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WO2002083033A2 - Systeme de lentille intraoculaire - Google Patents

Systeme de lentille intraoculaire Download PDF

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Publication number
WO2002083033A2
WO2002083033A2 PCT/US2002/011956 US0211956W WO02083033A2 WO 2002083033 A2 WO2002083033 A2 WO 2002083033A2 US 0211956 W US0211956 W US 0211956W WO 02083033 A2 WO02083033 A2 WO 02083033A2
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WO
WIPO (PCT)
Prior art keywords
lens
frame
center
optical element
lens system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/011956
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English (en)
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WO2002083033A3 (fr
Inventor
Jin Hui Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
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Vanderbilt University
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Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Priority to AU2002307341A priority Critical patent/AU2002307341A1/en
Priority to US10/474,988 priority patent/US20040158322A1/en
Publication of WO2002083033A2 publication Critical patent/WO2002083033A2/fr
Publication of WO2002083033A3 publication Critical patent/WO2002083033A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648—Multipart lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1632—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing radial position, i.e. perpendicularly to the visual axis when implanted

Definitions

  • the present invention generally relates to an intraocular lens system. More particularly, the present invention relates to an intraocular lens system that has an adjustable focal length responsive to changes of the diameter of the lens capsule
  • Accommodation or a change in the focus of the human lens, is a consequence of the ability of the lens to change its shape by contracting the capsule. This contraction function is what normally changes the shape of lens capsule in response to the need to accommodate.
  • the crystalline lens is one of the main optical elements in human vision. It provides the focus adjustment function in the eye.
  • the lens 100 has a capsule 102 and lens substance 104.
  • the lens 100 is suspended by zonules 106 from the ciliary processes 108. Normally, when the lens 100 is at a non-accommodating condition as shown in Fig. 1(A), which means the eye is focused at a distance, the ciliary muscle 108 is at a relaxed condition.
  • the shape of the lens 100 is relatively flat, which is determined by its own natural elasticity, and the lens 100 now has a lower focal power.
  • the ciliary muscle 108 contracts, and the lens 100 tends to accommodate.
  • the lens 100 has to increase its thickness.
  • the anterior surface of the lens 100 becomes more convex axially, and the posterior surface of the lens 100 also becomes more convex. Consequently, a higher focal power for the lens 100 is created.
  • Fig. 2 by Fincham, Brit. J. Ophthal, 35,381 (1951), J. Physiol, 128, 99 (1955), and Vision Res., 1,425 (1962), shows presbyopic changes in the amplitude of accommodation due to changes with age in the lens.
  • a typical procedure for a cataract surgery includes providing a opening at limbus, removal of the front portion of the lens capsule, ultrasonic fragmentation of the hard lens substance (nucleus), and implantation of an artificial intraocular lens.
  • Intraocular lenses are high optical quality lenses made of synthetic material such as PMMA, silicone, hydrogel or the like.
  • the diameter of an IOL is normally 5 to 7 mm, and the lens dioptric power is matched to the need of the patient.
  • Each IOL has two spring-like haptics, or loops, attached to the optic. When the IOL is inserted inside the lens capsule, the haptics help to position the optic lens in the center.
  • Haptics material are PMMA, polypropylene, or polyamide.
  • haptics material are PMMA, polypropylene, or polyamide.
  • There are varieties of haptic designs among different IOLs Some of the configurations are show in Fig. 3.
  • IOL 301 has optic 302 and haptics 304, where haptics 304 are J-shaped loops.
  • IOL 311 has haptics that are C-shaped loops
  • IOL 321 has haptics that are lone J-shaped loops
  • IOL 331 has haptics that are closed
  • a major disadvantage is the loss of accommodative capability that a natural lens can offer because the artificial intraocular lens has a fixed focusing power.
  • the normal procedure for this technique includes the steps of removing the crystalline lens through a small anterior capsular hole, and refilling the capsular bag with either pre-cured silicone gel, or an inflatable endocapsular balloon. All of these studies showed that the refilled lens recovered accommodation to some extent, but the amount was not sufficient to be clinically useful.
  • Bifocal or multifocal intraocular lens Bifocal or multifocal intraocular lens.
  • Bifocal or multifocal IOLs were first introduced clinically in 1987 by Keates et al. as shown in Keates R.H., Pearce J.L., Schneider R.T: Clinical results of the multifocal lens, J. Cataract Refract Surg. 13:557- 560, 1987.
  • multifocal IOL have been developed, including the multizone bifocal lens, as shown in Percival P., Indications for the multizone bifocal implant, J. Cataract Refract Surg.
  • Giardini P. Pseudoaccommodation with the 3M diffractive multifocal intraocular lens: A refraction study of 52 subjects.
  • Dr. Findl' s IOL design a fixed focus lens 402 is held by two pieces 404, 406 of ridged plastic holder, and the connection 408 between each plastic holder 404 or 406 and the lens 402 is flexible.
  • the IOL 400 will move forward.
  • up to 2.5D of the accommodation has been achieved. Still, no full scale of accommodation is available.
  • the present invention relates to an intraocular lens system for implantation in an eye having a lens capsule and lens substance contained in the lens capsule.
  • the intraocular lens system has a frame having a center, a first optical element with a focal power and a second optical element with a focal power.
  • the first optical element has a center, a surface and an edge, wherein the first optical element is coupled to the frame at its edge such that the center of the first optical element is at a distance from the center of the frame.
  • the second optical element has a center, a surface and an edge, wherein the second optical element is coupled to the frame at its edge such that the center of the second optical element is at a distance from the center of the frame.
  • the first optical element and the second optical element at a predetermined state are positioned such that the distance between the first optical element and the center of the frame and the distance between the second optical element and the center of the frame are substantially same, and the surfaces of the first optical element and the second optical element partially overlap to form a combined lens with an effective focal power that is different from either of the focal power of the first optical element and the focal power of the second optical element.
  • the frame is elastic and adapted to be in contact with the lens capsule of the eye.
  • the motion of the frame causes the first optical element and the second optical element to move toward the center of the frame from the first predetermined state to a second predetermined state in which the first optical element and the second optical element are substantially overlapping to each other so as to be substantially concentric with the center of the frame to form a combined lens with an effective focal power that is different from the effective focal power of the combined lens at the first predetermined state.
  • the effective focal power of the combined lens at the second predetermined state is larger than the effective focal power of the combined lens at the first predetermined state.
  • the frame can have various configurations.
  • the frame can comprise a closed-loop structure.
  • the closed-loop structure can be symmetrical to the center of the frame.
  • the frame is an annular structure.
  • the frame is a multi-round-cornered structure.
  • the frame can comprise an open-loop structure.
  • the intraocular lens system further includes an optional supporting portion that is attached to the frame.
  • the supporting portion has a first end, a second end, and a surface defined between the first end and the second end, wherein the surface of the supporting portion has a curvature corresponding to the curvature of the lens capsule so as to allow the supporting portion to be positioned between the lens capsule and the frame.
  • the first optical component comprises a lens that has a thickness.
  • the surface of the lens varies as a mathematical function of the distance from the center of the lens.
  • the mathematical function can be a Gaussian distribution, a distribution that can be represented by a spherical-harmonic approximation or the like.
  • the second optical component comprises a lens that has a thickness.
  • the surface of the lens varies as a mathematical function of the distance from the center of the lens.
  • the mathematical function can be a Gaussian distribution, a distribution that can be represented by a spherical-harmonic approximation or the like.
  • the lens utilized to practice the present invention may further have a ridged edge portion, where the dimension of the ridged portion is comparable to the thickness of the lens so that when the first optical component and the second optical component overlap to each other, the ridged portions of the lenses are in contact to avoid the optical sensitive portions of the lenses to rub against each other.
  • the lenses utilized to practice the present invention in one intraocular lens system can be different, they are chosen to be substantially identical to each other for the embodiments disclosed in this specification.
  • the present invention relates to an intraocular lens system for implantation in an eye having a lens capsule and lens substance contained in the lens capsule.
  • the intraocular lens system includes a frame having a center and a plurality of lenses.
  • Each of the plurality of lenses has a center, a surface and an edge, wherein the surface of each lens varies as a Gaussian function of the distance from the center of the lens.
  • Each of the plurality of lenses is coupled to the frame at the edge such that the center of each lens is at a distance from the center of the frame, wherein the plurality of lenses at a first predetermined state are positioned such that the distances between the center of each lens and the center of the frame are substantially same, and the surfaces of the lenses partially overlap to form a combined lens with an effective focal power.
  • the frame is elastic and adapted to be in contact with the lens capsule of the eye.
  • the motion of the frame causes the plurality of the lenses to move toward the center of the frame from the first predetermined state to a second predetermined state in which the plurality of lenses are substantially overlapping to each other so as to be substantially concentric with the center of the frame to form a combined lens with an effective focal power that is different from the effective focal power of the combined lens at the first predetermined state.
  • the effective focal power of the combined lens at the second predetermined state is larger than the effective focal power of the combined lens at the first predetermined state.
  • the plurality of lenses is positioned such that the centers of the plurality of lenses are symmetrical about the center of the frame.
  • the total number of the plurality of lenses is N, wherein N is an integer that is not smaller than 2.
  • the present invention relates to an intraocular lens system for implantation in an eye having a lens capsule and lens substance contained in the lens capsule.
  • the intraocular lens system includes a frame having a center and a plurality of lenses, total number being N.
  • Each of the plurality of lenses has a center, a surface and an edge, wherein the surface of each lens varies as a mathematical function of the distance from the center of the lens.
  • Each of the plurality of lenses is coupled to the frame at the edge such that the center of each lens is at a distance from the center of the frame, wherein the plurality of lenses at a first predetermined state are positioned such that the distances between the center of each lens and the center of the frame are substantially same and the surfaces of the lenses partially overlap to form a combined lens with an effective focal power.
  • the frame is elastic and adapted to be in contact with the lens capsule of the eye.
  • the motion of the frame causes the plurality of the lenses to move toward the center of the frame from the first predetermined state to a second predetermined state in which the plurality of lenses are substantially overlapping to each other so as to be substantially concentric with the center of the frame to form a combined lens with an effective focal power that is different from the effective focal power of the combined lens at the first predetermined state.
  • the effective focal power of the combined lens at the second predetermined state is larger than the effective focal power of the combined lens at the first predetermined state.
  • the plurality of lenses is positioned such that the centers of the plurality of lenses are symmetrical about the center of the frame.
  • the total number of the plurality of lenses is N, wherein N is an integer that is not smaller than 2.
  • the surface of each lens varies as a mathematical function of the distance from the center of the lens, wherein the mathematical function can be a Gaussian distribution, a distribution that can be represented by a spherical-harmonic approximation, a distribution that is symmetrically decreasing with the distance from the center of lens or the like.
  • the present invention relates to an intraocular lens system for implantation in an eye having a lens capsule and lens substance contained in the lens capsule.
  • the focal length of the combined lens can change with the change of the eccentric distance in response to the change in the diameter of the lens capsule, which in turn may generate the accommodation effect.
  • an intraocular lens system according to the present invention can have a plurality of lenses each having a surface curvature other than a Gaussian surface curvature such as sine, cosine, exponential or the like.
  • Fig. 1 is a perspective view of (A) an unaccommodated lens; and (B) an accommodated lens.
  • Fig. 2 is a chart showing presbyopic changes in the amplitude of accommodation due to changes with age in the lens.
  • Fig. 3 illustrates several configurations of the IOL in the prior art.
  • Fig. 4 illustrates an accommodative intraocular lens studied by Oliver Findl. Up to 2.5 diopter of accommodative power has been reported.
  • Fig. 5 illustrates an IOL that has six eccentric lenses partially overlapping to form a combined lens in one embodiment of the present invention.
  • Fig. 6 shows that a combined lens having concentric overlapped lenses at pressed state have more focus power than a combined lens having eccentric overlapped lenses at a relaxed state in one embodiment of the invention.
  • Fig. 6A schematically shows an IOL according to one embodiment of the present invention.
  • Fig. 7 illustrates the surface of an optical lens that can be utilized to practice the present invention.
  • Fig. 8 illustrates an IOL having symmetrically overlapped six lenses with the off-center distance of D in one embodiment of the invention.
  • Fig. 9 shows a profile of a single Gaussian lens with t m
  • Fig. 11 illustrates an experimental set up for measuring the force to move the
  • Gaussian lenses the required distance employed in one embodiment of the invention.
  • Fig. 12 shows cross-sectionally an IOL positioned in the lens capsule, in one embodiment of the present invention.
  • Fig. 13 illustrates an optical lens that prevents the central portion of the lens from rub each other: (A) a perspective view of the ridged ring edge; (B) a perspective view of the optical lens with a frame; (C) a cross-sectional view of the optical lens with the ridged edge portion; and (D) a top view of (C) according to one embodiment of the present invention.
  • an intraocular lens system 600 for implantation in an eye having a lens capsule and lens substance contained in the lens capsule.
  • an intraocular lens system 600 has a frame 601 having a center O, a first optical element 602 with a focal power and a second optical element 604 with a focal power.
  • the first optical element 602 has a center Ofact a surface 621 and an edge 623.
  • the first optical element 602 is coupled to the frame 601 at its edge 623 at a position 603 such that the center of the first optical element 602, O,, is at a distance, D,, from the center of the frame 601, O.
  • the first optical element 602 is positioned eccentrically from the center of the frame 601, O at a distance D,.
  • the second optical element 604 has a center 0 2 , a surface 641 and an edge 643.
  • the second optical element 604 is coupled to the frame 601 at its edge at a position 605 such that the center of the second optical element 604, O 2 , is at a distance, D 2 , from the center of the frame 601, O.
  • the second optical element 604 is positioned eccentrically from the center of the frame 601 , O at a distance D 2 .
  • the first optical element 602 and the second optical element 604 are positioned in a configuration corresponding to a first predetermined state such that the distance D t between the first optical element 602 and the center of the frame 601 and the distance D 2 between the second optical element 604 and the center of the frame 601 are substantially same to a distance D.
  • the surface 621 of the first optical element 602 and the surface 641 of the second optical element 604 partially overlap to form a combined, or an effective, lens 600A with an effective focal power that is different from either of the focal power of the first optical element 602 and the focal power of the second optical element 604.
  • the combined lens 600 can be characterized by a thickness T A and a length L A , in addition to the effective focal power.
  • the first predetermined state thus is corresponding to a state where both, or at least one, of the first optical element 602 and the second optical element 604 are positioned eccentrically from the center of the frame 601, O.
  • the intraocular lens system 600A at this state is in a relaxed state.
  • the frame 601 is elastic and adapted to be in contact with the lens capsule of the eye.
  • the frame 601 can be chosen in a shape to fit to lens capsule equator so that the frame 601 and the lens capsule of the eye are closely in contact to each other.
  • the lens capsule presses the frame 601 in a direction toward to the center of frame, O.
  • the motion of the frame 601 causes the first optical element 602 and the second optical element 604 to move toward the center of the frame 601, O, from the first predetermined state to a second predetermined state, or a pressed state.
  • a pressed state as shown in Fig.
  • the first optical element 602 and the second optical element 604 are substantially overlapping to each other so as to be substantially concentric with the center of the frame 601 to form a combined lens 600B with an effective focal power that is different from the effective focal power of the combined lens 600A at the first predetermined state.
  • the combined lens 600B can be characterized by a thickness T B and a length L B , in addition to the effective focal power.
  • the thickness T B of the combined lens 600B at the pressed state is greater than the thickness T A of the combined lens 600 A at the relaxed state, and the length L B of the combined lens 600B at the pressed state is smaller than the thickness L A of the combined lens 600 A at the relaxed state.
  • the effective focal power of the combined lens 600B at the second predetermined state is larger than the effective focal power of the combined lens 600A at the first predetermined state, which allows the intraocular lens system 600 to be able to offer accommodation.
  • the first optical component 602 comprises a lens that has a thickness T,.
  • the surface 621 of the lens 602 varies as a mathematical function of the distance from the center of the lens.
  • the mathematical function can be a Gaussian distribution, a distribution that can be represented by a spherical-harmonic approximation, a distribution that is symmetrically decreasing with the distance from the center of lens as curves 712, 714 shown in Fig. 7 or the like.
  • the second optical component 604 comprises a lens that has a thickness T 2 .
  • the surface 641 of the lens 604 varies as a mathematical function of the distance from the center of the lens.
  • the mathematical function can be a Gaussian distribution, a distribution that can be represented by a spherical-harmonic approximation, a distribution that is symmetrically decreasing with the distance from the center of lens as curves 712, 714 shown in Fig. 7 or the like.
  • a Gaussian distribution a distribution that can be represented by a spherical-harmonic approximation
  • lenses with surfaces varying as a Gaussian distribution will be discussed in more detail below.
  • the frame 601 can have various configurations.
  • the frame 601 can be a closed-loop structure.
  • the closed-loop structure can be symmetrical to the center of the frame 601, O.
  • the frame 601 can be an annular or ring structure.
  • the frame 601 can be a multi-round-cornered structure.
  • the frame can be an open-loop structure.
  • an intraocular lens system 1200 has a first optical element 1210A and a second optical element 1210B positioned in a relaxed state.
  • the intraocular lens system 1200 further has a frame 1212 to which the first optical element 1210A and the second optical element 1210B are attached.
  • the frame 1212 is configured to fit into the lens capsule equator 102'.
  • the intraocular lens system 1200 has an optional supporting portion 1230 attached to the frame 1212.
  • the supporting portion 1236 has a first end 1232, a second end 1234, and a surface 1236 defined between the first end 1232 and the second end 1234.
  • the surface 1236 of the supporting portion 1230 has a curvature corresponding to the curvature of the lens capsule equator 102' so as to allow the supporting portion to be positioned between the lens capsule and the frame 1212.
  • the supporting portion 1230 thus can be utilized to hold the lens capsule open and provide a better fit between the intraocular lens system 1200 and the lens capsule.
  • Additional supporting portions can be introduced for each of additional optical elements.
  • an additional optional supporting portion 1240 attached to the frame 1212 is introduced.
  • the supporting portion 1240 has a first end 1242, a second end 1244, and a surface 1246 defined between the first end 1242 and the second end 1244.
  • the surface 1246 of the supporting portion 1240 has a curvature corresponding to the curvature of the lens capsule equator 102' so as to allow the supporting portion to be positioned between the lens capsule and the frame 1212.
  • the intraocular lens system 500 for implantation in an eye having a lens capsule and lens substance contained in the lens capsule is shown.
  • the intraocular lens system 500 has a frame 512 having a center, O, and a plurality of lenses 510.
  • the total number of the plurality of lenses 510 is an integer N.
  • N can be any number equal to or grater than 2.
  • N is chosen as six (6).
  • the intraocular lens system 500 has lenses 510A, 510B, 510C, 510D, 510E, and 51 OF.
  • Each of the plurality of lenses has a center, a surface and an edge, wherein the surface of each lens varies as mathematical function such as a Gaussian function of the distance from the center of the lens, being coupled to the frame 512 at the edge such that the center of each lens is at a distance from the center 0 of the frame 512.
  • lens 510A has a center Ofact a surface 516A and an edge 514A.
  • Lens 510A is coupled to the frame 512 at the edge 514A at a position 511 A such that the center of lens 510A, O, is at a distance from the center of the frame 512, O.
  • the plurality of lenses 510 at a first predetermined state, or relaxed state, are positioned such that the distances between the center of each lens and the center of the frame 512 are substantially same, and the surfaces of the lenses 510 partially overlap to form a combined lens 500 with an effective focal power.
  • Fig. 8 schematically shows six (6) lenses 802 with a center Oon 804 with a center O 2 , 806 with a center O 3 , 808 with a center O 4 , 810 with a center O 5 , and 812 with a center O 6 that are eccentrically and symmetrically positioned about the center O with an eccentric distance D.
  • the frame 512 is elastic and adapted to be in contact with and responsive to the lens capsule of the eye.
  • the frame 512 can have various configurations.
  • the frame 512 is a closed-loop structure that has a multi- round-corners 513 A, 513B, 513C, 513D, 513E and 513F.
  • One advantage of the multi- round-corners structure is that it allows less contact between the frame 512 and the lens capsule of the eye, which may be more suitable to people having sensitive eyes, for instance.
  • the motion of the frame 512 causes the plurality of the lenses to move toward the center of the frame 512 from the first determined state to a second predetermined state, or pressed state, in which the plurality of lenses 510A, 510B, 510C, 510D, 510E, and 51 OF are substantially overlapping to each other so as to be substantially concentric with the center of the frame 512 to form a combined lens with an effective focal power that is different from the effective focal power of the combined lens 500 at the first predetermined state.
  • the effective focal power of the combined lens 500 at the second predetermined state is larger than the effective focal power of the combined lens 500 at the first predetermined state that provides accommodation. If more lenses are introduced, the range of accommodation the intraocular lens system can offer is increased.
  • the intraocular lens system 1000 for implantation in an eye having a lens capsule and lens substance contained in the lens capsule is schematically shown.
  • the intraocular lens system 1000 has a frame 1012 having a center, O, and a plurality of lenses 1010.
  • the total number of the plurality of lenses 510 is an integer N.
  • N can be any number equal to or grater than 2.
  • N is chosen as six (6).
  • the intraocular lens system 1000 has lenses 1010A, 1010B, 1010C, 1010D, 1010E, and 1010F.
  • Each of the plurality of lenses has a center, a surface and an edge, wherein the surface of each lens varies as a mathematical function of the distance from the center of the lens, being coupled to the frame 1012 at the edge such that the center of each lens is at a distance from the center O of the frame 1012.
  • the intraocular lens system 1000 has a frame 1012 that is annular.
  • the intraocular lens system 100 has a frame 1012 that is annular.
  • One advantage of the annular structure is that it allows more contact between the frame 1012 and the lens capsule of the eye. Moreover, it is stable and easy to make.
  • each lens is coupled to the frame 1012 through an elastic thin wire, which allows some mobility capacity for the corresponding lens.
  • lens 1010A is coupled to the frame 1012 through an elastic thin wire 1014A.
  • a lens can be coupled to the frame through wire, by gluing, by molding, or the like methods know to people skilled in the art.
  • the mathematical function can be a Gaussian distribution, a distribution that can be represented by a spherical-harmonic approximation, a distribution that is symmetrically decreasing with the distance from the center of lens, or the like.
  • the focal power in diopter would be:
  • the peak height of the Gaussian function is 21 ⁇ m, and the Gaussian function above 5% of the peak height spread about 4 mm in diameter as curve 911 shown in Fig. 9. If one adds 80 ⁇ m base thickness to this Gaussian function, then the thickness of each Gaussian lens would be only 100 ⁇ m.
  • the focal power of the combined intraocular lens system i.e., when the lenses at the pressed state, is given by:
  • the present invention provides an intraocular lens system that can offer accommodation to a range that no one else has been able to offer.
  • a measuring system 1101 can be utilized to measure the force to move the lenses 1110A, 1110B, 11 IOC, 1110D, 1110E and 111 IE in an IOL 1100 having frame 1112 the required distance(s) for a specific accommodation.
  • the measuring system 1101 has a measuring device for each lens.
  • the measuring system 1100 has spring 1120A, wheel 1122 A, and weight 1124 A for optical lens 1110A.
  • Optical ray tracing program can be utilized to precisely design the intraocular lens system according to the present invention.
  • the image quality at different overlap conditions, and with different parameter selections can be analyzed.
  • the dioptic change of the intraocular lens system versus overlapping of the Gaussian lenses, as well as the best parameters for customizing the Gaussian lenses can also be determined.
  • Rot curvatures such as sine, cosine, exponential, harmonics, or the like may also be calculated and/or utilized to compare with the Gaussian curve, so that one can determine which curve is likely to maximum accommodation.
  • Materials like PMMA can be used as the lens material.
  • a computer-controlled diamond-turning machine can be used to fabricate the mold for molding the lenses. After the mold is made, large numbers of lenses can be manufactured by a heat- compressing procedure. This can be done through commercialized industrial services, such as Argus International, Ltd., at Scotts Valley, California.
  • Polypropylene, or polyamide can be utilized as the elastic frame material.
  • Medical grade epoxy can be used to glue the lenses to the elastic frame.
  • Heat compressing can also be utilized to couple the lenses to the frame.
  • different or alternate frame configurations can be designed and utilized to couple the lenses to the frame. For example, as discussed above, an alternative configuration utilizing a thin wire is shown at Fig. 10 according to another embodiment of the invention.
  • a potential problem for the intraocular lens systems according to the present invention is that when neighboring optical elements or lenses are overlapping to each other to form a combined lens, surfaces of the lenses that are optical sensitive may be negatively affected due to rubbing, scratching and or pressing among them due to direct contact.
  • Various options can be chosen, individually or in combination, to solve the problem. For example, proper lubrication can be applied to the surface of each lens.
  • optional structure may be introduced as well.
  • a lens 1310 can be utilized to practice the present invention as a choice for optical elements.
  • the lens 1310 has a thickness L and an optical surface 1312.
  • the lens 1310 also has a peripheral frame 1348.
  • a ridged edge portion 1340 has a first end 1342 and a second end 1344 defining a channel 1346 therebetween.
  • the dimension of the channel 1346 is corresponding to that of the peripheral frame 1348 so that the peripheral frame 1348 can be received therein as best shown in Fig. 13C.
  • the ridged edge portion 1340 is characterized by a dimension R that is no smaller than the thickness L of the lens 1310.
  • the ridged edge portion 1340 can be made from different materials and have different configurations.
  • the ridged edge portion 1340 can comprise a strip made from elastic material compatible to the lens. Note that the strip should be narrow, and positioned only on the periphery of the lens so that they will not have significant influence on the refractive power of the intraocular lens system.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un système de lentille intraoculaire, destiné à être implanté dans un oeil et composé d'une capsule de lentille et d'une substance contenue dans cette capsule. Dans un mode de réalisation, le système de lentille intraoculaire a une monture dotée d'un centre, d'un premier élément optique développant une puissance optique et d'un deuxième élément optique développant une puissance optique. Le premier élément optique, qui comprend un centre, une surface et un bord, est solidaire de la monture par son bord, de sorte que le centre dudit élément est écarté du centre de la monture. Le deuxième élément optique, qui comprend un centre, une surface et un bord, est solidaire de la monture par son bord, de sorte que le centre dudit élément est écarté du centre de la monture. Dans un état défini, le premier et le deuxième élément optique sont positionnés de manière à ce que la distance entre le premier élément et le centre de la monture, d'une part, et le deuxième élément et le centre de la monture, d'autre part, est sensiblement la même, les surfaces des deux éléments optiques se chevauchant partiellement pour former une lentille combinée, dont la puissance optique est différente de celle de chacun des éléments optiques.
PCT/US2002/011956 2001-04-17 2002-04-17 Systeme de lentille intraoculaire Ceased WO2002083033A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002307341A AU2002307341A1 (en) 2001-04-17 2002-04-17 Intraocular lens system
US10/474,988 US20040158322A1 (en) 2002-04-17 2002-04-17 Intraocular lens system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28435901P 2001-04-17 2001-04-17
US60/284,359 2001-04-17

Publications (2)

Publication Number Publication Date
WO2002083033A2 true WO2002083033A2 (fr) 2002-10-24
WO2002083033A3 WO2002083033A3 (fr) 2003-08-21

Family

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PCT/US2002/011956 Ceased WO2002083033A2 (fr) 2001-04-17 2002-04-17 Systeme de lentille intraoculaire

Country Status (2)

Country Link
AU (1) AU2002307341A1 (fr)
WO (1) WO2002083033A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007020184A1 (fr) 2005-08-16 2007-02-22 Forschungszentrum Karlsruhe Gmbh Systeme d'accommodation artificiel
DE102007008374A1 (de) 2007-02-21 2008-08-28 Forschungszentrum Karlsruhe Gmbh Implantierbares System zur Bestimmung des Akkommodationsbedarfes durch Messung der Augapfelorientierung unter Nutzung eines externen Magnetfelds
WO2009138468A1 (fr) 2008-05-15 2009-11-19 Karlsruhe Institute Of Technology Système implantable pour restaurer la capacité d'accommodation par utilisation d'énergie interne
DE102009059229A1 (de) 2009-12-18 2011-06-22 Karlsruher Institut für Technologie, 76131 Implantierbares System zur Bestimmung des Akkommodationsbedarfs
WO2013136105A1 (fr) 2012-03-12 2013-09-19 Doci Innovations GmbH Lentille intraoculaire ayant des haptiques hélicoïdaux en matériaux à mémoire de forme

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906245A (en) * 1987-08-24 1990-03-06 Grendahl Dennis T Multiple element zone of focus artificial hydrogel lens
US5260727A (en) * 1990-10-22 1993-11-09 Oksman Henry C Wide depth of focus intraocular and contact lenses
US5507806A (en) * 1994-05-13 1996-04-16 Pharmacia Iovision, Inc. Multi-faceted intraocular lens
US5965330A (en) * 1996-12-06 1999-10-12 Pbh, Inc. Methods for fabricating annular mask lens having diffraction-reducing edges

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007020184A1 (fr) 2005-08-16 2007-02-22 Forschungszentrum Karlsruhe Gmbh Systeme d'accommodation artificiel
US8043370B2 (en) 2005-08-16 2011-10-25 Forschungszentrum Karlsruhe Gmbh Optical device for restoring accommodative capacity of the eye
DE102007008374A1 (de) 2007-02-21 2008-08-28 Forschungszentrum Karlsruhe Gmbh Implantierbares System zur Bestimmung des Akkommodationsbedarfes durch Messung der Augapfelorientierung unter Nutzung eines externen Magnetfelds
DE102007008374B4 (de) * 2007-02-21 2008-11-20 Forschungszentrum Karlsruhe Gmbh Implantierbares System zur Bestimmung des Akkommodationsbedarfes durch Messung der Augapfelorientierung unter Nutzung eines externen Magnetfelds
WO2009138468A1 (fr) 2008-05-15 2009-11-19 Karlsruhe Institute Of Technology Système implantable pour restaurer la capacité d'accommodation par utilisation d'énergie interne
DE102008023726A1 (de) 2008-05-15 2009-12-03 Forschungszentrum Karlsruhe Gmbh Implantierbares System zur Herstellung der Akkommodationsfähigkeit unter Nutzung interner Energie
US8425598B2 (en) 2008-05-15 2013-04-23 Karlsruher Institut Fuer Technologie Implantable system for restoring accommodation capacity using internal energy
DE102009059229A1 (de) 2009-12-18 2011-06-22 Karlsruher Institut für Technologie, 76131 Implantierbares System zur Bestimmung des Akkommodationsbedarfs
WO2011080107A2 (fr) 2009-12-18 2011-07-07 Karlsruher Institut für Technologie Système implantable servant à déterminer la demande en accommodation
WO2013136105A1 (fr) 2012-03-12 2013-09-19 Doci Innovations GmbH Lentille intraoculaire ayant des haptiques hélicoïdaux en matériaux à mémoire de forme
US9381081B2 (en) 2012-03-12 2016-07-05 Doci Innovations GmbH (Claus Simandi) Intraocular lens having helical haptics of shape memory

Also Published As

Publication number Publication date
WO2002083033A3 (fr) 2003-08-21
AU2002307341A1 (en) 2002-10-28

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