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WO2002079414A3 - Transgenic mice containing clcn7 chloride channel gene disruptions - Google Patents

Transgenic mice containing clcn7 chloride channel gene disruptions Download PDF

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Publication number
WO2002079414A3
WO2002079414A3 PCT/US2002/009646 US0209646W WO02079414A3 WO 2002079414 A3 WO2002079414 A3 WO 2002079414A3 US 0209646 W US0209646 W US 0209646W WO 02079414 A3 WO02079414 A3 WO 02079414A3
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
chloride channel
mice containing
gene disruptions
channel gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/009646
Other languages
French (fr)
Other versions
WO2002079414A8 (en
WO2002079414A2 (en
Inventor
Keith D Allen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deltagen Inc
Original Assignee
Deltagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc filed Critical Deltagen Inc
Priority to AU2002306942A priority Critical patent/AU2002306942A1/en
Publication of WO2002079414A2 publication Critical patent/WO2002079414A2/en
Publication of WO2002079414A8 publication Critical patent/WO2002079414A8/en
Publication of WO2002079414A3 publication Critical patent/WO2002079414A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a CLCN7 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
PCT/US2002/009646 2001-03-29 2002-03-29 Transgenic mice containing clcn7 chloride channel gene disruptions Ceased WO2002079414A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002306942A AU2002306942A1 (en) 2001-03-29 2002-03-29 Transgenic mice containing clcn7 chloride channel gene disruptions

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US28032401P 2001-03-29 2001-03-29
US60/280,324 2001-03-29
US32466401P 2001-09-24 2001-09-24
US60/324,664 2001-09-24
US10953602A 2002-03-28 2002-03-28
US10/109,536 2002-03-28

Publications (3)

Publication Number Publication Date
WO2002079414A2 WO2002079414A2 (en) 2002-10-10
WO2002079414A8 WO2002079414A8 (en) 2003-03-27
WO2002079414A3 true WO2002079414A3 (en) 2003-09-12

Family

ID=27380675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/009646 Ceased WO2002079414A2 (en) 2001-03-29 2002-03-29 Transgenic mice containing clcn7 chloride channel gene disruptions

Country Status (2)

Country Link
AU (1) AU2002306942A1 (en)
WO (1) WO2002079414A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062821A1 (en) * 2002-01-23 2003-07-31 Bristol-Myers Squibb Company Modulators of the clc-7 chloride channel and methods for their identification and use in the treatment and prevention of osteoporosis and related disease states
GB0227243D0 (en) * 2002-11-21 2002-12-31 Univ Aberdeen Genetic markers for bone mass
GB0525898D0 (en) 2005-12-20 2006-02-01 Pharmo Bioscience As Screening compounds for activity in modulating chloride ion transport
JP6795492B2 (en) * 2014-05-23 2020-12-02 ウニヴェルシタ デッリ ストゥディ デラクイア Short Interfering RNA (siRNA) for autosomal dominant osteopetrosis type 2 (ADO2) therapy caused by CLCN7 (ADO2 CLCN7 dependent) gene mutations

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BRANDT ET AL.: "CIC-6 and CIC-7 are two novel broadly expressed members of the CLC chloride channel family", FEBS LETTERS, vol. 377, no. 1, 11 December 1995 (1995-12-11), pages 15 - 20, XP002902613 *
CAPECCHI M.R.: "Targeted gene replacement", SCIENTIFIC AM., vol. 270, no. 3, March 1994 (1994-03-01), pages 34 - 41, XP002911711 *
DAVIDSON ET AL.: "The CF mouse: an important tool for studying cystic fibrosis", EXPERT REVIEWS IN MOLECULAR MEDICINE, 12 March 2001 (2001-03-12), pages 1 - 27, XP002964209, Retrieved from the Internet <URL:www-ermm.cbcu.cam.ac.uk/01002551a.pdf> *
GUNTHER ET AL.: "The CIC-5 chloride channel knock-out mouse - an animal model for Dent's disease", PFLUGERS ARCHIV. EUROPEAN J. OF PHYSIOLOGY, vol. 445, no. 4, January 2003 (2003-01-01), pages 456 - 462, XP002964210 *
KORNAK ET AL.: "Loss of the CIC-7 chloride channel leads to osteopetrosis in mice and man", CELL, vol. 104, 26 January 2001 (2001-01-26), pages 205 - 215, XP002902614 *
MANKODI ET AL.: "Myotonia is associated with loss of transmembrane chloride conductance and aberrant splicing of Clcn1, the skeletal muscule chloride channel, in a transgenic model of myotonic dystrophy", AM. J. HUMAN GENETICS, vol. 69, no. 4 SUPPLEMENT, October 2001 (2001-10-01), pages 211 ABSTRACT #180, XP002964211 *
MASON ET AL.: "Whole body analysis of the knockout gene mouse model for cystic fibrosis using thermal and fast neutron activation analysis", J. RADIOANALYTICAL AND NUCLEAR CHEM., vol. 236, no. 1-2, 1998, pages 107 - 112, XP002964205 *
NEHRKE ET AL.: "Loss of hyperpolarization-activated Cl-current in salivary acinar cells from Clcn2 knockout mice", J. BIOLOGICAL CHEM., vol. 277, no. 26, 28 June 2002 (2002-06-28), pages 23604 - 23611, XP002964208 *
RAI ET AL.: "Establishment of conditionally immortalized CIC-3 deficient epithelial cell line from small intestine of Clcn3-/-, H-2Kb-ts A58 double transgenic mice", J. AM. SOC. NEPHROLOGY, vol. 12, no. PROGRAM AND ABSTRACT ISSUE, September 2001 (2001-09-01), pages 39A ABSTRACT #A0203, XP002964212 *
UCHIDA ET AL.: "Physiological role of CLC-K1 chloride channel in the kidney", NEPHROL. DIAL. TRANSPLANT., vol. 15, no. SUPPL. 6, 2000, pages 14 - 15, XP002964207 *
YOSHIKAWA ET AL.: "CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis", GENES TO CELLS, vol. 7, no. 6, June 2002 (2002-06-01), pages 597 - 605, XP002964206 *

Also Published As

Publication number Publication date
AU2002306942A1 (en) 2002-10-15
WO2002079414A8 (en) 2003-03-27
WO2002079414A2 (en) 2002-10-10

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