

Publication Number Publication Date
WO2002088345A2 WO2002088345A2 (en) 2002-11-07
WO2002088345A3 true WO2002088345A3 (en) 2003-08-28

Family

ID=8177115

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/004003 Ceased WO2002088345A2 (en) 2001-04-11 2002-04-10 Murine dnasex, medicament containing the same and non-human mammal comprising modified dnasex gene

Country Status (3)

Country Link
EP (1) EP1249495A1 (en)
AU (1) AU2002338549A1 (en)
WO (1) WO2002088345A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60219809T2 (en) * 2002-12-18 2008-01-17 Coy, Johannes F., Dr. Compounds and methods for the detection of carcinomas and their precursors
CN107677821A (en) * 2016-08-02 2018-02-09 北京金沐医疗科技有限公司 A kind of liquid phase chip reagent box and its detection method for being used to detect tumour antigen

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19521046C1 (en) * 1995-06-09 1996-08-08 Deutsches Krebsforsch DNA encoding DNase and related vectors, host cells and antibodies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19521046C1 (en) * 1995-06-09 1996-08-08 Deutsches Krebsforsch DNA encoding DNase and related vectors, host cells and antibodies

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
COY J F ET AL: "ISOLATION, DIFFERENTIAL SPLICING AND PROTEIN EXPRESSION OF A DNASE ON THE HUMAN X CHROMOSOME", CELL DEATH AND DIFFERENTIATION, EDWARD ARNOLD, OXFORD, GB, vol. 3, no. 2, 1 April 1996 (1996-04-01), pages 199 - 206, XP000603900, ISSN: 1350-9047 *
DATABASE EMBL Hinxton, GB; 16 March 2001 (2001-03-16), BIREN B. ET AL: "Mus musculus clone RP23-142E5, *** Sequencing in progress ***, 6 unordered pieces", XP002176963 *
DATABASE EMBL Hinxton, GB; 8 February 2001 (2001-02-08), ADACHI J. ET AL: "Mus musculus adult male tongue cDNA, RIKEN full length enriched library, clone: 2310005K03, full insert sequence", XP002176580 *
DATABASE EMBL Hinxton, GB; 9 September 2000 (2000-09-09), MCCOMBIE W.R. ET AL: "Mus musculus clone RP23-65M16, WORKING DRAFT SEQUENCE, 21 unordered pieces.", XP002176581 *
LOS MAREK ET AL: "Functional characterization of DNase X, a novel endonuclease expressed in muscle cells.", BIOCHEMISTRY, vol. 39, no. 25, 27 June 2000 (2000-06-27), pages 7365 - 7373, XP002176578, ISSN: 0006-2960 *
PERGOLIZZI R ET AL: "Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 168, no. 2, 12 February 1996 (1996-02-12), pages 267 - 270, XP004042973, ISSN: 0378-1119 *
SHIOKAWA DAISUKE ET AL: "Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis.", BIOCHEMISTRY, vol. 40, no. 1, 9 January 2000 (2000-01-09), pages 143 - 152, XP002176579, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
AU2002338549A1 (en) 2002-11-11
EP1249495A1 (en) 2002-10-16
WO2002088345A2 (en) 2002-11-07

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