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WO2002087665A1 - Pompe pour administrer des medicaments de façon dosee et regulee dans le temps - Google Patents

Pompe pour administrer des medicaments de façon dosee et regulee dans le temps Download PDF

Info

Publication number
WO2002087665A1
WO2002087665A1 PCT/EP2002/004662 EP0204662W WO02087665A1 WO 2002087665 A1 WO2002087665 A1 WO 2002087665A1 EP 0204662 W EP0204662 W EP 0204662W WO 02087665 A1 WO02087665 A1 WO 02087665A1
Authority
WO
WIPO (PCT)
Prior art keywords
pump according
profile
pump
stamp
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/004662
Other languages
German (de)
English (en)
Inventor
Rüdiger GRÖNING
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2002087665A1 publication Critical patent/WO2002087665A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M2005/14533—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons cam actuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2086—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically having piston damping means, e.g. axially or rotationally acting retarders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3143—Damping means for syringe components executing relative movements, e.g. retarders or attenuators slowing down or timing syringe mechanisms

Definitions

  • the present invention relates to a drug pump with programmable active ingredient release for long-term administration of drugs.
  • Drug pumps are preferably used to deliver drug solutions or drug emulsions parenterally (e.g. subcutaneously, intravenously, intraperitoneally) into humans or animals into the organism over several hours or days at a given uniform or variable delivery rate. Drug pumps are also suitable for oral, rectal and transdermal drug delivery.
  • Implantable infusion pumps (EP00513299B1) and externally portable pumps (EP00168472B1) are described for the parenteral administration of medicinal substances. Pumps can be combined with injection syringes, from which the drug is released by advancing the syringe plunger (EP00142736B). Controlling the release via a threaded rod is described in EP0916353.
  • the object of the present invention is to provide a medicament pump which is simple to use, insensitive to malfunction and inexpensive and which permits an individual dosage of the medicament.
  • This object is achieved by means of a pump for the time-controlled, meterable administration of medicinal substances with a medicinal substance reservoir to which pressure is exerted by means of a stamp, the pressure being exerted by scanning a profile or a plurality of profiles which are applied to plates, disks, cylinders and / or spirals is / are incorporated, regulated and transferred to the stamp via an adapter.
  • the drug reservoir is a column-like or syringe-like construction, for example a cylindrical ampoule or a plunger syringe.
  • a tensile or compressive stress preferably a spring or gas compressive stress, is advantageously applied to the stamp and / or adapter of the pump according to the invention.
  • This tensile or compressive stress serves as a preload or counter pressure to the force by scanning the profile on the adapter and then transferred to the stamp.
  • Adapters and stamps can be connected to one another via a fixed connection unit, for example a rod.
  • profiles are to be understood as so-called cams, gears, shafts, spirals, furrows or similar configurations which are incorporated, for example milled, embossed, punched or cut, onto cards, plates, disks, cylinders, spirals or other three-dimensional supports
  • the material from which the profiles are made is preferably light, but nevertheless so abrasion-resistant and durable that it can withstand being scanned over the long term.
  • the profile is scanned mechanically or electronically.
  • the speed at which the profile is scanned e.g. in which the scanner moves along the profile enables a continuous release of drugs over time. That the speed with which the scanner scans the profile (or several profiles) regulates the delivery of the drugs over time.
  • the amount of drug released is regulated by the amount of pressure exerted on the stamp over the drug reservoir by the adapter.
  • the profile moves or is moved along the scanner.
  • the speed at which the profile moves can regulate the release of the drugs over time.
  • the scanner can interact with the adapter via the profile or it can be connected directly to the adapter his.
  • the latter is the case, for example, when the profile moves along the scanner.
  • a continuous drug delivery over several hours, preferably at least 24 hours, particularly preferably at least 48 hours.
  • the speed of the scanning is regulated by a control unit.
  • the scanner of the pump according to the invention is driven mechanically, electrically, electronically or by a combination of these forces.
  • the scanner can advantageously be driven by a gear train, spring mechanism, spring motor, electric motor, a software-controlled drive unit or a combination thereof.
  • Such drive units are known and can advantageously be in a miniaturized configuration.
  • a simple example of a drive unit can be a clockwork.
  • the medicaments are administered parenterally from the medicament reservoir via a catheter or a cannula.
  • the pump according to the invention also has a device for advancing or resetting the stamp, which makes it possible to increase or reduce the dose delivered by the pump. It advantageously has a flow limiter which limits the maximum delivery rate of the pump. This device is used primarily for patient safety.
  • a particular advantage of the pump according to the invention is that the profile is interchangeable.
  • the exchange can be carried out quickly and easily, for example using plug-in, clamping or screwing devices that are easy for the patient to handle. This enables the patient to quickly and easily adjust the drug delivery according to his current needs or planned activities.
  • the time-controlled movement of the stamp can be achieved with the aid of several “profiles”.
  • the pump according to the invention is further characterized in that it is portable. In further embodiment variants, the pump according to the invention is characterized in that it is small and light.
  • the pump according to the invention thus has the advantage that it can be individually programmed and, at the same time, is very easy to use due to the use of the profiles according to the invention. Furthermore, due to the simple functional principle, it is very insensitive to faults.
  • the present invention also relates to the use of the pump according to the invention for oral, peroral, rectal or transdermal administration of medicinal substances. Also included is the use of the pump according to the invention for long-term administration of drugs.
  • the pump according to the invention can be used for the treatment of diabetes or for dialysis. For example, insulins and other peptides can be administered as drugs.
  • the invention of the figures is explained in more detail below, but these are not limiting for the present invention:
  • Fig. 1 shows a schematic representation of an embodiment of the pump according to the invention with a wavy profile.
  • Fig. 2 shows a schematic representation of an embodiment of the pump according to the invention in the form of a so-called "pen”.
  • FIG. 3 shows a schematic representation of an embodiment variant of the pump according to the invention with a spiral disk profile 9.
  • 4 a and b show an illustration of an insulin profile provided over 24 hours.
  • Fig. 4 c shows its transfer to a program card.
  • FIG 5 shows an illustration of two different profiles for controlling the drug release from the pumps according to the invention.
  • FIG. 6 shows an illustration of the result of an investigation of the release of insulin from an insulin pump according to the invention controlled by program cards.
  • the drug reservoir 2 is shown in the form of a plunger syringe with a stamp 12.
  • a compressive stress 3 is applied to the stamp, which is connected to an adapter via a rod.
  • the profile 1, which is scanned by a scanner 4, is attached to the adapter that moves in the direction of the arrow.
  • the speed at which the scanner 4 moves in the direction of the arrow is regulated by a drive unit, which is not shown.
  • the time course of the release of the drug (insulin solution) from the drug reservoir 2 (syringe 12) is milled as a wave profile 1 on a program card.
  • the scanner (4) is moved on a threaded rod evenly over 24 hours in the direction of the arrow.
  • This moves the adapter 10, which is under spring pressure (arrow direction 3) (with which the profile 1 is linked in the form of a program card), together with the rod 11, which establishes the connection to the stamp 7, which presses on the drug reservoir.
  • the adapter 10 which is under spring pressure (arrow direction 3) (with which the profile 1 is linked in the form of a program card), together with the rod 11, which establishes the connection to the stamp 7, which presses on the drug reservoir.
  • the results of release studies show that the drug dosage can be controlled variably over a period of 24 hours.
  • the pharmaceutical pump has the form of a so-called insulin pen.
  • the time course of the pumping rate of the drug pump is specified via a profile that is milled into the cylinder 5.
  • the motor 4 guides the scanner 4 uniformly with one revolution within 48 hours along the profile.
  • the piston advance and thus the release from the drug reservoir depends on the profile.
  • a pump with a spiral disk profile is moved by the movement of the profile disk along the scanner 4, a corresponding pressure on the adapter 8 under prestress and ultimately on the stamp above the drug reservoir 2.
  • the profile milled into the program card corresponds to the desired cumulative insulin delivery. If the scanner 4 moves smoothly in the direction of the arrow during the intended period of release, the syringe 12 is used to inject insulin via a catheter.
  • Figure 5 shows two different profiles for controlling drug release.
  • the extent of the release (5.6 mm or 12.9 mm total piston advance) and the course of the active ingredient delivery are predetermined by the different courses.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne une pompe pour administrer des médicaments de façon dosée et régulée dans le temps, cette pompe comprenant un réservoir à médicaments sur lequel une pression est exercée par l'intermédiaire d'un piston. Selon l'invention, la pression est régulée par lecture d'un ou de plusieurs profils produits sur des plaques, des disques, des cylindres et/ou des spirales, puis elle est transmise au piston par l'intermédiaire d'un adaptateur.
PCT/EP2002/004662 2001-04-26 2002-04-26 Pompe pour administrer des medicaments de façon dosee et regulee dans le temps Ceased WO2002087665A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10120543A DE10120543A1 (de) 2001-04-26 2001-04-26 Arzneimittelpumpe mit programmierter Abgaberate
DE10120543.0 2001-04-26

Publications (1)

Publication Number Publication Date
WO2002087665A1 true WO2002087665A1 (fr) 2002-11-07

Family

ID=35034383

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/004662 Ceased WO2002087665A1 (fr) 2001-04-26 2002-04-26 Pompe pour administrer des medicaments de façon dosee et regulee dans le temps

Country Status (2)

Country Link
DE (3) DE10120543A1 (fr)
WO (1) WO2002087665A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021083496A (ja) * 2019-11-25 2021-06-03 ミネベアミツミ株式会社 シリンジポンプ

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1922941A (en) * 1930-04-16 1933-08-15 Charles C Francis Apparatus for the automatic administration of medication
US3543752A (en) * 1964-06-01 1970-12-01 Ruth Leo Hesse Infusion apparatus
US3901231A (en) * 1974-02-07 1975-08-26 Baxter Laboratories Inc Infusion pump apparatus
US4265241A (en) 1979-02-28 1981-05-05 Andros Incorporated Implantable infusion device
US4386929A (en) 1980-01-18 1983-06-07 Alza Corporation Elastomeric bladder assembly
EP0142736B1 (fr) 1983-11-09 1987-05-13 Intermedicat Gmbh Appareil d'infusion sous pression avec une seringue jetable
US4744786A (en) 1986-06-17 1988-05-17 Cordis Corporation Infusion pump
EP0168472B1 (fr) 1984-01-06 1990-12-27 Pacesetter Systems, Inc. Dispositif de pompe a perfusion externe et son procede d'utilisation
US5100389A (en) 1988-06-21 1992-03-31 Vaillancourt Vincent L Ambulatory infusion pump
WO1993020864A1 (fr) * 1992-04-10 1993-10-28 Novo Nordisk A/S Pompe d'infusion
EP0513299B1 (fr) 1990-11-29 1995-05-24 ANSCHÜTZ & CO. GmbH Pompe a perfusion implantable
EP0916353A1 (fr) 1997-01-10 1999-05-19 Japan Servo Co. Ltd. Appareil de transport de liquides
US6095757A (en) * 1995-07-10 2000-08-01 Compagnie Developpement Aguettant Liquid drug infusion pump

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DE2609699C2 (de) * 1974-05-28 1985-05-23 Imed Corp., 92131 San Diego, Calif. Infusionsapparat
US4078562A (en) * 1976-08-16 1978-03-14 Diana W. Friedman Infusion pump with feedback control
US4474309A (en) * 1981-10-22 1984-10-02 Oximetrix, Inc. Stepping motor control procedure for achieving variable rate, quasi-continuous fluid infusion
US4919650A (en) * 1987-03-30 1990-04-24 Bionica Pty. Limited Infusion pump
US4884013A (en) * 1988-01-15 1989-11-28 Sherwood Medical Company Motor unit for a fluid pump and method of operation
US5074756A (en) * 1988-05-17 1991-12-24 Patient Solutions, Inc. Infusion device with disposable elements
US5131816A (en) * 1988-07-08 1992-07-21 I-Flow Corporation Cartridge fed programmable ambulatory infusion pumps powered by DC electric motors
DE3912405C1 (fr) * 1989-04-15 1990-10-31 B. Braun Melsungen Ag, 3508 Melsungen, De
US5055001A (en) * 1990-03-15 1991-10-08 Abbott Laboratories Volumetric pump with spring-biased cracking valves
WO1993012828A1 (fr) * 1991-12-20 1993-07-08 Abbott Laboratories Systeme de securite pour pompe d'injection
JP3236057B2 (ja) * 1992-04-03 2001-12-04 シャープ株式会社 輸液装置
AU5747894A (en) * 1992-12-18 1994-07-19 Abbott Laboratories Solution pumping system for maximizing output while minimizing pumping pressures
JP3320179B2 (ja) * 1993-12-17 2002-09-03 シャープ株式会社 輸液ポンプ
US5716194A (en) * 1994-09-12 1998-02-10 Ivac Medical Systems, Inc. System for increasing flow uniformity
DE69611869T2 (de) * 1996-08-26 2001-09-13 Fluidsense Corp., Newburyport Dynamischer Fluid-Durchflussregler mit veränderbaren Impulsen

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1922941A (en) * 1930-04-16 1933-08-15 Charles C Francis Apparatus for the automatic administration of medication
US3543752A (en) * 1964-06-01 1970-12-01 Ruth Leo Hesse Infusion apparatus
US3901231A (en) * 1974-02-07 1975-08-26 Baxter Laboratories Inc Infusion pump apparatus
US4265241A (en) 1979-02-28 1981-05-05 Andros Incorporated Implantable infusion device
US4386929A (en) 1980-01-18 1983-06-07 Alza Corporation Elastomeric bladder assembly
EP0142736B1 (fr) 1983-11-09 1987-05-13 Intermedicat Gmbh Appareil d'infusion sous pression avec une seringue jetable
EP0168472B1 (fr) 1984-01-06 1990-12-27 Pacesetter Systems, Inc. Dispositif de pompe a perfusion externe et son procede d'utilisation
US4744786A (en) 1986-06-17 1988-05-17 Cordis Corporation Infusion pump
US5100389A (en) 1988-06-21 1992-03-31 Vaillancourt Vincent L Ambulatory infusion pump
EP0513299B1 (fr) 1990-11-29 1995-05-24 ANSCHÜTZ & CO. GmbH Pompe a perfusion implantable
WO1993020864A1 (fr) * 1992-04-10 1993-10-28 Novo Nordisk A/S Pompe d'infusion
US6095757A (en) * 1995-07-10 2000-08-01 Compagnie Developpement Aguettant Liquid drug infusion pump
EP0916353A1 (fr) 1997-01-10 1999-05-19 Japan Servo Co. Ltd. Appareil de transport de liquides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021083496A (ja) * 2019-11-25 2021-06-03 ミネベアミツミ株式会社 シリンジポンプ
JP7449680B2 (ja) 2019-11-25 2024-03-14 ミネベアミツミ株式会社 シリンジポンプ

Also Published As

Publication number Publication date
DE10120543A1 (de) 2002-11-07
DE20122407U1 (de) 2005-09-15
DE202005008808U1 (de) 2005-09-15

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