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WO2002075282A1 - Tige a canal - Google Patents

Tige a canal Download PDF

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Publication number
WO2002075282A1
WO2002075282A1 PCT/SE2002/000460 SE0200460W WO02075282A1 WO 2002075282 A1 WO2002075282 A1 WO 2002075282A1 SE 0200460 W SE0200460 W SE 0200460W WO 02075282 A1 WO02075282 A1 WO 02075282A1
Authority
WO
WIPO (PCT)
Prior art keywords
rod
cup
channel
sample
fluid sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE2002/000460
Other languages
English (en)
Inventor
Mats RÅNBY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medirox AB
Global Hemostasis Institute MGR AB
Original Assignee
Medirox AB
Global Hemostasis Institute MGR AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medirox AB, Global Hemostasis Institute MGR AB filed Critical Medirox AB
Publication of WO2002075282A1 publication Critical patent/WO2002075282A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/10—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material
    • G01N11/16—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material by measuring damping effect upon oscillatory body
    • G01N11/162—Oscillations being torsional, e.g. produced by rotating bodies
    • G01N11/167—Sample holder oscillates, e.g. rotating crucible

Definitions

  • the present invention relates to a rod, especially for use in an apparatus for measuring viscoelastic properties of fluid samples, which apparatus comprises a movable cup and a stationary rod.
  • the present invention also relates to a rod and cup assembly.
  • the assembly is particularly suitable as a disposable article.
  • a rheometer typically consists of a cup or container with holds the sample, and a rod, bob or plate that is inserted into the sample but without physical contact with the cup or container.
  • the parts of the rheometer that are outside and inside the sample are referred to as cup and rod, respectively, and this regardless of their physical shape and number, unless otherwise specified.
  • the rheological properties, also called viscoelastic properties, of the sample are deduced from the forces that are displayed when the sample is strained, i.e. forces that are displayed when parts of the sample move or have been moved relative to each other. Movement between cup and rod is one way of inducing strain in the sample. In some rheometers forces are registered by either the cup or the rod, and the strain induced by the other. In other rheometers both strain induction and registration are restricted to one of the two, the second being passive, i.e. neither inducing strain nor registering forces.
  • the present invention pertains to rheometers with passive rods.
  • FOR free oscillation rheometer
  • such other rheometers with a passive rod are characterized by concepts like plate-cone, Couette, parallel plate, lateral movement, parallel movement, rotation, pumping, forced oscillation and forced resonance oscillation.
  • Free oscillation rheometry may be selected in advance of other rheometric techniques because it requires small sample volumes, allows low-cost disposables, determines viscosity of the magnitude displayed by water and can deliver correct viscoelastic information for biological gels, such as jams, creams, cheeses and coagulated blood and plasma.
  • FOR the sample (in practice the cup with sample inside) is set into free oscillation and the damping and frequency of the oscillation are measured.
  • the method was invented by Leif Bohlin ( Bohlin, L. Method for measuring rheological properties and rheometer for carrying out the method. WO 94/08222.
  • a convenient way to practice the method according to Bohlin is a torsion pendulum where the sample is set into oscillation around its axis. The frequency and damping of the oscillation are influenced by the rheological properties of the sample. By repeated initiations of the oscillation, rheological and rapid calculations rheological changes in the sample, the sample can be studied and displayed in real-time on a computer screen.
  • a torsion pendulum FOR can encompass a passive rod, which, if cylindrical in shape and placed in the center of the sample, will create a concentric tube of sample, the thickness of which is referred to as a gap. At some conditions, and if the level of liquid is adjusted to be unchanged, this passive rod has no influence on the determination.
  • Disposal equipment is also suitable if the analysis irreversibly alters the surfaces of, or in other ways destroys, the rod and/or the cup. Description of the drawings
  • Figure 1 shows a cross-sectional view of a first embodiment of a rod according to the invention in a cup.
  • Figure 2 shows a cross-sectional view of a second embodiment of a rod according to the invention in a cup
  • Figure 3 shows a cross-sectional view of a rod and cup assembly according to the invention.
  • Figure 4 shows a cross-sectional view of a third embodiment of a rod according to the invention in a cup.
  • Figure 5 shows a cross-sectional view of a fourth embodiment of a rod according to the invention.
  • the present invention provides an improved rod for use in an apparatus for viscoelastic measurements.
  • the rod is provided with one ore more channels for supplying or removing liquid samples or reagents to the measuring cup of the apparatus.
  • one aspect of the invention relates to a rod for use in an apparatus for measuring viscoelastic properties of fluid samples, which apparatus comprises a movable cup (1) and a stationary rod (2), having a first end (3) and a second end (4), the second end being intended for insertion into the cup (1), wherein the rod is provided with at least one channel (5) for supplying or removing fluid sample(s) or reagent(s) into or out of the cup.
  • rod is used to cover any suitable device that is used for immersion into a fluid sample placed in a cup in an apparatus for elastic measurements, and the rod is e.g. in . the form of a stick or a bob on a bob-shaft.
  • cup is used to cover any suitable vessel that is used for a fluid sample in an apparatus for viscoelastic measurements.
  • the second end (4) of the rod (2) will be inserted into the cup (1) prior to supplying samples and/or reagents.
  • the samples and or reagents are thereafter supplied through one or more channels (5) of the rod into the cup.
  • Channels in the rod (2) can also be used for removal of sample from the cup (1), before, during or after the measuring operation.
  • the supply and/or removal of samples and/or reagents to or from the cup through a channel in the rod essentially simplifies the handling, since the supply/removal does not require such a great precision. It further reduces the drawback of the staff being exposed to hazardous samples and/or reagents, since the staff nee not come into direct contact with the sample and/or reagent.
  • the sample or reagent must be fluid, i.e. liquid, gas, powder, emulsion or suspension.
  • One or more samples and/or reagents might be supplied or removed through the rod channel(s).
  • At least one channel (5) extends from an inlet/outlet (7) on the rod that is positioned at a distance from the second end (4) of the rod, through the rod and to an outlet/inlet (11) at the second end (4) of the rod.
  • the distance between the openings of the channel is preferably exceeding the depth of the cup.
  • At least one channel extends to the bottom (6) of said second end (4) of the rod. This end of the channel will be inserted into the cup before supplying samples and/or reagents.
  • the inlet/outlet of at least one channel is situated at said first end (3) of the rod, i.e. at or near the top of the rod when it is an upright position.
  • At least one channel has an extension parallel to the longitudinal axis of the rod.
  • one channel has an extension, which coincides with the longitudinal axis of the rod.
  • At least one channel (5) is adapted to embrace a syringe (51) with which fluid sample(s) or reagent(s) can be supplied to or removed from the cup. More specifically a section (8) of at least one channel (5) facing the first end (3) of the rod (2) has dimensions adapted to embrace the barrel (52) of the syringe, whereas a section (9) of said channel facing the second end (4) is tapered to fit the narrow end (53) of the syringe.
  • the cross-section of the channel is about the same as the cross-section of the syringe, so that the barrel of the syringe can be fully inserted into the channel of the rod, thus leading to a very easy and safe supply of the sample and/or reagent .to the cup. Since the syringe exactly fits into the channel, unintentional use of a larger syringe is avoided thus giving no risk for supplying too much sample to the cup. This is a great advantage since overflow of sample would flow out into the interior of the apparatus and in the worst case damage the apparatus.
  • the rod is provided with at least two channels (5, 10) wherein a first channel (5) extends to a point (11) at the second end (4) of the rod, which point is intended to be situated below the desired surface level (12) of the fluid sample (13) in the cup (1) during measuring, and wherein a second channel (10) extends to a point (14) at the second end (4) of the rod that equals the desired surface level (12) of fluid sample in the cup.
  • one or more of the inlets/outlets can be provided with membranes of elastic material so that the supplying and/or removal of sample and/or reagent is accomplished with a hypodermic needle pierced through the membrane.
  • At least one channel consists of a main channel with an outlet/inlet at the second end (4) of the rod and at least two inlets/outlets (22, 23; 42,43) at the first end (3) of the rod.
  • samples and/or reagents can be supplied simultaneously.
  • samples and/or reagents can be supplied to the cup through the main channel via an inlet, and be removed from the cup through an outlet via the same main channel.
  • the rod consists of a shaft (31) and a bob (32).
  • the bob is detachable.
  • the bob is thus exchangeable, indicating that different types of bobs can be used together with the same shaft or that disposable bobs can be used, while the shaft is recycled.
  • Another advantage with a detachable bob appears if a surface modification is required for the surfaces, which are to be in contact with the fluid sample, for example a bob coated with noble metal.
  • the surface modified bob can then be attached to the shaft, to form a rod according to the invention, and be used in performing the viscoelastic analysis.
  • a rod and cup assembly comprising a rod according to the invention.
  • the rod and/or the cup is provided with means for attaching a cup to the second end of the rod. This leads to the opportunity of inserting the rod and cup as one assembly into the measuring apparatus, which simplifies the handling of the equipment. It might also be especially advantageous in cases where extraordinary high level of cleanliness is required to avoid contamination of the sample. Providing the rod and cup as an engaged assembly also decreases the contact between sample and operator, which is important when handling infectious samples.
  • a disposable rod-cup assembly may, after the analysis, be removed from the instrument and disposed with a minimum of risk. It is emphasized that there has been practically no possibility to use an engaged rod-cup assembly, according to prior art, since no convenient means of supplying the sample to the cup has been available. ' The attaching means specifically involves protruding edges (33, 34) extending from the cup and/or the rod. This indicates that a cup can be attached, loosely hanging, to the rod. When such an assembly is inserted into a measuring apparatus, the cup will be lifted off the protruding edges and will thus be free to move in relation to the rod. Such rod and cup assemblies can be delivered as disposal articles, which simplifies the handling and is especially advantageous when performing measurements on hazardous samples. Moreover, disposal equipment is advantageous when performing measurements on samples, which destroy the cup and/or the rod.
  • the described rod and cup assembly is particularly suitable for measuring changes of the viscoelastic properties of a sample during a reaction, e.g. polymerization or curing of polymers, curing of two-component adhesives or coagulation of blood.
  • a rod provided with two or more channels is especially suitable.
  • the rod can be made of any. suitable material, such as thermoplastic material, thermosetting plastics, rubber or metal. It can be formed by molding or turning or any other suitable forming method. As an example, injection molding of thermoplastic material would be appropriate for the manufacture of rods.
  • the rod might also be provided with a surface coating if desired.

Landscapes

  • Investigating Or Analysing Biological Materials (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)

Abstract

L'invention concerne une tige s'utilisant dans un appareil qui sert à mesurer les propriétés viscoélastiques d'un échantillon liquide. Cet appareil comprend une coupelle amovible et une tige fixe. L'invention concerne par ailleurs de nombreux modes de réalisation comprenant tous au moins un canal qui sert à introduire ou à retirer un ou plusieurs échantillons ou réactifs dans la coupelle. Enfin, l'invention concerne un ensemble tige-coupelle dans lequel la tige et la coupelle sont correctement associés, tels une unité solidaire.
PCT/SE2002/000460 2001-03-16 2002-03-13 Tige a canal Ceased WO2002075282A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0100918-2 2001-03-16
SE0100918A SE0100918D0 (sv) 2001-03-16 2001-03-16 Rod provided with channel

Publications (1)

Publication Number Publication Date
WO2002075282A1 true WO2002075282A1 (fr) 2002-09-26

Family

ID=20283390

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2002/000460 Ceased WO2002075282A1 (fr) 2001-03-16 2002-03-13 Tige a canal

Country Status (2)

Country Link
SE (1) SE0100918D0 (fr)
WO (1) WO2002075282A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3574321A1 (fr) * 2017-01-26 2019-12-04 enicor GmbH Dispositifs et procédés de mesure de changements viscoélastiques d'un échantillon

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154093A (en) * 1977-04-12 1979-05-15 Imperial Chemical Industries Limited Measurement of viscoelastic properties
US4602501A (en) * 1983-05-31 1986-07-29 Keisuke Hirata Rheometer
US5327778A (en) * 1992-02-10 1994-07-12 Park Noh A Apparatus and method for viscosity measurements using a controlled needle viscometer
WO1997039332A1 (fr) * 1996-04-18 1997-10-23 Corning Incorporated Rheometre destine a des suspensions a forte teneur en particules solides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154093A (en) * 1977-04-12 1979-05-15 Imperial Chemical Industries Limited Measurement of viscoelastic properties
US4602501A (en) * 1983-05-31 1986-07-29 Keisuke Hirata Rheometer
US5327778A (en) * 1992-02-10 1994-07-12 Park Noh A Apparatus and method for viscosity measurements using a controlled needle viscometer
WO1997039332A1 (fr) * 1996-04-18 1997-10-23 Corning Incorporated Rheometre destine a des suspensions a forte teneur en particules solides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3574321A1 (fr) * 2017-01-26 2019-12-04 enicor GmbH Dispositifs et procédés de mesure de changements viscoélastiques d'un échantillon

Also Published As

Publication number Publication date
SE0100918D0 (sv) 2001-03-16

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