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WO2002088183A3 - G-protein coupled receptor - Google Patents

G-protein coupled receptor Download PDF

Info

Publication number
WO2002088183A3
WO2002088183A3 PCT/GB2002/001923 GB0201923W WO02088183A3 WO 2002088183 A3 WO2002088183 A3 WO 2002088183A3 GB 0201923 W GB0201923 W GB 0201923W WO 02088183 A3 WO02088183 A3 WO 02088183A3
Authority
WO
WIPO (PCT)
Prior art keywords
seq
coupled receptor
protein coupled
tarzan
gpcr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2002/001923
Other languages
French (fr)
Other versions
WO2002088183A2 (en
Inventor
Mark Carlton
Samuel Aparicio
John Dixon
Alan Hendrick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paradigm Therapeutics Ltd
Original Assignee
Paradigm Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0110662A external-priority patent/GB0110662D0/en
Application filed by Paradigm Therapeutics Ltd filed Critical Paradigm Therapeutics Ltd
Priority to AU2002307903A priority Critical patent/AU2002307903A1/en
Publication of WO2002088183A2 publication Critical patent/WO2002088183A2/en
Publication of WO2002088183A3 publication Critical patent/WO2002088183A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

We disclose Tarzan G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO: 3, SED ID NO: 5, SEQ ID NO: 6 OR SEQ ID NO: 8, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding Tarzan polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 4.
PCT/GB2002/001923 2001-05-01 2002-04-25 G-protein coupled receptor Ceased WO2002088183A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002307903A AU2002307903A1 (en) 2001-05-01 2002-04-25 G-protein coupled receptor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0110662.4 2001-05-01
GB0110662A GB0110662D0 (en) 2001-05-01 2001-05-01 Receptor
US28816001P 2001-05-02 2001-05-02
US60/288,160 2001-05-02

Publications (2)

Publication Number Publication Date
WO2002088183A2 WO2002088183A2 (en) 2002-11-07
WO2002088183A3 true WO2002088183A3 (en) 2003-05-01

Family

ID=26246024

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/001923 Ceased WO2002088183A2 (en) 2001-05-01 2002-04-25 G-protein coupled receptor

Country Status (2)

Country Link
AU (1) AU2002307903A1 (en)
WO (1) WO2002088183A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312086B2 (en) 2000-12-07 2007-12-25 Bristol-Myers Squibb Company Methods of diagnosing colon adenocarcinoma using the human g-protein coupled receptor hgprbmy23
EP1546725A1 (en) * 2002-09-27 2005-06-29 Bayer HealthCare AG Regulation of human p2y15 g protein-coupled receptor
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors
WO2001087980A2 (en) * 2000-05-18 2001-11-22 Applera Corporation Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof
WO2001087937A2 (en) * 2000-05-18 2001-11-22 Incyte Genomics, Inc. G-protein coupled receptors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors
WO2001087980A2 (en) * 2000-05-18 2001-11-22 Applera Corporation Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof
WO2001087937A2 (en) * 2000-05-18 2001-11-22 Incyte Genomics, Inc. G-protein coupled receptors

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AYYANATHAN KASIRAJAN ET AL: "Cloning and chromosomal localization of the human P2Y1 purinoceptor", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 218, no. 3, 1996, pages 783 - 788, XP002195807, ISSN: 0006-291X *
DATABASE EMBL [online] 21 May 2000 (2000-05-21), SKUCE C.: "Human DNA sequence from clone RP11-721F14 on chromosome 13", XP002216296, retrieved from EMBL Database accession no. AL356486 *
DATABASE EMBL [online] ABOLA ET AL.: "Homo sapiens chromosome 13 clone RP11-286P8, complete sequence.", XP002216311, retrieved from EMBL Database accession no. ac026756 *
DATABASE EMBL [online] NCI-CGAP; 18 May 2000 (2000-05-18), ROBERT STRAUSBERG, XP002216297, retrieved from EMBL Database accession no. AW827323 *
KUEGELGEN VON I ET AL: "Molecular pharmacology of P2Y-receptors", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, SPRINGER, BERLIN, DE, vol. 362, no. 4-5, November 2000 (2000-11-01), pages 310 - 323, XP002199630, ISSN: 0028-1298 *
LEE D K ET AL: "Cloning and characterization of additional members of the G protein-coupled receptor family", BIOCHIMICA ET BIOPHYSICA ACTA. GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, vol. 1490, no. 3, 29 February 2000 (2000-02-29), pages 311 - 323, XP004275600, ISSN: 0167-4781 *
TOKUYAMA Y ET AL: "CLONING OF RAT AND MOUSE P2Y PURINOCEPTORS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 211, no. 1, 6 June 1995 (1995-06-06), pages 211 - 218, XP000673449, ISSN: 0006-291X *

Also Published As

Publication number Publication date
WO2002088183A2 (en) 2002-11-07
AU2002307903A1 (en) 2002-11-11

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