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WO2002072268A1 - Dispositif de support pour substrat - Google Patents

Dispositif de support pour substrat Download PDF

Info

Publication number
WO2002072268A1
WO2002072268A1 PCT/EP2002/002446 EP0202446W WO02072268A1 WO 2002072268 A1 WO2002072268 A1 WO 2002072268A1 EP 0202446 W EP0202446 W EP 0202446W WO 02072268 A1 WO02072268 A1 WO 02072268A1
Authority
WO
WIPO (PCT)
Prior art keywords
opening
plates
openings
shielding member
plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/002446
Other languages
English (en)
Inventor
Hendrik Sibolt Van Damme
Wilhelmus Marinus Carpaij
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PamGene BV
Original Assignee
PamGene BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PamGene BV filed Critical PamGene BV
Priority to DE60212089T priority Critical patent/DE60212089T2/de
Priority to EP02724203A priority patent/EP1370360B1/fr
Priority to JP2002571220A priority patent/JP2004531707A/ja
Publication of WO2002072268A1 publication Critical patent/WO2002072268A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Definitions

  • H H- 13 03 ⁇ 0 ⁇ ⁇ ⁇ ⁇ ⁇ tQ ⁇ 0 ⁇ ⁇ 3 ⁇ ⁇ ! 3 ⁇ i ⁇ rt ⁇ ⁇ 13 * t-> ⁇ ii •d M Ml ⁇ - ⁇ ft ) 03 Mi r rt 0 ⁇ ii ⁇ ⁇ rt ii
  • Figs. 2 and 3 show a device for holding the substrate 1 during performing an assay.
  • the device 5 comprises upper and lower plates 6,7, wherein in the embodiment shown each plate 6,7 is provided with an array of four openings 8,9.
  • the upper and lower plates 6,7 are made of a suitable plastic material in an injection moulding process for example.
  • the upper and lower plates 6,7 are adapted to receive the substrate 1 sandwiched in the interface 10 between the plates 6,7.
  • the openings 8,9 are partially aligned, wherein the axes of openings 9 in the lower plate 7 are staggered with respect to the axes of openings 8 in the upper plate 6.
  • each opening 8 of the upper plate 6 is surrounded by an upwardly projecting rim 11 and each opening 9 in the lower plate 7 is surrounded by a downwardly projecting rim 12.
  • the openings 8,9 are circular and the rims 11,12 are made as cylindrical structures.
  • Each shielding member 13 has a wedge-shaped cross-section in the embodiment shown having a preferably flat upper surface 14 inclined with respect to the interface 10 of the plates 6,7. In this manner a fluid passing through the capillary channels will gradually contact the upper surface 14 from the left to right according to the cross- section of fig. 3 thus avoiding enclosing of air bubbles.
  • the angle of inclination of the upper surface 14 of the shielding member 13 is preferably at least 5°.
  • the staggering of the lower openings 9 with respect to the upper openings 8 allows for a complete screening of the openings 9 if the device 5 is viewed from the top side. In this manner a real time reading of the areas 4 of the substrate 1 is possible when the sample fluid is fully transported to the lower side of the sub- strate 1. Any background signal caused by free label in the sample fluid under the substrate 1 is avoided.
  • the shape of the shielding member 13 with the inclined upper surface 14 further improves the mixing of the sample fluid during transporting the sample fluid through the capil- lary channels of the substrate 1.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Dram (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Reinforced Plastic Materials (AREA)
  • External Artificial Organs (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)

Abstract

L'invention concerne un dispositif de support pour substrat, comprenant une plaque supérieure et une plaque inférieure conçues pour recevoir le substrat en sandwich dans l'interface située entre les plaques. Chaque plaque possède au moins une ouverture équipée d'un rebord saillant entourant l'ouverture et s'éloignant de l'interface. Les ouvertures situées dans la plaque supérieure et la plaque inférieure sont au moins en partie alignées lorsque les plaques sont en sandwich. Chaque ouverture de la plaque inférieure peut comprendre un élément de protection destiné à protéger en partie l'ouverture de la plaque inférieure.
PCT/EP2002/002446 2001-03-13 2002-03-05 Dispositif de support pour substrat Ceased WO2002072268A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE60212089T DE60212089T2 (de) 2001-03-13 2002-03-05 Haltesystem für ein substrat
EP02724203A EP1370360B1 (fr) 2001-03-13 2002-03-05 Dispositif de support pour substrat
JP2002571220A JP2004531707A (ja) 2001-03-13 2002-03-05 基板保持装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200947.8 2001-03-13
EP01200947 2001-03-13

Publications (1)

Publication Number Publication Date
WO2002072268A1 true WO2002072268A1 (fr) 2002-09-19

Family

ID=8180010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/002446 Ceased WO2002072268A1 (fr) 2001-03-13 2002-03-05 Dispositif de support pour substrat

Country Status (6)

Country Link
EP (1) EP1370360B1 (fr)
JP (1) JP2004531707A (fr)
AT (1) ATE328665T1 (fr)
DE (1) DE60212089T2 (fr)
ES (1) ES2266488T3 (fr)
WO (1) WO2002072268A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4687756B2 (ja) * 2008-07-07 2011-05-25 株式会社村田製作所 プローブアレイおよびその製造方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427415A (en) * 1979-01-05 1984-01-24 Cleveland Patrick H Manifold vacuum biochemical test method and device
US4549655A (en) * 1983-12-05 1985-10-29 E. I. Du Pont De Nemours And Company Container for a layered chemical analysis system
US4948564A (en) * 1986-10-28 1990-08-14 Costar Corporation Multi-well filter strip and composite assemblies
US5366902A (en) * 1990-10-30 1994-11-22 Hypoguard (Uk) Limited Collection and display device
WO1999023475A1 (fr) * 1997-10-31 1999-05-14 Dade Behring Inc. Dispositif d'analyse chromogene et turbidimetrique
WO1999061152A1 (fr) * 1998-05-26 1999-12-02 Mj Research, Inc. Cartouche de prelevement en forme de microplaquette pouvant etre automatisee
WO2001019517A1 (fr) * 1999-09-14 2001-03-22 Pamgene, B.V. Dispositif analytique d'essai comprenant un substrat a canaux traversants et procedes d'utilisation et appareil perfectionnes

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427415A (en) * 1979-01-05 1984-01-24 Cleveland Patrick H Manifold vacuum biochemical test method and device
US4549655A (en) * 1983-12-05 1985-10-29 E. I. Du Pont De Nemours And Company Container for a layered chemical analysis system
US4948564A (en) * 1986-10-28 1990-08-14 Costar Corporation Multi-well filter strip and composite assemblies
US5366902A (en) * 1990-10-30 1994-11-22 Hypoguard (Uk) Limited Collection and display device
WO1999023475A1 (fr) * 1997-10-31 1999-05-14 Dade Behring Inc. Dispositif d'analyse chromogene et turbidimetrique
WO1999061152A1 (fr) * 1998-05-26 1999-12-02 Mj Research, Inc. Cartouche de prelevement en forme de microplaquette pouvant etre automatisee
WO2001019517A1 (fr) * 1999-09-14 2001-03-22 Pamgene, B.V. Dispositif analytique d'essai comprenant un substrat a canaux traversants et procedes d'utilisation et appareil perfectionnes

Also Published As

Publication number Publication date
EP1370360B1 (fr) 2006-06-07
ES2266488T3 (es) 2007-03-01
JP2004531707A (ja) 2004-10-14
ATE328665T1 (de) 2006-06-15
DE60212089T2 (de) 2007-01-04
EP1370360A1 (fr) 2003-12-17
DE60212089D1 (de) 2006-07-20

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