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WO2002085368A3 - Utilisation de composes antiradicalaires dans le traitement et la prevention de troubles de la microcirculation no-dependants - Google Patents

Utilisation de composes antiradicalaires dans le traitement et la prevention de troubles de la microcirculation no-dependants Download PDF

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Publication number
WO2002085368A3
WO2002085368A3 PCT/EP2002/004129 EP0204129W WO02085368A3 WO 2002085368 A3 WO2002085368 A3 WO 2002085368A3 EP 0204129 W EP0204129 W EP 0204129W WO 02085368 A3 WO02085368 A3 WO 02085368A3
Authority
WO
WIPO (PCT)
Prior art keywords
microcirculation disorders
treatment
human
prevention
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/004129
Other languages
English (en)
Other versions
WO2002085368A2 (fr
Inventor
Wolfgang Eisert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to MXPA03009506A priority Critical patent/MXPA03009506A/es
Priority to NZ529115A priority patent/NZ529115A/en
Priority to AU2002338396A priority patent/AU2002338396B2/en
Priority to JP2002582941A priority patent/JP2004525979A/ja
Priority to EP02764059A priority patent/EP1389112A2/fr
Priority to HU0303754A priority patent/HUP0303754A3/hu
Priority to IL15809102A priority patent/IL158091A0/xx
Priority to CA002444370A priority patent/CA2444370A1/fr
Publication of WO2002085368A2 publication Critical patent/WO2002085368A2/fr
Publication of WO2002085368A3 publication Critical patent/WO2002085368A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une méthode pour traiter un corps animal humain ou non humain par rapport à des troubles de la microcirculation NO-dépendants, par exemple des troubles de la microcirculation causés par des maladies métaboliques, comme des niveaux élevés de réactions inflammatoires à homocystine-homocystéine, ou par des maladies auto-immunes, à des troubles de la microcirculation périphérique ou à des troubles de la microcirculation associés à une fragmentation cellulaire élevée. Cette méthode consiste à administrer à un corps animal humain ou non humain nécessitant un tel traitement une quantité efficace d'une composition pharmaceutique contenant une substance anti-radicaux libres, telle qu'une pyrimido-pyrimidine choisie parmi Dipyridamole, Mopidamol et les sels de ceux-ci acceptables d'un point de vue pharmaceutique. La présente invention concerne également l'utilisation de cette substance pour produire une composition pharmaceutique correspondante, éventuellement en combinaison avec un agent capable d'augmenter la production de NO.
PCT/EP2002/004129 2001-04-20 2002-04-13 Utilisation de composes antiradicalaires dans le traitement et la prevention de troubles de la microcirculation no-dependants Ceased WO2002085368A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MXPA03009506A MXPA03009506A (es) 2001-04-20 2002-04-13 USO DE COMPUESTOS ELIMINADORES DE RADICALES PARA EL TRATAMIENTO Y PREVENCIoN DE TRASTORNOS DE LA MICRO-CIRCULACION DEPENDIENTES DE NO.
NZ529115A NZ529115A (en) 2001-04-20 2002-04-13 Use of probucol, ascorbic acid, vitamin E, dipyridamole and mopidamol for treatment and prevention of NO-dependent microcirculation disorders
AU2002338396A AU2002338396B2 (en) 2001-04-20 2002-04-13 Use of radical scavenging compounds for treatment and prevention of no-dependent microcirculation disorders
JP2002582941A JP2004525979A (ja) 2001-04-20 2002-04-13 Ｎｏ−依存性微小循環障害の治療及び予防のためのラジカル除去化合物の使用
EP02764059A EP1389112A2 (fr) 2001-04-20 2002-04-13 Utilisation de composes antiradicalaires dans le traitement et la prevention de troubles de la microcirculation no-dependants
HU0303754A HUP0303754A3 (en) 2001-04-20 2002-04-13 Use of radical scavenging compounds for preparation of pharmaceutical compsoition suitable for treatment and prevention of no-dependent microcirculation disorders
IL15809102A IL158091A0 (en) 2001-04-20 2002-04-13 Use of radical scavenging compounds for treatment and prevention of no-dependent microcirculation disorders
CA002444370A CA2444370A1 (fr) 2001-04-20 2002-04-13 Utilisation de composes antiradicalaires dans le traitement et la prevention de troubles de la microcirculation no-dependants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10119680A DE10119680A1 (de) 2001-04-20 2001-04-20 Verwendung von Radikalfänger-Verbindungen zur Behandlung und Verhinderung von no-abhängigen Störungen der Mikrozirkulation
DE10119680.6 2001-04-20

Publications (2)

Publication Number Publication Date
WO2002085368A2 WO2002085368A2 (fr) 2002-10-31
WO2002085368A3 true WO2002085368A3 (fr) 2003-02-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/004129 Ceased WO2002085368A2 (fr) 2001-04-20 2002-04-13 Utilisation de composes antiradicalaires dans le traitement et la prevention de troubles de la microcirculation no-dependants

Country Status (10)

Country Link
EP (1) EP1389112A2 (fr)
JP (1) JP2004525979A (fr)
AU (1) AU2002338396B2 (fr)
CA (1) CA2444370A1 (fr)
DE (1) DE10119680A1 (fr)
HU (1) HUP0303754A3 (fr)
IL (1) IL158091A0 (fr)
MX (1) MXPA03009506A (fr)
NZ (1) NZ529115A (fr)
WO (1) WO2002085368A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006084912A1 (fr) * 2005-02-11 2006-08-17 Nolabs Ab Dispositif, procede et utilisation destines a traiter une neuropathie impliquant l'oxyde nitrique
MD4341C1 (ro) * 2013-11-21 2015-11-30 Ион МЕРЕУЦЭ Sirop pentru tratamentul stărilor precanceroase gastrice
CN107106541A (zh) 2015-01-28 2017-08-29 瑞采生技有限公司 用于增强PPARγ表现及核转位之化合物及其医疗用途
CN113244395B (zh) * 2020-02-10 2024-07-23 广州市妇女儿童医疗中心 纤维化疾病机制及其治疗药物

Citations (8)

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Publication number Priority date Publication date Assignee Title
EP0457671A2 (fr) * 1990-05-14 1991-11-21 FIDIA S.p.A. Dipyridamide pour le traitement du système nerveux central ou périphérique
SU1711892A1 (ru) * 1989-01-06 1992-02-15 Московский медицинский стоматологический институт им.Н.А.Семашко Способ лечени диабетической ангиопатии
SU1711894A1 (ru) * 1989-08-08 1992-02-15 Детская Клиническая Больница N1 Способ лечени декомпенсированных форм стенозирующего ларинготрахеита у детей
EP0543653A1 (fr) * 1991-11-21 1993-05-26 Eli Lilly And Company Dipyridamole pour le traitement de maladies prolifératives
WO1995006470A1 (fr) * 1993-08-30 1995-03-09 Merck & Co., Inc. Prevention et traitement de la maladie d'alzheimer
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
WO2000067737A2 (fr) * 1999-05-07 2000-11-16 The Brigham And Women's Hospital, Inc. UTILISATION D'INHIBITEURS DE HMGCoA REDUCTASE POUR LA PREVENTION DE MALADIES DONT LA PATHOGENESE DEPEND D'UNE NEOFORMATION DE VAISSEAUX SANGUINS
EP1093814A1 (fr) * 1999-10-22 2001-04-25 Boehringer Ingelheim Pharma KG Utilisation du dipyridamole ou du mopidamol dans la fabrication d'un médicament pour le traitement et la prévention des troubles de la microcirculation dépendants de la fibrine

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1711892A1 (ru) * 1989-01-06 1992-02-15 Московский медицинский стоматологический институт им.Н.А.Семашко Способ лечени диабетической ангиопатии
SU1711894A1 (ru) * 1989-08-08 1992-02-15 Детская Клиническая Больница N1 Способ лечени декомпенсированных форм стенозирующего ларинготрахеита у детей
EP0457671A2 (fr) * 1990-05-14 1991-11-21 FIDIA S.p.A. Dipyridamide pour le traitement du système nerveux central ou périphérique
EP0543653A1 (fr) * 1991-11-21 1993-05-26 Eli Lilly And Company Dipyridamole pour le traitement de maladies prolifératives
WO1995006470A1 (fr) * 1993-08-30 1995-03-09 Merck & Co., Inc. Prevention et traitement de la maladie d'alzheimer
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
WO2000067737A2 (fr) * 1999-05-07 2000-11-16 The Brigham And Women's Hospital, Inc. UTILISATION D'INHIBITEURS DE HMGCoA REDUCTASE POUR LA PREVENTION DE MALADIES DONT LA PATHOGENESE DEPEND D'UNE NEOFORMATION DE VAISSEAUX SANGUINS
EP1093814A1 (fr) * 1999-10-22 2001-04-25 Boehringer Ingelheim Pharma KG Utilisation du dipyridamole ou du mopidamol dans la fabrication d'un médicament pour le traitement et la prévention des troubles de la microcirculation dépendants de la fibrine

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DIABETOLOGIA. GERMANY DEC 2001, vol. 44, no. 12, December 2001 (2001-12-01), pages 2165 - 2170, ISSN: 0012-186X *
KAISER H J ET AL: "SHORT-TERM EFFECT OF DIPYRIDAMOLE ON BLOOD FLOW VELOCITIES IN THE EXTRAOCULAR VESSELS", INTERNATIONAL OPHTHALMOLOGY,NL,NIJHOFF/JUNK, DORDRECHT, vol. 19, no. 6, 1 January 1996 (1996-01-01), pages 355 - 358, XP000650843, ISSN: 0165-5701 *
MARMONT AM ET AL: "Thrombotic thrombocytopenic purpura successfully treated with a combination of dipyridamole and aspirin.", HAEMATOLOGICA, APR 1980, 65 (2) P222-31, ITALY, XP002130770 *
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Also Published As

Publication number Publication date
AU2002338396B2 (en) 2007-10-18
DE10119680A1 (de) 2002-11-14
MXPA03009506A (es) 2004-02-12
HUP0303754A3 (en) 2006-02-28
CA2444370A1 (fr) 2002-10-31
EP1389112A2 (fr) 2004-02-18
NZ529115A (en) 2005-08-26
WO2002085368A2 (fr) 2002-10-31
IL158091A0 (en) 2004-03-28
JP2004525979A (ja) 2004-08-26
HUP0303754A2 (hu) 2004-03-01

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