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WO2002078834A3 - Procede et dispositif reposant sur l'emploi de capillaires en faisceau pour criblage a fort debit - Google Patents

Procede et dispositif reposant sur l'emploi de capillaires en faisceau pour criblage a fort debit Download PDF

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Publication number
WO2002078834A3
WO2002078834A3 PCT/US2002/005316 US0205316W WO02078834A3 WO 2002078834 A3 WO2002078834 A3 WO 2002078834A3 US 0205316 W US0205316 W US 0205316W WO 02078834 A3 WO02078834 A3 WO 02078834A3
Authority
WO
WIPO (PCT)
Prior art keywords
capillaries
methods
reaction
disclosed
capillary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/005316
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English (en)
Other versions
WO2002078834A2 (fr
Inventor
Jianming Xiao
Shiping Chen
Yuling Luo
John Butler
Masoud Qazen
Jochen Thiele
Anthony Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GenoSpectra Inc
Original Assignee
GenoSpectra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/791,410 external-priority patent/US20020028160A1/en
Priority claimed from US09/791,411 external-priority patent/US20010055801A1/en
Application filed by GenoSpectra Inc filed Critical GenoSpectra Inc
Priority to AU2002255581A priority Critical patent/AU2002255581A1/en
Publication of WO2002078834A2 publication Critical patent/WO2002078834A2/fr
Publication of WO2002078834A3 publication Critical patent/WO2002078834A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G01N2035/1027—General features of the devices
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    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention concerne des systèmes et des procédés utilisés pour le criblage à fort débit de composés présentant une affinité pour une cible biologique. Le système repose sur l'emploi d'un faisceau de capillaires présentant deux extrémités distinctes, les capillaires étant reliés à une extrémité à des composés stockés dans des réservoirs séparés et étant reliés et traités à l'autre extrémité de manière à former un microréseau bidimensionnel. L'invention porte sur un faisceau de capillaires qui comportent à l'une de leurs extrémités des puits de réaction pour hybridation et réaction des composés. Les capillaires peuvent être photoconducteurs. L'invention concerne également divers procédés permettant d'identifier un composant cible dans un liquide au moyen dudit faisceau de capillaires, ainsi que des procédés de fabrication de ce faisceau. Elle porte également sur une chambre de réaction guidée par effet tensioactif, ainsi que sur des procédés et des opérations chimiques permettant de fabriquer et d'utiliser une telle chambre de réaction pour des essais de liaison et d'hybridation. Sont en outre décrits des systèmes garantissant un dosage précis de liquides dans les capillaires et au niveau des chambres de réaction, y compris du puits de réaction « virtuel » guidé par effet tensioactif. L'invention concerne également des criblages à fort débit réalisés au moyen de capillaires recouverts intérieurement de fibre optique. Les ensembles de capillaires s'utilisent aussi bien avec des sondes liquides qu'avec des sondes immobilisés sur leurs parois.
PCT/US2002/005316 2001-02-16 2002-02-19 Procede et dispositif reposant sur l'emploi de capillaires en faisceau pour criblage a fort debit Ceased WO2002078834A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002255581A AU2002255581A1 (en) 2001-02-16 2002-02-19 Bundled capillaries apparatus for high throughput screening

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US26964201P 2001-02-16 2001-02-16
US60/269,642 2001-02-16
US27100201P 2001-02-22 2001-02-22
US09/791,411 2001-02-22
US60/271,002 2001-02-22
US09/791,410 2001-02-22
US09/791,410 US20020028160A1 (en) 2000-02-22 2001-02-22 Method and apparatus based on bundled capillaries for high throughput screening
US09/791,411 US20010055801A1 (en) 2000-02-22 2001-02-22 Liquid arrays
US30273501P 2001-07-03 2001-07-03
US60/302,735 2001-07-03
US31474701P 2001-08-24 2001-08-24
US60/314,747 2001-08-24
US31528501P 2001-08-27 2001-08-27
US60/315,285 2001-08-27
US32768601P 2001-10-04 2001-10-04
US60/327,686 2001-10-04
US35727502P 2002-02-15 2002-02-15
US60/357,275 2002-02-15

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WO2002078834A3 true WO2002078834A3 (fr) 2003-06-05

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US7547556B2 (en) 1998-01-12 2009-06-16 Massachusetts Institute Of Technology Methods for filing a sample array by droplet dragging
US7604983B2 (en) 2000-02-18 2009-10-20 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US9266108B2 (en) 2004-03-12 2016-02-23 Life Technologies Corporation Nanoliter array loading

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CA2521999A1 (fr) 2002-12-20 2004-09-02 Biotrove, Inc. Appareil et procede de dosage utilisant des reseaux microfluidiques
FR2872290A1 (fr) * 2004-06-24 2005-12-30 Commissariat Energie Atomique Methode d'analyse hautement parallele de reactions enzymatiques et ses applications
WO2006005371A1 (fr) * 2004-07-13 2006-01-19 Commissariat A L'energie Atomique Dispositif microfluidique destine a effectuer une pluralite de reactions et ses utilisations
US7682816B2 (en) * 2005-04-07 2010-03-23 454 Life Sciences Corporation Thin film coated microwell arrays and methods of using same
US7785862B2 (en) 2005-04-07 2010-08-31 454 Life Sciences Corporation Thin film coated microwell arrays
EP1972937A4 (fr) * 2006-01-10 2011-03-02 Murata Manufacturing Co Substrat de reseau de sondes, procede de production correspondant et procede de production du reseau de sondes
EP1832874B1 (fr) * 2006-03-07 2009-06-03 Micronas Holding GmbH Surface d'un support avec des régions hydrophobes et hydrophiles
WO2016166295A1 (fr) * 2015-04-15 2016-10-20 Attomol Gmbh Molekulare Diagnostika Procédé pour la recherche d'un ou de plusieurs analytes, limitée à la chambre de réaction
EP3269444A1 (fr) * 2016-07-14 2018-01-17 Base4 Innovation Ltd Procédé d'identification de gouttelettes dans un empilement et séquenceur associé

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US7547556B2 (en) 1998-01-12 2009-06-16 Massachusetts Institute Of Technology Methods for filing a sample array by droplet dragging
US7604983B2 (en) 2000-02-18 2009-10-20 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US8906618B2 (en) 2000-02-18 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US9518299B2 (en) 2000-02-18 2016-12-13 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US9266108B2 (en) 2004-03-12 2016-02-23 Life Technologies Corporation Nanoliter array loading

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